Motif ID: Twist1

Z-value: 1.067


Transcription factors associated with Twist1:

Gene SymbolEntrez IDGene Name
Twist1 ENSMUSG00000035799.5 Twist1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Twist1mm10_v2_chr12_+_33957645_339576710.095.0e-01Click!


Activity profile for motif Twist1.

activity profile for motif Twist1


Sorted Z-values histogram for motif Twist1

Sorted Z-values for motif Twist1



Network of associatons between targets according to the STRING database.



First level regulatory network of Twist1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_172940299 11.008 ENSMUST00000009143.7
Bmp7
bone morphogenetic protein 7
chr1_-_119053339 7.452 ENSMUST00000161301.1
ENSMUST00000161451.1
ENSMUST00000162607.1
Gli2


GLI-Kruppel family member GLI2


chr6_-_95718800 6.801 ENSMUST00000079847.5
Suclg2
succinate-Coenzyme A ligase, GDP-forming, beta subunit
chr9_+_60794468 6.673 ENSMUST00000050183.6
Uaca
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr7_+_45216671 5.497 ENSMUST00000134420.1
Tead2
TEA domain family member 2
chr19_+_25610533 5.284 ENSMUST00000048935.4
Dmrt3
doublesex and mab-3 related transcription factor 3
chr5_+_105519388 4.350 ENSMUST00000067924.6
ENSMUST00000150981.1
Lrrc8c

leucine rich repeat containing 8 family, member C

chr2_-_137116624 4.325 ENSMUST00000028735.7
Jag1
jagged 1
chr9_-_54661870 4.119 ENSMUST00000034822.5
Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr16_-_18811615 4.059 ENSMUST00000096990.3
Cdc45
cell division cycle 45
chrX_+_100730178 4.054 ENSMUST00000113744.1
Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr7_+_4119556 3.925 ENSMUST00000079415.5
Ttyh1
tweety homolog 1 (Drosophila)
chr2_-_180225812 3.862 ENSMUST00000015791.5
Lama5
laminin, alpha 5
chr7_+_4119525 3.801 ENSMUST00000119661.1
ENSMUST00000129423.1
Ttyh1

tweety homolog 1 (Drosophila)

chr9_-_54661666 3.783 ENSMUST00000128624.1
Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr9_-_44342332 3.766 ENSMUST00000097558.3
Hmbs
hydroxymethylbilane synthase
chr10_-_127341583 3.681 ENSMUST00000026474.3
Gli1
GLI-Kruppel family member GLI1
chr11_-_59290746 3.606 ENSMUST00000010044.7
Wnt3a
wingless-related MMTV integration site 3A
chr9_-_114844090 3.441 ENSMUST00000047013.3
Cmtm8
CKLF-like MARVEL transmembrane domain containing 8
chr10_-_127030813 3.278 ENSMUST00000040560.4
Tsfm
Ts translation elongation factor, mitochondrial
chr1_+_74791516 3.068 ENSMUST00000006718.8
Wnt10a
wingless related MMTV integration site 10a
chr6_+_83135812 3.060 ENSMUST00000065512.4
Rtkn
rhotekin
chr7_-_127218390 2.957 ENSMUST00000142356.1
ENSMUST00000106314.1
Sept1

septin 1

chrX_+_71050160 2.918 ENSMUST00000082088.3
ENSMUST00000114629.3
Mamld1

mastermind-like domain containing 1

chr4_-_11386757 2.881 ENSMUST00000108313.1
ENSMUST00000108311.2
Esrp1

epithelial splicing regulatory protein 1

chr8_+_72135247 2.853 ENSMUST00000003575.9
Tpm4
tropomyosin 4
chr18_-_67724560 2.749 ENSMUST00000120934.1
ENSMUST00000025420.7
ENSMUST00000122412.1
Ptpn2


protein tyrosine phosphatase, non-receptor type 2


chr8_+_105305572 2.745 ENSMUST00000109375.2
Elmo3
engulfment and cell motility 3
chr19_-_3686549 2.674 ENSMUST00000025856.10
ENSMUST00000176867.1
Lrp5

low density lipoprotein receptor-related protein 5

chr5_-_62766153 2.647 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr1_+_171437535 2.511 ENSMUST00000043839.4
F11r
F11 receptor
chr9_+_118478851 2.509 ENSMUST00000150633.1
Eomes
eomesodermin homolog (Xenopus laevis)
chr7_-_127218303 2.487 ENSMUST00000106313.1
Sept1
septin 1
chr9_+_65265173 2.465 ENSMUST00000048762.1
Cilp
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
chr6_-_124813065 2.417 ENSMUST00000149610.2
Tpi1
triosephosphate isomerase 1
chr11_-_119355484 2.369 ENSMUST00000100172.2
ENSMUST00000005173.4
Sgsh

