Motif ID: Spdef

Z-value: 0.533


Transcription factors associated with Spdef:

Gene SymbolEntrez IDGene Name
Spdef ENSMUSG00000024215.7 Spdef

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Spdefmm10_v2_chr17_-_27728889_27728956-0.047.5e-01Click!


Activity profile for motif Spdef.

activity profile for motif Spdef


Sorted Z-values histogram for motif Spdef

Sorted Z-values for motif Spdef



Network of associatons between targets according to the STRING database.



First level regulatory network of Spdef

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_34861200 3.080 ENSMUST00000165033.1
 Egr1
early growth response 1
chr14_+_54936456 2.478 ENSMUST00000037814.6
 Cmtm5
CKLF-like MARVEL transmembrane domain containing 5
chr10_-_58675631 2.449 ENSMUST00000003312.4
 Edar
ectodysplasin-A receptor
chr14_+_54254124 2.354 ENSMUST00000180359.1
 Abhd4
abhydrolase domain containing 4
chr3_+_27938638 2.224 ENSMUST00000120834.1
 Pld1
phospholipase D1
chr14_-_70207637 2.079 ENSMUST00000022682.5
 Sorbs3
sorbin and SH3 domain containing 3
chr11_+_78176711 1.902 ENSMUST00000098545.5
 Tlcd1
TLC domain containing 1
chr4_+_3678108 1.741 ENSMUST00000041377.6
ENSMUST00000103010.3
 Lyn

Yamaguchi sarcoma viral (v-yes-1) oncogene homolog

chr9_-_65908676 1.698 ENSMUST00000119245.1
ENSMUST00000134338.1
ENSMUST00000179395.1
 Trip4


thyroid hormone receptor interactor 4


chr11_-_55419898 1.693 ENSMUST00000108858.1
ENSMUST00000141530.1
 Sparc

secreted acidic cysteine rich glycoprotein

chr2_+_129592818 1.656 ENSMUST00000153491.1
ENSMUST00000161620.1
ENSMUST00000179001.1
 Sirpa


signal-regulatory protein alpha


chr15_-_37458523 1.590 ENSMUST00000116445.2
 Ncald
neurocalcin delta
chr19_+_23687385 1.577 ENSMUST00000099560.3
 Ptar1
protein prenyltransferase alpha subunit repeat containing 1
chr3_+_37639945 1.553 ENSMUST00000108109.1
ENSMUST00000038569.1
 Spry1

sprouty homolog 1 (Drosophila)

chr3_+_37639985 1.500 ENSMUST00000108107.1
 Spry1
sprouty homolog 1 (Drosophila)
chr11_-_78176619 1.398 ENSMUST00000148154.2
ENSMUST00000017549.6
 Nek8

NIMA (never in mitosis gene a)-related expressed kinase 8

chr3_+_135825788 1.388 ENSMUST00000167390.1
 Slc39a8
solute carrier family 39 (metal ion transporter), member 8
chr15_-_99820072 1.338 ENSMUST00000109024.2
 Lima1
LIM domain and actin binding 1
chr6_+_4003926 1.338 ENSMUST00000031670.8
 Gng11
guanine nucleotide binding protein (G protein), gamma 11
chr9_+_80165079 1.332 ENSMUST00000184480.1
 Myo6
myosin VI

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 132 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 4.4 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
1.0 3.1 GO:0072223 metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.1 3.0 GO:0006910 phagocytosis, recognition(GO:0006910)
0.2 2.6 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.3 2.4 GO:0060662 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0 2.4 GO:0019915 lipid storage(GO:0019915)
0.3 2.2 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.2 2.2 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.0 2.2 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.1 2.1 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.6 1.9 GO:0002447 eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil degranulation(GO:0043308) regulation of eosinophil activation(GO:1902566)
0.6 1.8 GO:0035696 monocyte extravasation(GO:0035696) regulation of monocyte extravasation(GO:2000437)
0.1 1.8 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
0.6 1.7 GO:0002765 immune response-inhibiting signal transduction(GO:0002765) positive regulation of dendritic cell apoptotic process(GO:2000670)
0.2 1.7 GO:0035330 regulation of hippo signaling(GO:0035330)
0.0 1.7 GO:0030520 intracellular estrogen receptor signaling pathway(GO:0030520)
0.1 1.6 GO:0018342 protein prenylation(GO:0018342) prenylation(GO:0097354)
0.1 1.6 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 1.6 GO:0031529 ruffle organization(GO:0031529)
0.0 1.6 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 2.7 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 2.5 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 2.4 GO:0005811 lipid particle(GO:0005811)
0.0 2.2 GO:0031985 Golgi cisterna(GO:0031985)
0.0 2.0 GO:0072562 blood microparticle(GO:0072562)
0.3 1.9 GO:0000322 storage vacuole(GO:0000322)
0.0 1.8 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.6 1.7 GO:0034666 integrin alpha2-beta1 complex(GO:0034666)
0.4 1.7 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 1.7 GO:0016605 PML body(GO:0016605)
0.2 1.5 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 1.5 GO:0032420 stereocilium(GO:0032420)
0.0 1.5 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.5 1.4 GO:0097543 ciliary inversin compartment(GO:0097543)
0.0 1.3 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 1.3 GO:0098878 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.3 1.2 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.2 1.2 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0 1.2 GO:0005871 kinesin complex(GO:0005871)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 95 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.8 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.2 3.1 GO:0017166 vinculin binding(GO:0017166)
0.1 3.0 GO:0045309 protein phosphorylated amino acid binding(GO:0045309)
0.0 2.9 GO:0003774 motor activity(GO:0003774)
0.2 2.6 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.1 2.6 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.1 2.4 GO:0052771 coenzyme F390-A hydrolase activity(GO:0052770) coenzyme F390-G hydrolase activity(GO:0052771)
0.3 2.2 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.1 2.2 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 2.1 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.0 2.1 GO:0005125 cytokine activity(GO:0005125)
0.5 1.9 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.1 1.8 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 1.8 GO:0005518 collagen binding(GO:0005518)
0.6 1.7 GO:0005128 erythropoietin receptor binding(GO:0005128)
0.0 1.7 GO:0017137 Rab GTPase binding(GO:0017137)
0.5 1.6 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.1 1.6 GO:0008318 protein prenyltransferase activity(GO:0008318)
0.1 1.6 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 1.6 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)