Motif ID: Sp1

Z-value: 1.909


Transcription factors associated with Sp1:

Gene SymbolEntrez IDGene Name
Sp1 ENSMUSG00000001280.6 Sp1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sp1mm10_v2_chr15_+_102406143_102406380-0.104.3e-01Click!


Activity profile for motif Sp1.

activity profile for motif Sp1


Sorted Z-values histogram for motif Sp1

Sorted Z-values for motif Sp1



Network of associatons between targets according to the STRING database.



First level regulatory network of Sp1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_172345565 20.164 ENSMUST00000028995.4
 Fam210b
family with sequence similarity 210, member B
chr8_-_84800024 19.434 ENSMUST00000126806.1
ENSMUST00000076715.6
 Nfix

nuclear factor I/X

chr12_+_12262139 17.081 ENSMUST00000069066.6
ENSMUST00000069005.8
 Fam49a

family with sequence similarity 49, member A

chr5_-_109558957 16.501 ENSMUST00000044579.7
 Crlf2
cytokine receptor-like factor 2
chr11_+_78322965 16.346 ENSMUST00000017534.8
 Aldoc
aldolase C, fructose-bisphosphate
chr12_-_100725028 16.215 ENSMUST00000043599.6
 Rps6ka5
ribosomal protein S6 kinase, polypeptide 5
chr4_-_148130678 15.386 ENSMUST00000030862.4
 Draxin
dorsal inhibitory axon guidance protein
chr8_-_29219338 15.065 ENSMUST00000168630.2
 Unc5d
unc-5 homolog D (C. elegans)
chr9_+_44043384 14.853 ENSMUST00000114840.1
 Thy1
thymus cell antigen 1, theta
chr1_-_56971762 14.686 ENSMUST00000114415.3
 Satb2
special AT-rich sequence binding protein 2
chr4_-_133498538 14.645 ENSMUST00000125541.1
 Trnp1
TMF1-regulated nuclear protein 1
chr3_-_88000350 14.141 ENSMUST00000090971.5
 Bcan
brevican
chr14_-_25769033 13.962 ENSMUST00000069180.7
 Zcchc24
zinc finger, CCHC domain containing 24
chr15_-_66969616 13.764 ENSMUST00000170903.1
ENSMUST00000166420.1
ENSMUST00000005256.6
ENSMUST00000164070.1
 Ndrg1



N-myc downstream regulated gene 1



chr4_-_120287349 13.614 ENSMUST00000102656.3
 Foxo6
forkhead box O6
chr2_-_73386396 13.388 ENSMUST00000112044.1
ENSMUST00000112043.1
ENSMUST00000076463.5
 Gpr155


G protein-coupled receptor 155


chr7_-_79149042 13.168 ENSMUST00000032825.8
ENSMUST00000107409.3
 Mfge8

milk fat globule-EGF factor 8 protein

chr8_-_84800344 13.148 ENSMUST00000099070.3
 Nfix
nuclear factor I/X
chr7_+_57591147 13.062 ENSMUST00000039697.7
 Gabrb3
gamma-aminobutyric acid (GABA) A receptor, subunit beta 3
chr16_+_93711907 13.005 ENSMUST00000045004.9
 Dopey2
dopey family member 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 960 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.1 49.1 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
3.4 47.3 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.4 39.3 GO:0071805 potassium ion transmembrane transport(GO:0071805)
1.0 38.6 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
1.7 38.4 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
2.1 37.9 GO:0014047 glutamate secretion(GO:0014047)
1.5 30.9 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
1.8 29.5 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
2.9 28.7 GO:0071468 cellular response to acidic pH(GO:0071468)
1.7 28.5 GO:0071625 vocalization behavior(GO:0071625)
1.8 26.4 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
1.0 26.1 GO:0060074 synapse maturation(GO:0060074)
4.2 25.5 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
2.3 25.3 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
3.6 24.9 GO:0014053 negative regulation of gamma-aminobutyric acid secretion(GO:0014053)
4.6 23.1 GO:0034441 plasma lipoprotein particle oxidation(GO:0034441)
1.4 23.1 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
7.6 22.9 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
2.0 22.3 GO:0097688 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
3.7 22.0 GO:0032229 negative regulation of synaptic transmission, GABAergic(GO:0032229)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 281 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 545.2 GO:0016021 integral component of membrane(GO:0016021)
0.6 106.4 GO:0045211 postsynaptic membrane(GO:0045211)
0.8 88.0 GO:0031225 anchored component of membrane(GO:0031225)
0.7 78.7 GO:0055037 recycling endosome(GO:0055037)
0.4 73.1 GO:0000139 Golgi membrane(GO:0000139)
1.7 70.5 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.5 63.6 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.5 59.0 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.8 53.7 GO:0043195 terminal bouton(GO:0043195)
1.4 50.5 GO:0032809 neuronal cell body membrane(GO:0032809)
2.0 47.1 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.5 45.5 GO:0070382 exocytic vesicle(GO:0070382)
1.5 43.0 GO:0060077 inhibitory synapse(GO:0060077)
1.5 40.7 GO:0048786 presynaptic active zone(GO:0048786)
0.8 39.6 GO:0045335 phagocytic vesicle(GO:0045335)
0.3 39.1 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.8 37.0 GO:0005905 clathrin-coated pit(GO:0005905)
2.2 36.9 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.8 36.8 GO:0031901 early endosome membrane(GO:0031901)
0.9 36.6 GO:0034704 calcium channel complex(GO:0034704)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 546 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 90.4 GO:0005096 GTPase activator activity(GO:0005096)
2.5 58.5 GO:0034185 apolipoprotein binding(GO:0034185)
1.1 50.7 GO:0045296 cadherin binding(GO:0045296)
1.2 43.1 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.3 38.6 GO:0051015 actin filament binding(GO:0051015)
0.4 38.5 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.9 38.4 GO:0017080 sodium channel regulator activity(GO:0017080)
1.4 37.6 GO:0022824 transmitter-gated ion channel activity(GO:0022824) transmitter-gated channel activity(GO:0022835)
1.3 36.6 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.5 35.4 GO:0019210 protein kinase inhibitor activity(GO:0004860) kinase inhibitor activity(GO:0019210)
1.0 35.0 GO:0030215 semaphorin receptor binding(GO:0030215)
0.3 33.9 GO:0017124 SH3 domain binding(GO:0017124)
1.0 32.5 GO:0005246 calcium channel regulator activity(GO:0005246)
1.4 32.3 GO:0031489 myosin V binding(GO:0031489)
3.9 31.5 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
1.2 29.1 GO:0017075 syntaxin-1 binding(GO:0017075)
0.5 28.9 GO:0048306 calcium-dependent protein binding(GO:0048306)
4.6 27.8 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.7 26.7 GO:0001540 beta-amyloid binding(GO:0001540)
1.4 26.4 GO:0005245 voltage-gated calcium channel activity(GO:0005245)