Motif ID: Srf

Z-value: 1.462


Transcription factors associated with Srf:

Gene SymbolEntrez IDGene Name
Srf ENSMUSG00000015605.5 Srf

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Srfmm10_v2_chr17_-_46556158_46556188-0.066.8e-01Click!


Activity profile for motif Srf.

activity profile for motif Srf


Sorted Z-values histogram for motif Srf

Sorted Z-values for motif Srf



Network of associatons between targets according to the STRING database.



First level regulatory network of Srf

PNG image of the network

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Top targets:


Showing 1 to 20 of 130 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 27.100 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr10_-_120899067 23.736 ENSMUST00000092143.5
 Msrb3
methionine sulfoxide reductase B3
chr7_-_142661305 13.024 ENSMUST00000105936.1
 Igf2
insulin-like growth factor 2
chr10_+_79988584 12.719 ENSMUST00000004784.4
ENSMUST00000105374.1
 Cnn2

calponin 2

chr19_+_53529100 12.003 ENSMUST00000038287.6
 Dusp5
dual specificity phosphatase 5
chr7_-_137314394 8.220 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3



chr11_-_5898771 7.167 ENSMUST00000102921.3
 Myl7
myosin, light polypeptide 7, regulatory
chr10_+_67537861 6.955 ENSMUST00000048289.7
ENSMUST00000105438.2
ENSMUST00000130933.1
ENSMUST00000146986.1
 Egr2



early growth response 2



chr5_-_24329556 6.508 ENSMUST00000115098.2
 Kcnh2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr7_-_44997221 6.366 ENSMUST00000152341.1
 Bcl2l12
BCL2-like 12 (proline rich)
chr4_+_132351768 6.181 ENSMUST00000172202.1
 Gm17300
predicted gene, 17300
chr19_-_4928241 6.131 ENSMUST00000025851.3
 Dpp3
dipeptidylpeptidase 3
chr7_-_44997535 5.929 ENSMUST00000124232.1
ENSMUST00000003290.4
 Bcl2l12

BCL2-like 12 (proline rich)

chr2_-_152415044 4.969 ENSMUST00000099207.3
 Zcchc3
zinc finger, CCHC domain containing 3
chr7_-_19310035 4.959 ENSMUST00000003640.2
 Fosb
FBJ osteosarcoma oncogene B
chr14_+_5071040 4.930 ENSMUST00000163719.1
 Gm8281
predicted gene, 8281
chr4_-_132351636 4.909 ENSMUST00000105951.1
 Rcc1
regulator of chromosome condensation 1
chr8_-_47675130 4.807 ENSMUST00000080353.2
 Ing2
inhibitor of growth family, member 2
chr4_+_43957678 4.714 ENSMUST00000107855.1
 Glipr2
GLI pathogenesis-related 2
chr7_+_101896340 4.706 ENSMUST00000035395.7
ENSMUST00000106973.1
ENSMUST00000144207.1
 Anapc15


anaphase prompoting complex C subunit 15



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.5 27.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
4.7 23.7 GO:0030091 protein repair(GO:0030091)
2.2 17.3 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.4 14.2 GO:0001706 endoderm formation(GO:0001706)
0.7 12.7 GO:0050765 negative regulation of phagocytosis(GO:0050765)
1.2 12.3 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166)
1.8 8.8 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.6 7.8 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
1.2 7.0 GO:0021593 rhombomere morphogenesis(GO:0021593)
2.0 6.0 GO:0097623 potassium ion export across plasma membrane(GO:0097623)
0.1 5.3 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.1 4.9 GO:0007052 mitotic spindle organization(GO:0007052)
1.5 4.6 GO:0010814 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
1.5 4.6 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.5 4.6 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.1 4.6 GO:0071277 cellular response to calcium ion(GO:0071277)
1.5 4.5 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
0.5 4.5 GO:0003161 cardiac conduction system development(GO:0003161)
1.1 4.3 GO:0051295 establishment of meiotic spindle localization(GO:0051295)
0.0 3.7 GO:0006457 protein folding(GO:0006457)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 23.7 GO:0005739 mitochondrion(GO:0005739)
0.0 12.3 GO:0005615 extracellular space(GO:0005615)
1.5 8.8 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 8.0 GO:0000139 Golgi membrane(GO:0000139)
0.3 7.8 GO:0005680 anaphase-promoting complex(GO:0005680)
0.2 7.2 GO:0016459 myosin complex(GO:0016459)
0.0 6.5 GO:0009986 cell surface(GO:0009986)
0.2 6.1 GO:0090544 BAF-type complex(GO:0090544)
0.1 6.1 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 5.1 GO:0005829 cytosol(GO:0005829)
0.1 4.9 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.9 4.6 GO:0033093 Weibel-Palade body(GO:0033093)
0.2 4.6 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 4.6 GO:0032587 ruffle membrane(GO:0032587)
0.4 4.5 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.1 4.5 GO:0016328 lateral plasma membrane(GO:0016328)
0.9 4.3 GO:0005826 actomyosin contractile ring(GO:0005826)
0.2 3.9 GO:0002102 podosome(GO:0002102)
0.0 3.1 GO:0001726 ruffle(GO:0001726)
0.0 3.0 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.4 23.7 GO:0070191 methionine-R-sulfoxide reductase activity(GO:0070191)
0.1 23.1 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.8 17.3 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.1 16.9 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 15.3 GO:0003779 actin binding(GO:0003779)
0.4 14.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 12.3 GO:0002039 p53 binding(GO:0002039)
0.1 8.8 GO:0035064 methylated histone binding(GO:0035064)
0.2 7.0 GO:0071837 HMG box domain binding(GO:0071837)
2.2 6.5 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
1.0 6.1 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.7 4.9 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.1 4.6 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.1 4.6 GO:0008013 beta-catenin binding(GO:0008013)
0.1 4.6 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.7 4.5 GO:0030284 estrogen receptor activity(GO:0030284)
0.1 4.5 GO:0030552 cAMP binding(GO:0030552)
0.5 4.3 GO:0043495 protein anchor(GO:0043495)
0.0 3.9 GO:0005178 integrin binding(GO:0005178)
0.1 3.8 GO:0015459 potassium channel regulator activity(GO:0015459)