Motif ID: Spi1

Z-value: 1.439


Transcription factors associated with Spi1:

Gene SymbolEntrez IDGene Name
Spi1 ENSMUSG00000002111.8 Spi1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Spi1mm10_v2_chr2_+_91082362_91082390-0.095.1e-01Click!


Activity profile for motif Spi1.

activity profile for motif Spi1


Sorted Z-values histogram for motif Spi1

Sorted Z-values for motif Spi1



Network of associatons between targets according to the STRING database.



First level regulatory network of Spi1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 37.928 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr11_+_32276400 10.658 ENSMUST00000020531.2
 Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr3_-_95904683 10.004 ENSMUST00000147962.1
ENSMUST00000036181.8
 Car14

carbonic anhydrase 14

chr10_+_79988584 9.701 ENSMUST00000004784.4
ENSMUST00000105374.1
 Cnn2

calponin 2

chr19_+_25406661 8.018 ENSMUST00000146647.1
 Kank1
KN motif and ankyrin repeat domains 1
chr15_-_103366763 7.936 ENSMUST00000023128.6
 Itga5
integrin alpha 5 (fibronectin receptor alpha)
chr16_+_32608973 7.203 ENSMUST00000120680.1
 Tfrc
transferrin receptor
chr2_+_120463566 7.196 ENSMUST00000028749.7
ENSMUST00000110721.1
 Capn3

calpain 3

chr18_+_74442500 7.176 ENSMUST00000074157.6
 Myo5b
myosin VB
chr4_+_136143497 7.110 ENSMUST00000008016.2
 Id3
inhibitor of DNA binding 3
chr12_-_80260356 7.073 ENSMUST00000021554.8
 Actn1
actinin, alpha 1
chr16_+_32608920 6.951 ENSMUST00000023486.8
 Tfrc
transferrin receptor
chrX_-_141725181 6.901 ENSMUST00000067841.7
 Irs4
insulin receptor substrate 4
chr7_-_102250086 6.829 ENSMUST00000106923.1
ENSMUST00000098230.4
 Rhog

ras homolog gene family, member G

chr2_+_84840612 6.787 ENSMUST00000111625.1
 Slc43a1
solute carrier family 43, member 1
chr9_-_106199253 6.776 ENSMUST00000140761.1
 Ppm1m
protein phosphatase 1M
chr6_+_134035691 6.723 ENSMUST00000081028.6
ENSMUST00000111963.1
 Etv6

ets variant gene 6 (TEL oncogene)

chr17_+_47505117 6.698 ENSMUST00000183044.1
ENSMUST00000037333.10
 Ccnd3

cyclin D3

chr16_-_38713235 6.688 ENSMUST00000023487.4
 Arhgap31
Rho GTPase activating protein 31
chr2_+_105675478 6.588 ENSMUST00000167211.2
ENSMUST00000111083.3
 Pax6

paired box gene 6


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 778 entries
Log-likelihood per target Total log-likelihoodTermDescription
7.8 46.8 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
2.0 33.7 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
3.4 17.0 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918)
2.6 15.7 GO:0002553 histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553)
5.0 15.1 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
1.3 14.7 GO:0033572 transferrin transport(GO:0033572)
0.5 13.8 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.7 12.8 GO:0051127 positive regulation of actin nucleation(GO:0051127)
1.6 12.6 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
1.4 12.4 GO:0051639 actin filament network formation(GO:0051639)
1.2 12.3 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
3.0 11.8 GO:0010957 negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.5 11.3 GO:0006270 DNA replication initiation(GO:0006270)
1.4 11.0 GO:0015670 carbon dioxide transport(GO:0015670)
2.7 10.8 GO:0051311 spindle assembly involved in female meiosis(GO:0007056) meiotic metaphase plate congression(GO:0051311)
1.8 10.8 GO:0046645 positive regulation of gamma-delta T cell differentiation(GO:0045588) positive regulation of gamma-delta T cell activation(GO:0046645)
0.3 10.2 GO:0044380 protein localization to cytoskeleton(GO:0044380)
2.5 10.0 GO:0032439 endosome localization(GO:0032439)
1.1 9.8 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.5 9.7 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 317 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 94.6 GO:0005667 transcription factor complex(GO:0005667)
0.0 49.7 GO:0005654 nucleoplasm(GO:0005654)
0.7 30.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 29.5 GO:0005730 nucleolus(GO:0005730)
1.5 15.1 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.1 14.6 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
1.5 13.9 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.7 13.3 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.2 13.2 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
1.2 13.1 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
1.2 13.1 GO:1990907 beta-catenin-TCF complex(GO:1990907)
3.1 12.4 GO:0032127 dense core granule membrane(GO:0032127)
0.1 12.3 GO:0031012 extracellular matrix(GO:0031012)
0.6 12.2 GO:0000242 pericentriolar material(GO:0000242)
0.3 12.2 GO:0015030 Cajal body(GO:0015030)
0.1 11.7 GO:0009897 external side of plasma membrane(GO:0009897)
1.3 11.5 GO:0072687 meiotic spindle(GO:0072687)
1.9 11.4 GO:0045179 apical cortex(GO:0045179)
0.2 10.7 GO:0016328 lateral plasma membrane(GO:0016328)
0.6 10.1 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 438 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 73.3 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 33.0 GO:0003779 actin binding(GO:0003779)
0.7 32.3 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
1.7 28.8 GO:0017166 vinculin binding(GO:0017166)
1.2 26.0 GO:0070410 co-SMAD binding(GO:0070410)
0.1 25.1 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.1 20.6 GO:0005525 GTP binding(GO:0005525)
0.3 20.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 18.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.3 17.9 GO:0000049 tRNA binding(GO:0000049)
0.1 17.3 GO:0008134 transcription factor binding(GO:0008134)
0.3 15.6 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
4.7 14.2 GO:0004998 transferrin receptor activity(GO:0004998)
0.4 14.1 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.2 12.5 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.9 12.0 GO:0008301 DNA binding, bending(GO:0008301)
2.3 11.3 GO:0042610 CD8 receptor binding(GO:0042610)
0.7 11.1 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.7 10.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.8 10.0 GO:0004089 carbonate dehydratase activity(GO:0004089)