Motif ID: Tfdp1_Wt1_Egr2

Z-value: 1.832

Transcription factors associated with Tfdp1_Wt1_Egr2:

Gene SymbolEntrez IDGene Name
Egr2 ENSMUSG00000037868.9 Egr2
Tfdp1 ENSMUSG00000038482.10 Tfdp1
Wt1 ENSMUSG00000016458.7 Wt1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfdp1mm10_v2_chr8_+_13339656_133396740.481.4e-04Click!
Egr2mm10_v2_chr10_+_67537861_67537930-0.255.9e-02Click!


Activity profile for motif Tfdp1_Wt1_Egr2.

activity profile for motif Tfdp1_Wt1_Egr2


Sorted Z-values histogram for motif Tfdp1_Wt1_Egr2

Sorted Z-values for motif Tfdp1_Wt1_Egr2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfdp1_Wt1_Egr2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_48261427 10.765 ENSMUST00000021810.1
 Id4
inhibitor of DNA binding 4
chr13_-_29984219 9.716 ENSMUST00000146092.1
 E2f3
E2F transcription factor 3
chr2_-_156839790 7.954 ENSMUST00000134838.1
ENSMUST00000137463.1
ENSMUST00000149275.2
 Gm14230


predicted gene 14230


chr9_-_119578981 7.542 ENSMUST00000117911.1
ENSMUST00000120420.1
 Scn5a

sodium channel, voltage-gated, type V, alpha

chr16_-_22163299 6.764 ENSMUST00000100052.4
 Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr11_-_12037391 6.653 ENSMUST00000093321.5
 Grb10
growth factor receptor bound protein 10
chr6_-_38876163 6.434 ENSMUST00000161779.1
 Hipk2
homeodomain interacting protein kinase 2
chr6_+_120666388 6.175 ENSMUST00000112686.1
 Cecr2
cat eye syndrome chromosome region, candidate 2
chr10_-_120476469 5.711 ENSMUST00000072777.7
ENSMUST00000159699.1
 Hmga2

high mobility group AT-hook 2

chr14_+_122475397 5.660 ENSMUST00000075888.5
 Zic2
zinc finger protein of the cerebellum 2
chr13_+_15463202 5.591 ENSMUST00000130065.1
 Gli3
GLI-Kruppel family member GLI3
chr2_+_168081004 5.471 ENSMUST00000052125.6
 Pard6b
par-6 (partitioning defective 6) homolog beta (C. elegans)
chr17_-_70851189 5.390 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chrX_-_162159717 5.253 ENSMUST00000087085.3
 Nhs
Nance-Horan syndrome (human)
chr9_-_44234014 5.222 ENSMUST00000037644.6
 Cbl
Casitas B-lineage lymphoma
chr18_+_82914632 5.086 ENSMUST00000071233.6
 Zfp516
zinc finger protein 516
chrX_-_52165252 5.084 ENSMUST00000033450.2
 Gpc4
glypican 4
chr13_-_56252163 5.069 ENSMUST00000058475.4
 Neurog1
neurogenin 1
chr6_-_38875965 5.011 ENSMUST00000160360.1
 Hipk2
homeodomain interacting protein kinase 2
chr7_+_117380937 4.985 ENSMUST00000032892.5
 Xylt1
xylosyltransferase 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,189 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.4 24.5 GO:0060059 embryonic retina morphogenesis in camera-type eye(GO:0060059)
1.2 18.6 GO:0038092 nodal signaling pathway(GO:0038092)
0.6 17.9 GO:0006270 DNA replication initiation(GO:0006270)
0.4 16.3 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
1.7 15.6 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.2 14.3 GO:0051028 mRNA transport(GO:0051028)
0.2 13.9 GO:0006334 nucleosome assembly(GO:0006334)
0.6 13.6 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 13.1 GO:0006397 mRNA processing(GO:0006397)
0.1 12.8 GO:0006281 DNA repair(GO:0006281)
1.3 11.3 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
3.7 11.1 GO:1904274 tricellular tight junction assembly(GO:1904274)
2.2 11.1 GO:2000382 positive regulation of mesoderm development(GO:2000382)
1.2 10.5 GO:0046499 S-adenosylmethioninamine metabolic process(GO:0046499)
1.5 10.4 GO:0001842 neural fold formation(GO:0001842)
1.5 10.2 GO:0060842 arterial endothelial cell differentiation(GO:0060842)
3.3 10.0 GO:0060364 frontal suture morphogenesis(GO:0060364)
1.9 9.6 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
1.4 9.6 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
1.9 9.3 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 373 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 148.4 GO:0005634 nucleus(GO:0005634)
0.1 142.9 GO:0005654 nucleoplasm(GO:0005654)
0.1 35.8 GO:0005730 nucleolus(GO:0005730)
0.3 31.2 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 29.6 GO:0005694 chromosome(GO:0005694)
0.4 28.0 GO:0031519 PcG protein complex(GO:0031519)
0.3 23.2 GO:0005643 nuclear pore(GO:0005643)
0.4 19.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.4 17.6 GO:0016592 mediator complex(GO:0016592)
0.2 17.0 GO:0005814 centriole(GO:0005814)
0.7 15.6 GO:0001741 XY body(GO:0001741)
0.2 15.4 GO:0005844 polysome(GO:0005844)
0.3 14.9 GO:0005720 nuclear heterochromatin(GO:0005720)
0.7 14.7 GO:0016580 Sin3 complex(GO:0016580)
0.1 13.5 GO:0032993 protein-DNA complex(GO:0032993)
0.1 12.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.2 11.6 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
1.9 11.2 GO:0061689 tricellular tight junction(GO:0061689)
0.2 10.8 GO:0000776 kinetochore(GO:0000776)
0.3 10.3 GO:0005876 spindle microtubule(GO:0005876)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 613 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 63.6 GO:0003682 chromatin binding(GO:0003682)
0.1 58.3 GO:0044822 poly(A) RNA binding(GO:0044822)
0.2 34.0 GO:0001047 core promoter binding(GO:0001047)
0.0 30.1 GO:0003677 DNA binding(GO:0003677)
0.1 28.4 GO:0001159 core promoter proximal region DNA binding(GO:0001159)
0.2 23.5 GO:0042393 histone binding(GO:0042393)
0.4 20.9 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.7 19.7 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.9 19.5 GO:0001784 phosphotyrosine binding(GO:0001784)
0.3 18.2 GO:0035064 methylated histone binding(GO:0035064)
2.1 16.4 GO:0046790 virion binding(GO:0046790)
0.5 16.3 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.9 16.1 GO:0017166 vinculin binding(GO:0017166)
0.1 15.6 GO:0061659 ubiquitin-like protein ligase activity(GO:0061659)
0.7 15.5 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.3 14.3 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.9 13.6 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.2 12.8 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.3 12.6 GO:0033613 activating transcription factor binding(GO:0033613)
0.4 11.8 GO:0070888 E-box binding(GO:0070888)