Motif ID: Sox3_Sox10

Z-value: 2.376

Transcription factors associated with Sox3_Sox10:

Gene SymbolEntrez IDGene Name
Sox10 ENSMUSG00000033006.9 Sox10
Sox3 ENSMUSG00000045179.8 Sox3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox10mm10_v2_chr15_-_79164477_79164496-0.481.4e-04Click!
Sox3mm10_v2_chrX_-_60893430_60893440-0.321.4e-02Click!


Activity profile for motif Sox3_Sox10.

activity profile for motif Sox3_Sox10


Sorted Z-values histogram for motif Sox3_Sox10

Sorted Z-values for motif Sox3_Sox10



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox3_Sox10

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_79355082 39.406 ENSMUST00000068958.7
 Cdc42ep3
CDC42 effector protein (Rho GTPase binding) 3
chr11_-_98329641 37.227 ENSMUST00000041685.6
 Neurod2
neurogenic differentiation 2
chr11_+_67586520 36.820 ENSMUST00000108682.2
 Gas7
growth arrest specific 7
chrX_-_143933089 36.732 ENSMUST00000087313.3
 Dcx
doublecortin
chrX_-_143933204 35.851 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr8_-_84773381 34.152 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr18_+_37484955 33.567 ENSMUST00000053856.4
 Pcdhb17
protocadherin beta 17
chr11_+_67586675 31.171 ENSMUST00000108680.1
 Gas7
growth arrest specific 7
chr18_-_43059418 30.478 ENSMUST00000025377.7
 Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr4_-_82705735 29.767 ENSMUST00000155821.1
 Nfib
nuclear factor I/B
chr1_+_34579693 28.889 ENSMUST00000052670.8
 Amer3
APC membrane recruitment 3
chr10_-_29144194 27.078 ENSMUST00000070359.2
 Gm9996
predicted gene 9996
chr2_-_156312470 26.867 ENSMUST00000079125.6
 Scand1
SCAN domain-containing 1
chr13_-_14523178 26.602 ENSMUST00000110516.2
 Hecw1
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
chr10_+_29143996 25.552 ENSMUST00000092629.2
 Soga3
SOGA family member 3
chr6_+_51432663 23.776 ENSMUST00000005103.5
 Nfe2l3
nuclear factor, erythroid derived 2, like 3
chr9_+_112234257 23.540 ENSMUST00000149308.3
ENSMUST00000144424.2
ENSMUST00000139552.2
 2900079G21Rik


RIKEN cDNA 2900079G21 gene


chr6_-_13839916 22.233 ENSMUST00000060442.7
 Gpr85
G protein-coupled receptor 85
chr4_-_148130678 21.744 ENSMUST00000030862.4
 Draxin
dorsal inhibitory axon guidance protein
chr1_+_136131382 20.675 ENSMUST00000075164.4
 Kif21b
kinesin family member 21B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 338 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.6 106.0 GO:0021819 layer formation in cerebral cortex(GO:0021819)
4.3 69.4 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
0.4 54.1 GO:0030041 actin filament polymerization(GO:0030041)
4.1 49.0 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
13.7 41.1 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.6 39.9 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.2 34.4 GO:0007018 microtubule-based movement(GO:0007018)
2.3 32.7 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
1.8 32.4 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194) negative regulation of cyclase activity(GO:0031280)
0.5 31.9 GO:0021954 central nervous system neuron development(GO:0021954)
0.3 31.1 GO:0010506 regulation of autophagy(GO:0010506)
4.4 30.5 GO:0034047 regulation of protein phosphatase type 2A activity(GO:0034047)
7.4 29.8 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.5 29.8 GO:0000045 autophagosome assembly(GO:0000045)
0.2 26.5 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
8.6 25.7 GO:0042560 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
4.9 24.4 GO:0046684 response to pyrethroid(GO:0046684)
1.2 23.9 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
5.8 23.3 GO:1904529 regulation of actin filament binding(GO:1904529) regulation of actin binding(GO:1904616)
2.1 22.8 GO:0086018 SA node cell action potential(GO:0086015) SA node cell to atrial cardiac muscle cell signalling(GO:0086018) SA node cell to atrial cardiac muscle cell communication(GO:0086070)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 146 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 209.2 GO:0030425 dendrite(GO:0030425)
3.0 75.9 GO:0071565 nBAF complex(GO:0071565)
7.0 70.0 GO:0045298 tubulin complex(GO:0045298)
1.3 57.3 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.5 50.1 GO:0005884 actin filament(GO:0005884)
0.9 45.3 GO:0031941 filamentous actin(GO:0031941)
4.9 44.2 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
2.5 39.3 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.5 35.1 GO:0005871 kinesin complex(GO:0005871)
1.8 34.1 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.5 33.8 GO:0042734 presynaptic membrane(GO:0042734)
1.4 29.8 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.5 28.2 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.5 26.6 GO:0030173 integral component of Golgi membrane(GO:0030173)
6.0 24.1 GO:0044307 dendritic branch(GO:0044307)
0.5 23.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.5 21.4 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.2 19.9 GO:0045211 postsynaptic membrane(GO:0045211)
3.2 19.4 GO:1990635 proximal dendrite(GO:1990635)
0.3 19.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 237 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 86.3 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.5 83.1 GO:0008017 microtubule binding(GO:0008017)
3.2 72.9 GO:0034185 apolipoprotein binding(GO:0034185)
3.0 71.4 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.2 55.3 GO:0003779 actin binding(GO:0003779)
6.3 50.5 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.6 37.2 GO:0003777 microtubule motor activity(GO:0003777)
0.5 35.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.7 32.0 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
2.0 31.5 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
1.5 31.1 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
2.2 30.5 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
5.6 28.2 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
1.6 26.9 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
2.0 26.5 GO:0031005 filamin binding(GO:0031005)
1.9 26.5 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.9 26.4 GO:0030552 cAMP binding(GO:0030552)
8.6 25.7 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.7 24.1 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
1.1 24.0 GO:0017049 GTP-Rho binding(GO:0017049)