N-sulfoglucosamine sulfohydrolase (sulfamidase)

chr10_-_127030789 2.368 ENSMUST00000120547.1
ENSMUST00000152054.1
Tsfm

Ts translation elongation factor, mitochondrial

chr4_-_57143437 2.326 ENSMUST00000095076.3
ENSMUST00000030142.3
Epb4.1l4b

erythrocyte protein band 4.1-like 4b

chr11_+_53770458 2.320 ENSMUST00000138913.1
ENSMUST00000123376.1
ENSMUST00000019043.6
ENSMUST00000133291.1
Irf1



interferon regulatory factor 1



chr18_+_60911757 2.299 ENSMUST00000040359.5
Arsi
arylsulfatase i
chr7_-_70360593 2.146 ENSMUST00000032768.7
Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr16_+_37776873 2.113 ENSMUST00000114763.2
Fstl1
follistatin-like 1
chrX_-_18461371 2.004 ENSMUST00000044188.4
4930578C19Rik
RIKEN cDNA 4930578C19 gene
chr7_+_82867327 1.947 ENSMUST00000082237.5
Mex3b
mex3 homolog B (C. elegans)
chr15_-_79164477 1.939 ENSMUST00000040019.4
Sox10
SRY-box containing gene 10
chr7_+_127800844 1.922 ENSMUST00000106271.1
ENSMUST00000138432.1
Hsd3b7

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7

chr17_+_34039437 1.921 ENSMUST00000131134.1
ENSMUST00000087497.4
ENSMUST00000114255.1
ENSMUST00000114252.1
Col11a2



collagen, type XI, alpha 2



chr2_-_26122769 1.892 ENSMUST00000140993.1
ENSMUST00000028300.5
Nacc2

nucleus accumbens associated 2, BEN and BTB (POZ) domain containing

chr9_+_55150050 1.870 ENSMUST00000122441.1
Ube2q2
ubiquitin-conjugating enzyme E2Q (putative) 2
chr7_+_122289297 1.834 ENSMUST00000064989.5
ENSMUST00000064921.4
Prkcb

protein kinase C, beta

chr6_+_85187438 1.752 ENSMUST00000045942.8
Emx1
empty spiracles homeobox 1
chr11_+_97663366 1.746 ENSMUST00000044730.5
Mllt6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr8_-_64693027 1.728 ENSMUST00000048967.7
Cpe
carboxypeptidase E
chr16_+_78930940 1.722 ENSMUST00000114216.1
ENSMUST00000069148.6
ENSMUST00000023568.7
Chodl


chondrolectin


chr7_-_75308373 1.717 ENSMUST00000085164.5
Sv2b
synaptic vesicle glycoprotein 2 b
chr4_-_129558387 1.634 ENSMUST00000067240.4
Lck
lymphocyte protein tyrosine kinase
chr8_-_71381907 1.630 ENSMUST00000002466.8
Nr2f6
nuclear receptor subfamily 2, group F, member 6
chr4_-_129558355 1.627 ENSMUST00000167288.1
ENSMUST00000134336.1
Lck

lymphocyte protein tyrosine kinase

chr11_+_94741782 1.607 ENSMUST00000021240.6
Cdc34-ps
cell division cycle 34 homolog, pseudogene (S. cerevisiae)
chrX_-_104671048 1.604 ENSMUST00000042070.5
Zdhhc15
zinc finger, DHHC domain containing 15
chr14_-_62761112 1.544 ENSMUST00000053959.6
Ints6
integrator complex subunit 6
chr15_+_100334929 1.492 ENSMUST00000075420.4
Mettl7a3
methyltransferase like 7A3
chr15_+_100227819 1.435 ENSMUST00000023769.4
Atf1
activating transcription factor 1
chr17_+_45563928 1.411 ENSMUST00000041353.6
Slc35b2
solute carrier family 35, member B2
chr8_+_13757663 1.359 ENSMUST00000043962.8
Cdc16
CDC16 cell division cycle 16
chr2_+_174110340 1.329 ENSMUST00000044415.9
Npepl1
aminopeptidase-like 1
chr19_-_24280551 1.316 ENSMUST00000081333.4
Fxn
frataxin
chr2_-_142901506 1.293 ENSMUST00000043589.7
Kif16b
kinesin family member 16B
chr13_-_98891036 1.273 ENSMUST00000109399.2
Tnpo1
transportin 1
chr3_+_90051630 1.151 ENSMUST00000159064.1
4933434E20Rik
RIKEN cDNA 4933434E20 gene
chr11_+_69935894 1.132 ENSMUST00000149194.1
Ybx2
Y box protein 2
chr10_+_61175206 1.084 ENSMUST00000079235.5
Tbata
thymus, brain and testes associated
chr13_+_67863324 1.058 ENSMUST00000078471.5
BC048507
cDNA sequence BC048507
chr6_+_29398920 1.054 ENSMUST00000181464.1
ENSMUST00000180829.1
Ccdc136

