Motif ID: Trp53

Z-value: 0.900


Transcription factors associated with Trp53:

Gene SymbolEntrez IDGene Name
Trp53 ENSMUSG00000059552.7 Trp53

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Trp53mm10_v2_chr11_+_69580392_695804190.283.2e-02Click!


Activity profile for motif Trp53.

activity profile for motif Trp53


Sorted Z-values histogram for motif Trp53

Sorted Z-values for motif Trp53



Network of associatons between targets according to the STRING database.



First level regulatory network of Trp53

PNG image of the network

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Top targets:


Showing 1 to 20 of 164 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_98004695 6.750 ENSMUST00000023123.8
 Col2a1
collagen, type II, alpha 1
chr10_+_56377300 6.458 ENSMUST00000068581.7
 Gja1
gap junction protein, alpha 1
chr15_-_98004634 6.166 ENSMUST00000131560.1
ENSMUST00000088355.5
 Col2a1

collagen, type II, alpha 1

chr17_-_33890584 5.744 ENSMUST00000114361.2
ENSMUST00000173492.1
 Kifc1

kinesin family member C1

chr2_-_69206146 5.631 ENSMUST00000127243.1
ENSMUST00000149643.1
ENSMUST00000167875.2
ENSMUST00000005365.8
 Spc25



SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)



chr17_-_33890539 5.479 ENSMUST00000173386.1
 Kifc1
kinesin family member C1
chr5_-_116422858 5.201 ENSMUST00000036991.4
 Hspb8
heat shock protein 8
chr17_+_29090969 4.962 ENSMUST00000119901.1
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr2_-_69206133 4.794 ENSMUST00000112320.1
 Spc25
SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr4_-_135573623 4.013 ENSMUST00000105855.1
 Grhl3
grainyhead-like 3 (Drosophila)
chr14_+_73237891 3.956 ENSMUST00000044405.6
 Lpar6
lysophosphatidic acid receptor 6
chr8_-_22185758 3.754 ENSMUST00000046916.7
 Ckap2
cytoskeleton associated protein 2
chr9_+_66946057 3.708 ENSMUST00000040917.7
ENSMUST00000127896.1
 Rps27l

ribosomal protein S27-like

chr1_+_6487231 3.678 ENSMUST00000140079.1
ENSMUST00000131494.1
 St18

suppression of tumorigenicity 18

chr14_+_47001336 3.437 ENSMUST00000125113.1
 Samd4
sterile alpha motif domain containing 4
chr15_+_85859689 3.407 ENSMUST00000170629.1
 Gtse1
G two S phase expressed protein 1
chr2_-_155074447 3.307 ENSMUST00000137242.1
ENSMUST00000054607.9
 Ahcy

S-adenosylhomocysteine hydrolase

chr15_-_102350692 3.289 ENSMUST00000041208.7
 Aaas
achalasia, adrenocortical insufficiency, alacrimia
chr9_-_106158109 3.283 ENSMUST00000159809.1
ENSMUST00000162562.1
ENSMUST00000036382.6
ENSMUST00000112543.2
 Glyctk



glycerate kinase



chr14_-_34374617 3.150 ENSMUST00000023826.4
 Sncg
synuclein, gamma

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 13.5 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
2.8 11.2 GO:0072385 minus-end-directed organelle transport along microtubule(GO:0072385)
0.1 10.4 GO:0007052 mitotic spindle organization(GO:0007052)
2.2 6.5 GO:0003104 positive regulation of glomerular filtration(GO:0003104) cell communication by chemical coupling(GO:0010643)
0.1 6.3 GO:0007019 microtubule depolymerization(GO:0007019)
0.4 5.3 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
1.7 5.2 GO:0060217 hemangioblast cell differentiation(GO:0060217)
0.6 5.0 GO:0071493 cellular response to UV-B(GO:0071493)
0.4 4.0 GO:0061436 establishment of skin barrier(GO:0061436)
0.2 3.8 GO:0070986 left/right axis specification(GO:0070986)
0.2 3.7 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.4 3.3 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 3.3 GO:0009566 fertilization(GO:0009566)
0.0 3.3 GO:0009101 glycoprotein biosynthetic process(GO:0009101)
0.3 3.2 GO:0099625 regulation of ventricular cardiac muscle cell membrane repolarization(GO:0060307) ventricular cardiac muscle cell membrane repolarization(GO:0099625)
1.0 3.1 GO:0046078 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177) dUMP metabolic process(GO:0046078)
0.5 3.1 GO:0010694 positive regulation of alkaline phosphatase activity(GO:0010694)
0.1 3.1 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
1.0 3.0 GO:0002765 immune response-inhibiting signal transduction(GO:0002765)
0.7 3.0 GO:0060266 positive regulation of respiratory burst involved in inflammatory response(GO:0060265) negative regulation of respiratory burst involved in inflammatory response(GO:0060266) negative regulation of respiratory burst(GO:0060268)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 12.9 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.7 11.2 GO:0031616 spindle pole centrosome(GO:0031616)
1.7 10.4 GO:0031262 Ndc80 complex(GO:0031262)
0.1 7.2 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 6.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.6 6.5 GO:0005916 fascia adherens(GO:0005916)
1.3 5.3 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
1.7 5.2 GO:0033193 Lsd1/2 complex(GO:0033193)
1.7 5.0 GO:0070557 PCNA-p21 complex(GO:0070557)
0.0 4.3 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 3.7 GO:0043679 axon terminus(GO:0043679)
0.6 3.1 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.3 2.9 GO:0031091 platelet alpha granule(GO:0031091) extrinsic component of external side of plasma membrane(GO:0031232)
0.2 2.8 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 2.7 GO:0005882 intermediate filament(GO:0005882)
0.4 2.5 GO:0000235 astral microtubule(GO:0000235)
0.0 2.4 GO:0005643 nuclear pore(GO:0005643)
0.0 2.4 GO:0005604 basement membrane(GO:0005604)
0.0 2.2 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 2.1 GO:0030173 integral component of Golgi membrane(GO:0030173)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 12.9 GO:0048407 platelet-derived growth factor binding(GO:0048407)
2.8 11.2 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
1.3 6.5 GO:0071253 connexin binding(GO:0071253)
0.3 5.3 GO:0000400 four-way junction DNA binding(GO:0000400)
0.1 5.3 GO:0031490 chromatin DNA binding(GO:0031490)
0.1 5.2 GO:0070888 E-box binding(GO:0070888)
0.4 5.0 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.6 3.7 GO:0008494 translation activator activity(GO:0008494)
0.1 3.4 GO:0030371 translation repressor activity(GO:0030371)
0.5 3.3 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 3.3 GO:0050694 galactose 3-O-sulfotransferase activity(GO:0050694)
0.2 3.1 GO:0005542 folic acid binding(GO:0005542)
0.1 3.1 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 3.1 GO:0005178 integrin binding(GO:0005178)
0.8 3.0 GO:0042015 interleukin-20 binding(GO:0042015)
0.1 3.0 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.1 2.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.4 2.8 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 2.7 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.2 2.5 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)