Motif ID: Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2
Z-value: 1.122






Transcription factors associated with Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Bhlhe41 | ENSMUSG00000030256.5 | Bhlhe41 |
Srebf1 | ENSMUSG00000020538.9 | Srebf1 |
Srebf2 | ENSMUSG00000022463.7 | Srebf2 |
Tfeb | ENSMUSG00000023990.12 | Tfeb |
Usf1 | ENSMUSG00000026641.7 | Usf1 |
Usf2 | ENSMUSG00000058239.7 | Usf2 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Tfeb | mm10_v2_chr17_+_47737030_47737107 | 0.66 | 1.7e-08 | Click! |
Srebf1 | mm10_v2_chr11_-_60210410_60210465 | 0.59 | 9.4e-07 | Click! |
Srebf2 | mm10_v2_chr15_+_82147238_82147275 | 0.36 | 4.9e-03 | Click! |
Usf2 | mm10_v2_chr7_-_30956742_30956803 | 0.34 | 8.7e-03 | Click! |
Usf1 | mm10_v2_chr1_+_171411305_171411337 | -0.14 | 2.8e-01 | Click! |
First level regulatory network of Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2
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Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 345 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 62.3 | GO:0008643 | carbohydrate transport(GO:0008643) |
6.0 | 18.0 | GO:1901254 | positive regulation of intracellular transport of viral material(GO:1901254) |
0.4 | 17.7 | GO:0036465 | synaptic vesicle recycling(GO:0036465) |
4.0 | 15.8 | GO:0033540 | fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540) |
0.5 | 15.3 | GO:0015991 | energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662) |
1.0 | 14.1 | GO:0072010 | renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311) |
0.6 | 13.3 | GO:0097576 | autophagosome maturation(GO:0097352) vacuole fusion(GO:0097576) |
1.5 | 12.2 | GO:0097118 | neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118) |
2.9 | 11.8 | GO:0016340 | calcium-dependent cell-matrix adhesion(GO:0016340) |
3.9 | 11.6 | GO:0043323 | positive regulation of natural killer cell degranulation(GO:0043323) |
1.6 | 11.4 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
0.1 | 11.0 | GO:0043473 | pigmentation(GO:0043473) |
2.7 | 10.6 | GO:0035434 | copper ion transmembrane transport(GO:0035434) |
0.7 | 10.0 | GO:0097154 | GABAergic neuron differentiation(GO:0097154) |
0.2 | 10.0 | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle(GO:2000134) |
0.7 | 9.9 | GO:0042759 | long-chain fatty acid biosynthetic process(GO:0042759) |
1.9 | 9.6 | GO:1902683 | regulation of receptor localization to synapse(GO:1902683) |
3.2 | 9.5 | GO:0019482 | beta-alanine metabolic process(GO:0019482) |
0.3 | 9.5 | GO:0051703 | social behavior(GO:0035176) intraspecies interaction between organisms(GO:0051703) |
0.4 | 9.2 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 160 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 91.7 | GO:0016021 | integral component of membrane(GO:0016021) |
0.2 | 60.8 | GO:0000139 | Golgi membrane(GO:0000139) |
6.0 | 18.0 | GO:0042025 | viral replication complex(GO:0019034) host cell nucleus(GO:0042025) host cell nuclear part(GO:0044094) |
0.2 | 15.1 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
0.1 | 15.1 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
3.5 | 14.0 | GO:0031084 | BLOC-2 complex(GO:0031084) |
0.2 | 12.1 | GO:0005905 | clathrin-coated pit(GO:0005905) |
0.8 | 11.8 | GO:0043196 | varicosity(GO:0043196) |
3.9 | 11.6 | GO:0044194 | cytolytic granule(GO:0044194) |
0.0 | 10.2 | GO:0045211 | postsynaptic membrane(GO:0045211) |
1.4 | 9.7 | GO:0033263 | CORVET complex(GO:0033263) |
1.1 | 9.6 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
0.3 | 8.2 | GO:0035861 | site of double-strand break(GO:0035861) |
1.5 | 7.7 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
0.9 | 7.5 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
0.1 | 7.5 | GO:0031225 | anchored component of membrane(GO:0031225) |
0.1 | 7.2 | GO:0055037 | recycling endosome(GO:0055037) |
1.0 | 6.7 | GO:0000220 | vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) |
0.1 | 6.7 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
0.3 | 6.0 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 254 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.5 | 58.5 | GO:0005351 | sugar:proton symporter activity(GO:0005351) |
0.7 | 19.7 | GO:0046961 | proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
3.4 | 16.9 | GO:1990825 | sequence-specific mRNA binding(GO:1990825) |
2.6 | 15.8 | GO:0016401 | palmitoyl-CoA oxidase activity(GO:0016401) |
0.1 | 15.8 | GO:0005096 | GTPase activator activity(GO:0005096) |
0.2 | 14.2 | GO:0005262 | calcium channel activity(GO:0005262) |
0.1 | 13.0 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
0.4 | 12.0 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
0.1 | 11.8 | GO:0035091 | phosphatidylinositol binding(GO:0035091) |
0.7 | 11.7 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
0.1 | 11.7 | GO:0008565 | protein transporter activity(GO:0008565) |
0.6 | 11.6 | GO:0034236 | protein kinase A catalytic subunit binding(GO:0034236) |
0.1 | 10.7 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
0.2 | 10.0 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
0.4 | 9.5 | GO:0004029 | aldehyde dehydrogenase (NAD) activity(GO:0004029) |
0.0 | 9.1 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
0.1 | 9.0 | GO:0004714 | transmembrane receptor protein tyrosine kinase activity(GO:0004714) |
0.4 | 8.6 | GO:0005234 | extracellular-glutamate-gated ion channel activity(GO:0005234) |
1.0 | 8.1 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
0.1 | 7.8 | GO:0042626 | ATPase activity, coupled to transmembrane movement of substances(GO:0042626) |