Motif ID: Sp2

Z-value: 0.748


Transcription factors associated with Sp2:

Gene SymbolEntrez IDGene Name
Sp2 ENSMUSG00000018678.6 Sp2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sp2mm10_v2_chr11_-_96968655_96968673-0.095.2e-01Click!


Activity profile for motif Sp2.

activity profile for motif Sp2


Sorted Z-values histogram for motif Sp2

Sorted Z-values for motif Sp2



Network of associatons between targets according to the STRING database.



First level regulatory network of Sp2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_87948666 13.065 ENSMUST00000005019.5
 Crabp2
cellular retinoic acid binding protein II
chr12_+_112644828 4.872 ENSMUST00000021728.4
ENSMUST00000109755.3
 Siva1

SIVA1, apoptosis-inducing factor

chrX_-_48034842 3.765 ENSMUST00000039026.7
 Apln
apelin
chrX_-_133688978 3.551 ENSMUST00000149154.1
ENSMUST00000167944.1
 Pcdh19

protocadherin 19

chr1_+_72824482 3.549 ENSMUST00000047328.4
 Igfbp2
insulin-like growth factor binding protein 2
chr2_-_92370999 3.050 ENSMUST00000176810.1
ENSMUST00000090582.4
 Gyltl1b

glycosyltransferase-like 1B

chr17_+_23679363 3.017 ENSMUST00000024699.2
 Cldn6
claudin 6
chr6_-_82774448 3.012 ENSMUST00000000642.4
 Hk2
hexokinase 2
chr10_+_128194446 2.851 ENSMUST00000044776.6
 Gls2
glutaminase 2 (liver, mitochondrial)
chr4_+_3938888 2.818 ENSMUST00000121110.1
ENSMUST00000108386.1
ENSMUST00000149544.1
 Chchd7


coiled-coil-helix-coiled-coil-helix domain containing 7


chr2_-_92371039 2.716 ENSMUST00000068586.6
 Gyltl1b
glycosyltransferase-like 1B
chr4_+_46450892 2.690 ENSMUST00000102926.4
 Anp32b
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr2_+_38339258 2.681 ENSMUST00000143783.2
 Lhx2
LIM homeobox protein 2
chr17_-_70851189 2.620 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr4_+_108579445 2.564 ENSMUST00000102744.3
 Orc1
origin recognition complex, subunit 1
chr7_-_110061319 2.484 ENSMUST00000098110.2
 AA474408
expressed sequence AA474408
chr18_+_82914632 2.471 ENSMUST00000071233.6
 Zfp516
zinc finger protein 516
chr2_-_92370968 2.467 ENSMUST00000176774.1
 Gyltl1b
glycosyltransferase-like 1B
chr2_-_120154600 2.453 ENSMUST00000028755.7
 Ehd4
EH-domain containing 4
chr6_+_120666388 2.405 ENSMUST00000112686.1
 Cecr2
cat eye syndrome chromosome region, candidate 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 229 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 14.2 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.6 8.2 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.1 4.7 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.3 4.6 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.5 3.8 GO:0031652 positive regulation of heat generation(GO:0031652)
0.4 3.8 GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901030)
0.3 3.8 GO:0002227 innate immune response in mucosa(GO:0002227)
0.1 3.6 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.1 3.6 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.1 3.6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.1 3.4 GO:0007290 spermatid nucleus elongation(GO:0007290)
0.1 3.2 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
1.0 3.1 GO:0000087 mitotic M phase(GO:0000087)
0.8 3.0 GO:0035795 negative regulation of mitochondrial membrane permeability(GO:0035795)
0.6 2.9 GO:0006543 glutamine catabolic process(GO:0006543)
0.2 2.9 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 2.9 GO:0043966 histone H3 acetylation(GO:0043966)
0.9 2.8 GO:0097402 neuroblast migration(GO:0097402)
0.4 2.7 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.4 2.7 GO:0070561 vitamin D receptor signaling pathway(GO:0070561)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 110 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 28.9 GO:0005654 nucleoplasm(GO:0005654)
0.1 4.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 4.9 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 4.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 4.2 GO:0005840 ribosome(GO:0005840)
0.0 3.5 GO:0005903 brush border(GO:0005903)
0.2 2.7 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.3 2.6 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 2.6 GO:0045120 pronucleus(GO:0045120)
0.1 2.6 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 2.6 GO:0031513 nonmotile primary cilium(GO:0031513)
0.0 2.5 GO:0072562 blood microparticle(GO:0072562)
0.0 2.5 GO:0000922 spindle pole(GO:0000922)
0.6 2.4 GO:0090537 CERF complex(GO:0090537)
0.4 2.4 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.1 2.3 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 2.3 GO:0002102 podosome(GO:0002102)
0.2 2.2 GO:0034719 SMN-Sm protein complex(GO:0034719)
0.4 2.1 GO:0031523 Myb complex(GO:0031523)
0.7 2.0 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 171 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 13.1 GO:0019841 retinol binding(GO:0019841)
0.0 11.3 GO:0003735 structural constituent of ribosome(GO:0003735)
1.6 8.2 GO:0018121 imidazoleglycerol-phosphate synthase activity(GO:0000107) NAD(P)-cysteine ADP-ribosyltransferase activity(GO:0018071) NAD(P)-asparagine ADP-ribosyltransferase activity(GO:0018121) NAD(P)-serine ADP-ribosyltransferase activity(GO:0018127) 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity(GO:0043867) purine deoxyribosyltransferase activity(GO:0044102)
0.0 7.5 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.1 6.9 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 6.2 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.1 4.7 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 4.2 GO:0033613 activating transcription factor binding(GO:0033613)
0.1 3.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 3.8 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.2 3.8 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.4 3.5 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 3.4 GO:0018602 sulfonate dioxygenase activity(GO:0000907) 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity(GO:0018602) hypophosphite dioxygenase activity(GO:0034792) gibberellin 2-beta-dioxygenase activity(GO:0045543) C-19 gibberellin 2-beta-dioxygenase activity(GO:0052634) C-20 gibberellin 2-beta-dioxygenase activity(GO:0052635)
0.6 3.0 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.1 3.0 GO:0070410 co-SMAD binding(GO:0070410)
0.6 2.9 GO:0004359 glutaminase activity(GO:0004359)
0.1 2.8 GO:0001222 transcription corepressor binding(GO:0001222)
0.3 2.6 GO:0001618 virus receptor activity(GO:0001618)
0.2 2.5 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.2 2.5 GO:0001848 complement binding(GO:0001848)