Motif ID: Tbx4

Z-value: 1.352


Transcription factors associated with Tbx4:

Gene SymbolEntrez IDGene Name
Tbx4 ENSMUSG00000000094.6 Tbx4



Activity profile for motif Tbx4.

activity profile for motif Tbx4


Sorted Z-values histogram for motif Tbx4

Sorted Z-values for motif Tbx4



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx4

PNG image of the network

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Top targets:


Showing 1 to 20 of 122 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_134018829 23.539 ENSMUST00000051674.2
 Lin28a
lin-28 homolog A (C. elegans)
chr2_+_164562579 20.178 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2


chr10_+_26229707 19.247 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr9_-_43239816 16.138 ENSMUST00000034512.5
 Oaf
OAF homolog (Drosophila)
chr1_+_6730051 15.998 ENSMUST00000043578.6
ENSMUST00000131467.1
ENSMUST00000150761.1
ENSMUST00000151281.1
 St18



suppression of tumorigenicity 18



chr14_-_70642268 14.315 ENSMUST00000022697.5
 Fgf17
fibroblast growth factor 17
chr10_-_120899067 12.939 ENSMUST00000092143.5
 Msrb3
methionine sulfoxide reductase B3
chr6_-_94700137 12.148 ENSMUST00000101126.2
ENSMUST00000032105.4
 Lrig1

leucine-rich repeats and immunoglobulin-like domains 1

chr12_+_3891728 10.404 ENSMUST00000172689.1
ENSMUST00000111186.1
 Dnmt3a

DNA methyltransferase 3A

chr1_+_6730135 9.934 ENSMUST00000155921.1
 St18
suppression of tumorigenicity 18
chr10_-_127341583 9.013 ENSMUST00000026474.3
 Gli1
GLI-Kruppel family member GLI1
chr1_-_138847579 8.700 ENSMUST00000093486.3
ENSMUST00000046870.6
 Lhx9

LIM homeobox protein 9

chr11_-_94507337 8.471 ENSMUST00000040692.8
 Mycbpap
MYCBP associated protein
chr17_+_29093763 8.463 ENSMUST00000023829.6
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr6_+_15196949 8.457 ENSMUST00000151301.1
ENSMUST00000131414.1
ENSMUST00000140557.1
ENSMUST00000115469.1
 Foxp2



forkhead box P2



chr7_-_100658394 8.280 ENSMUST00000138830.1
ENSMUST00000107044.3
ENSMUST00000116287.2
 Plekhb1


pleckstrin homology domain containing, family B (evectins) member 1


chr5_+_115908644 8.221 ENSMUST00000141101.1
 Cit
citron
chr4_+_11191726 8.025 ENSMUST00000029866.9
ENSMUST00000108324.3
 Ccne2

cyclin E2

chr19_+_55894508 7.959 ENSMUST00000142291.1
 Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chrX_-_53269020 7.862 ENSMUST00000114838.1
 Fam122b
family with sequence similarity 122, member B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.6 23.5 GO:0010587 miRNA catabolic process(GO:0010587)
1.5 20.0 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
4.9 14.6 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.2 14.3 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
2.6 12.9 GO:0030091 protein repair(GO:0030091)
1.2 12.5 GO:0090527 actin filament reorganization(GO:0090527)
4.0 12.1 GO:0032474 otolith morphogenesis(GO:0032474)
0.4 11.8 GO:0006270 DNA replication initiation(GO:0006270)
3.8 11.3 GO:0045014 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594)
0.8 10.6 GO:0097067 negative regulation of erythrocyte differentiation(GO:0045647) cellular response to thyroid hormone stimulus(GO:0097067)
1.3 10.4 GO:0044027 hypermethylation of CpG island(GO:0044027)
2.3 9.0 GO:0060032 notochord regression(GO:0060032)
1.7 8.7 GO:0035262 gonad morphogenesis(GO:0035262)
0.9 8.5 GO:0071493 cellular response to UV-B(GO:0071493) replicative senescence(GO:0090399)
0.7 8.5 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.5 8.2 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
1.0 8.0 GO:0048625 myoblast fate commitment(GO:0048625)
1.9 7.6 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.2 6.6 GO:0042149 cellular response to glucose starvation(GO:0042149)
1.2 6.2 GO:0007386 compartment pattern specification(GO:0007386)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 23.5 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 20.6 GO:0005667 transcription factor complex(GO:0005667)
0.5 20.0 GO:0032809 neuronal cell body membrane(GO:0032809)
0.2 13.7 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 12.5 GO:0005884 actin filament(GO:0005884)
0.0 11.0 GO:0098793 presynapse(GO:0098793)
0.5 10.4 GO:0001741 XY body(GO:0001741)
0.7 9.0 GO:0097542 ciliary tip(GO:0097542)
2.8 8.5 GO:0070557 PCNA-p21 complex(GO:0070557)
0.1 8.2 GO:0031985 Golgi cisterna(GO:0031985)
0.9 8.0 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.9 5.7 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.0 5.7 GO:0030018 Z disc(GO:0030018)
1.0 5.1 GO:1990357 terminal web(GO:1990357)
0.4 4.7 GO:0000124 SAGA complex(GO:0000124)
0.2 4.4 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.3 4.1 GO:0005922 connexon complex(GO:0005922)
0.0 4.0 GO:0000775 chromosome, centromeric region(GO:0000775)
0.3 3.4 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 3.3 GO:0034707 chloride channel complex(GO:0034707)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 28.9 GO:0008270 zinc ion binding(GO:0008270)
1.2 23.5 GO:0035198 miRNA binding(GO:0035198)
0.4 20.2 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.5 20.0 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.4 16.8 GO:0070888 E-box binding(GO:0070888)
2.4 14.6 GO:0015375 glycine:sodium symporter activity(GO:0015375)
4.8 14.3 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 13.7 GO:0008022 protein C-terminus binding(GO:0008022)
0.4 13.4 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
1.8 12.9 GO:0070191 methionine-R-sulfoxide reductase activity(GO:0070191)
1.2 12.5 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.3 11.3 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
1.3 10.4 GO:0051718 DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.1 9.0 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 8.8 GO:0097110 scaffold protein binding(GO:0097110)
0.1 8.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.6 8.5 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.4 8.0 GO:0045295 gamma-catenin binding(GO:0045295)
1.3 7.6 GO:0001758 retinal dehydrogenase activity(GO:0001758) 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0 6.6 GO:0000287 magnesium ion binding(GO:0000287)