Motif ID: Tfap2a

Z-value: 1.382


Transcription factors associated with Tfap2a:

Gene SymbolEntrez IDGene Name
Tfap2a ENSMUSG00000021359.9 Tfap2a

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap2amm10_v2_chr13_-_40733768_40733836-0.365.3e-03Click!


Activity profile for motif Tfap2a.

activity profile for motif Tfap2a


Sorted Z-values histogram for motif Tfap2a

Sorted Z-values for motif Tfap2a



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap2a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_64046925 15.176 ENSMUST00000107377.3
 Tnc
tenascin C
chr17_+_69969073 11.475 ENSMUST00000133983.1
 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr1_+_159737510 10.394 ENSMUST00000111669.3
 Tnr
tenascin R
chr17_+_69969217 9.881 ENSMUST00000060072.5
 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr17_+_69969387 9.372 ENSMUST00000146730.1
 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr5_-_146585239 8.895 ENSMUST00000036211.6
 Gpr12
G-protein coupled receptor 12
chr13_-_110280103 8.680 ENSMUST00000167824.1
 Rab3c
RAB3C, member RAS oncogene family
chr5_+_117841839 8.628 ENSMUST00000142742.2
 Nos1
nitric oxide synthase 1, neuronal
chr9_+_26733728 8.555 ENSMUST00000160899.1
ENSMUST00000161431.1
ENSMUST00000159799.1
 B3gat1


beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)


chr13_+_54949388 8.432 ENSMUST00000026994.7
ENSMUST00000109994.2
 Unc5a

unc-5 homolog A (C. elegans)

chr11_-_102897123 8.081 ENSMUST00000067444.3
 Gfap
glial fibrillary acidic protein
chr10_+_100015817 8.019 ENSMUST00000130190.1
ENSMUST00000020129.7
 Kitl

kit ligand

chr4_-_148287927 7.586 ENSMUST00000047720.8
 Ptchd2
patched domain containing 2
chr10_+_81575306 7.094 ENSMUST00000146916.1
 Tle2
transducin-like enhancer of split 2, homolog of Drosophila E(spl)
chr11_-_116110211 6.714 ENSMUST00000106441.1
ENSMUST00000021120.5
 Trim47

tripartite motif-containing 47

chr14_-_29721835 6.680 ENSMUST00000022567.7
 Cacna2d3
calcium channel, voltage-dependent, alpha2/delta subunit 3
chr11_+_78322965 6.642 ENSMUST00000017534.8
 Aldoc
aldolase C, fructose-bisphosphate
chr10_-_86498836 6.383 ENSMUST00000120638.1
 Syn3
synapsin III
chr11_-_118909487 6.330 ENSMUST00000117731.1
ENSMUST00000106278.2
ENSMUST00000120061.1
ENSMUST00000017576.4
 Rbfox3



RNA binding protein, fox-1 homolog (C. elegans) 3



chr2_+_91945703 6.056 ENSMUST00000178895.1
 Gm9821
predicted gene 9821

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 243 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.4 30.7 GO:0070842 aggresome assembly(GO:0070842)
1.0 20.6 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
4.1 16.4 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
2.6 13.0 GO:0010624 regulation of Schwann cell proliferation(GO:0010624)
0.4 12.0 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
3.5 10.4 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.4 10.2 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
2.2 8.6 GO:1901204 positive regulation of guanylate cyclase activity(GO:0031284) regulation of adrenergic receptor signaling pathway involved in heart process(GO:1901204)
1.1 8.4 GO:0033564 anterior/posterior axon guidance(GO:0033564)
1.7 8.3 GO:0034441 plasma lipoprotein particle oxidation(GO:0034441)
0.1 8.2 GO:0002028 regulation of sodium ion transport(GO:0002028)
2.0 8.0 GO:0033024 mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.3 7.8 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
2.3 7.0 GO:0060060 post-embryonic retina morphogenesis in camera-type eye(GO:0060060)
1.0 6.9 GO:0032811 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) negative regulation of epinephrine secretion(GO:0032811)
0.2 6.8 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
1.3 6.7 GO:0070305 response to cGMP(GO:0070305) cellular response to cGMP(GO:0071321)
0.1 6.7 GO:0099643 neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
1.1 6.6 GO:0000820 regulation of glutamine family amino acid metabolic process(GO:0000820)
0.7 6.6 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 113 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 33.9 GO:0045211 postsynaptic membrane(GO:0045211)
0.3 16.2 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.9 15.2 GO:0005614 interstitial matrix(GO:0005614)
3.3 13.0 GO:0097450 astrocyte end-foot(GO:0097450)
0.1 12.3 GO:0030426 growth cone(GO:0030426)
0.3 11.8 GO:0032809 neuronal cell body membrane(GO:0032809)
3.5 10.4 GO:0072534 perineuronal net(GO:0072534)
0.5 10.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 9.6 GO:0005794 Golgi apparatus(GO:0005794)
0.2 8.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 8.8 GO:0000139 Golgi membrane(GO:0000139)
0.6 8.3 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.7 7.9 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.2 7.2 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 7.0 GO:0008021 synaptic vesicle(GO:0008021)
1.4 6.9 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1 6.7 GO:0031225 anchored component of membrane(GO:0031225)
0.2 6.1 GO:0032590 dendrite membrane(GO:0032590)
0.2 6.0 GO:0060077 inhibitory synapse(GO:0060077)
0.1 5.9 GO:0008076 voltage-gated potassium channel complex(GO:0008076)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 179 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.4 20.6 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
2.8 17.0 GO:0045545 syndecan binding(GO:0045545)
0.1 16.3 GO:0017137 Rab GTPase binding(GO:0017137)
1.0 15.5 GO:0046625 sphingolipid binding(GO:0046625)
0.1 10.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 9.6 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 9.5 GO:0030695 GTPase regulator activity(GO:0030695)
1.0 8.9 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.2 8.9 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.4 8.7 GO:0031489 myosin V binding(GO:0031489)
2.9 8.6 GO:0004517 nitric-oxide synthase activity(GO:0004517)
1.4 8.4 GO:0005042 netrin receptor activity(GO:0005042)
0.9 8.3 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) calcium-independent phospholipase A2 activity(GO:0047499)
1.3 8.0 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.2 7.5 GO:0030552 cAMP binding(GO:0030552)
0.0 7.5 GO:0019904 protein domain specific binding(GO:0019904)
0.6 7.0 GO:0004143 diacylglycerol kinase activity(GO:0004143)
1.1 6.9 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.2 6.7 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
1.1 6.6 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)