Motif ID: Tlx2

Z-value: 0.956


Transcription factors associated with Tlx2:

Gene SymbolEntrez IDGene Name
Tlx2 ENSMUSG00000068327.3 Tlx2



Activity profile for motif Tlx2.

activity profile for motif Tlx2


Sorted Z-values histogram for motif Tlx2

Sorted Z-values for motif Tlx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tlx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_48662740 10.978 ENSMUST00000122009.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr16_+_91225550 6.295 ENSMUST00000035608.8
 Olig2
oligodendrocyte transcription factor 2
chr10_+_79988584 5.591 ENSMUST00000004784.4
ENSMUST00000105374.1
 Cnn2

calponin 2

chr10_-_103028771 4.592 ENSMUST00000040859.5
 Alx1
ALX homeobox 1
chr3_+_134236483 4.397 ENSMUST00000181904.1
ENSMUST00000053048.9
 Cxxc4

CXXC finger 4

chr14_-_48667508 4.199 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
 Otx2



orthodenticle homolog 2 (Drosophila)



chr12_+_24708984 4.016 ENSMUST00000154588.1
 Rrm2
ribonucleotide reductase M2
chr10_+_94036001 3.894 ENSMUST00000020208.4
 Fgd6
FYVE, RhoGEF and PH domain containing 6
chr18_-_31949571 3.887 ENSMUST00000064016.5
 Gpr17
G protein-coupled receptor 17
chr7_-_109438998 3.824 ENSMUST00000121378.1
 Stk33
serine/threonine kinase 33
chr7_-_109438786 3.649 ENSMUST00000121748.1
 Stk33
serine/threonine kinase 33
chr3_+_159839729 3.626 ENSMUST00000068952.5
 Wls
wntless homolog (Drosophila)
chr11_-_52282564 3.565 ENSMUST00000086844.3
 Tcf7
transcription factor 7, T cell specific
chr5_+_146845071 3.447 ENSMUST00000031646.7
 Rasl11a
RAS-like, family 11, member A
chr7_+_113766119 3.394 ENSMUST00000084696.4
 Spon1
spondin 1, (f-spondin) extracellular matrix protein
chr2_-_181039286 3.321 ENSMUST00000067120.7
 Chrna4
cholinergic receptor, nicotinic, alpha polypeptide 4
chr2_-_120154600 3.227 ENSMUST00000028755.7
 Ehd4
EH-domain containing 4
chr19_-_24031006 3.107 ENSMUST00000096164.4
 Fam189a2
family with sequence similarity 189, member A2
chr19_-_28680077 3.033 ENSMUST00000162022.1
ENSMUST00000112612.2
 Glis3

GLIS family zinc finger 3

chr11_-_76027726 3.020 ENSMUST00000021207.6
 Fam101b
family with sequence similarity 101, member B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 219 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.8 15.2 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.0 7.4 GO:0046777 protein autophosphorylation(GO:0046777)
0.3 6.4 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
2.1 6.3 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
2.1 6.3 GO:1903048 regulation of acetylcholine-gated cation channel activity(GO:1903048)
0.6 5.9 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.6 5.6 GO:1902715 positive regulation of interferon-gamma secretion(GO:1902715)
0.1 4.8 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.5 4.7 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.4 3.9 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.6 3.8 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.1 3.7 GO:0070206 protein trimerization(GO:0070206)
0.4 3.6 GO:0002681 somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153)
0.3 3.6 GO:0031017 exocrine pancreas development(GO:0031017)
0.1 3.6 GO:0032465 regulation of cytokinesis(GO:0032465)
1.2 3.5 GO:0071603 endothelial cell-cell adhesion(GO:0071603)
0.3 3.5 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.2 3.5 GO:0042178 xenobiotic catabolic process(GO:0042178)
0.1 3.4 GO:0045943 positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.4 3.2 GO:0009404 toxin metabolic process(GO:0009404)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 108 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.8 GO:0005667 transcription factor complex(GO:0005667)
0.0 9.0 GO:0030426 growth cone(GO:0030426)
0.1 8.3 GO:0005923 bicellular tight junction(GO:0005923)
0.1 6.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 6.6 GO:0032432 actin filament bundle(GO:0032432)
0.6 6.3 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
1.2 6.1 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.3 4.7 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 4.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.4 3.8 GO:0005642 annulate lamellae(GO:0005642)
0.4 3.7 GO:0098533 ATPase dependent transmembrane transport complex(GO:0098533)
0.3 3.4 GO:0042612 MHC class I protein complex(GO:0042612)
0.2 3.2 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 3.2 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 2.9 GO:0005771 multivesicular body(GO:0005771)
0.1 2.9 GO:0014704 intercalated disc(GO:0014704)
0.1 2.8 GO:0005844 polysome(GO:0005844)
0.2 2.7 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 2.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.3 2.6 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 159 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 17.1 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.6 6.3 GO:0004889 acetylcholine-activated cation-selective channel activity(GO:0004889)
0.2 6.3 GO:0071837 HMG box domain binding(GO:0071837)
1.2 6.1 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0 6.0 GO:0030165 PDZ domain binding(GO:0030165)
0.5 5.6 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 5.1 GO:0005525 GTP binding(GO:0005525)
0.1 5.0 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.8 4.7 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 4.6 GO:0008013 beta-catenin binding(GO:0008013)
0.4 4.3 GO:1990405 protein antigen binding(GO:1990405)
0.1 3.9 GO:0043014 alpha-tubulin binding(GO:0043014)
0.3 3.8 GO:0017070 U6 snRNA binding(GO:0017070)
0.4 3.6 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.0 3.5 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.3 3.4 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.6 3.2 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 3.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.5 3.0 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.2 3.0 GO:0031005 filamin binding(GO:0031005)