Motif ID: Tgif1_Meis3

Z-value: 3.597

Transcription factors associated with Tgif1_Meis3:

Gene SymbolEntrez IDGene Name
Meis3 ENSMUSG00000041420.12 Meis3
Tgif1 ENSMUSG00000047407.11 Tgif1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tgif1mm10_v2_chr17_-_70851710_70851738-0.909.3e-22Click!
Meis3mm10_v2_chr7_+_16175085_161751390.706.0e-10Click!


Activity profile for motif Tgif1_Meis3.

activity profile for motif Tgif1_Meis3


Sorted Z-values histogram for motif Tgif1_Meis3

Sorted Z-values for motif Tgif1_Meis3



Network of associatons between targets according to the STRING database.



First level regulatory network of Tgif1_Meis3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_49246131 53.511 ENSMUST00000064395.6
 Nav2
neuron navigator 2
chr1_-_132542934 51.095 ENSMUST00000086521.4
 Cntn2
contactin 2
chr4_-_64046925 48.763 ENSMUST00000107377.3
 Tnc
tenascin C
chr15_-_66831625 46.466 ENSMUST00000164163.1
 Sla
src-like adaptor
chr15_-_66801577 38.742 ENSMUST00000168589.1
 Sla
src-like adaptor
chr8_-_84800024 32.142 ENSMUST00000126806.1
ENSMUST00000076715.6
 Nfix

nuclear factor I/X

chr6_-_88874045 30.800 ENSMUST00000038409.5
 Podxl2
podocalyxin-like 2
chr3_+_26331150 30.442 ENSMUST00000099182.2
 A830092H15Rik
RIKEN cDNA A830092H15 gene
chr15_+_18818895 27.564 ENSMUST00000166873.2
 Cdh10
cadherin 10
chr4_-_82705735 27.510 ENSMUST00000155821.1
 Nfib
nuclear factor I/B
chr8_+_57455898 27.368 ENSMUST00000034023.3
 Scrg1
scrapie responsive gene 1
chr19_+_23758819 26.356 ENSMUST00000025830.7
 Apba1
amyloid beta (A4) precursor protein binding, family A, member 1
chr4_+_102254993 24.686 ENSMUST00000106908.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr7_+_49246812 24.566 ENSMUST00000184945.1
 Nav2
neuron navigator 2
chr7_-_97417730 24.052 ENSMUST00000043077.7
 Thrsp
thyroid hormone responsive
chr11_+_98348404 23.247 ENSMUST00000078694.6
 Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr1_+_194619815 22.632 ENSMUST00000027952.5
 Plxna2
plexin A2
chr3_-_116968969 22.495 ENSMUST00000143611.1
ENSMUST00000040097.7
 Palmd

palmdelphin

chr16_-_18621366 21.679 ENSMUST00000051160.2
 Gp1bb
glycoprotein Ib, beta polypeptide
chr2_-_168712853 21.464 ENSMUST00000123156.1
ENSMUST00000156555.1
 Atp9a

