Motif ID: Tcf21_Msc

Z-value: 1.151

Transcription factors associated with Tcf21_Msc:

Gene SymbolEntrez IDGene Name
Msc ENSMUSG00000025930.5 Msc
Tcf21 ENSMUSG00000045680.7 Tcf21



Activity profile for motif Tcf21_Msc.

activity profile for motif Tcf21_Msc


Sorted Z-values histogram for motif Tcf21_Msc

Sorted Z-values for motif Tcf21_Msc



Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf21_Msc

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_106485214 20.426 ENSMUST00000039447.7
 Fndc3c1
fibronectin type III domain containing 3C1
chr2_-_122611238 17.094 ENSMUST00000028624.8
 Gatm
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chrX_-_106485367 15.308 ENSMUST00000140707.1
 Fndc3c1
fibronectin type III domain containing 3C1
chr13_-_71963713 6.940 ENSMUST00000077337.8
 Irx1
Iroquois related homeobox 1 (Drosophila)
chr3_+_90537242 6.702 ENSMUST00000098911.3
 S100a16
S100 calcium binding protein A16
chr12_+_109459843 6.391 ENSMUST00000173812.1
 Dlk1
delta-like 1 homolog (Drosophila)
chr14_-_20181773 6.182 ENSMUST00000024011.8
 Kcnk5
potassium channel, subfamily K, member 5
chr18_+_73863672 5.955 ENSMUST00000134847.1
 Mro
maestro
chr6_+_107529717 5.812 ENSMUST00000049285.8
 Lrrn1
leucine rich repeat protein 1, neuronal
chr18_+_4994600 5.812 ENSMUST00000140448.1
 Svil
supervillin
chr18_+_50051702 5.709 ENSMUST00000134348.1
ENSMUST00000153873.2
 Tnfaip8

tumor necrosis factor, alpha-induced protein 8

chr3_+_14863495 5.705 ENSMUST00000029076.4
 Car3
carbonic anhydrase 3
chr11_-_4118778 5.686 ENSMUST00000003681.7
 Sec14l2
SEC14-like 2 (S. cerevisiae)
chr8_-_122432924 5.405 ENSMUST00000017604.8
 Cyba
cytochrome b-245, alpha polypeptide
chr3_+_90537306 5.148 ENSMUST00000107335.1
 S100a16
S100 calcium binding protein A16
chr13_-_100786402 5.125 ENSMUST00000174038.1
ENSMUST00000091295.7
ENSMUST00000072119.8
 Ccnb1


cyclin B1


chr2_-_105399286 4.884 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1
chr11_+_99864476 4.738 ENSMUST00000092694.3
 Gm11559
predicted gene 11559
chrX_+_71663665 4.712 ENSMUST00000070449.5
 Gpr50
G-protein-coupled receptor 50
chr15_+_78926720 4.391 ENSMUST00000089377.5
 Lgals1
lectin, galactose binding, soluble 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 235 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.7 17.1 GO:0006601 creatine biosynthetic process(GO:0006601)
0.2 8.7 GO:0006730 one-carbon metabolic process(GO:0006730)
0.1 8.7 GO:0051592 response to calcium ion(GO:0051592)
0.8 7.0 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.5 6.3 GO:0090205 positive regulation of cholesterol biosynthetic process(GO:0045542) positive regulation of cholesterol metabolic process(GO:0090205)
0.2 6.2 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.4 5.9 GO:0007202 activation of phospholipase C activity(GO:0007202)
0.1 5.7 GO:0032611 interleukin-1 beta production(GO:0032611)
1.8 5.4 GO:0033860 regulation of NAD(P)H oxidase activity(GO:0033860)
1.3 5.1 GO:0043987 histone H3-S10 phosphorylation(GO:0043987)
1.6 4.8 GO:0036292 DNA rewinding(GO:0036292)
0.4 4.6 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.9 4.4 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.2 4.3 GO:0051127 positive regulation of actin nucleation(GO:0051127)
0.2 4.3 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
1.3 4.0 GO:2000564 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) CD8-positive, alpha-beta T cell proliferation(GO:0035740) negative regulation of regulatory T cell differentiation(GO:0045590) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564)
0.7 4.0 GO:0035405 histone-threonine phosphorylation(GO:0035405) positive regulation of B cell receptor signaling pathway(GO:0050861)
0.4 4.0 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.4 4.0 GO:0090527 actin filament reorganization(GO:0090527)
0.1 4.0 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 107 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 13.6 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 10.4 GO:0005615 extracellular space(GO:0005615)
0.0 9.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 7.4 GO:0009897 external side of plasma membrane(GO:0009897)
0.2 5.6 GO:0043034 costamere(GO:0043034)
1.4 5.4 GO:0043020 NADPH oxidase complex(GO:0043020)
1.3 5.1 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.1 5.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 4.7 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 4.6 GO:0031526 brush border membrane(GO:0031526)
0.6 4.4 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.4 4.2 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 4.2 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
1.0 4.0 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 4.0 GO:0000118 histone deacetylase complex(GO:0000118)
0.6 3.7 GO:0016011 dystroglycan complex(GO:0016011)
0.1 3.7 GO:0043596 nuclear replication fork(GO:0043596)
0.4 3.6 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.2 3.5 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 3.5 GO:0072562 blood microparticle(GO:0072562)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 157 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 19.9 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
0.0 15.2 GO:0005509 calcium ion binding(GO:0005509)
0.1 9.3 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.7 8.7 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.2 7.7 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.2 7.2 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 6.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.2 5.9 GO:0001069 regulatory region RNA binding(GO:0001069)
1.4 5.4 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
1.0 5.1 GO:0005113 patched binding(GO:0005113)
0.1 4.9 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.4 4.8 GO:0036310 annealing helicase activity(GO:0036310)
1.6 4.7 GO:0008502 melatonin receptor activity(GO:0008502)
0.2 4.5 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
1.5 4.4 GO:0005534 galactose binding(GO:0005534)
0.4 4.3 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.4 4.3 GO:0038191 neuropilin binding(GO:0038191)
0.0 4.3 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.2 4.2 GO:0008307 structural constituent of muscle(GO:0008307)
0.6 4.0 GO:0045703 pinocarveol dehydrogenase activity(GO:0018446) chloral hydrate dehydrogenase activity(GO:0018447) hydroxymethylmethylsilanediol oxidase activity(GO:0018448) 1-phenylethanol dehydrogenase activity(GO:0018449) myrtenol dehydrogenase activity(GO:0018450) cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene dehydrogenase activity(GO:0034522) 3-hydroxy-4-methyloctanoyl-CoA dehydrogenase activity(GO:0034582) 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA dehydrogenase activity(GO:0034778) cis-9,10-dihydroanthracene-9,10-diol dehydrogenase activity(GO:0034817) citronellol dehydrogenase activity(GO:0034821) naphthyl-2-hydroxymethyl-succinyl-CoA dehydrogenase activity(GO:0034847) 2,4,4-trimethyl-1-pentanol dehydrogenase activity(GO:0034863) 2,4,4-trimethyl-3-hydroxypentanoyl-CoA dehydrogenase activity(GO:0034868) 1-hydroxy-4,4-dimethylpentan-3-one dehydrogenase activity(GO:0034871) endosulfan diol dehydrogenase activity(GO:0034891) endosulfan hydroxyether dehydrogenase activity(GO:0034901) 3-hydroxy-2-methylhexanoyl-CoA dehydrogenase activity(GO:0034918) 3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA dehydrogenase activity(GO:0034944) versicolorin reductase activity(GO:0042469) ketoreductase activity(GO:0045703)