Motif ID: Tcf7_Tcf7l2

Z-value: 0.922

Transcription factors associated with Tcf7_Tcf7l2:

Gene SymbolEntrez IDGene Name
Tcf7 ENSMUSG00000000782.9 Tcf7
Tcf7l2 ENSMUSG00000024985.12 Tcf7l2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf7mm10_v2_chr11_-_52282564_522825790.256.1e-02Click!
Tcf7l2mm10_v2_chr19_+_55742242_557424680.123.9e-01Click!


Activity profile for motif Tcf7_Tcf7l2.

activity profile for motif Tcf7_Tcf7l2


Sorted Z-values histogram for motif Tcf7_Tcf7l2

Sorted Z-values for motif Tcf7_Tcf7l2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf7_Tcf7l2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_20737306 4.069 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chr17_-_47016956 3.764 ENSMUST00000165525.1
 Gm16494
predicted gene 16494
chr12_-_91384403 3.250 ENSMUST00000141429.1
 Cep128
centrosomal protein 128
chr15_+_102296256 3.216 ENSMUST00000064924.4
 Espl1
extra spindle poles-like 1 (S. cerevisiae)
chr3_+_76074270 3.129 ENSMUST00000038364.8
 Fstl5
follistatin-like 5
chr10_-_63421739 3.056 ENSMUST00000054760.4
 Gm7075
predicted gene 7075
chr14_+_63436394 2.896 ENSMUST00000121288.1
 Fam167a
family with sequence similarity 167, member A
chr11_-_87108656 2.797 ENSMUST00000051395.8
 Prr11
proline rich 11
chr15_+_85859689 2.765 ENSMUST00000170629.1
 Gtse1
G two S phase expressed protein 1
chr7_-_144939823 2.736 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr1_+_88227005 2.660 ENSMUST00000061013.6
ENSMUST00000113130.1
 Mroh2a

maestro heat-like repeat family member 2A

chr12_+_53248677 2.621 ENSMUST00000101432.2
 Npas3
neuronal PAS domain protein 3
chr2_+_102706356 2.584 ENSMUST00000123759.1
ENSMUST00000111212.1
ENSMUST00000005220.4
 Slc1a2


solute carrier family 1 (glial high affinity glutamate transporter), member 2


chr4_+_105789869 2.429 ENSMUST00000184254.1
 Gm12728
predicted gene 12728
chr3_+_54481429 2.423 ENSMUST00000091130.3
 Gm5641
predicted gene 5641
chr1_+_157458554 2.419 ENSMUST00000046743.4
ENSMUST00000119891.1
 BC026585

cDNA sequence BC026585

chr4_-_43499608 2.382 ENSMUST00000136005.1
ENSMUST00000054538.6
 Arhgef39

Rho guanine nucleotide exchange factor (GEF) 39

chr7_+_45216671 2.367 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr7_+_67655414 2.353 ENSMUST00000107470.1
 Ttc23
tetratricopeptide repeat domain 23
chr10_-_13388753 2.296 ENSMUST00000105546.1
 Phactr2
phosphatase and actin regulator 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 134 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 5.0 GO:0000212 meiotic spindle organization(GO:0000212)
1.2 4.7 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.0 3.8 GO:0048706 embryonic skeletal system development(GO:0048706)
0.1 3.6 GO:0007638 mechanosensory behavior(GO:0007638)
0.1 3.2 GO:0001947 heart looping(GO:0001947)
0.2 3.1 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.4 2.7 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.4 2.7 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.4 2.6 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.2 2.6 GO:0042711 maternal behavior(GO:0042711)
0.3 2.4 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.1 2.4 GO:0030903 notochord development(GO:0030903)
0.1 2.3 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.0 2.3 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.7 2.2 GO:0014005 microglia differentiation(GO:0014004) microglia development(GO:0014005)
0.1 2.2 GO:0032288 myelin assembly(GO:0032288)
0.0 2.2 GO:0016126 sterol biosynthetic process(GO:0016126)
0.1 2.1 GO:0001573 ganglioside metabolic process(GO:0001573)
0.5 2.0 GO:0071449 cellular response to lipid hydroperoxide(GO:0071449)
0.6 1.8 GO:0072139 glomerular parietal epithelial cell differentiation(GO:0072139)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.6 GO:0005667 transcription factor complex(GO:0005667)
0.0 4.5 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.2 4.4 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.2 4.3 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 3.6 GO:0072686 mitotic spindle(GO:0072686)
0.0 3.6 GO:0005814 centriole(GO:0005814)
0.1 2.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 2.6 GO:0030673 axolemma(GO:0030673)
0.6 2.5 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.2 2.2 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.4 2.1 GO:0036449 microtubule minus-end(GO:0036449)
0.0 2.0 GO:0005813 centrosome(GO:0005813)
0.0 1.9 GO:0005844 polysome(GO:0005844)
0.6 1.8 GO:0071914 prominosome(GO:0071914)
0.0 1.8 GO:0016605 PML body(GO:0016605)
0.1 1.6 GO:0010369 chromocenter(GO:0010369)
0.1 1.6 GO:0045120 pronucleus(GO:0045120)
0.2 1.5 GO:0030056 hemidesmosome(GO:0030056)
0.1 1.5 GO:0097228 sperm principal piece(GO:0097228)
0.0 1.5 GO:0000788 nuclear nucleosome(GO:0000788)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 89 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.7 GO:0070411 I-SMAD binding(GO:0070411)
0.1 4.0 GO:0008748 N-ethylmaleimide reductase activity(GO:0008748) reduced coenzyme F420 dehydrogenase activity(GO:0043738) sulfur oxygenase reductase activity(GO:0043826) malolactic enzyme activity(GO:0043883) epoxyqueuosine reductase activity(GO:0052693)
0.0 4.0 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.0 3.9 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 3.5 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 3.0 GO:0070064 proline-rich region binding(GO:0070064)
0.3 2.9 GO:0001846 opsonin binding(GO:0001846)
0.0 2.9 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 2.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 2.7 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.6 2.6 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 2.4 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0 2.4 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 2.4 GO:0008017 microtubule binding(GO:0008017)
0.0 2.3 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.3 2.2 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 2.1 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 1.9 GO:0003714 transcription corepressor activity(GO:0003714)
0.5 1.8 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.1 1.8 GO:0017025 TBP-class protein binding(GO:0017025)