Motif ID: Tfap2e

Z-value: 0.695


Transcription factors associated with Tfap2e:

Gene SymbolEntrez IDGene Name
Tfap2e ENSMUSG00000042477.7 Tfap2e

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap2emm10_v2_chr4_-_126736236_126736245-0.402.0e-03Click!


Activity profile for motif Tfap2e.

activity profile for motif Tfap2e


Sorted Z-values histogram for motif Tfap2e

Sorted Z-values for motif Tfap2e



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap2e

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_102897123 12.829 ENSMUST00000067444.3
 Gfap
glial fibrillary acidic protein
chr11_-_102897146 9.318 ENSMUST00000077902.4
 Gfap
glial fibrillary acidic protein
chr2_+_91945703 8.799 ENSMUST00000178895.1
 Gm9821
predicted gene 9821
chr8_+_94152607 5.295 ENSMUST00000034211.8
 Mt3
metallothionein 3
chr1_+_159737510 4.651 ENSMUST00000111669.3
 Tnr
tenascin R
chr2_+_102658640 3.734 ENSMUST00000080210.3
 Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr13_-_101768154 3.667 ENSMUST00000055518.6
 Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr6_-_137649211 2.651 ENSMUST00000134630.1
ENSMUST00000058210.6
ENSMUST00000111878.1
 Eps8


epidermal growth factor receptor pathway substrate 8


chr6_+_108213086 2.489 ENSMUST00000032192.6
 Itpr1
inositol 1,4,5-trisphosphate receptor 1
chr13_+_54949388 2.163 ENSMUST00000026994.7
ENSMUST00000109994.2
 Unc5a

unc-5 homolog A (C. elegans)

chr17_+_37046555 2.106 ENSMUST00000172789.1
 Gabbr1
gamma-aminobutyric acid (GABA) B receptor, 1
chr8_+_41239718 2.074 ENSMUST00000045218.7
 Pcm1
pericentriolar material 1
chr1_-_125913101 1.954 ENSMUST00000161361.1
 Lypd1
Ly6/Plaur domain containing 1
chr5_-_34187670 1.815 ENSMUST00000042701.6
ENSMUST00000119171.1
 Mxd4

Max dimerization protein 4

chr7_-_19629355 1.594 ENSMUST00000049912.8
ENSMUST00000094762.3
ENSMUST00000098754.4
 Relb


avian reticuloendotheliosis viral (v-rel) oncogene related B


chr15_-_102524615 1.575 ENSMUST00000023814.7
 Npff
neuropeptide FF-amide peptide precursor
chr3_-_113630068 1.529 ENSMUST00000092154.3
ENSMUST00000106536.1
ENSMUST00000106535.1
 Rnpc3


RNA-binding region (RNP1, RRM) containing 3


chr16_+_93832121 1.467 ENSMUST00000044068.6
 Morc3
microrchidia 3
chr9_+_25252439 1.418 ENSMUST00000115272.2
ENSMUST00000165594.2
 Sept7

septin 7

chr5_+_64970069 1.412 ENSMUST00000031080.8
 Fam114a1
family with sequence similarity 114, member A1
chr9_+_100643605 1.292 ENSMUST00000041418.6
 Stag1
stromal antigen 1
chr9_-_97111117 1.283 ENSMUST00000085206.4
 Slc25a36
solute carrier family 25, member 36
chr8_+_107293463 1.262 ENSMUST00000169453.1
 Nfat5
nuclear factor of activated T cells 5
chr2_-_150904620 1.251 ENSMUST00000056149.8
 Abhd12
abhydrolase domain containing 12
chr9_+_100643448 1.243 ENSMUST00000146312.1
ENSMUST00000129269.1
 Stag1

stromal antigen 1

chr9_+_100643755 1.243 ENSMUST00000133388.1
 Stag1
stromal antigen 1
chr6_-_39725448 1.238 ENSMUST00000002487.8
 Braf
Braf transforming gene
chr19_-_53944621 1.222 ENSMUST00000135402.2
 Bbip1
BBSome interacting protein 1
chr11_-_51756378 1.192 ENSMUST00000109092.1
ENSMUST00000064297.4
ENSMUST00000109097.2
 Sec24a


