Motif ID: Tead3_Tead4

Z-value: 3.065

Transcription factors associated with Tead3_Tead4:

Gene SymbolEntrez IDGene Name
Tead3 ENSMUSG00000002249.11 Tead3
Tead4 ENSMUSG00000030353.9 Tead4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tead3mm10_v2_chr17_-_28350600_283506810.496.8e-05Click!


Activity profile for motif Tead3_Tead4.

activity profile for motif Tead3_Tead4


Sorted Z-values histogram for motif Tead3_Tead4

Sorted Z-values for motif Tead3_Tead4



Network of associatons between targets according to the STRING database.



First level regulatory network of Tead3_Tead4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_+_6386598 55.369 ENSMUST00000080880.5
ENSMUST00000110664.2
ENSMUST00000110663.2
ENSMUST00000161812.1
ENSMUST00000160134.1
 Dab2




disabled 2, mitogen-responsive phosphoprotein




chr10_+_24595623 50.110 ENSMUST00000176228.1
ENSMUST00000129142.1
 Ctgf

connective tissue growth factor

chr10_+_24595434 50.093 ENSMUST00000020171.5
 Ctgf
connective tissue growth factor
chr1_+_189728264 45.244 ENSMUST00000097442.2
 Ptpn14
protein tyrosine phosphatase, non-receptor type 14
chr18_+_23415400 43.667 ENSMUST00000115832.2
ENSMUST00000047954.7
 Dtna

dystrobrevin alpha

chr4_-_43558386 34.668 ENSMUST00000130353.1
 Tln1
talin 1
chr15_+_78842632 29.738 ENSMUST00000059619.1
 Cdc42ep1
CDC42 effector protein (Rho GTPase binding) 1
chr7_-_19698206 23.109 ENSMUST00000172808.1
ENSMUST00000174191.1
 Apoe

apolipoprotein E

chr7_-_109616548 22.045 ENSMUST00000077909.1
ENSMUST00000084738.3
 St5

suppression of tumorigenicity 5

chr18_+_50030977 22.024 ENSMUST00000145726.1
ENSMUST00000128377.1
 Tnfaip8

tumor necrosis factor, alpha-induced protein 8

chr1_+_51289106 20.995 ENSMUST00000051572.6
 Sdpr
serum deprivation response
chr6_+_104492790 19.473 ENSMUST00000161446.1
ENSMUST00000161070.1
ENSMUST00000089215.5
 Cntn6


contactin 6


chr12_-_80112998 18.948 ENSMUST00000165114.1
ENSMUST00000021552.1
 Zfp36l1

zinc finger protein 36, C3H type-like 1

chr8_-_47990535 17.938 ENSMUST00000057561.7
 Wwc2
WW, C2 and coiled-coil domain containing 2
chr9_+_69454066 17.716 ENSMUST00000134907.1
 Anxa2
annexin A2
chr6_-_37442095 17.508 ENSMUST00000041093.5
 Creb3l2
cAMP responsive element binding protein 3-like 2
chr11_+_98412461 17.241 ENSMUST00000058295.5
 Erbb2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
chr15_-_37458523 17.151 ENSMUST00000116445.2
 Ncald
neurocalcin delta
chr18_+_50053282 17.099 ENSMUST00000148159.2
 Tnfaip8
tumor necrosis factor, alpha-induced protein 8
chr8_-_105966038 16.862 ENSMUST00000116429.2
ENSMUST00000034370.9
 Slc12a4

