Motif ID: Twist1

Z-value: 1.067


Transcription factors associated with Twist1:

Gene SymbolEntrez IDGene Name
Twist1 ENSMUSG00000035799.5 Twist1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Twist1mm10_v2_chr12_+_33957645_339576710.095.0e-01Click!


Activity profile for motif Twist1.

activity profile for motif Twist1


Sorted Z-values histogram for motif Twist1

Sorted Z-values for motif Twist1



Network of associatons between targets according to the STRING database.



First level regulatory network of Twist1

PNG image of the network

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Top targets:


Showing 1 to 20 of 115 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_172940299 11.008 ENSMUST00000009143.7
 Bmp7
bone morphogenetic protein 7
chr1_-_119053339 7.452 ENSMUST00000161301.1
ENSMUST00000161451.1
ENSMUST00000162607.1
 Gli2


GLI-Kruppel family member GLI2


chr6_-_95718800 6.801 ENSMUST00000079847.5
 Suclg2
succinate-Coenzyme A ligase, GDP-forming, beta subunit
chr9_+_60794468 6.673 ENSMUST00000050183.6
 Uaca
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr7_+_45216671 5.497 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr19_+_25610533 5.284 ENSMUST00000048935.4
 Dmrt3
doublesex and mab-3 related transcription factor 3
chr5_+_105519388 4.350 ENSMUST00000067924.6
ENSMUST00000150981.1
 Lrrc8c

leucine rich repeat containing 8 family, member C

chr2_-_137116624 4.325 ENSMUST00000028735.7
 Jag1
jagged 1
chr9_-_54661870 4.119 ENSMUST00000034822.5
 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr16_-_18811615 4.059 ENSMUST00000096990.3
 Cdc45
cell division cycle 45
chrX_+_100730178 4.054 ENSMUST00000113744.1
 Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr7_+_4119556 3.925 ENSMUST00000079415.5
 Ttyh1
tweety homolog 1 (Drosophila)
chr2_-_180225812 3.862 ENSMUST00000015791.5
 Lama5
laminin, alpha 5
chr7_+_4119525 3.801 ENSMUST00000119661.1
ENSMUST00000129423.1
 Ttyh1

tweety homolog 1 (Drosophila)

chr9_-_54661666 3.783 ENSMUST00000128624.1
 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr9_-_44342332 3.766 ENSMUST00000097558.3
 Hmbs
hydroxymethylbilane synthase
chr10_-_127341583 3.681 ENSMUST00000026474.3
 Gli1
GLI-Kruppel family member GLI1
chr11_-_59290746 3.606 ENSMUST00000010044.7
 Wnt3a
wingless-related MMTV integration site 3A
chr9_-_114844090 3.441 ENSMUST00000047013.3
 Cmtm8
CKLF-like MARVEL transmembrane domain containing 8
chr10_-_127030813 3.278 ENSMUST00000040560.4
 Tsfm
Ts translation elongation factor, mitochondrial

