Motif ID: Stat2

Z-value: 2.416


Transcription factors associated with Stat2:

Gene SymbolEntrez IDGene Name
Stat2 ENSMUSG00000040033.9 Stat2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Stat2mm10_v2_chr10_+_128270546_1282705770.644.6e-08Click!


Activity profile for motif Stat2.

activity profile for motif Stat2


Sorted Z-values histogram for motif Stat2

Sorted Z-values for motif Stat2



Network of associatons between targets according to the STRING database.



First level regulatory network of Stat2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_103434211 33.077 ENSMUST00000079294.5
ENSMUST00000076788.5
ENSMUST00000076702.5
ENSMUST00000066701.6
ENSMUST00000085065.5
ENSMUST00000140838.1
Ifi27





interferon, alpha-inducible protein 27





chr7_-_141010759 32.283 ENSMUST00000026565.6
Ifitm3
interferon induced transmembrane protein 3
chr6_+_90550789 32.131 ENSMUST00000130418.1
ENSMUST00000032175.8
Aldh1l1

aldehyde dehydrogenase 1 family, member L1

chr16_+_23609895 20.720 ENSMUST00000038423.5
Rtp4
receptor transporter protein 4
chr16_+_26581704 20.404 ENSMUST00000096129.2
ENSMUST00000166294.2
ENSMUST00000174202.1
ENSMUST00000023156.6
Il1rap



interleukin 1 receptor accessory protein



chr2_-_51972990 16.563 ENSMUST00000145481.1
ENSMUST00000112705.2
Nmi

N-myc (and STAT) interactor

chr8_-_84773381 16.156 ENSMUST00000109764.1
Nfix
nuclear factor I/X
chr3_+_81932601 15.752 ENSMUST00000029649.2
Ctso
cathepsin O
chr1_-_173942445 15.129 ENSMUST00000042228.8
ENSMUST00000081216.5
ENSMUST00000129829.1
ENSMUST00000123708.1
ENSMUST00000111210.2
Ifi203



Mndal
interferon activated gene 203



myeloid nuclear differentiation antigen like
chr1_-_170110491 14.754 ENSMUST00000027985.2
Ddr2
discoidin domain receptor family, member 2
chr15_-_66812593 14.077 ENSMUST00000100572.3
Sla
src-like adaptor
chr18_+_61045139 14.016 ENSMUST00000025522.4
ENSMUST00000115274.1
Pdgfrb

platelet derived growth factor receptor, beta polypeptide

chrX_+_166238901 12.759 ENSMUST00000112235.1
Gpm6b
glycoprotein m6b
chr16_-_22439719 12.556 ENSMUST00000079601.6
Etv5
ets variant gene 5
chr6_-_39118211 12.515 ENSMUST00000038398.6
Parp12
poly (ADP-ribose) polymerase family, member 12
chr10_-_94944578 12.450 ENSMUST00000099337.3
Plxnc1
plexin C1
chr11_+_88999376 12.293 ENSMUST00000100627.2
ENSMUST00000107896.3
ENSMUST00000000284.6
Trim25


tripartite motif-containing 25


chr11_+_119393060 11.804 ENSMUST00000131035.2
ENSMUST00000093902.5
Rnf213

ring finger protein 213

chr16_+_42907563 11.783 ENSMUST00000151244.1
ENSMUST00000114694.2
Zbtb20

zinc finger and BTB domain containing 20

chr18_-_39489776 11.749 ENSMUST00000025300.6
Nr3c1
nuclear receptor subfamily 3, group C, member 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 104 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 39.0 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
1.3 38.9 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
2.4 37.9 GO:2001275 positive regulation of glucose import in response to insulin stimulus(GO:2001275)
6.7 33.3 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
10.7 32.1 GO:0042560 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
1.0 27.7 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.5 25.0 GO:0046825 regulation of protein export from nucleus(GO:0046825)
0.5 20.8 GO:0001919 regulation of receptor recycling(GO:0001919)
6.9 20.7 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
2.6 20.4 GO:0072602 interleukin-4 secretion(GO:0072602)
2.4 16.8 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
5.5 16.6 GO:1902524 negative regulation of interferon-alpha production(GO:0032687) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) negative regulation of interferon-beta biosynthetic process(GO:0045358) positive regulation of protein K48-linked ubiquitination(GO:1902524)
1.2 16.2 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
2.1 14.8 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
3.6 14.5 GO:0044565 dendritic cell proliferation(GO:0044565)
4.7 14.0 GO:0035441 cell migration involved in vasculogenesis(GO:0035441) metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
4.4 13.3 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
1.8 12.8 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
1.2 12.4 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
2.0 12.1 GO:0010528 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 88.4 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 71.6 GO:0016021 integral component of membrane(GO:0016021)
0.4 39.1 GO:0016363 nuclear matrix(GO:0016363)
0.0 38.4 GO:0005739 mitochondrion(GO:0005739)
0.1 33.3 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.8 33.1 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 22.1 GO:0005887 integral component of plasma membrane(GO:0005887)
1.9 20.8 GO:0043083 synaptic cleft(GO:0043083)
0.3 14.0 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
1.2 13.7 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
0.0 13.0 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
1.1 12.4 GO:0002116 semaphorin receptor complex(GO:0002116)
0.1 11.6 GO:0032587 ruffle membrane(GO:0032587)
3.7 11.1 GO:1990682 CSF1-CSF1R complex(GO:1990682)
1.5 10.7 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.0 9.6 GO:0005829 cytosol(GO:0005829)
0.5 8.5 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 8.0 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 7.7 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 7.7 GO:0016324 apical plasma membrane(GO:0016324)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 90 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 43.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
2.9 37.9 GO:0016443 bidentate ribonuclease III activity(GO:0016443)
8.3 33.3 GO:0038049 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.1 33.3 GO:0005525 GTP binding(GO:0005525)
1.4 33.1 GO:0005521 lamin binding(GO:0005521)
10.7 32.1 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.1 24.4 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
3.0 20.8 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
1.6 20.4 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.9 18.7 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.2 15.8 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
1.6 14.8 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
2.8 14.0 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.2 13.7 GO:0033613 activating transcription factor binding(GO:0033613)
0.2 13.4 GO:0003727 single-stranded RNA binding(GO:0003727)
1.0 12.4 GO:0017154 semaphorin receptor activity(GO:0017154)
0.9 12.3 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
3.0 12.1 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.5 12.0 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.3 11.5 GO:0070412 R-SMAD binding(GO:0070412)