Sec24 related gene family, member A (S. cerevisiae)


chr13_-_111490111 1.167 ENSMUST00000047627.7
 Gpbp1
GC-rich promoter binding protein 1
chr2_-_38287174 1.141 ENSMUST00000130472.1
 Dennd1a
DENN/MADD domain containing 1A
chr8_+_107293500 1.127 ENSMUST00000151114.1
ENSMUST00000075922.4
ENSMUST00000125721.1
 Nfat5


nuclear factor of activated T cells 5


chrX_-_103981242 1.086 ENSMUST00000121153.1
ENSMUST00000070705.4
 Rlim

ring finger protein, LIM domain interacting

chr13_-_111490028 1.053 ENSMUST00000091236.4
 Gpbp1
GC-rich promoter binding protein 1
chr15_-_58214882 1.019 ENSMUST00000022986.6
 Fbxo32
F-box protein 32
chr7_-_116443439 0.998 ENSMUST00000170430.1
 Pik3c2a
phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide
chr2_+_109890846 0.998 ENSMUST00000028583.7
 Lin7c
lin-7 homolog C (C. elegans)
chr17_-_63863791 0.956 ENSMUST00000050753.3
 A930002H24Rik
RIKEN cDNA A930002H24 gene
chr17_-_79020816 0.893 ENSMUST00000168887.1
ENSMUST00000119284.1
 Prkd3

protein kinase D3

chr19_-_42752710 0.841 ENSMUST00000076505.3
 Pyroxd2
pyridine nucleotide-disulphide oxidoreductase domain 2
chr3_+_103914560 0.775 ENSMUST00000106806.1
 Rsbn1
rosbin, round spermatid basic protein 1
chr4_-_149774238 0.750 ENSMUST00000105686.2
 Slc25a33
solute carrier family 25, member 33
chr7_-_45333754 0.645 ENSMUST00000042194.8
 Trpm4
transient receptor potential cation channel, subfamily M, member 4
chrX_+_73716577 0.631 ENSMUST00000002084.7
 Abcd1
ATP-binding cassette, sub-family D (ALD), member 1
chrX_+_7722267 0.609 ENSMUST00000125991.1
ENSMUST00000148624.1
 Wdr45

WD repeat domain 45

chr10_-_127211528 0.585 ENSMUST00000013970.7
 Pip4k2c
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
chr9_-_121759788 0.417 ENSMUST00000181325.1
 E530011L22Rik
RIKEN cDNA E530011L22 gene
chrX_+_7723278 0.349 ENSMUST00000144148.1
 Wdr45
WD repeat domain 45
chr9_+_109931774 0.289 ENSMUST00000169851.2
 Map4
microtubule-associated protein 4
chr3_-_88455302 0.287 ENSMUST00000125526.1
 Sema4a
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr6_-_39725193 0.259 ENSMUST00000101497.3
 Braf
Braf transforming gene
chr2_+_22895583 0.151 ENSMUST00000152170.1
 Pdss1
prenyl (solanesyl) diphosphate synthase, subunit 1
chr10_+_121365078 0.124 ENSMUST00000040344.6
 Gns
glucosamine (N-acetyl)-6-sulfatase
chr9_-_44735189 0.116 ENSMUST00000034611.8
 Phldb1
pleckstrin homology-like domain, family B, member 1
chr7_+_19004047 0.085 ENSMUST00000053713.3
 Irf2bp1
interferon regulatory factor 2 binding protein 1
chrX_+_73716712 0.027 ENSMUST00000114461.2
 Abcd1
ATP-binding cassette, sub-family D (ALD), member 1
chr3_-_84040151 0.011 ENSMUST00000052342.7
 D930015E06Rik
RIKEN cDNA D930015E06 gene
chr4_+_151089570 0.006 ENSMUST00000105667.2
 Gm13090
predicted gene 13090

