Motif ID: Tcf4_Mesp1

Z-value: 2.186

Transcription factors associated with Tcf4_Mesp1:

Gene SymbolEntrez IDGene Name
Mesp1 ENSMUSG00000030544.5 Mesp1
Tcf4 ENSMUSG00000053477.9 Tcf4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf4mm10_v2_chr18_+_69346143_693462030.462.2e-04Click!


Activity profile for motif Tcf4_Mesp1.

activity profile for motif Tcf4_Mesp1


Sorted Z-values histogram for motif Tcf4_Mesp1

Sorted Z-values for motif Tcf4_Mesp1



Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf4_Mesp1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66831625 42.544 ENSMUST00000164163.1
 Sla
src-like adaptor
chr13_-_57907587 41.767 ENSMUST00000172326.1
 Spock1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1
chr5_+_37028329 30.708 ENSMUST00000173836.1
 Jakmip1
janus kinase and microtubule interacting protein 1
chr13_+_83504032 26.173 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr3_+_75557530 24.053 ENSMUST00000161776.1
ENSMUST00000029423.8
 Serpini1

serine (or cysteine) peptidase inhibitor, clade I, member 1

chr11_-_67922136 23.522 ENSMUST00000021288.3
ENSMUST00000108677.1
 Usp43

ubiquitin specific peptidase 43

chr5_-_139130159 19.648 ENSMUST00000129851.1
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr11_+_113619318 18.796 ENSMUST00000146390.2
ENSMUST00000106630.1
 Sstr2

somatostatin receptor 2

chr16_-_97170707 18.480 ENSMUST00000056102.7
 Dscam
Down syndrome cell adhesion molecule
chr18_-_42899294 17.973 ENSMUST00000117687.1
 Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr18_-_42899470 17.438 ENSMUST00000120632.1
 Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr7_+_16310412 16.793 ENSMUST00000136781.1
 Bbc3
BCL2 binding component 3
chr15_+_98634743 16.721 ENSMUST00000003442.7
 Cacnb3
calcium channel, voltage-dependent, beta 3 subunit
chr12_+_102948843 16.455 ENSMUST00000101099.5
 Unc79
unc-79 homolog (C. elegans)
chr12_+_82616885 16.380 ENSMUST00000161801.1
 Rgs6
regulator of G-protein signaling 6
chr10_+_123264076 16.215 ENSMUST00000050756.7
 Fam19a2
family with sequence similarity 19, member A2
chr7_+_44384803 16.083 ENSMUST00000120262.1
 Syt3
synaptotagmin III
chr7_-_4546567 15.709 ENSMUST00000065957.5
 Syt5
synaptotagmin V
chr7_+_44384604 15.325 ENSMUST00000130707.1
ENSMUST00000130844.1
 Syt3

synaptotagmin III

chr12_-_79007276 14.839 ENSMUST00000056660.6
ENSMUST00000174721.1
 Tmem229b

transmembrane protein 229B


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 518 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.8 50.4 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.7 38.6 GO:0010812 negative regulation of cell-substrate adhesion(GO:0010812)
5.1 35.4 GO:0034047 regulation of protein phosphatase type 2A activity(GO:0034047)
0.8 30.1 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.6 29.6 GO:0017158 regulation of calcium ion-dependent exocytosis(GO:0017158)
0.2 29.4 GO:0050890 cognition(GO:0050890)
1.8 26.9 GO:0006750 glutathione biosynthetic process(GO:0006750)
6.7 26.8 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
1.8 26.4 GO:0060081 membrane hyperpolarization(GO:0060081)
8.7 26.2 GO:2000111 cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
2.4 24.3 GO:0048149 behavioral response to ethanol(GO:0048149)
1.1 23.6 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
3.1 21.6 GO:0061502 early endosome to recycling endosome transport(GO:0061502)
0.5 21.4 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.2 20.9 GO:0016579 protein deubiquitination(GO:0016579)
0.5 20.5 GO:0034605 cellular response to heat(GO:0034605)
0.9 19.8 GO:0043496 regulation of protein homodimerization activity(GO:0043496)
1.8 19.7 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
2.4 18.9 GO:0030432 peristalsis(GO:0030432)
6.2 18.5 GO:0060060 post-embryonic retina morphogenesis in camera-type eye(GO:0060060)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 187 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 83.6 GO:0060076 excitatory synapse(GO:0060076)
1.2 62.5 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.4 57.2 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.6 53.3 GO:0043195 terminal bouton(GO:0043195)
0.4 46.5 GO:0055037 recycling endosome(GO:0055037)
2.3 43.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
1.3 40.6 GO:0033268 node of Ranvier(GO:0033268)
0.3 39.5 GO:0097060 synaptic membrane(GO:0097060)
0.2 31.8 GO:0019898 extrinsic component of membrane(GO:0019898)
0.3 23.0 GO:0070382 exocytic vesicle(GO:0070382)
0.1 22.6 GO:0031410 cytoplasmic vesicle(GO:0031410)
0.7 22.1 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
2.2 21.8 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
1.6 20.9 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.5 20.5 GO:0031901 early endosome membrane(GO:0031901)
0.1 15.8 GO:0005768 endosome(GO:0005768)
0.6 15.5 GO:0001891 phagocytic cup(GO:0001891)
0.4 15.1 GO:0042734 presynaptic membrane(GO:0042734)
1.6 14.5 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.2 14.5 GO:0030139 endocytic vesicle(GO:0030139)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 339 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 62.5 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
2.4 43.9 GO:0050811 GABA receptor binding(GO:0050811)
3.1 43.7 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
1.4 39.6 GO:0001786 phosphatidylserine binding(GO:0001786)
0.2 36.8 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.8 34.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
2.5 32.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.7 31.1 GO:0045499 chemorepellent activity(GO:0045499)
1.4 28.8 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.8 26.6 GO:0030552 cAMP binding(GO:0030552)
2.3 25.3 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.2 25.3 GO:0101005 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
1.3 25.0 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
2.2 23.8 GO:0003680 AT DNA binding(GO:0003680)
2.5 22.1 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
1.6 21.8 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.8 21.1 GO:0004027 alcohol sulfotransferase activity(GO:0004027)
0.4 20.2 GO:0030507 spectrin binding(GO:0030507)
0.6 19.4 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
6.3 18.8 GO:0004994 somatostatin receptor activity(GO:0004994)