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.8 11.1 GO:0060032 notochord regression(GO:0060032)
3.7 11.0 GO:0072076 hyaluranon cable assembly(GO:0036118) nephrogenic mesenchyme development(GO:0072076) negative regulation of glomerular mesangial cell proliferation(GO:0072125) negative regulation of glomerulus development(GO:0090194) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.9 8.4 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.2 7.9 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.8 6.8 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.4 6.7 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.2 6.7 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
1.1 5.6 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.3 5.5 GO:0030903 notochord development(GO:0030903)
1.4 5.4 GO:0051311 spindle assembly involved in female meiosis(GO:0007056) meiotic metaphase plate congression(GO:0051311)
0.1 4.5 GO:1902476 chloride transmembrane transport(GO:1902476)
0.9 4.3 GO:0072015 ciliary body morphogenesis(GO:0061073) glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
1.4 4.1 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.4 4.1 GO:0090527 actin filament reorganization(GO:0090527)
0.4 3.8 GO:0018065 protein-cofactor linkage(GO:0018065)
1.2 3.6 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892) dermatome development(GO:0061054) regulation of dermatome development(GO:0061183) negative regulation of dopaminergic neuron differentiation(GO:1904339) regulation of cardiac cell fate specification(GO:2000043)
0.4 3.3 GO:0046645 positive regulation of gamma-delta T cell differentiation(GO:0045588) positive regulation of gamma-delta T cell activation(GO:0046645) positive regulation of uterine smooth muscle contraction(GO:0070474)
0.9 2.7 GO:0038145 interleukin-4-mediated signaling pathway(GO:0035771) macrophage colony-stimulating factor signaling pathway(GO:0038145) tyrosine phosphorylation of Stat6 protein(GO:0042505) regulation of tyrosine phosphorylation of Stat6 protein(GO:0042525) regulation of interleukin-6-mediated signaling pathway(GO:0070103) negative regulation of interleukin-6-mediated signaling pathway(GO:0070104)
0.9 2.7 GO:1904395 regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904393) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.0 2.7 GO:0006909 phagocytosis(GO:0006909)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 12.6 GO:0031012 extracellular matrix(GO:0031012)
0.9 11.1 GO:0097542 ciliary tip(GO:0097542)
0.0 7.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
2.6 7.7 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
1.1 6.8 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
1.7 6.7 GO:0043293 apoptosome(GO:0043293)
0.6 5.4 GO:0072687 meiotic spindle(GO:0072687)
0.0 4.9 GO:0005667 transcription factor complex(GO:0005667)
1.5 4.4 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
1.4 4.1 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
1.0 3.9 GO:0043259 laminin-10 complex(GO:0043259)
0.0 3.8 GO:0000793 condensed chromosome(GO:0000793)
0.1 3.3 GO:0000242 pericentriolar material(GO:0000242)
0.0 3.0 GO:0005884 actin filament(GO:0005884)
0.1 2.9 GO:0002102 podosome(GO:0002102)
0.0 2.7 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.5 2.5 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.6 2.4 GO:1990590 ATF1-ATF4 transcription factor complex(GO:1990590)
0.2 1.9 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.1 1.9 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 15.1 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.1 14.6 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
1.1 11.0 GO:0070700 BMP receptor binding(GO:0070700)
0.7 7.9 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
1.9 7.7 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
1.1 6.8 GO:0034943 acyl-CoA ligase activity(GO:0003996) 3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid CoA ligase activity(GO:0010435) 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity(GO:0018854) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity(GO:0018855) benzoyl acetate-CoA ligase activity(GO:0018856) 2,4-dichlorobenzoate-CoA ligase activity(GO:0018857) pivalate-CoA ligase activity(GO:0034783) cyclopropanecarboxylate-CoA ligase activity(GO:0034793) adipate-CoA ligase activity(GO:0034796) citronellyl-CoA ligase activity(GO:0034823) mentha-1,3-dione-CoA ligase activity(GO:0034841) thiophene-2-carboxylate-CoA ligase activity(GO:0034842) 2,4,4-trimethylpentanoate-CoA ligase activity(GO:0034865) cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034942) trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034943) branched-chain acyl-CoA synthetase (ADP-forming) activity(GO:0043759) aryl-CoA synthetase (ADP-forming) activity(GO:0043762) 3-hydroxypropionyl-CoA synthetase activity(GO:0043955) perillic acid:CoA ligase (ADP-forming) activity(GO:0052685) perillic acid:CoA ligase (AMP-forming) activity(GO:0052686) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity(GO:0052687) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity(GO:0052688) pristanate-CoA ligase activity(GO:0070251) malonyl-CoA synthetase activity(GO:0090409)
0.2 5.6 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 5.4 GO:0005525 GTP binding(GO:0005525)
0.3 4.7 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.5 4.4 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.1 4.3 GO:0005112 Notch binding(GO:0005112)
0.5 4.1 GO:0003688 DNA replication origin binding(GO:0003688)
0.4 4.1 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 3.9 GO:0005178 integrin binding(GO:0005178)
0.6 3.8 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
1.2 3.6 GO:0005110 frizzled-2 binding(GO:0005110)
0.2 3.5 GO:0015026 coreceptor activity(GO:0015026)
0.0 3.4 GO:0005125 cytokine activity(GO:0005125)
0.7 3.3 GO:0042610 CD8 receptor binding(GO:0042610)
0.3 3.1 GO:0005095 GTPase inhibitor activity(GO:0005095)