Motif ID: Tfap2d

Z-value: 1.066


Transcription factors associated with Tfap2d:

Gene SymbolEntrez IDGene Name
Tfap2d ENSMUSG00000042596.7 Tfap2d

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap2dmm10_v2_chr1_+_19103022_19103043-0.734.7e-11Click!


Activity profile for motif Tfap2d.

activity profile for motif Tfap2d


Sorted Z-values histogram for motif Tfap2d

Sorted Z-values for motif Tfap2d



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap2d

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_85688252 10.736 ENSMUST00000024947.7
ENSMUST00000163568.2
 Six2

sine oculis-related homeobox 2

chr5_-_24527276 9.865 ENSMUST00000088311.4
 Gbx1
gastrulation brain homeobox 1
chr18_+_82910863 8.992 ENSMUST00000171238.1
 Zfp516
zinc finger protein 516
chr2_+_119742306 8.541 ENSMUST00000028758.7
 Itpka
inositol 1,4,5-trisphosphate 3-kinase A
chr4_+_114406717 6.820 ENSMUST00000094894.3
 Trabd2b
TraB domain containing 2B
chr4_+_152008803 6.791 ENSMUST00000097773.3
 Klhl21
kelch-like 21
chr13_+_72628802 6.709 ENSMUST00000074372.4
 Irx2
Iroquois related homeobox 2 (Drosophila)
chr11_+_120949053 6.691 ENSMUST00000154187.1
ENSMUST00000100130.3
ENSMUST00000129473.1
ENSMUST00000168579.1
 Slc16a3



solute carrier family 16 (monocarboxylic acid transporters), member 3



chr4_-_106464167 6.459 ENSMUST00000049507.5
 Pcsk9
proprotein convertase subtilisin/kexin type 9
chr2_+_26586607 6.356 ENSMUST00000174211.1
ENSMUST00000145575.2
ENSMUST00000173920.1
 Egfl7


EGF-like domain 7


chr8_+_92357787 6.355 ENSMUST00000034184.10
 Irx5
Iroquois related homeobox 5 (Drosophila)
chr9_+_65141154 5.908 ENSMUST00000034961.4
 Igdcc3
immunoglobulin superfamily, DCC subclass, member 3
chr6_+_107529717 5.600 ENSMUST00000049285.8
 Lrrn1
leucine rich repeat protein 1, neuronal
chr4_+_46450892 5.529 ENSMUST00000102926.4
 Anp32b
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr3_+_107595031 5.518 ENSMUST00000014747.1
 Alx3
aristaless-like homeobox 3
chr19_+_42147373 5.495 ENSMUST00000061111.9
 Marveld1
MARVEL (membrane-associating) domain containing 1
chr11_+_59306920 5.465 ENSMUST00000000128.3
ENSMUST00000108783.3
 Wnt9a

wingless-type MMTV integration site 9A

chr2_-_28916412 5.449 ENSMUST00000050776.2
ENSMUST00000113849.1
 Barhl1

BarH-like 1 (Drosophila)

chrX_-_48454152 5.395 ENSMUST00000114958.1
 Elf4
E74-like factor 4 (ets domain transcription factor)
chr4_-_140774196 5.319 ENSMUST00000026381.6
 Padi4
peptidyl arginine deiminase, type IV

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 165 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 11.0 GO:0035115 embryonic forelimb morphogenesis(GO:0035115)
2.7 10.7 GO:0097168 condensed mesenchymal cell proliferation(GO:0072137) mesenchymal stem cell proliferation(GO:0097168)
1.0 10.1 GO:0006020 inositol metabolic process(GO:0006020)
2.5 9.9 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.3 9.3 GO:0050873 brown fat cell differentiation(GO:0050873)
1.8 9.1 GO:0006447 regulation of translational initiation by iron(GO:0006447) positive regulation of translational initiation by iron(GO:0045994)
0.2 8.4 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.6 7.4 GO:0044458 motile cilium assembly(GO:0044458)
1.0 6.8 GO:0018158 protein oxidation(GO:0018158)
0.2 6.8 GO:0034629 cellular protein complex localization(GO:0034629)
2.2 6.7 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.3 6.7 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
1.1 6.4 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.5 6.3 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.6 5.8 GO:0060836 lymphatic endothelial cell differentiation(GO:0060836)
1.8 5.4 GO:0001866 NK T cell proliferation(GO:0001866)
0.6 5.3 GO:0019240 citrulline biosynthetic process(GO:0019240)
0.1 5.3 GO:0050885 neuromuscular process controlling balance(GO:0050885)
1.7 5.2 GO:0086017 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) Purkinje myocyte action potential(GO:0086017) membrane depolarization during SA node cell action potential(GO:0086046)
1.3 5.2 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 74 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.5 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 8.0 GO:0005844 polysome(GO:0005844)
0.3 7.3 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 7.3 GO:0031012 extracellular matrix(GO:0031012)
0.5 7.2 GO:0042555 MCM complex(GO:0042555)
1.0 7.0 GO:0005827 polar microtubule(GO:0005827)
0.0 6.8 GO:0005667 transcription factor complex(GO:0005667)
0.1 6.7 GO:0036126 sperm flagellum(GO:0036126)
0.0 6.7 GO:0015629 actin cytoskeleton(GO:0015629)
2.2 6.5 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.0 6.5 GO:0016604 nuclear body(GO:0016604)
0.1 6.1 GO:0016459 myosin complex(GO:0016459)
0.0 6.1 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 5.7 GO:0005681 spliceosomal complex(GO:0005681)
0.3 5.2 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 5.0 GO:0005925 focal adhesion(GO:0005925)
0.1 4.5 GO:0005923 bicellular tight junction(GO:0005923)
0.1 4.5 GO:0016605 PML body(GO:0016605)
0.1 4.3 GO:0016591 DNA-directed RNA polymerase II, holoenzyme(GO:0016591)
0.3 4.2 GO:0042612 MHC class I protein complex(GO:0042612)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 114 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 31.7 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 29.5 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.1 11.5 GO:0033613 activating transcription factor binding(GO:0033613)
0.5 10.2 GO:0008266 poly(U) RNA binding(GO:0008266)
0.3 10.1 GO:0017147 Wnt-protein binding(GO:0017147)
1.5 9.1 GO:0070644 vitamin D response element binding(GO:0070644)
1.2 8.6 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.3 8.4 GO:0005112 Notch binding(GO:0005112)
0.3 8.3 GO:0005109 frizzled binding(GO:0005109)
1.6 7.8 GO:0032027 myosin light chain binding(GO:0032027)
0.4 6.7 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
2.2 6.5 GO:0034190 very-low-density lipoprotein particle binding(GO:0034189) apolipoprotein receptor binding(GO:0034190)
0.1 6.3 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 6.1 GO:0005179 hormone activity(GO:0005179)
0.9 5.3 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.7 5.2 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.3 5.2 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
1.0 5.1 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.5 5.0 GO:0001047 core promoter binding(GO:0001047)
0.0 5.0 GO:0003774 motor activity(GO:0003774)