coiled-coil domain containing 136

chr7_+_27486910 1.046 ENSMUST00000008528.7
Sertad1
SERTA domain containing 1
chr7_+_35119285 1.033 ENSMUST00000042985.9
Cebpa
CCAAT/enhancer binding protein (C/EBP), alpha
chr15_+_100227871 1.009 ENSMUST00000163855.1
Atf1
activating transcription factor 1
chr11_-_102406783 0.846 ENSMUST00000155104.1
ENSMUST00000130436.1
Slc25a39

solute carrier family 25, member 39

chr6_-_134566913 0.819 ENSMUST00000032322.8
Lrp6
low density lipoprotein receptor-related protein 6
chr15_+_100304782 0.812 ENSMUST00000067752.3
Mettl7a1
methyltransferase like 7A1
chr15_+_100353149 0.805 ENSMUST00000088142.5
ENSMUST00000176287.1
ENSMUST00000075675.5
Mettl7a2

AB099516
methyltransferase like 7A2

cDNA sequence AB099516
chr11_+_102189620 0.804 ENSMUST00000070334.3
ENSMUST00000078975.7
G6pc3

glucose 6 phosphatase, catalytic, 3

chr11_-_68927049 0.786 ENSMUST00000038932.7
Odf4
outer dense fiber of sperm tails 4
chr2_-_33942111 0.778 ENSMUST00000130988.1
ENSMUST00000127936.1
ENSMUST00000134271.1
Gm13403


predicted gene 13403


chr10_-_75517324 0.751 ENSMUST00000039796.7
Gucd1
guanylyl cyclase domain containing 1
chr11_+_72207537 0.750 ENSMUST00000021158.3
Txndc17
thioredoxin domain containing 17
chr11_+_69935796 0.743 ENSMUST00000018698.5
Ybx2
Y box protein 2
chr9_+_111118070 0.743 ENSMUST00000035078.6
ENSMUST00000098340.2
Lrrfip2

leucine rich repeat (in FLII) interacting protein 2

chr6_-_29165003 0.742 ENSMUST00000007993.9
Rbm28
RNA binding motif protein 28
chr11_-_94549165 0.727 ENSMUST00000040487.3
Rsad1
radical S-adenosyl methionine domain containing 1
chr18_-_16809233 0.721 ENSMUST00000025166.7
Cdh2
cadherin 2
chr11_+_76179658 0.621 ENSMUST00000129853.1
ENSMUST00000179223.1
Fam57a
Fam57a
family with sequence similarity 57, member A
family with sequence similarity 57, member A
chr9_-_109082372 0.611 ENSMUST00000167504.1
Tma7
translational machinery associated 7 homolog (S. cerevisiae)
chr8_-_126475062 0.559 ENSMUST00000170518.1
Gm17296
predicted gene, 17296
chr5_+_24364804 0.549 ENSMUST00000030834.4
ENSMUST00000115090.1
Nos3

nitric oxide synthase 3, endothelial cell

chr16_+_18426415 0.498 ENSMUST00000115606.1
ENSMUST00000115604.1
ENSMUST00000178093.1
ENSMUST00000177856.1
Txnrd2



thioredoxin reductase 2



chr11_+_58009064 0.465 ENSMUST00000071487.6
ENSMUST00000178636.1
Larp1

La ribonucleoprotein domain family, member 1

chr13_-_98890974 0.429 ENSMUST00000179301.1
ENSMUST00000179271.1
Tnpo1

transportin 1

chr8_+_122269569 0.406 ENSMUST00000055537.2
Gm22
predicted gene 22
chr18_+_77065195 0.402 ENSMUST00000114777.2
Pias2
protein inhibitor of activated STAT 2
chr7_-_29232478 0.400 ENSMUST00000085818.4
Kcnk6
potassium inwardly-rectifying channel, subfamily K, member 6
chr16_+_62814676 0.398 ENSMUST00000055557.5
Stx19
syntaxin 19
chr7_-_133123770 0.338 ENSMUST00000164896.1
ENSMUST00000171968.1
Ctbp2

