Motif ID: Tcf3

Z-value: 0.852


Transcription factors associated with Tcf3:

Gene SymbolEntrez IDGene Name
Tcf3 ENSMUSG00000020167.8 Tcf3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf3mm10_v2_chr10_-_80421847_804218760.444.2e-04Click!


Activity profile for motif Tcf3.

activity profile for motif Tcf3


Sorted Z-values histogram for motif Tcf3

Sorted Z-values for motif Tcf3



Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_109459843 11.590 ENSMUST00000173812.1
 Dlk1
delta-like 1 homolog (Drosophila)
chr6_+_29694204 7.187 ENSMUST00000046750.7
ENSMUST00000115250.3
 Tspan33

tetraspanin 33

chr4_-_43523388 6.461 ENSMUST00000107913.3
ENSMUST00000030184.5
 Tpm2

tropomyosin 2, beta

chr2_-_122611238 6.324 ENSMUST00000028624.8
 Gatm
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr14_+_27039001 6.258 ENSMUST00000035336.3
 Il17rd
interleukin 17 receptor D
chr4_-_43523746 6.034 ENSMUST00000150592.1
 Tpm2
tropomyosin 2, beta
chr6_-_72235559 6.022 ENSMUST00000042646.7
 Atoh8
atonal homolog 8 (Drosophila)
chr8_+_105518736 5.873 ENSMUST00000034363.5
 Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
chr4_-_43523595 5.693 ENSMUST00000107914.3
 Tpm2
tropomyosin 2, beta
chr15_+_34238026 5.624 ENSMUST00000022867.3
 Laptm4b
lysosomal-associated protein transmembrane 4B
chr19_-_45560508 5.300 ENSMUST00000026239.6
 Poll
polymerase (DNA directed), lambda
chr11_-_102365111 5.166 ENSMUST00000006749.9
 Slc4a1
solute carrier family 4 (anion exchanger), member 1
chrX_-_106485214 5.006 ENSMUST00000039447.7
 Fndc3c1
fibronectin type III domain containing 3C1
chr4_-_133872997 4.652 ENSMUST00000137486.2
 Rps6ka1
ribosomal protein S6 kinase polypeptide 1
chr1_+_74791516 4.449 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr14_-_20181773 4.401 ENSMUST00000024011.8
 Kcnk5
potassium channel, subfamily K, member 5
chr9_+_58134535 4.389 ENSMUST00000128378.1
ENSMUST00000150820.1
ENSMUST00000167479.1
ENSMUST00000134450.1
 Stra6



stimulated by retinoic acid gene 6



chr5_-_98566762 4.301 ENSMUST00000086912.4
 1700010H22Rik
RIKEN cDNA 1700010H22 gene
chrX_-_48034842 4.192 ENSMUST00000039026.7
 Apln
apelin
chr19_+_45560569 4.148 ENSMUST00000047057.7
 Dpcd
deleted in primary ciliary dyskinesia

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 244 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 11.8 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.3 9.3 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.7 8.3 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.7 7.8 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.6 7.5 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
1.0 7.0 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.5 7.0 GO:0097067 negative regulation of erythrocyte differentiation(GO:0045647) cellular response to thyroid hormone stimulus(GO:0097067)
2.1 6.3 GO:0006601 creatine biosynthetic process(GO:0006601)
0.5 6.0 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.5 5.9 GO:0001977 renal system process involved in regulation of blood volume(GO:0001977)
0.8 5.8 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.9 5.3 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.2 5.2 GO:0014823 response to activity(GO:0014823)
1.2 4.9 GO:0046836 glycolipid transport(GO:0046836)
0.3 4.8 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.9 4.4 GO:0046864 retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865) alveolar primary septum development(GO:0061143)
1.1 4.3 GO:0060032 notochord regression(GO:0060032)
0.6 4.2 GO:0051461 positive regulation of heat generation(GO:0031652) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.5 4.1 GO:0021678 third ventricle development(GO:0021678)
1.3 4.0 GO:0032650 regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730) cardiac cell fate determination(GO:0060913)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 109 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 18.2 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 12.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 7.6 GO:0005819 spindle(GO:0005819)
1.0 7.2 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 6.8 GO:0031970 organelle envelope lumen(GO:0031970)
0.1 6.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.5 6.3 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 6.2 GO:0000922 spindle pole(GO:0000922)
0.1 5.7 GO:0072562 blood microparticle(GO:0072562)
0.0 5.3 GO:0031012 extracellular matrix(GO:0031012)
0.1 4.7 GO:0031594 neuromuscular junction(GO:0031594)
1.5 4.5 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.3 4.3 GO:0097542 ciliary tip(GO:0097542)
0.1 3.9 GO:0016459 myosin complex(GO:0016459)
0.1 3.8 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 3.8 GO:0005923 bicellular tight junction(GO:0005923)
0.1 3.7 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 3.7 GO:0016323 basolateral plasma membrane(GO:0016323)
0.6 3.4 GO:0045179 apical cortex(GO:0045179)
0.1 3.3 GO:0032839 dendrite cytoplasm(GO:0032839)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 167 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 14.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.3 13.0 GO:0070888 E-box binding(GO:0070888)
0.4 11.7 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
0.0 9.2 GO:0005525 GTP binding(GO:0005525)
0.2 8.0 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.4 7.5 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.2 7.0 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.7 6.7 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
2.1 6.3 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.1 6.3 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.3 6.2 GO:0035380 C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity(GO:0000252) mevaldate reductase activity(GO:0004495) gluconate dehydrogenase activity(GO:0008875) epoxide dehydrogenase activity(GO:0018451) 5-exo-hydroxycamphor dehydrogenase activity(GO:0018452) 2-hydroxytetrahydrofuran dehydrogenase activity(GO:0018453) acetoin dehydrogenase activity(GO:0019152) phenylcoumaran benzylic ether reductase activity(GO:0032442) D-xylose:NADP reductase activity(GO:0032866) L-arabinose:NADP reductase activity(GO:0032867) D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity(GO:0033709) (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity(GO:0034831) 3-hydroxymenthone dehydrogenase activity(GO:0034840) very long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0035380) dihydrotestosterone 17-beta-dehydrogenase activity(GO:0035410) (R)-2-hydroxyisocaproate dehydrogenase activity(GO:0043713) L-arabinose 1-dehydrogenase (NADP+) activity(GO:0044103) L-xylulose reductase (NAD+) activity(GO:0044105) 3-ketoglucose-reductase activity(GO:0048258) D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity(GO:0052677)
0.0 6.2 GO:0003774 motor activity(GO:0003774)
0.3 5.9 GO:0008307 structural constituent of muscle(GO:0008307)
0.4 5.8 GO:0048407 platelet-derived growth factor binding(GO:0048407)
1.4 5.4 GO:0050436 microfibril binding(GO:0050436)
0.8 5.4 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.3 5.2 GO:0015106 bicarbonate transmembrane transporter activity(GO:0015106)
0.2 5.1 GO:0005112 Notch binding(GO:0005112)
0.1 5.1 GO:0005109 frizzled binding(GO:0005109)
0.1 5.1 GO:0004364 glutathione transferase activity(GO:0004364)