Motif ID: Spic

Z-value: 1.038


Transcription factors associated with Spic:

Gene SymbolEntrez IDGene Name
Spic ENSMUSG00000004359.10 Spic

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Spicmm10_v2_chr10_-_88683021_88683025-0.047.8e-01Click!


Activity profile for motif Spic.

activity profile for motif Spic


Sorted Z-values histogram for motif Spic

Sorted Z-values for motif Spic



Network of associatons between targets according to the STRING database.



First level regulatory network of Spic

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_136892867 8.048 ENSMUST00000046332.5
 C1qc
complement component 1, q subcomponent, C chain
chr4_-_136886187 7.029 ENSMUST00000046384.8
 C1qb
complement component 1, q subcomponent, beta polypeptide
chr1_-_171234290 6.910 ENSMUST00000079957.6
 Fcer1g
Fc receptor, IgE, high affinity I, gamma polypeptide
chr4_+_130913264 6.236 ENSMUST00000156225.1
ENSMUST00000156742.1
 Laptm5

lysosomal-associated protein transmembrane 5

chr4_+_130913120 6.101 ENSMUST00000151698.1
 Laptm5
lysosomal-associated protein transmembrane 5
chr11_+_32276400 5.769 ENSMUST00000020531.2
 Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr3_+_95526777 4.807 ENSMUST00000015667.2
ENSMUST00000116304.2
 Ctss

cathepsin S

chr1_-_56978534 4.406 ENSMUST00000177282.1
 Satb2
special AT-rich sequence binding protein 2
chr12_+_112760652 4.354 ENSMUST00000063888.3
 Pld4
phospholipase D family, member 4
chr6_-_136941694 4.125 ENSMUST00000032344.5
 Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr6_+_5725639 3.921 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
 Dync1i1


dynein cytoplasmic 1 intermediate chain 1


chr10_-_117282262 3.797 ENSMUST00000092163.7
 Lyz2
lysozyme 2
chr1_-_170976112 3.132 ENSMUST00000027966.7
ENSMUST00000081103.5
ENSMUST00000159688.1
 Fcgr2b


Fc receptor, IgG, low affinity IIb


chr15_-_66812593 3.085 ENSMUST00000100572.3
 Sla
src-like adaptor
chr19_-_11604828 3.077 ENSMUST00000025582.4
 Ms4a6d
membrane-spanning 4-domains, subfamily A, member 6D
chr19_+_53529100 2.950 ENSMUST00000038287.6
 Dusp5
dual specificity phosphatase 5
chr6_-_136941887 2.801 ENSMUST00000111891.1
 Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr1_-_171059390 2.740 ENSMUST00000164044.1
ENSMUST00000169017.1
 Fcgr3

Fc receptor, IgG, low affinity III

chr6_-_136941494 2.721 ENSMUST00000111892.1
 Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr19_+_12460749 2.706 ENSMUST00000081035.7
 Mpeg1
macrophage expressed gene 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 174 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.9 11.8 GO:0001803 type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805)
1.9 9.6 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
1.3 9.0 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
1.3 7.6 GO:0032796 uropod organization(GO:0032796)
0.4 7.0 GO:0006958 complement activation, classical pathway(GO:0006958)
0.4 6.7 GO:0030574 collagen catabolic process(GO:0030574)
1.2 5.8 GO:0015671 oxygen transport(GO:0015671)
0.2 4.7 GO:0019835 cytolysis(GO:0019835)
0.3 4.4 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.0 3.9 GO:0006909 phagocytosis(GO:0006909)
0.0 3.8 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.9 3.5 GO:0006742 NADP catabolic process(GO:0006742) pyridine nucleotide catabolic process(GO:0019364)
0.3 3.5 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.8 3.4 GO:0002309 T cell proliferation involved in immune response(GO:0002309)
0.4 3.3 GO:0071569 protein ufmylation(GO:0071569)
0.1 3.2 GO:0042255 ribosome assembly(GO:0042255)
1.0 3.1 GO:0016068 regulation of type I hypersensitivity(GO:0001810) type I hypersensitivity(GO:0016068)
0.7 3.0 GO:0010700 negative regulation of norepinephrine secretion(GO:0010700)
0.9 2.6 GO:0002538 arachidonic acid metabolite production involved in inflammatory response(GO:0002538)
0.8 2.5 GO:0030321 transepithelial chloride transport(GO:0030321)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 99 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.9 GO:0009897 external side of plasma membrane(GO:0009897)
0.2 15.3 GO:0005581 collagen trimer(GO:0005581)
0.0 12.9 GO:0005829 cytosol(GO:0005829)
0.1 10.3 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 8.0 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.3 7.6 GO:0001891 phagocytic cup(GO:0001891)
0.1 5.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.7 5.8 GO:0005833 hemoglobin complex(GO:0005833)
0.1 5.5 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 5.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.8 3.8 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.3 3.8 GO:0042555 MCM complex(GO:0042555)
0.0 3.6 GO:0001726 ruffle(GO:0001726)
0.3 3.1 GO:0030008 TRAPP complex(GO:0030008)
0.0 3.1 GO:0009986 cell surface(GO:0009986)
0.0 3.0 GO:0005884 actin filament(GO:0005884)
0.6 2.4 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 2.4 GO:0001772 immunological synapse(GO:0001772)
0.0 2.4 GO:0000118 histone deacetylase complex(GO:0000118)
0.5 2.3 GO:0030485 smooth muscle contractile fiber(GO:0030485)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 127 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 14.9 GO:0019864 IgG binding(GO:0019864)
1.4 9.6 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.8 7.6 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 7.0 GO:0003735 structural constituent of ribosome(GO:0003735)
1.2 5.8 GO:0005344 oxygen transporter activity(GO:0005344)
0.2 4.4 GO:0001968 fibronectin binding(GO:0001968)
0.1 4.3 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
1.1 4.2 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.8 3.9 GO:0045503 dynein light chain binding(GO:0045503)
0.5 3.7 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.4 3.6 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 3.6 GO:0005096 GTPase activator activity(GO:0005096)
0.1 3.2 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 3.1 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 3.1 GO:0019905 syntaxin binding(GO:0019905)
0.1 3.0 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.2 2.9 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.0 2.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 2.8 GO:0070628 proteasome binding(GO:0070628)
0.2 2.7 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)