Motif ID: Sox5_Sry

Z-value: 1.801

Transcription factors associated with Sox5_Sry:

Gene SymbolEntrez IDGene Name
Sox5 ENSMUSG00000041540.10 Sox5
Sry ENSMUSG00000069036.3 Sry

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox5mm10_v2_chr6_-_144209558_1442096470.705.7e-10Click!


Activity profile for motif Sox5_Sry.

activity profile for motif Sox5_Sry


Sorted Z-values histogram for motif Sox5_Sry

Sorted Z-values for motif Sox5_Sry



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox5_Sry

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_98329641 46.133 ENSMUST00000041685.6
 Neurod2
neurogenic differentiation 2
chr4_-_82505274 24.971 ENSMUST00000050872.8
ENSMUST00000064770.2
 Nfib

nuclear factor I/B

chr8_-_84773381 23.017 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr4_-_82505749 21.438 ENSMUST00000107245.2
ENSMUST00000107246.1
 Nfib

nuclear factor I/B

chr4_-_82505707 21.437 ENSMUST00000107248.1
ENSMUST00000107247.1
 Nfib

nuclear factor I/B

chr12_+_29528382 20.228 ENSMUST00000049784.9
 Myt1l
myelin transcription factor 1-like
chr5_+_17574268 17.927 ENSMUST00000030568.7
 Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr9_-_49798729 17.695 ENSMUST00000166811.2
 Ncam1
neural cell adhesion molecule 1
chr10_+_69706326 16.466 ENSMUST00000182992.1
 Ank3
ankyrin 3, epithelial
chr4_-_129121889 14.391 ENSMUST00000139450.1
ENSMUST00000125931.1
ENSMUST00000116444.2
 Hpca


hippocalcin


chr18_-_43059418 13.342 ENSMUST00000025377.7
 Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr1_+_19103022 12.635 ENSMUST00000037294.7
 Tfap2d
transcription factor AP-2, delta
chr3_+_18054258 12.399 ENSMUST00000026120.6
 Bhlhe22
basic helix-loop-helix family, member e22
chr3_+_95160449 12.319 ENSMUST00000090823.1
ENSMUST00000090821.3
 Sema6c

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C

chr18_+_69344503 12.244 ENSMUST00000114985.3
 Tcf4
transcription factor 4
chr18_+_69593361 12.236 ENSMUST00000114978.2
ENSMUST00000114977.1
 Tcf4

transcription factor 4

chr1_+_143640664 12.155 ENSMUST00000038252.2
 B3galt2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr4_+_13743424 11.895 ENSMUST00000006761.3
 Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr3_+_127633134 11.717 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chr9_-_49798905 10.806 ENSMUST00000114476.2
 Ncam1
neural cell adhesion molecule 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 157 entries
Log-likelihood per target Total log-likelihoodTermDescription
18.8 75.3 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
4.4 48.2 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
15.4 46.1 GO:2000297 negative regulation of synapse maturation(GO:2000297)
2.2 30.3 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
9.5 28.5 GO:0001928 regulation of exocyst assembly(GO:0001928)
2.4 24.5 GO:0042118 endothelial cell activation(GO:0042118)
0.6 22.7 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843)
1.0 18.7 GO:0021860 pyramidal neuron development(GO:0021860)
2.6 17.9 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.4 16.1 GO:0006376 mRNA splice site selection(GO:0006376)
4.8 14.4 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
1.9 13.3 GO:0034047 regulation of protein phosphatase type 2A activity(GO:0034047)
2.1 12.4 GO:0021960 anterior commissure morphogenesis(GO:0021960)
0.9 12.2 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.4 11.6 GO:0030204 chondroitin sulfate metabolic process(GO:0030204)
0.1 11.2 GO:0043488 regulation of mRNA stability(GO:0043488)
2.5 10.1 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.3 9.9 GO:0060074 synapse maturation(GO:0060074)
1.4 9.6 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.7 9.2 GO:0032808 lacrimal gland development(GO:0032808)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 74 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.6 75.3 GO:0044300 cerebellar mossy fiber(GO:0044300)
2.4 48.2 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.3 42.6 GO:0031225 anchored component of membrane(GO:0031225)
1.4 14.4 GO:0044327 dendritic spine head(GO:0044327)
0.0 14.3 GO:0005874 microtubule(GO:0005874)
0.7 13.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.9 11.7 GO:0042788 polysomal ribosome(GO:0042788)
0.3 9.4 GO:0032809 neuronal cell body membrane(GO:0032809)
0.6 9.2 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
2.3 9.1 GO:0031673 H zone(GO:0031673)
0.0 9.0 GO:0005802 trans-Golgi network(GO:0005802)
0.0 7.8 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.1 7.2 GO:0016363 nuclear matrix(GO:0016363)
1.7 6.7 GO:0097165 nuclear stress granule(GO:0097165)
0.6 6.4 GO:0005677 chromatin silencing complex(GO:0005677)
0.1 6.2 GO:0005905 clathrin-coated pit(GO:0005905)
0.3 5.9 GO:0031430 M band(GO:0031430)
0.0 5.9 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.2 5.8 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.8 5.7 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 97 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 68.3 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
1.8 54.1 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
1.1 46.2 GO:0070888 E-box binding(GO:0070888)
1.6 32.0 GO:0030275 LRR domain binding(GO:0030275)
0.1 25.9 GO:0008017 microtubule binding(GO:0008017)
3.1 25.2 GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
6.1 24.5 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.8 22.7 GO:0030215 semaphorin receptor binding(GO:0030215)
0.8 18.7 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.5 18.4 GO:0017091 AU-rich element binding(GO:0017091)
0.1 18.0 GO:0008270 zinc ion binding(GO:0008270)
1.6 17.9 GO:0038191 neuropilin binding(GO:0038191)
0.1 14.9 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 14.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
1.0 13.3 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
1.9 13.2 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.2 12.5 GO:0044824 integrase activity(GO:0008907) T/G mismatch-specific endonuclease activity(GO:0043765) retroviral integrase activity(GO:0044823) retroviral 3' processing activity(GO:0044824)
0.1 11.9 GO:0051117 ATPase binding(GO:0051117)
2.0 10.0 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.0 9.1 GO:0061630 ubiquitin protein ligase activity(GO:0061630)