ATPase, class II, type 9A


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 553 entries
Log-likelihood per target Total log-likelihoodTermDescription
19.5 78.1 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
3.9 59.0 GO:0050901 leukocyte tethering or rolling(GO:0050901)
4.3 55.4 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
1.3 53.8 GO:0006376 mRNA splice site selection(GO:0006376)
1.7 52.4 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
12.8 51.1 GO:0031133 regulation of axon diameter(GO:0031133)
12.2 48.8 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
2.3 46.1 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
4.5 45.1 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
6.2 43.1 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
1.0 38.1 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843)
2.8 36.5 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
2.1 36.1 GO:0021860 pyramidal neuron development(GO:0021860)
2.8 33.4 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.9 29.4 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
6.9 27.5 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.4 25.7 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.4 24.7 GO:0031338 regulation of vesicle fusion(GO:0031338)
8.2 24.5 GO:0016191 synaptic vesicle uncoating(GO:0016191) regulation of endosome organization(GO:1904978) positive regulation of endosome organization(GO:1904980)
0.7 24.1 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 209 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 245.7 GO:0016021 integral component of membrane(GO:0016021)
0.6 147.5 GO:0045211 postsynaptic membrane(GO:0045211)
0.3 129.3 GO:0005768 endosome(GO:0005768)
7.5 120.7 GO:0005614 interstitial matrix(GO:0005614)
2.6 64.7 GO:0030132 clathrin coat of coated pit(GO:0030132)
0.5 58.4 GO:0043197 dendritic spine(GO:0043197)
2.3 57.3 GO:0071565 nBAF complex(GO:0071565)
2.6 52.1 GO:0044224 juxtaparanode region of axon(GO:0044224)
2.1 48.5 GO:0000930 gamma-tubulin complex(GO:0000930)
0.4 40.5 GO:0055037 recycling endosome(GO:0055037)
2.8 36.7 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.3 36.3 GO:0005802 trans-Golgi network(GO:0005802)
0.7 35.3 GO:0042734 presynaptic membrane(GO:0042734)
0.4 34.3 GO:0044437 vacuolar part(GO:0044437)
1.1 31.2 GO:0033268 node of Ranvier(GO:0033268) axon initial segment(GO:0043194)
2.4 30.7 GO:0016342 catenin complex(GO:0016342)
0.2 29.7 GO:0030427 site of polarized growth(GO:0030427)
0.3 29.3 GO:0060076 excitatory synapse(GO:0060076)
1.0 28.6 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
2.5 27.9 GO:0043083 synaptic cleft(GO:0043083)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 365 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 93.4 GO:0030552 cAMP binding(GO:0030552)
0.5 85.9 GO:0003714 transcription corepressor activity(GO:0003714)
0.5 52.2 GO:0008201 heparin binding(GO:0008201)
8.1 48.6 GO:0045545 syndecan binding(GO:0045545)
0.4 46.8 GO:0017137 Rab GTPase binding(GO:0017137)
0.8 44.9 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
2.0 42.4 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
1.0 42.1 GO:0001540 beta-amyloid binding(GO:0001540)
4.5 40.6 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.4 38.3 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.3 35.5 GO:0017124 SH3 domain binding(GO:0017124)
1.1 32.0 GO:0030215 semaphorin receptor binding(GO:0030215)
2.2 31.4 GO:0017154 semaphorin receptor activity(GO:0017154)
0.6 29.3 GO:0043621 protein self-association(GO:0043621)
1.2 29.2 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
1.0 29.2 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
2.7 27.4 GO:0052872 3-(3-hydroxyphenyl)propionate hydroxylase activity(GO:0008688) 4-chlorobenzaldehyde oxidase activity(GO:0018471) 3,5-xylenol methylhydroxylase activity(GO:0018630) phenylacetate hydroxylase activity(GO:0018631) 4-nitrophenol 4-monooxygenase activity(GO:0018632) dimethyl sulfide monooxygenase activity(GO:0018633) alpha-pinene monooxygenase [NADH] activity(GO:0018634) phenanthrene 9,10-monooxygenase activity(GO:0018636) 1-hydroxy-2-naphthoate hydroxylase activity(GO:0018637) toluene 4-monooxygenase activity(GO:0018638) xylene monooxygenase activity(GO:0018639) dibenzothiophene monooxygenase activity(GO:0018640) 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018641) chlorophenol 4-monooxygenase activity(GO:0018642) carbon disulfide oxygenase activity(GO:0018643) toluene 2-monooxygenase activity(GO:0018644) 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity(GO:0018646) phenanthrene 1,2-monooxygenase activity(GO:0018647) tetrahydrofuran hydroxylase activity(GO:0018649) styrene monooxygenase activity(GO:0018650) toluene-4-sulfonate monooxygenase activity(GO:0018651) toluene-sulfonate methyl-monooxygenase activity(GO:0018652) 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018653) 2-hydroxy-phenylacetate hydroxylase activity(GO:0018654) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity(GO:0018655) phenanthrene 3,4-monooxygenase activity(GO:0018656) toluene 3-monooxygenase activity(GO:0018657) 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity(GO:0018660) limonene monooxygenase activity(GO:0019113) 2-methylnaphthalene hydroxylase activity(GO:0034526) 1-methylnaphthalene hydroxylase activity(GO:0034534) bisphenol A hydroxylase A activity(GO:0034560) salicylate 5-hydroxylase activity(GO:0034785) isobutylamine N-hydroxylase activity(GO:0034791) branched-chain dodecylbenzene sulfonate monooxygenase activity(GO:0034802) 3-HSA hydroxylase activity(GO:0034819) 4-hydroxypyridine-3-hydroxylase activity(GO:0034894) 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity(GO:0043719) 6-hydroxynicotinate 3-monooxygenase activity(GO:0043731) tocotrienol omega-hydroxylase activity(GO:0052872) thalianol hydroxylase activity(GO:0080014)
6.6 26.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.7 24.3 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
3.4 23.9 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)