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.7 22.1 GO:0010624 regulation of Schwann cell proliferation(GO:0010624)
1.8 5.3 GO:0097212 lysosomal membrane organization(GO:0097212)
1.6 4.7 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.7 2.7 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.6 3.7 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.5 5.2 GO:0010459 negative regulation of heart rate(GO:0010459)
0.5 2.1 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.4 2.5 GO:0042045 epithelial fluid transport(GO:0042045)
0.4 1.2 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.3 1.0 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.3 1.0 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.3 2.1 GO:0032811 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) negative regulation of epinephrine secretion(GO:0032811)
0.3 2.2 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.2 0.7 GO:0072531 pyrimidine-containing compound transmembrane transport(GO:0072531)
0.2 1.2 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.2 0.7 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.2 1.1 GO:1900095 regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
0.2 1.0 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.2 1.1 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.2 1.5 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.2 0.6 GO:1904177 regulation of adipose tissue development(GO:1904177)
0.1 1.6 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.1 2.4 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.1 1.3 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.1 1.4 GO:0031268 pseudopodium organization(GO:0031268)
0.1 1.0 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.1 2.0 GO:0007271 synaptic transmission, cholinergic(GO:0007271)
0.1 1.5 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.1 0.6 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)
0.1 1.3 GO:0006862 nucleotide transport(GO:0006862)
0.1 0.3 GO:0051012 microtubule sliding(GO:0051012) negative regulation of nonmotile primary cilium assembly(GO:1902856)
0.0 0.3 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
0.0 3.8 GO:0007059 chromosome segregation(GO:0007059)
0.0 0.1 GO:2001197 regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
5.5 22.1 GO:0097450 astrocyte end-foot(GO:0097450)
1.6 4.7 GO:0072534 perineuronal net(GO:0072534)
0.8 2.5 GO:0031088 platelet dense granule membrane(GO:0031088)
0.5 1.4 GO:0005940 septin ring(GO:0005940)
0.4 2.1 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.2 1.6 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.2 4.7 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.2 1.0 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.2 1.2 GO:0030127 COPII vesicle coat(GO:0030127)
0.2 2.7 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 3.7 GO:0030673 axolemma(GO:0030673)
0.1 1.2 GO:0034464 BBSome(GO:0034464)
0.1 2.1 GO:0000242 pericentriolar material(GO:0000242)
0.1 1.0 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 2.2 GO:0032589 neuron projection membrane(GO:0032589)
0.1 1.5 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 5.3 GO:0008021 synaptic vesicle(GO:0008021)
0.0 1.1 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.0 1.3 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.7 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.0 2.0 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.6 GO:0005776 autophagosome(GO:0005776)
0.0 1.6 GO:0043679 axon terminus(GO:0043679)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.7 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.9 3.7 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.8 2.5 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.4 2.2 GO:0005042 netrin receptor activity(GO:0005042)
0.4 2.1 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.3 4.7 GO:0046625 sphingolipid binding(GO:0046625)
0.3 22.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.2 2.0 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.2 1.0 GO:0097016 L27 domain binding(GO:0097016)
0.2 0.6 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.1 1.5 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.1 0.7 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.1 2.0 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.1 1.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 1.0 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.1 1.6 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 2.1 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 1.5 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.0 2.7 GO:0035591 signaling adaptor activity(GO:0035591)
0.0 0.2 GO:0050347 trans-hexaprenyltranstransferase activity(GO:0000010) trans-octaprenyltranstransferase activity(GO:0050347)
0.0 0.1 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.9 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.6 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 0.8 GO:0008748 N-ethylmaleimide reductase activity(GO:0008748) reduced coenzyme F420 dehydrogenase activity(GO:0043738) sulfur oxygenase reductase activity(GO:0043826) malolactic enzyme activity(GO:0043883) epoxyqueuosine reductase activity(GO:0052693)