Motif ID: Sox6_Sox9

Z-value: 0.700

Transcription factors associated with Sox6_Sox9:

Gene SymbolEntrez IDGene Name
Sox6 ENSMUSG00000051910.7 Sox6
Sox9 ENSMUSG00000000567.5 Sox9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox9mm10_v2_chr11_+_112782182_112782248-0.436.3e-04Click!
Sox6mm10_v2_chr7_-_116038734_116038750-0.228.7e-02Click!


Activity profile for motif Sox6_Sox9.

activity profile for motif Sox6_Sox9


Sorted Z-values histogram for motif Sox6_Sox9

Sorted Z-values for motif Sox6_Sox9



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox6_Sox9

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_29528382 9.843 ENSMUST00000049784.9
 Myt1l
myelin transcription factor 1-like
chr11_-_98329641 9.231 ENSMUST00000041685.6
 Neurod2
neurogenic differentiation 2
chr18_+_37484955 6.028 ENSMUST00000053856.4
 Pcdhb17
protocadherin beta 17
chr8_-_84773381 5.989 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr18_-_43059418 5.143 ENSMUST00000025377.7
 Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr17_+_55445550 5.134 ENSMUST00000025000.3
 St6gal2
beta galactoside alpha 2,6 sialyltransferase 2
chr17_-_79355082 4.753 ENSMUST00000068958.7
 Cdc42ep3
CDC42 effector protein (Rho GTPase binding) 3
chr10_-_29144194 4.479 ENSMUST00000070359.2
 Gm9996
predicted gene 9996
chr5_+_66968559 4.442 ENSMUST00000127184.1
 Limch1
LIM and calponin homology domains 1
chr10_+_69534039 4.419 ENSMUST00000182557.1
 Ank3
ankyrin 3, epithelial
chr11_+_67586520 4.408 ENSMUST00000108682.2
 Gas7
growth arrest specific 7
chr5_+_66968416 4.366 ENSMUST00000038188.7
 Limch1
LIM and calponin homology domains 1
chr9_-_29411736 4.171 ENSMUST00000115236.1
 Ntm
neurotrimin
chr1_-_56972437 4.008 ENSMUST00000042857.7
 Satb2
special AT-rich sequence binding protein 2
chr5_+_3928033 3.988 ENSMUST00000143365.1
 Akap9
A kinase (PRKA) anchor protein (yotiao) 9
chr10_+_29143996 3.980 ENSMUST00000092629.2
 Soga3
SOGA family member 3
chr9_-_29412204 3.931 ENSMUST00000115237.1
 Ntm
neurotrimin
chr7_+_96210107 3.889 ENSMUST00000138760.1
 Tenm4
teneurin transmembrane protein 4
chr9_+_27790947 3.856 ENSMUST00000115243.2
 Opcml
opioid binding protein/cell adhesion molecule-like
chr10_-_83534130 3.848 ENSMUST00000020497.7
 Aldh1l2
aldehyde dehydrogenase 1 family, member L2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 147 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.5 10.4 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.4 7.2 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.4 6.0 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.3 5.2 GO:0021819 layer formation in cerebral cortex(GO:0021819)
0.7 5.1 GO:0034047 regulation of protein phosphatase type 2A activity(GO:0034047)
0.3 5.1 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.1 5.1 GO:0007019 microtubule depolymerization(GO:0007019)
0.4 4.8 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.2 4.8 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 4.8 GO:0010977 negative regulation of neuron projection development(GO:0010977)
1.1 4.6 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.5 4.6 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.0 4.6 GO:0010506 regulation of autophagy(GO:0010506)
0.4 4.4 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 4.1 GO:0030705 cytoskeleton-dependent intracellular transport(GO:0030705)
0.0 4.0 GO:0051017 actin filament bundle assembly(GO:0051017)
1.3 3.9 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
1.0 3.9 GO:0032289 central nervous system myelin formation(GO:0032289) cardiac cell fate specification(GO:0060912)
1.3 3.8 GO:0042560 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
0.6 3.8 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 71 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.4 GO:0030425 dendrite(GO:0030425)
1.8 7.2 GO:0044307 dendritic branch(GO:0044307)
0.0 5.8 GO:0005884 actin filament(GO:0005884)
0.3 5.1 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
1.2 4.6 GO:0097165 nuclear stress granule(GO:0097165)
1.1 4.6 GO:0043259 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259)
0.2 4.4 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 4.3 GO:0005871 kinesin complex(GO:0005871)
0.0 4.0 GO:0031225 anchored component of membrane(GO:0031225)
0.2 3.6 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 3.2 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 2.9 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.1 2.6 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.3 2.5 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.2 2.3 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 2.3 GO:0009925 basal plasma membrane(GO:0009925)
0.1 2.2 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 2.2 GO:0005923 bicellular tight junction(GO:0005923)
0.0 2.0 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.9 GO:0005770 late endosome(GO:0005770)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 99 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 9.8 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.4 8.0 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
1.5 7.4 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.0 6.1 GO:0005096 GTPase activator activity(GO:0005096)
0.2 6.0 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 6.0 GO:0008017 microtubule binding(GO:0008017)
0.1 5.5 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.2 5.2 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.4 5.1 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.0 5.0 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 4.8 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 4.7 GO:0017091 AU-rich element binding(GO:0017091)
0.0 4.7 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738) protein-glutamic acid ligase activity(GO:0070739) tubulin-glutamic acid ligase activity(GO:0070740)
0.6 4.6 GO:0043208 glycosphingolipid binding(GO:0043208)
0.6 4.3 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1 4.3 GO:0003777 microtubule motor activity(GO:0003777)
0.0 3.9 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
1.3 3.8 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.2 3.6 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 3.6 GO:0051117 ATPase binding(GO:0051117)