Motif ID: Tbx5

Z-value: 0.749


Transcription factors associated with Tbx5:

Gene SymbolEntrez IDGene Name
Tbx5 ENSMUSG00000018263.8 Tbx5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tbx5mm10_v2_chr5_+_119834663_119834663-0.171.9e-01Click!


Activity profile for motif Tbx5.

activity profile for motif Tbx5


Sorted Z-values histogram for motif Tbx5

Sorted Z-values for motif Tbx5



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx5

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_54085542 3.628 ENSMUST00000100089.2
 Rprm
reprimo, TP53 dependent G2 arrest mediator candidate
chr1_-_75219245 3.579 ENSMUST00000079464.6
 Tuba4a
tubulin, alpha 4A
chr17_-_8566869 3.046 ENSMUST00000184183.1
 Gm17087
predicted gene 17087
chr10_+_96136603 2.713 ENSMUST00000074615.6
 Gm5426
predicted pseudogene 5426
chr17_-_46440099 2.660 ENSMUST00000166852.1
 Gm5093
predicted gene 5093
chr11_+_94741782 2.434 ENSMUST00000021240.6
 Cdc34-ps
cell division cycle 34 homolog, pseudogene (S. cerevisiae)
chr9_-_59146210 2.357 ENSMUST00000085631.2
 Gm7589
predicted gene 7589
chr3_+_75557530 2.298 ENSMUST00000161776.1
ENSMUST00000029423.8
 Serpini1

serine (or cysteine) peptidase inhibitor, clade I, member 1

chr11_+_98348404 2.242 ENSMUST00000078694.6
 Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr5_-_22344690 2.200 ENSMUST00000062372.7
ENSMUST00000161356.1
 Reln

reelin

chr1_-_138848576 1.899 ENSMUST00000112030.2
 Lhx9
LIM homeobox protein 9
chr5_+_98180866 1.824 ENSMUST00000112959.1
 Prdm8
PR domain containing 8
chr8_-_105637403 1.814 ENSMUST00000182046.1
 Gm5914
predicted gene 5914
chr8_+_5639514 1.716 ENSMUST00000051687.3
 Gm1840
predicted gene 1840
chr10_-_120899067 1.706 ENSMUST00000092143.5
 Msrb3
methionine sulfoxide reductase B3
chr1_-_16770138 1.697 ENSMUST00000071842.8
 Gm5828
predicted gene 5828
chr6_+_17307632 1.485 ENSMUST00000115453.1
 Cav1
caveolin 1, caveolae protein
chr6_+_115134899 1.431 ENSMUST00000009538.5
ENSMUST00000169345.1
 Syn2

synapsin II

chr11_-_84068766 1.391 ENSMUST00000018792.5
 Dusp14
dual specificity phosphatase 14
chr19_+_4003334 1.358 ENSMUST00000025806.3
 Doc2g
double C2, gamma

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 124 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 3.7 GO:1900085 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085)
0.0 2.9 GO:0007050 cell cycle arrest(GO:0007050)
0.1 2.6 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 2.3 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.7 2.2 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.5 1.9 GO:0097477 lateral motor column neuron migration(GO:0097477)
0.4 1.9 GO:0035262 gonad morphogenesis(GO:0035262)
0.1 1.8 GO:0021540 corpus callosum morphogenesis(GO:0021540)
0.1 1.8 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.3 1.7 GO:0030091 protein repair(GO:0030091)
0.0 1.7 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.1 1.4 GO:0097067 negative regulation of erythrocyte differentiation(GO:0045647) cellular response to thyroid hormone stimulus(GO:0097067)
0.0 1.4 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 1.4 GO:0099643 neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
0.2 1.3 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.1 1.3 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.0 1.3 GO:0015909 long-chain fatty acid transport(GO:0015909)
0.2 1.2 GO:0015671 oxygen transport(GO:0015671)
0.1 1.2 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.4 1.1 GO:0070634 transepithelial ammonium transport(GO:0070634)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.7 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 3.4 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 2.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 2.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 1.7 GO:0009925 basal plasma membrane(GO:0009925)
0.0 1.7 GO:0030496 midbody(GO:0030496)
0.0 1.4 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 1.2 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 1.1 GO:0019867 mitochondrial outer membrane(GO:0005741) outer membrane(GO:0019867) organelle outer membrane(GO:0031968)
0.0 1.1 GO:0005814 centriole(GO:0005814)
0.2 0.9 GO:0002177 manchette(GO:0002177)
0.1 0.8 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.8 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.7 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.7 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.2 0.6 GO:0048179 activin receptor complex(GO:0048179)
0.2 0.6 GO:0035061 interchromatin granule(GO:0035061)
0.1 0.6 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.1 0.6 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.6 GO:0000124 SAGA complex(GO:0000124)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 93 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 3.7 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.0 3.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.7 2.2 GO:0031752 D3 dopamine receptor binding(GO:0031750) D5 dopamine receptor binding(GO:0031752)
0.4 2.2 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.0 2.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.8 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 1.8 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.2 1.7 GO:0070191 methionine-R-sulfoxide reductase activity(GO:0070191)
0.2 1.7 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.3 1.6 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095)
0.0 1.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 1.4 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 1.4 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 1.4 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.3 1.2 GO:0004096 catalase activity(GO:0004096)
0.0 1.2 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 1.0 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 0.9 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.1 0.9 GO:0030506 ankyrin binding(GO:0030506)