Motif ID: Trp73

Z-value: 0.631


Transcription factors associated with Trp73:

Gene SymbolEntrez IDGene Name
Trp73 ENSMUSG00000029026.10 Trp73

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Trp73mm10_v2_chr4_-_154097105_1540971730.238.0e-02Click!


Activity profile for motif Trp73.

activity profile for motif Trp73


Sorted Z-values histogram for motif Trp73

Sorted Z-values for motif Trp73



Network of associatons between targets according to the STRING database.



First level regulatory network of Trp73

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_+_48261427 5.358 ENSMUST00000021810.1
 Id4
inhibitor of DNA binding 4
chr15_+_99055164 3.136 ENSMUST00000047104.7
ENSMUST00000024249.3
 Prph

peripherin

chr12_-_45074112 2.965 ENSMUST00000120531.1
ENSMUST00000143376.1
 Stxbp6

syntaxin binding protein 6 (amisyn)

chr7_-_116038734 2.586 ENSMUST00000166877.1
 Sox6
SRY-box containing gene 6
chr7_-_116308241 2.557 ENSMUST00000183057.1
ENSMUST00000182487.1
ENSMUST00000181998.1
 Plekha7


pleckstrin homology domain containing, family A member 7


chr12_-_45074457 2.524 ENSMUST00000053768.6
 Stxbp6
syntaxin binding protein 6 (amisyn)
chr7_-_141443314 2.397 ENSMUST00000106005.2
 Lrdd
leucine-rich and death domain containing
chr19_-_50030735 2.300 ENSMUST00000071866.1
 Rpl13a-ps1
ribosomal protein 13A, pseudogene 1
chrX_+_10717390 2.287 ENSMUST00000115524.1
ENSMUST00000008179.6
 Mid1ip1

Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish))

chr1_+_72824482 2.278 ENSMUST00000047328.4
 Igfbp2
insulin-like growth factor binding protein 2
chr16_-_17125106 2.249 ENSMUST00000093336.6
 2610318N02Rik
RIKEN cDNA 2610318N02 gene
chr1_+_135729147 2.246 ENSMUST00000027677.7
 Csrp1
cysteine and glycine-rich protein 1
chr2_-_164857542 2.243 ENSMUST00000109316.1
ENSMUST00000156255.1
ENSMUST00000128110.1
ENSMUST00000109317.3
 Pltp



phospholipid transfer protein



chr1_-_5070281 2.231 ENSMUST00000147158.1
ENSMUST00000118000.1
 Rgs20

regulator of G-protein signaling 20

chr2_-_164857671 2.176 ENSMUST00000059954.7
 Pltp
phospholipid transfer protein
chrX_+_10717451 1.977 ENSMUST00000156321.1
 Mid1ip1
Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish))
chr18_+_56432116 1.864 ENSMUST00000070166.5
 Gramd3
GRAM domain containing 3
chr4_+_101068983 1.807 ENSMUST00000038463.8
ENSMUST00000106955.1
 Raver2

ribonucleoprotein, PTB-binding 2

chr3_+_159839729 1.805 ENSMUST00000068952.5
 Wls
wntless homolog (Drosophila)
chr17_+_29090969 1.766 ENSMUST00000119901.1
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr4_-_11386757 1.517 ENSMUST00000108313.1
ENSMUST00000108311.2
 Esrp1

epithelial splicing regulatory protein 1

chr14_+_53665912 1.348 ENSMUST00000181768.1
 Trav3-3
T cell receptor alpha variable 3-3
chr3_+_14641722 1.332 ENSMUST00000029071.8
 Car13
carbonic anhydrase 13
chr19_+_41911851 1.329 ENSMUST00000011896.6
 Pgam1
phosphoglycerate mutase 1
chr4_+_129820198 1.290 ENSMUST00000030578.7
 Ptp4a2
protein tyrosine phosphatase 4a2
chr13_+_12702362 1.261 ENSMUST00000104944.2
 Gm2399
predicted gene 2399
chr11_+_60931998 1.206 ENSMUST00000019076.3
 Map2k3
mitogen-activated protein kinase kinase 3
chr9_-_58158498 1.177 ENSMUST00000168864.2
 Islr
immunoglobulin superfamily containing leucine-rich repeat
chr9_-_67760208 1.166 ENSMUST00000068526.5
 M5C1000I18Rik
RIKEN cDNA M5C1000I18 gene
chr1_+_153665274 1.139 ENSMUST00000152114.1
ENSMUST00000111812.1
 Rgs8