solute carrier family 12, member 4


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 201 entries
Log-likelihood per target Total log-likelihoodTermDescription
25.1 100.2 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
11.1 55.4 GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
2.3 52.3 GO:0001946 lymphangiogenesis(GO:0001946) lymph vessel morphogenesis(GO:0036303)
5.4 43.3 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
3.3 39.3 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.8 39.1 GO:0032611 interleukin-1 beta production(GO:0032611)
12.3 37.0 GO:2001139 negative regulation of postsynaptic membrane organization(GO:1901627) negative regulation of dendritic spine maintenance(GO:1902951) negative regulation of phospholipid efflux(GO:1902999) regulation of lipid transport across blood brain barrier(GO:1903000) negative regulation of lipid transport across blood brain barrier(GO:1903001) positive regulation of lipid transport across blood brain barrier(GO:1903002) negative regulation of phospholipid transport(GO:2001139)
4.7 28.0 GO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804)
3.8 26.7 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
5.2 25.9 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
1.8 25.5 GO:0035269 protein O-linked mannosylation(GO:0035269)
5.9 23.5 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
4.6 23.2 GO:0035331 negative regulation of hippo signaling(GO:0035331)
4.4 21.8 GO:0046533 negative regulation of photoreceptor cell differentiation(GO:0046533)
5.2 20.9 GO:1903251 multi-ciliated epithelial cell differentiation(GO:1903251)
0.3 20.8 GO:0061077 chaperone-mediated protein folding(GO:0061077)
5.1 20.6 GO:0042360 vitamin E metabolic process(GO:0042360)
1.2 19.9 GO:0048642 negative regulation of skeletal muscle tissue development(GO:0048642)
0.4 19.8 GO:1901184 regulation of ERBB signaling pathway(GO:1901184)
2.8 19.7 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 104 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 138.2 GO:0005925 focal adhesion(GO:0005925)
1.9 95.3 GO:0005801 cis-Golgi network(GO:0005801)
0.1 65.4 GO:0005829 cytosol(GO:0005829)
13.8 55.4 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 54.5 GO:0005783 endoplasmic reticulum(GO:0005783)
0.1 50.9 GO:0005667 transcription factor complex(GO:0005667)
2.8 48.2 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.4 42.2 GO:0005901 caveola(GO:0005901)
12.3 37.0 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.1 31.6 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.3 30.3 GO:0031225 anchored component of membrane(GO:0031225)
9.6 28.7 GO:0005595 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
9.3 28.0 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
1.8 26.7 GO:0043196 varicosity(GO:0043196)
1.9 26.4 GO:0005614 interstitial matrix(GO:0005614)
0.5 24.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.3 21.9 GO:0005871 kinesin complex(GO:0005871)
0.2 21.5 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
2.6 20.9 GO:0098536 deuterosome(GO:0098536)
0.2 17.4 GO:0017053 transcriptional repressor complex(GO:0017053)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 145 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.8 126.9 GO:0005520 insulin-like growth factor binding(GO:0005520)
1.1 61.3 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
6.2 55.4 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.4 49.6 GO:0030165 PDZ domain binding(GO:0030165)
2.1 45.6 GO:0017049 GTP-Rho binding(GO:0017049)
0.3 44.2 GO:0051015 actin filament binding(GO:0051015)
1.1 39.1 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
12.3 37.0 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
3.5 34.7 GO:0030274 LIM domain binding(GO:0030274)
7.0 28.0 GO:0004859 phospholipase inhibitor activity(GO:0004859) phospholipase A2 inhibitor activity(GO:0019834)
0.2 27.6 GO:0005539 glycosaminoglycan binding(GO:0005539)
2.2 26.7 GO:0047372 acylglycerol lipase activity(GO:0047372)
5.2 26.2 GO:0018121 imidazoleglycerol-phosphate synthase activity(GO:0000107) NAD(P)-cysteine ADP-ribosyltransferase activity(GO:0018071) NAD(P)-asparagine ADP-ribosyltransferase activity(GO:0018121) NAD(P)-serine ADP-ribosyltransferase activity(GO:0018127) 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity(GO:0043867) purine deoxyribosyltransferase activity(GO:0044102)
0.1 25.9 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
3.0 23.6 GO:0018741 alkyl sulfatase activity(GO:0018741) endosulfan hemisulfate sulfatase activity(GO:0034889) endosulfan sulfate hydrolase activity(GO:0034902)
0.6 23.5 GO:0030332 cyclin binding(GO:0030332)
0.3 21.9 GO:0003777 microtubule motor activity(GO:0003777)
0.1 21.2 GO:0008022 protein C-terminus binding(GO:0008022)
0.3 21.0 GO:0005080 protein kinase C binding(GO:0005080)
0.8 20.8 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)