Motif ID: Stat6

Z-value: 0.980


Transcription factors associated with Stat6:

Gene SymbolEntrez IDGene Name
Stat6 ENSMUSG00000002147.12 Stat6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Stat6mm10_v2_chr10_+_127642975_1276430340.374.3e-03Click!


Activity profile for motif Stat6.

activity profile for motif Stat6


Sorted Z-values histogram for motif Stat6

Sorted Z-values for motif Stat6



Network of associatons between targets according to the STRING database.



First level regulatory network of Stat6

PNG image of the network

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Top targets:


Showing 1 to 20 of 140 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_136143497 9.371 ENSMUST00000008016.2
 Id3
inhibitor of DNA binding 3
chr1_+_146497614 9.367 ENSMUST00000132847.1
ENSMUST00000166814.1
 Brinp3

bone morphogenetic protein/retinoic acid inducible neural specific 3

chr18_-_15403680 8.823 ENSMUST00000079081.6
 Aqp4
aquaporin 4
chr2_-_147186389 8.140 ENSMUST00000109970.3
ENSMUST00000067075.5
 Nkx2-2

NK2 homeobox 2

chr18_+_50053282 6.271 ENSMUST00000148159.2
 Tnfaip8
tumor necrosis factor, alpha-induced protein 8
chr11_-_55419898 6.070 ENSMUST00000108858.1
ENSMUST00000141530.1
 Sparc

secreted acidic cysteine rich glycoprotein

chr1_+_146495621 5.624 ENSMUST00000074622.4
 Brinp3
bone morphogenetic protein/retinoic acid inducible neural specific 3
chr7_+_107567445 5.496 ENSMUST00000120990.1
 Olfml1
olfactomedin-like 1
chr15_+_32920723 4.784 ENSMUST00000022871.5
 Sdc2
syndecan 2
chr14_-_21989475 4.687 ENSMUST00000043409.7
 Zfp503
zinc finger protein 503
chr2_-_113848601 4.556 ENSMUST00000110949.2
 Arhgap11a
Rho GTPase activating protein 11A
chr9_-_70421533 4.507 ENSMUST00000034742.6
 Ccnb2
cyclin B2
chr2_-_125723387 4.414 ENSMUST00000042246.7
 Shc4
SHC (Src homology 2 domain containing) family, member 4
chr9_+_44066993 4.381 ENSMUST00000034508.7
 Usp2
ubiquitin specific peptidase 2
chr2_-_113848655 4.364 ENSMUST00000102545.1
ENSMUST00000110948.1
 Arhgap11a

Rho GTPase activating protein 11A

chr6_-_125313844 4.358 ENSMUST00000032489.7
 Ltbr
lymphotoxin B receptor
chr6_+_66896397 4.207 ENSMUST00000043148.6
ENSMUST00000114228.1
ENSMUST00000114227.1
ENSMUST00000114226.1
ENSMUST00000114225.1
ENSMUST00000114224.1
 Gng12





guanine nucleotide binding protein (G protein), gamma 12





chr3_+_97032416 4.129 ENSMUST00000132256.1
ENSMUST00000072600.6
 Gja5

gap junction protein, alpha 5

chr3_-_86548268 3.826 ENSMUST00000077524.3
 Mab21l2
mab-21-like 2 (C. elegans)
chr7_-_70366735 3.808 ENSMUST00000089565.5
 Nr2f2
nuclear receptor subfamily 2, group F, member 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 15.0 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.4 10.5 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.6 9.5 GO:0048642 negative regulation of skeletal muscle tissue development(GO:0048642)
1.8 8.8 GO:0070295 renal water absorption(GO:0070295)
2.7 8.1 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.1 6.3 GO:0050830 defense response to Gram-positive bacterium(GO:0050830)
1.0 6.2 GO:0098700 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842) neurotransmitter loading into synaptic vesicle(GO:0098700)
0.2 6.1 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
0.2 5.3 GO:1903077 negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0 4.8 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
1.6 4.7 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
0.4 4.5 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.3 4.4 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
1.4 4.1 GO:0086017 renin secretion into blood stream(GO:0002001) cell communication by chemical coupling(GO:0010643) Purkinje myocyte action potential(GO:0086017) regulation of renin secretion into blood stream(GO:1900133)
0.8 3.8 GO:0060838 lymphatic endothelial cell fate commitment(GO:0060838) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.1 3.8 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.1 3.8 GO:0043029 T cell homeostasis(GO:0043029)
1.2 3.7 GO:1902524 negative regulation of interferon-alpha production(GO:0032687) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) negative regulation of interferon-beta biosynthetic process(GO:0045358) positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.0 3.7 GO:0048863 stem cell differentiation(GO:0048863)
0.7 3.5 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 13.2 GO:0005813 centrosome(GO:0005813)
0.1 8.8 GO:0009925 basal plasma membrane(GO:0009925)
0.2 7.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
1.5 6.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 5.3 GO:0031225 anchored component of membrane(GO:0031225)
0.3 4.5 GO:0035686 sperm fibrous sheath(GO:0035686)
0.3 4.1 GO:0005922 connexon complex(GO:0005922)
0.0 3.7 GO:0000776 kinetochore(GO:0000776)
0.1 3.6 GO:0031985 Golgi cisterna(GO:0031985)
0.1 3.5 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 2.9 GO:0005802 trans-Golgi network(GO:0005802)
0.1 2.5 GO:0098644 complex of collagen trimers(GO:0098644)
0.1 2.5 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.5 2.4 GO:1990131 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 1.9 GO:0043209 myelin sheath(GO:0043209)
0.0 1.7 GO:0005884 actin filament(GO:0005884)
0.4 1.6 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 1.6 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.0 1.5 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 1.4 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 8.8 GO:0015288 porin activity(GO:0015288)
0.2 8.6 GO:0050840 extracellular matrix binding(GO:0050840)
0.2 8.2 GO:0030332 cyclin binding(GO:0030332)
0.2 7.9 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.7 7.4 GO:0042301 phosphate ion binding(GO:0042301)
0.2 6.4 GO:0005504 fatty acid binding(GO:0005504)
0.2 6.3 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
1.6 6.2 GO:0036468 aromatic-L-amino-acid decarboxylase activity(GO:0004058) L-dopa decarboxylase activity(GO:0036468)
0.0 6.0 GO:0051015 actin filament binding(GO:0051015)
0.7 5.3 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.7 4.5 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.2 4.4 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1 4.4 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.8 4.1 GO:0071253 connexin binding(GO:0071253)
0.0 4.1 GO:0005096 GTPase activator activity(GO:0005096)
0.4 3.8 GO:0001972 retinoic acid binding(GO:0001972)
0.9 3.5 GO:0030156 benzodiazepine receptor binding(GO:0030156)
0.1 3.3 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.2 3.2 GO:0015026 coreceptor activity(GO:0015026)
0.1 2.6 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)