regulator of G-protein signaling 8

chr4_+_62583568 1.118 ENSMUST00000098031.3
 Rgs3
regulator of G-protein signaling 3
chr2_+_150909565 1.071 ENSMUST00000028948.4
 Gins1
GINS complex subunit 1 (Psf1 homolog)
chr8_+_27085835 0.994 ENSMUST00000165366.2
 Gpr124
G protein-coupled receptor 124
chr11_+_114851507 0.979 ENSMUST00000177952.1
 Gprc5c
G protein-coupled receptor, family C, group 5, member C
chr11_-_69948145 0.953 ENSMUST00000179298.1
ENSMUST00000018710.6
ENSMUST00000135437.1
ENSMUST00000141837.2
ENSMUST00000142500.1
 Slc2a4




solute carrier family 2 (facilitated glucose transporter), member 4




chr4_+_119232896 0.945 ENSMUST00000121111.2
ENSMUST00000030393.6
ENSMUST00000102662.4
 Lepre1


leprecan 1


chr10_-_67912620 0.944 ENSMUST00000064656.7
 Zfp365
zinc finger protein 365
chr3_+_89245952 0.798 ENSMUST00000040888.5
 Krtcap2
keratinocyte associated protein 2
chr4_-_106804998 0.768 ENSMUST00000065253.6
 Acot11
acyl-CoA thioesterase 11
chr19_+_46304709 0.750 ENSMUST00000073116.5
 Nfkb2
nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
chr2_+_34772089 0.741 ENSMUST00000028222.6
ENSMUST00000100171.2
 Hspa5

heat shock protein 5

chr9_-_109082372 0.716 ENSMUST00000167504.1
 Tma7
translational machinery associated 7 homolog (S. cerevisiae)
chr8_+_27085520 0.708 ENSMUST00000178514.1
ENSMUST00000033876.7
 Gpr124

G protein-coupled receptor 124

chr7_+_140882430 0.705 ENSMUST00000164681.1
ENSMUST00000163610.1
 Psmd13

proteasome (prosome, macropain) 26S subunit, non-ATPase, 13

chr10_-_105841323 0.694 ENSMUST00000046638.9
 Mettl25
methyltransferase like 25
chr14_-_52104015 0.680 ENSMUST00000111610.4
ENSMUST00000164655.1
 Hnrnpc

heterogeneous nuclear ribonucleoprotein C

chr15_+_76696725 0.676 ENSMUST00000023203.4
 Gpt
glutamic pyruvic transaminase, soluble
chr7_+_140881898 0.672 ENSMUST00000026560.7
 Psmd13
proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
chr11_+_98026918 0.671 ENSMUST00000017548.6
 Rpl19
ribosomal protein L19
chr10_+_127642975 0.664 ENSMUST00000092074.5
ENSMUST00000120279.1
 Stat6

signal transducer and activator of transcription 6

chr15_+_84232030 0.652 ENSMUST00000023072.6
 Parvb
parvin, beta
chr7_-_65371210 0.632 ENSMUST00000102592.3
 Tjp1
tight junction protein 1
chrX_-_109013389 0.618 ENSMUST00000033597.8
 Hmgn5
high-mobility group nucleosome binding domain 5
chr7_-_31054815 0.569 ENSMUST00000071697.4
ENSMUST00000108110.3
 Fxyd1

FXYD domain-containing ion transport regulator 1

chr11_+_69913888 0.527 ENSMUST00000072581.2
ENSMUST00000116358.1
 Gps2

G protein pathway suppressor 2

chr7_-_5014645 0.523 ENSMUST00000165320.1
 Fiz1
Flt3 interacting zinc finger protein 1
chr10_+_110745433 0.523 ENSMUST00000174857.1
ENSMUST00000073781.5
ENSMUST00000173471.1
ENSMUST00000173634.1
 E2f7



