Motif ID: Tfap2c

Z-value: 1.035


Transcription factors associated with Tfap2c:

Gene SymbolEntrez IDGene Name
Tfap2c ENSMUSG00000028640.5 Tfap2c

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap2cmm10_v2_chr2_+_172550761_172550782-0.581.4e-06Click!


Activity profile for motif Tfap2c.

activity profile for motif Tfap2c


Sorted Z-values histogram for motif Tfap2c

Sorted Z-values for motif Tfap2c



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap2c

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_70493156 8.072 ENSMUST00000008032.7
 Crlf1
cytokine receptor-like factor 1
chr6_+_4505493 6.767 ENSMUST00000031668.8
 Col1a2
collagen, type I, alpha 2
chr14_+_119138415 6.296 ENSMUST00000065904.3
 Hs6st3
heparan sulfate 6-O-sulfotransferase 3
chr6_+_4504814 5.791 ENSMUST00000141483.1
 Col1a2
collagen, type I, alpha 2
chr11_+_67455339 4.619 ENSMUST00000108681.1
 Gas7
growth arrest specific 7
chr4_+_124657646 4.468 ENSMUST00000053491.7
 Pou3f1
POU domain, class 3, transcription factor 1
chr9_-_29412204 4.287 ENSMUST00000115237.1
 Ntm
neurotrimin
chr9_+_89909775 4.277 ENSMUST00000034912.4
ENSMUST00000034909.4
 Rasgrf1

RAS protein-specific guanine nucleotide-releasing factor 1

chr5_-_131307848 4.204 ENSMUST00000086023.5
 Wbscr17
Williams-Beuren syndrome chromosome region 17 homolog (human)
chr18_-_61911783 4.201 ENSMUST00000049378.8
ENSMUST00000166783.1
 Ablim3

actin binding LIM protein family, member 3

chr4_+_152338887 4.082 ENSMUST00000005175.4
 Chd5
chromodomain helicase DNA binding protein 5
chr9_-_29411736 4.029 ENSMUST00000115236.1
 Ntm
neurotrimin
chr1_+_75479529 3.791 ENSMUST00000113575.2
ENSMUST00000148980.1
ENSMUST00000050899.6
 Tmem198


transmembrane protein 198


chr16_+_35154870 3.768 ENSMUST00000114913.1
 Adcy5
adenylate cyclase 5
chr10_+_13966268 3.670 ENSMUST00000015645.4
 Hivep2
human immunodeficiency virus type I enhancer binding protein 2
chr4_+_152338619 3.576 ENSMUST00000030775.5
ENSMUST00000164662.1
 Chd5

chromodomain helicase DNA binding protein 5

chr6_+_38663061 3.478 ENSMUST00000114874.3
 Clec2l
C-type lectin domain family 2, member L
chr9_+_58823512 3.420 ENSMUST00000034889.8
 Hcn4
hyperpolarization-activated, cyclic nucleotide-gated K+ 4
chr7_+_99535652 3.176 ENSMUST00000032995.8
ENSMUST00000162404.1
 Arrb1

arrestin, beta 1

chr3_-_89089955 3.004 ENSMUST00000166687.1
 Rusc1
RUN and SH3 domain containing 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 110 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 13.0 GO:0043589 skin morphogenesis(GO:0043589)
0.0 8.3 GO:0010977 negative regulation of neuron projection development(GO:0010977)
1.3 8.1 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
1.5 7.7 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
1.0 6.3 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.2 5.8 GO:0032292 myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
1.3 5.1 GO:1904177 regulation of adipose tissue development(GO:1904177)
0.3 5.1 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.0 4.6 GO:0051017 actin filament bundle assembly(GO:0051017)
0.1 4.2 GO:0030032 lamellipodium assembly(GO:0030032)
0.8 4.0 GO:0051012 microtubule sliding(GO:0051012) negative regulation of nonmotile primary cilium assembly(GO:1902856)
0.5 3.8 GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.7 3.4 GO:0070305 response to cGMP(GO:0070305) cellular response to cGMP(GO:0071321)
0.5 3.2 GO:0034393 positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.4 3.0 GO:1903423 positive regulation of synaptic vesicle recycling(GO:1903423)
0.9 2.8 GO:0086017 Purkinje myocyte action potential(GO:0086017)
0.0 2.8 GO:0090263 positive regulation of canonical Wnt signaling pathway(GO:0090263)
0.2 2.7 GO:0032482 Rab protein signal transduction(GO:0032482)
0.9 2.6 GO:0021837 motogenic signaling involved in postnatal olfactory bulb interneuron migration(GO:0021837) positive regulation of mitotic cell cycle DNA replication(GO:1903465)
0.6 2.6 GO:0051562 negative regulation of mitochondrial calcium ion concentration(GO:0051562)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.2 12.6 GO:0005584 collagen type I trimer(GO:0005584)
0.0 8.6 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 8.3 GO:0031225 anchored component of membrane(GO:0031225)
2.7 8.1 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.3 7.7 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 7.4 GO:0042383 sarcolemma(GO:0042383)
0.7 5.1 GO:0005638 lamin filament(GO:0005638)
0.0 5.0 GO:0005667 transcription factor complex(GO:0005667)
0.0 4.7 GO:0005884 actin filament(GO:0005884)
0.0 4.6 GO:0043679 axon terminus(GO:0043679)
0.2 4.3 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 4.0 GO:0072686 mitotic spindle(GO:0072686)
0.2 3.2 GO:0031143 pseudopodium(GO:0031143)
0.0 3.1 GO:0042641 actomyosin(GO:0042641)
0.2 3.0 GO:0043196 varicosity(GO:0043196)
0.1 2.9 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.2 2.8 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 2.7 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 2.7 GO:0044295 axonal growth cone(GO:0044295)
0.4 2.4 GO:0061689 tricellular tight junction(GO:0061689)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 91 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 12.6 GO:0048407 platelet-derived growth factor binding(GO:0048407)
1.2 8.1 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.1 7.7 GO:0008026 ATP-dependent helicase activity(GO:0008026) purine NTP-dependent helicase activity(GO:0070035)
0.0 7.5 GO:0003779 actin binding(GO:0003779)
0.1 6.6 GO:0035254 glutamate receptor binding(GO:0035254)
0.2 6.3 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
0.0 5.6 GO:0051015 actin filament binding(GO:0051015)
0.0 5.4 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 5.3 GO:0005096 GTPase activator activity(GO:0005096)
0.2 5.1 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 4.4 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.2 4.2 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 4.2 GO:0015631 tubulin binding(GO:0015631)
0.6 3.8 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.4 3.8 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.0 3.7 GO:0030246 carbohydrate binding(GO:0030246)
0.9 3.5 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.7 3.4 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
1.1 3.2 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.4 2.8 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)