Motif ID: Tfap4

Z-value: 1.199


Transcription factors associated with Tfap4:

Gene SymbolEntrez IDGene Name
Tfap4 ENSMUSG00000005718.7 Tfap4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap4mm10_v2_chr16_-_4559720_4559747-0.741.7e-11Click!


Activity profile for motif Tfap4.

activity profile for motif Tfap4


Sorted Z-values histogram for motif Tfap4

Sorted Z-values for motif Tfap4



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_91269759 16.949 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr15_-_66812593 13.096 ENSMUST00000100572.3
 Sla
src-like adaptor
chr9_-_40346290 12.667 ENSMUST00000121357.1
 Gramd1b
GRAM domain containing 1B
chr2_+_170731807 11.290 ENSMUST00000029075.4
 Dok5
docking protein 5
chr7_-_120202104 10.697 ENSMUST00000033198.5
 Crym
crystallin, mu
chr4_+_119814495 10.506 ENSMUST00000106307.2
 Hivep3
human immunodeficiency virus type I enhancer binding protein 3
chr6_-_136171722 10.097 ENSMUST00000053880.6
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr7_-_97417730 9.795 ENSMUST00000043077.7
 Thrsp
thyroid hormone responsive
chr6_-_58907120 9.011 ENSMUST00000059539.3
 Nap1l5
nucleosome assembly protein 1-like 5
chr2_+_37516618 8.905 ENSMUST00000065441.6
 Gpr21
G protein-coupled receptor 21
chr13_+_54949388 8.496 ENSMUST00000026994.7
ENSMUST00000109994.2
 Unc5a

unc-5 homolog A (C. elegans)

chr3_+_90537242 8.401 ENSMUST00000098911.3
 S100a16
S100 calcium binding protein A16
chr4_+_48045144 8.141 ENSMUST00000030025.3
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr18_-_23041641 7.509 ENSMUST00000097651.3
 Nol4
nucleolar protein 4
chr8_+_66386292 7.102 ENSMUST00000039540.5
ENSMUST00000110253.2
 March1

membrane-associated ring finger (C3HC4) 1

chr1_-_79761752 6.584 ENSMUST00000113512.1
ENSMUST00000113513.1
ENSMUST00000113515.1
ENSMUST00000113514.1
ENSMUST00000113510.1
ENSMUST00000113511.1
ENSMUST00000048820.7
 Wdfy1






WD repeat and FYVE domain containing 1






chr6_+_90465287 6.513 ENSMUST00000113530.1
 Klf15
Kruppel-like factor 15
chr15_-_102722150 6.440 ENSMUST00000023818.3
 Calcoco1
calcium binding and coiled coil domain 1
chr2_-_52335134 6.222 ENSMUST00000075301.3
 Neb
nebulin
chr13_+_29014399 6.215 ENSMUST00000146336.1
ENSMUST00000130109.1
 A330102I10Rik

RIKEN cDNA A330102I10 gene


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 128 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 14.4 GO:0051592 response to calcium ion(GO:0051592)
0.1 13.9 GO:0048709 oligodendrocyte differentiation(GO:0048709)
0.8 12.9 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
1.0 11.3 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
2.1 10.7 GO:0070327 thyroid hormone transport(GO:0070327)
0.2 10.5 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.3 9.8 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
0.1 9.0 GO:0006334 nucleosome assembly(GO:0006334)
1.5 8.9 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
2.2 8.7 GO:0001920 negative regulation of receptor recycling(GO:0001920)
1.1 8.5 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.1 8.3 GO:0030518 intracellular steroid hormone receptor signaling pathway(GO:0030518)
2.7 8.1 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
0.4 7.1 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
1.6 6.6 GO:0034145 positive regulation of toll-like receptor 4 signaling pathway(GO:0034145)
0.2 6.5 GO:0071625 vocalization behavior(GO:0071625)
0.2 6.2 GO:0045214 sarcomere organization(GO:0045214)
0.2 5.8 GO:0070306 lens fiber cell differentiation(GO:0070306)
0.2 5.6 GO:0060765 regulation of androgen receptor signaling pathway(GO:0060765)
0.2 5.6 GO:0032728 positive regulation of interferon-beta production(GO:0032728)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 25.1 GO:0005768 endosome(GO:0005768)
0.0 15.3 GO:0005730 nucleolus(GO:0005730)
0.0 13.3 GO:0000790 nuclear chromatin(GO:0000790)
0.1 12.2 GO:0005802 trans-Golgi network(GO:0005802)
0.9 10.1 GO:0043083 synaptic cleft(GO:0043083)
0.2 8.5 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 8.5 GO:0005667 transcription factor complex(GO:0005667)
0.1 7.7 GO:0005776 autophagosome(GO:0005776)
0.2 7.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 6.5 GO:0031966 mitochondrial membrane(GO:0031966)
0.3 6.2 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 5.6 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
1.8 5.4 GO:0097512 cardiac myofibril(GO:0097512)
0.1 5.3 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
1.2 4.8 GO:1990795 lateral part of cell(GO:0097574) basolateral part of cell(GO:1990794) rod bipolar cell terminal bouton(GO:1990795)
0.5 4.7 GO:0005883 neurofilament(GO:0005883)
0.2 4.5 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 4.4 GO:0045211 postsynaptic membrane(GO:0045211)
0.8 4.2 GO:0070820 tertiary granule(GO:0070820)
0.5 4.2 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 88 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 12.7 GO:0005158 insulin receptor binding(GO:0005158)
0.5 12.6 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 12.2 GO:0042803 protein homodimerization activity(GO:0042803)
0.6 11.0 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
1.3 10.7 GO:0070324 thyroid hormone binding(GO:0070324)
1.0 10.1 GO:0031749 D2 dopamine receptor binding(GO:0031749)
3.0 8.9 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
1.1 8.7 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
1.4 8.5 GO:0005042 netrin receptor activity(GO:0005042)
0.5 8.1 GO:0001223 transcription coactivator binding(GO:0001223)
0.4 7.1 GO:0042287 MHC protein binding(GO:0042287)
0.2 6.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 6.4 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.0 5.5 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.6 5.4 GO:0005212 structural constituent of eye lens(GO:0005212)
0.6 4.8 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 4.7 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
1.5 4.5 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.7 4.2 GO:0009374 biotin binding(GO:0009374)
0.5 4.2 GO:0019869 chloride channel inhibitor activity(GO:0019869)