Motif ID: Tbr1

Z-value: 1.201


Transcription factors associated with Tbr1:

Gene SymbolEntrez IDGene Name
Tbr1 ENSMUSG00000035033.9 Tbr1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tbr1mm10_v2_chr2_+_61804453_61804538-0.612.6e-07Click!


Activity profile for motif Tbr1.

activity profile for motif Tbr1


Sorted Z-values histogram for motif Tbr1

Sorted Z-values for motif Tbr1



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbr1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_120899067 11.654 ENSMUST00000092143.5
 Msrb3
methionine sulfoxide reductase B3
chr17_+_34263209 8.947 ENSMUST00000040828.5
 H2-Ab1
histocompatibility 2, class II antigen A, beta 1
chr12_+_109459843 8.406 ENSMUST00000173812.1
 Dlk1
delta-like 1 homolog (Drosophila)
chrX_+_96455359 7.973 ENSMUST00000033553.7
 Heph
hephaestin
chr9_-_43239816 7.915 ENSMUST00000034512.5
 Oaf
OAF homolog (Drosophila)
chr10_+_26229707 7.713 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr7_-_144939823 7.696 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr17_+_87635974 7.314 ENSMUST00000053577.8
 Epcam
epithelial cell adhesion molecule
chr1_+_12692430 6.628 ENSMUST00000180062.1
ENSMUST00000177608.1
 Sulf1

sulfatase 1

chr6_-_94700137 6.260 ENSMUST00000101126.2
ENSMUST00000032105.4
 Lrig1

leucine-rich repeats and immunoglobulin-like domains 1

chr11_+_32283511 5.446 ENSMUST00000093209.3
 Hba-a1
hemoglobin alpha, adult chain 1
chr9_-_106199253 5.278 ENSMUST00000140761.1
 Ppm1m
protein phosphatase 1M
chr13_+_56609516 5.263 ENSMUST00000045173.8
 Tgfbi
transforming growth factor, beta induced
chr11_+_32296489 5.244 ENSMUST00000093207.3
 Hba-a2
hemoglobin alpha, adult chain 2
chr2_+_164562579 5.210 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2


chr7_-_116237767 4.804 ENSMUST00000182834.1
 Plekha7
pleckstrin homology domain containing, family A member 7
chr19_+_55894508 4.772 ENSMUST00000142291.1
 Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr6_+_4504814 4.760 ENSMUST00000141483.1
 Col1a2
collagen, type I, alpha 2
chr3_-_157925056 4.675 ENSMUST00000118539.1
 Cth
cystathionase (cystathionine gamma-lyase)
chr7_-_141443314 4.583 ENSMUST00000106005.2
 Lrdd
leucine-rich and death domain containing

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 336 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 9.4 GO:0030091 protein repair(GO:0030091)
2.2 8.9 GO:0002339 B cell selection(GO:0002339)
2.9 8.6 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.3 8.0 GO:0006825 copper ion transport(GO:0006825)
1.9 7.8 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.4 7.8 GO:0001913 T cell mediated cytotoxicity(GO:0001913)
1.1 7.7 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
1.3 7.5 GO:0045218 zonula adherens maintenance(GO:0045218)
1.4 7.1 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520)
1.2 7.0 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.1 6.7 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
1.7 6.6 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 6.6 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
2.1 6.4 GO:1903232 melanosome assembly(GO:1903232)
2.1 6.3 GO:0032474 otolith morphogenesis(GO:0032474)
0.5 6.3 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.2 5.6 GO:0016578 histone deubiquitination(GO:0016578)
0.1 5.4 GO:0035690 cellular response to drug(GO:0035690)
0.6 4.8 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 4.8 GO:0050658 nucleic acid transport(GO:0050657) RNA transport(GO:0050658)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 159 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 14.7 GO:0005667 transcription factor complex(GO:0005667)
0.1 12.7 GO:0005741 mitochondrial outer membrane(GO:0005741)
2.7 10.7 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.2 9.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
1.3 8.9 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 8.8 GO:0005925 focal adhesion(GO:0005925)
0.0 8.6 GO:0016324 apical plasma membrane(GO:0016324)
0.4 8.0 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 7.8 GO:0001750 photoreceptor outer segment(GO:0001750)
0.7 7.5 GO:0005915 zonula adherens(GO:0005915)
0.1 7.4 GO:0005871 kinesin complex(GO:0005871)
2.4 7.2 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.3 7.0 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.5 6.8 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 6.5 GO:0015934 large ribosomal subunit(GO:0015934)
0.1 6.3 GO:0005604 basement membrane(GO:0005604)
0.0 5.9 GO:0043209 myelin sheath(GO:0043209)
0.0 5.5 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 5.3 GO:0016328 lateral plasma membrane(GO:0016328)
1.6 4.8 GO:0005584 collagen type I trimer(GO:0005584)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 239 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 15.9 GO:0004364 glutathione transferase activity(GO:0004364)
1.7 11.7 GO:0070191 methionine-R-sulfoxide reductase activity(GO:0070191)
1.2 10.8 GO:0015643 toxic substance binding(GO:0015643)
0.2 10.8 GO:0050840 extracellular matrix binding(GO:0050840)
2.7 10.7 GO:0031720 haptoglobin binding(GO:0031720)
0.2 10.5 GO:0043425 bHLH transcription factor binding(GO:0043425)
1.7 10.1 GO:0015375 glycine:sodium symporter activity(GO:0015375)
1.1 8.4 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
1.6 8.0 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.3 7.7 GO:0070064 proline-rich region binding(GO:0070064)
0.6 7.5 GO:0070097 delta-catenin binding(GO:0070097)
0.9 7.3 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.9 7.1 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.3 7.1 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
1.4 7.0 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.1 6.9 GO:0048487 beta-tubulin binding(GO:0048487)
0.1 6.8 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
1.3 6.7 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 6.5 GO:0003779 actin binding(GO:0003779)
2.1 6.4 GO:0035651 AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651)