E2F transcription factor 7



chr17_+_28232723 0.520 ENSMUST00000002320.8
 Ppard
peroxisome proliferator activator receptor delta
chr10_+_41810528 0.495 ENSMUST00000099931.3
 Sesn1
sestrin 1
chr2_-_90904827 0.487 ENSMUST00000005647.3
 Ndufs3
NADH dehydrogenase (ubiquinone) Fe-S protein 3
chr8_-_70659645 0.451 ENSMUST00000070173.7
 Pgpep1
pyroglutamyl-peptidase I
chr1_+_55088132 0.450 ENSMUST00000075242.6
 Hspe1
heat shock protein 1 (chaperonin 10)
chr2_-_180920925 0.375 ENSMUST00000037299.8
ENSMUST00000108876.2
 Ythdf1

YTH domain family 1

chr10_-_127311740 0.362 ENSMUST00000037290.5
ENSMUST00000171564.1
 Mars

methionine-tRNA synthetase

chr12_+_109747903 0.313 ENSMUST00000183084.1
ENSMUST00000182300.1
 Mirg

miRNA containing gene

chr1_-_55088024 0.282 ENSMUST00000027123.8
 Hspd1
heat shock protein 1 (chaperonin)
chr19_-_47138280 0.254 ENSMUST00000140512.1
ENSMUST00000035822.1
 Calhm2

calcium homeostasis modulator 2

chr11_-_103344651 0.240 ENSMUST00000041385.7
 Arhgap27
Rho GTPase activating protein 27
chr11_+_114851142 0.221 ENSMUST00000133245.1
ENSMUST00000122967.2
 Gprc5c

G protein-coupled receptor, family C, group 5, member C

chr10_+_105841064 0.193 ENSMUST00000020049.8
 Ccdc59
coiled-coil domain containing 59
chr7_+_25282179 0.192 ENSMUST00000163320.1
ENSMUST00000005578.6
 Cic

capicua homolog (Drosophila)

chr1_-_170215380 0.157 ENSMUST00000027979.7
ENSMUST00000123399.1
 Uhmk1

U2AF homology motif (UHM) kinase 1

chr9_+_108662098 0.149 ENSMUST00000035222.5
 Slc25a20
solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20
chr6_+_29398920 0.111 ENSMUST00000181464.1
ENSMUST00000180829.1
 Ccdc136

coiled-coil domain containing 136

chr10_+_39369750 0.105 ENSMUST00000063091.6
ENSMUST00000099967.3
ENSMUST00000126486.1
 Fyn


Fyn proto-oncogene


chr17_+_33940660 0.077 ENSMUST00000025170.9
 Wdr46
WD repeat domain 46
chr15_-_98607611 0.076 ENSMUST00000096224.4
 Adcy6
adenylate cyclase 6
chr19_-_7483212 0.046 ENSMUST00000088169.5
 Rtn3
reticulon 3
chr9_-_65885024 0.035 ENSMUST00000122410.1
ENSMUST00000117083.1
 Trip4

