Motif ID: Stat4_Stat3_Stat5b

Z-value: 0.981

Transcription factors associated with Stat4_Stat3_Stat5b:

Gene SymbolEntrez IDGene Name
Stat3 ENSMUSG00000004040.10 Stat3
Stat4 ENSMUSG00000062939.5 Stat4
Stat5b ENSMUSG00000020919.5 Stat5b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Stat4mm10_v2_chr1_+_51987139_51987151-0.652.0e-08Click!
Stat3mm10_v2_chr11_-_100939540_1009395660.606.3e-07Click!
Stat5bmm10_v2_chr11_-_100822525_100822576-0.238.1e-02Click!


Activity profile for motif Stat4_Stat3_Stat5b.

activity profile for motif Stat4_Stat3_Stat5b


Sorted Z-values histogram for motif Stat4_Stat3_Stat5b

Sorted Z-values for motif Stat4_Stat3_Stat5b



Network of associatons between targets according to the STRING database.



First level regulatory network of Stat4_Stat3_Stat5b

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_64046925 21.427 ENSMUST00000107377.3
 Tnc
tenascin C
chr3_-_80802789 17.640 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chrX_-_61185558 14.550 ENSMUST00000166381.1
 Cdr1
cerebellar degeneration related antigen 1
chr17_+_26715644 6.768 ENSMUST00000062519.7
ENSMUST00000144221.1
ENSMUST00000142539.1
ENSMUST00000151681.1
 Crebrf



CREB3 regulatory factor



chr6_+_115134899 6.475 ENSMUST00000009538.5
ENSMUST00000169345.1
 Syn2

synapsin II

chr8_-_124569696 6.373 ENSMUST00000063278.6
 Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr6_-_5496296 6.367 ENSMUST00000019721.4
 Pdk4
pyruvate dehydrogenase kinase, isoenzyme 4
chr16_-_23988852 6.354 ENSMUST00000023151.5
 Bcl6
B cell leukemia/lymphoma 6
chr12_+_74297474 5.892 ENSMUST00000072100.3
 Dbpht2
DNA binding protein with his-thr domain
chr11_+_3488275 5.472 ENSMUST00000064265.6
 Pla2g3
phospholipase A2, group III
chr3_-_88000350 5.304 ENSMUST00000090971.5
 Bcan
brevican
chr7_+_107567445 5.210 ENSMUST00000120990.1
 Olfml1
olfactomedin-like 1
chr1_+_134182404 5.033 ENSMUST00000153856.1
ENSMUST00000082060.3
ENSMUST00000133701.1
ENSMUST00000132873.1
 Chi3l1



chitinase 3-like 1



chr15_-_54919961 4.946 ENSMUST00000167541.2
ENSMUST00000041591.9
ENSMUST00000173516.1
 Enpp2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr5_+_88886809 4.887 ENSMUST00000148750.1
 Slc4a4
solute carrier family 4 (anion exchanger), member 4
chr15_-_37458523 4.869 ENSMUST00000116445.2
 Ncald
neurocalcin delta
chr4_+_148602527 4.790 ENSMUST00000105701.2
ENSMUST00000052060.6
 Masp2

mannan-binding lectin serine peptidase 2

chr12_+_11265867 4.768 ENSMUST00000020931.5
 Smc6
structural maintenance of chromosomes 6
chr10_-_95417099 4.749 ENSMUST00000135822.1
 Socs2
suppressor of cytokine signaling 2
chr16_-_67620880 4.553 ENSMUST00000114292.1
ENSMUST00000120898.1
 Cadm2

cell adhesion molecule 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 215 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.4 21.4 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.7 16.3 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
1.7 10.1 GO:1902847 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of tau-protein kinase activity(GO:1902949)
0.2 9.5 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
1.2 8.7 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.1 8.7 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
2.8 8.4 GO:0008065 establishment of blood-nerve barrier(GO:0008065)
0.2 8.4 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
2.8 8.3 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
1.4 6.8 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
2.1 6.4 GO:0043379 memory T cell differentiation(GO:0043379) negative regulation of isotype switching to IgE isotypes(GO:0048294)
1.6 6.4 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.6 6.3 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.3 5.9 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
1.4 5.5 GO:0071139 resolution of recombination intermediates(GO:0071139)
1.4 5.5 GO:0019372 lipoxygenase pathway(GO:0019372)
0.1 5.4 GO:0021766 hippocampus development(GO:0021766)
1.7 5.0 GO:2000569 T-helper 2 cell activation(GO:0035712) positive regulation of T-helper 17 type immune response(GO:2000318) regulation of T-helper 2 cell activation(GO:2000569) positive regulation of T-helper 2 cell activation(GO:2000570)
0.2 5.0 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.2 4.9 GO:0015701 bicarbonate transport(GO:0015701)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 101 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 22.6 GO:0005614 interstitial matrix(GO:0005614)
0.9 17.6 GO:0032279 asymmetric synapse(GO:0032279)
1.4 10.1 GO:0034366 spherical high-density lipoprotein particle(GO:0034366) neurofibrillary tangle(GO:0097418)
0.3 9.0 GO:0032809 neuronal cell body membrane(GO:0032809)
0.3 8.3 GO:0030673 axolemma(GO:0030673)
0.0 8.0 GO:0016604 nuclear body(GO:0016604)
0.2 6.3 GO:0030992 intraciliary transport particle B(GO:0030992)
0.1 6.0 GO:0005814 centriole(GO:0005814)
0.1 5.9 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.3 5.0 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 5.0 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
1.6 4.8 GO:0035061 interchromatin granule(GO:0035061)
0.1 4.5 GO:0001772 immunological synapse(GO:0001772)
0.1 4.3 GO:0051233 spindle midzone(GO:0051233)
0.1 4.2 GO:0072562 blood microparticle(GO:0072562)
0.1 4.1 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 3.9 GO:0042734 presynaptic membrane(GO:0042734)
1.1 3.2 GO:0017109 glutamate-cysteine ligase complex(GO:0017109)
0.1 3.2 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 3.2 GO:0030173 integral component of Golgi membrane(GO:0030173)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 145 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.6 21.4 GO:0045545 syndecan binding(GO:0045545)
2.9 17.6 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.5 10.1 GO:0051787 misfolded protein binding(GO:0051787)
0.3 9.2 GO:0043014 alpha-tubulin binding(GO:0043014)
2.2 8.7 GO:0004528 phosphodiesterase I activity(GO:0004528)
1.0 8.3 GO:0008046 axon guidance receptor activity(GO:0008046)
1.3 6.6 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
1.6 6.4 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.5 6.4 GO:0048018 receptor agonist activity(GO:0048018)
0.1 6.4 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.5 5.9 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.1 5.5 GO:0004697 protein kinase C activity(GO:0004697)
0.3 5.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 5.1 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.6 5.0 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
1.6 4.9 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
1.0 4.8 GO:0016972 thiol oxidase activity(GO:0016972)
0.0 4.7 GO:0005509 calcium ion binding(GO:0005509)
0.1 4.4 GO:0017091 AU-rich element binding(GO:0017091)
0.5 4.2 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)