Motif ID: Sox4

Z-value: 0.353


Transcription factors associated with Sox4:

Gene SymbolEntrez IDGene Name
Sox4 ENSMUSG00000076431.4 Sox4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox4mm10_v2_chr13_-_28953690_28953713-0.684.1e-09Click!


Activity profile for motif Sox4.

activity profile for motif Sox4


Sorted Z-values histogram for motif Sox4

Sorted Z-values for motif Sox4



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox4

PNG image of the network

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Top targets:


Showing 1 to 20 of 108 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_103853199 8.418 ENSMUST00000033229.3
 Hbb-y
hemoglobin Y, beta-like embryonic chain
chrX_+_73639414 3.646 ENSMUST00000019701.8
 Dusp9
dual specificity phosphatase 9
chr17_-_70851189 3.312 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr3_+_131110350 2.434 ENSMUST00000066849.6
ENSMUST00000106341.2
ENSMUST00000029611.7
 Lef1


lymphoid enhancer binding factor 1


chr7_+_45216671 2.193 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr13_+_117220584 2.152 ENSMUST00000022242.7
 Emb
embigin
chr4_+_115057683 1.775 ENSMUST00000161601.1
 Tal1
T cell acute lymphocytic leukemia 1
chr17_-_70853482 1.768 ENSMUST00000118283.1
 Tgif1
TGFB-induced factor homeobox 1
chr9_-_32541589 1.722 ENSMUST00000016231.7
 Fli1
Friend leukemia integration 1
chr7_+_100493795 1.711 ENSMUST00000129324.1
 Ucp2
uncoupling protein 2 (mitochondrial, proton carrier)
chr14_+_27039001 1.650 ENSMUST00000035336.3
 Il17rd
interleukin 17 receptor D
chr12_-_54986363 1.583 ENSMUST00000173433.1
ENSMUST00000173803.1
 Baz1a
Gm20403
bromodomain adjacent to zinc finger domain 1A
predicted gene 20403
chr7_+_127233044 1.539 ENSMUST00000106312.3
 Zfp553
zinc finger protein 553
chr1_+_153665274 1.508 ENSMUST00000152114.1
ENSMUST00000111812.1
 Rgs8

regulator of G-protein signaling 8

chr1_+_59482133 1.486 ENSMUST00000114246.2
ENSMUST00000037105.6
 Fzd7

frizzled homolog 7 (Drosophila)

chr12_+_24708984 1.484 ENSMUST00000154588.1
 Rrm2
ribonucleotide reductase M2
chr19_+_56874249 1.461 ENSMUST00000026068.7
 Vwa2
von Willebrand factor A domain containing 2
chr9_+_85842852 1.417 ENSMUST00000098500.3
 Tpbg
trophoblast glycoprotein
chr15_+_102296256 1.401 ENSMUST00000064924.4
 Espl1
extra spindle poles-like 1 (S. cerevisiae)
chr7_+_127233227 1.375 ENSMUST00000056232.6
 Zfp553
zinc finger protein 553

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 8.4 GO:0015671 oxygen transport(GO:0015671)
0.3 5.1 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.2 3.6 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.3 3.1 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.0 2.5 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.8 2.4 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
0.1 2.2 GO:0048368 notochord development(GO:0030903) lateral mesoderm development(GO:0048368)
0.6 1.8 GO:0060217 hemangioblast cell differentiation(GO:0060217)
0.1 1.7 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.1 1.7 GO:0035855 megakaryocyte development(GO:0035855)
0.1 1.6 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.5 1.5 GO:0007161 calcium-independent cell-matrix adhesion(GO:0007161)
0.4 1.5 GO:2000383 regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
0.1 1.5 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.1 1.5 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.2 1.4 GO:1901970 positive regulation of mitotic sister chromatid separation(GO:1901970)
0.2 1.3 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.3 1.2 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.2 1.2 GO:0031642 negative regulation of myelination(GO:0031642)
0.1 1.2 GO:0048853 forebrain morphogenesis(GO:0048853)

Gene overrepresentation in cellular_component category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 8.4 GO:0005833 hemoglobin complex(GO:0005833)
0.5 2.5 GO:0008623 CHRAC(GO:0008623)
0.2 2.4 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.6 1.8 GO:0033193 Lsd1/2 complex(GO:0033193)
0.3 1.5 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0 1.5 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 1.5 GO:0005604 basement membrane(GO:0005604)
0.4 1.3 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.0 1.2 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.2 GO:0072686 mitotic spindle(GO:0072686)
0.0 1.1 GO:0008180 COP9 signalosome(GO:0008180)
0.0 1.1 GO:0031985 Golgi cisterna(GO:0031985)
0.1 1.0 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 0.8 GO:0033269 internode region of axon(GO:0033269)
0.1 0.7 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.7 GO:0036038 MKS complex(GO:0036038)
0.2 0.6 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.0 0.5 GO:0097225 sperm midpiece(GO:0097225)
0.1 0.4 GO:0097543 ciliary inversin compartment(GO:0097543)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 8.4 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.2 5.1 GO:0070410 co-SMAD binding(GO:0070410)
0.0 4.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 3.6 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.4 2.4 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 2.4 GO:0030165 PDZ domain binding(GO:0030165)
0.0 2.2 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 1.8 GO:0070888 E-box binding(GO:0070888)
0.6 1.7 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.2 1.7 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 1.6 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.3 1.5 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.1 1.5 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 1.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 1.4 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.2 1.2 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 1.2 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.4 1.1 GO:0043532 angiostatin binding(GO:0043532)
0.3 1.0 GO:0004921 interleukin-11 receptor activity(GO:0004921) interleukin-11 binding(GO:0019970)
0.1 1.0 GO:0008430 selenium binding(GO:0008430)