Motif ID: Tcf7l1

Z-value: 1.081


Transcription factors associated with Tcf7l1:

Gene SymbolEntrez IDGene Name
Tcf7l1 ENSMUSG00000055799.7 Tcf7l1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf7l1mm10_v2_chr6_-_72788952_727890610.564.8e-06Click!


Activity profile for motif Tcf7l1.

activity profile for motif Tcf7l1


Sorted Z-values histogram for motif Tcf7l1

Sorted Z-values for motif Tcf7l1



Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf7l1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_180889660 12.164 ENSMUST00000137629.1
 Gm14342
predicted gene 14342
chr17_-_70851189 9.462 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr3_+_131110350 8.820 ENSMUST00000066849.6
ENSMUST00000106341.2
ENSMUST00000029611.7
 Lef1


lymphoid enhancer binding factor 1


chr7_-_49636847 8.362 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr14_-_98169542 7.283 ENSMUST00000069334.7
ENSMUST00000071533.6
 Dach1

dachshund 1 (Drosophila)

chr1_-_183147461 6.932 ENSMUST00000171366.1
 Disp1
dispatched homolog 1 (Drosophila)
chr11_+_108920800 6.803 ENSMUST00000140821.1
 Axin2
axin2
chrX_+_6415736 6.354 ENSMUST00000143641.3
 Shroom4
shroom family member 4
chr6_+_17065129 6.337 ENSMUST00000115467.4
ENSMUST00000154266.2
ENSMUST00000076654.7
 Tes


testis derived transcript


chr2_+_174760619 5.487 ENSMUST00000029030.2
 Edn3
endothelin 3
chr14_+_27039001 5.481 ENSMUST00000035336.3
 Il17rd
interleukin 17 receptor D
chrX_-_48034842 5.179 ENSMUST00000039026.7
 Apln
apelin
chr6_-_148944750 5.169 ENSMUST00000111562.1
ENSMUST00000081956.5
 Fam60a

family with sequence similarity 60, member A

chr2_+_173022360 5.119 ENSMUST00000173997.1
 Rbm38
RNA binding motif protein 38
chr7_-_144939823 4.873 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr13_-_102905740 4.726 ENSMUST00000167462.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr5_-_134946917 4.671 ENSMUST00000051401.2
 Cldn4
claudin 4
chr10_-_61979073 4.647 ENSMUST00000105453.1
ENSMUST00000105452.2
ENSMUST00000105454.2
 Col13a1


collagen, type XIII, alpha 1


chr15_+_34238026 4.560 ENSMUST00000022867.3
 Laptm4b
lysosomal-associated protein transmembrane 4B
chr17_-_89910449 4.491 ENSMUST00000086423.4
 Gm10184
predicted pseudogene 10184

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 120 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.9 11.6 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.6 10.0 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.8 9.1 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.5 8.9 GO:0048617 embryonic foregut morphogenesis(GO:0048617)
2.9 8.8 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
0.5 8.4 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
2.4 7.3 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.6 6.9 GO:0060539 diaphragm development(GO:0060539)
0.1 6.3 GO:0071300 cellular response to retinoic acid(GO:0071300)
1.8 5.5 GO:0003100 regulation of systemic arterial blood pressure by endothelin(GO:0003100) vein smooth muscle contraction(GO:0014826)
1.3 5.3 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.0 5.3 GO:0007015 actin filament organization(GO:0007015)
0.7 5.2 GO:0051461 positive regulation of heat generation(GO:0031652) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.1 5.2 GO:0007601 visual perception(GO:0007601)
0.7 4.9 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.6 4.7 GO:0061436 establishment of skin barrier(GO:0061436)
0.3 4.5 GO:0048368 lateral mesoderm development(GO:0048368)
1.5 4.4 GO:0060217 hemangioblast cell differentiation(GO:0060217)
0.4 4.4 GO:0045056 transcytosis(GO:0045056)
0.7 4.3 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 26.7 GO:0005667 transcription factor complex(GO:0005667)
1.0 11.3 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.1 8.0 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.3 7.9 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.1 7.6 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 6.7 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.4 6.4 GO:0016460 myosin II complex(GO:0016460)
0.6 6.3 GO:0001739 sex chromatin(GO:0001739)
0.0 5.6 GO:0005743 mitochondrial inner membrane(GO:0005743)
1.3 5.3 GO:0043259 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259)
0.2 5.2 GO:0016580 Sin3 complex(GO:0016580)
0.2 4.7 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.3 4.5 GO:0071564 npBAF complex(GO:0071564)
1.5 4.4 GO:0033193 Lsd1/2 complex(GO:0033193)
0.1 4.4 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 4.4 GO:0031526 brush border membrane(GO:0031526)
0.6 3.7 GO:0044530 supraspliceosomal complex(GO:0044530)
0.1 3.6 GO:0001772 immunological synapse(GO:0001772)
0.6 3.4 GO:0044294 dendritic growth cone(GO:0044294)
0.7 3.3 GO:0008623 CHRAC(GO:0008623)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 87 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.6 GO:0001047 core promoter binding(GO:0001047)
0.0 13.5 GO:0003682 chromatin binding(GO:0003682)
0.6 11.6 GO:0070411 I-SMAD binding(GO:0070411)
0.5 10.7 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.6 9.5 GO:0070410 co-SMAD binding(GO:0070410)
0.1 9.1 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
1.5 8.8 GO:0030284 estrogen receptor activity(GO:0030284)
0.6 7.8 GO:0015197 peptide transporter activity(GO:0015197)
2.4 7.3 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.2 6.0 GO:0070064 proline-rich region binding(GO:0070064)
0.0 5.8 GO:0051015 actin filament binding(GO:0051015)
1.8 5.5 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.2 5.5 GO:0071889 14-3-3 protein binding(GO:0071889)
0.1 5.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.7 5.3 GO:0043208 glycosphingolipid binding(GO:0043208)
1.7 5.2 GO:0005118 sevenless binding(GO:0005118)
0.0 4.9 GO:0000287 magnesium ion binding(GO:0000287)
0.1 4.5 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.9 4.4 GO:0030492 hemoglobin binding(GO:0030492)
0.0 4.4 GO:0061630 ubiquitin protein ligase activity(GO:0061630)