thyroid hormone receptor interactor 4

chr10_+_127677064 0.006 ENSMUST00000118612.1
ENSMUST00000048099.4
 Tmem194

transmembrane protein 194


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.4 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
1.1 4.4 GO:0042360 vitamin E metabolic process(GO:0042360)
0.7 5.5 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.4 1.3 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.4 2.6 GO:0045218 zonula adherens maintenance(GO:0045218)
0.4 4.3 GO:0045723 positive regulation of fatty acid biosynthetic process(GO:0045723)
0.3 0.9 GO:0033566 gamma-tubulin complex localization(GO:0033566)
0.2 0.7 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.2 2.6 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.2 0.7 GO:0002295 T-helper cell lineage commitment(GO:0002295) interleukin-4-mediated signaling pathway(GO:0035771)
0.2 1.8 GO:0071493 cellular response to UV-B(GO:0071493) replicative senescence(GO:0090399)
0.2 0.6 GO:1903795 regulation of inorganic anion transmembrane transport(GO:1903795)
0.2 2.2 GO:0090244 Wnt signaling pathway involved in somitogenesis(GO:0090244)
0.2 0.5 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
0.2 0.7 GO:0090365 regulation of mRNA modification(GO:0090365)
0.2 1.8 GO:0031017 exocrine pancreas development(GO:0031017)
0.2 2.3 GO:0042104 positive regulation of activated T cell proliferation(GO:0042104)
0.1 0.5 GO:0006776 vitamin A metabolic process(GO:0006776)
0.1 1.1 GO:1902969 mitotic DNA replication(GO:1902969)
0.1 1.1 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.1 3.1 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.1 1.4 GO:0043248 proteasome assembly(GO:0043248)
0.1 0.6 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.1 0.5 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.0 1.5 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
0.0 0.8 GO:0002467 germinal center formation(GO:0002467)
0.0 1.0 GO:0071470 cellular response to osmotic stress(GO:0071470)
0.0 0.5 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 1.3 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 0.5 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.0 0.1 GO:0035811 negative regulation of urine volume(GO:0035811)
0.0 0.8 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 1.2 GO:0042035 regulation of cytokine biosynthetic process(GO:0042035)
0.0 1.1 GO:0070527 platelet aggregation(GO:0070527)
0.0 1.0 GO:0007601 visual perception(GO:0007601)
0.0 0.5 GO:0046329 negative regulation of JNK cascade(GO:0046329)
0.0 0.1 GO:0036120 cellular response to platelet-derived growth factor stimulus(GO:0036120) positive regulation of tyrosine phosphorylation of Stat5 protein(GO:0042523)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.1 GO:0044299 C-fiber(GO:0044299)
0.6 1.8 GO:0070557 PCNA-p21 complex(GO:0070557)
0.4 1.1 GO:0000811 GINS complex(GO:0000811)
0.3 5.5 GO:0000145 exocyst(GO:0000145)
0.2 2.6 GO:0005915 zonula adherens(GO:0005915)
0.2 1.4 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1 0.8 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.1 2.2 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.1 0.6 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 0.8 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 2.0 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 0.7 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 1.0 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.5 GO:0061700 GATOR2 complex(GO:0061700)
0.0 0.9 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 1.9 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.7 GO:0045120 telomerase holoenzyme complex(GO:0005697) pronucleus(GO:0045120)
0.0 0.6 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.1 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.5 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.4 1.2 GO:0005118 sevenless binding(GO:0005118)
0.3 2.3 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.2 5.5 GO:0017049 GTP-Rho binding(GO:0017049)
0.2 1.0 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.2 2.6 GO:0070097 delta-catenin binding(GO:0070097)
0.2 1.8 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.1 0.5 GO:0004954 icosanoid receptor activity(GO:0004953) prostanoid receptor activity(GO:0004954) prostaglandin receptor activity(GO:0004955)
0.1 1.8 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 0.7 GO:1990932 5.8S rRNA binding(GO:1990932)
0.1 1.3 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 1.1 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 0.8 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 0.5 GO:0070728 leucine binding(GO:0070728)
0.1 2.2 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 1.1 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.0 0.5 GO:0016920 pyroglutamyl-peptidase activity(GO:0016920)
0.0 1.2 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.8 GO:0034946 2-oxoglutaryl-CoA thioesterase activity(GO:0034843) 2,4,4-trimethyl-3-oxopentanoyl-CoA thioesterase activity(GO:0034869) 3-isopropylbut-3-enoyl-CoA thioesterase activity(GO:0034946) glutaryl-CoA hydrolase activity(GO:0044466)
0.0 0.8 GO:0051787 misfolded protein binding(GO:0051787)
0.0 1.1 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 4.7 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 0.7 GO:0008483 transaminase activity(GO:0008483)
0.0 0.1 GO:0015651 quaternary ammonium group transmembrane transporter activity(GO:0015651)
0.0 0.1 GO:0042610 CD8 receptor binding(GO:0042610)
0.0 0.6 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.5 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.1 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0 4.2 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 0.6 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.7 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 1.3 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.5 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 5.7 GO:0046982 protein heterodimerization activity(GO:0046982)