C-terminal binding protein 2

chr14_-_50930803 0.325 ENSMUST00000160538.1
ENSMUST00000162957.1
ENSMUST00000161166.1
ENSMUST00000160835.1
ENSMUST00000049312.7
Tmem55b




transmembrane protein 55b




chr13_+_73467197 0.324 ENSMUST00000022099.8
Lpcat1
lysophosphatidylcholine acyltransferase 1
chr4_-_130275523 0.323 ENSMUST00000146478.1
Serinc2
serine incorporator 2
chr11_+_87737530 0.296 ENSMUST00000093955.5
Supt4a
suppressor of Ty 4A
chr7_+_44468020 0.285 ENSMUST00000117324.1
ENSMUST00000120852.1
ENSMUST00000118628.1
Josd2


Josephin domain containing 2


chr1_-_172590463 0.207 ENSMUST00000065679.6
Slamf8
SLAM family member 8
chr4_-_130275542 0.182 ENSMUST00000154846.1
ENSMUST00000105996.1
Serinc2

serine incorporator 2

chr17_+_3114957 0.091 ENSMUST00000076734.6
Scaf8
SR-related CTD-associated factor 8
chr8_+_119910792 0.085 ENSMUST00000108988.2
ENSMUST00000108982.4
ENSMUST00000127664.1
Usp10

Gm20388
ubiquitin specific peptidase 10

predicted gene 20388
chr16_-_20426375 0.050 ENSMUST00000079158.6
Abcc5
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
chr12_-_51829525 0.029 ENSMUST00000179265.1
ENSMUST00000042052.8
Hectd1

HECT domain containing 1

chr17_-_12992487 0.007 ENSMUST00000159551.1
ENSMUST00000160781.1
Wtap

Wilms' tumour 1-associating protein


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.7 11.0 GO:0072076 hyaluranon cable assembly(GO:0036118) nephrogenic mesenchyme development(GO:0072076) negative regulation of glomerular mesangial cell proliferation(GO:0072125) negative regulation of glomerulus development(GO:0090194) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
2.8 11.1 GO:0060032 notochord regression(GO:0060032)
1.4 5.4 GO:0051311 spindle assembly involved in female meiosis(GO:0007056) meiotic metaphase plate congression(GO:0051311)
1.4 4.1 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
1.2 3.6 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892) dermatome development(GO:0061054) regulation of dermatome development(GO:0061183) negative regulation of dopaminergic neuron differentiation(GO:1904339) regulation of cardiac cell fate specification(GO:2000043)
1.1 5.6 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.9 8.4 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.9 2.7 GO:0038145 interleukin-4-mediated signaling pathway(GO:0035771) macrophage colony-stimulating factor signaling pathway(GO:0038145) tyrosine phosphorylation of Stat6 protein(GO:0042505) regulation of tyrosine phosphorylation of Stat6 protein(GO:0042525) regulation of interleukin-6-mediated signaling pathway(GO:0070103) negative regulation of interleukin-6-mediated signaling pathway(GO:0070104)
0.9 2.7 GO:1904395 regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904393) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.9 4.3 GO:0072015 ciliary body morphogenesis(GO:0061073) glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.8 2.5 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.8 2.4 GO:0019405 alditol catabolic process(GO:0019405) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.8 2.3 GO:2000564 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) CD8-positive, alpha-beta T cell proliferation(GO:0035740) negative regulation of regulatory T cell differentiation(GO:0045590) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564)
0.8 6.8 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.6 1.9 GO:0060023 soft palate development(GO:0060023)
0.6 1.7 GO:0030070 insulin processing(GO:0030070)
0.5 1.9 GO:0072697 protein localization to cell cortex(GO:0072697)
0.4 2.1 GO:0060838 lymphatic endothelial cell fate commitment(GO:0060838) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.4 2.5 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.4 0.8 GO:0003308 negative regulation of Wnt signaling pathway involved in heart development(GO:0003308)
0.4 3.3 GO:0046645 positive regulation of gamma-delta T cell differentiation(GO:0045588) positive regulation of gamma-delta T cell activation(GO:0046645) positive regulation of uterine smooth muscle contraction(GO:0070474)
0.4 4.1 GO:0090527 actin filament reorganization(GO:0090527)
0.4 3.8 GO:0018065 protein-cofactor linkage(GO:0018065)
0.4 6.7 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.3 1.8 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.3 5.5 GO:0030903 notochord development(GO:0030903)
0.3 0.8 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.3 1.3 GO:0019230 protein autoprocessing(GO:0016540) proprioception(GO:0019230)
0.2 2.5 GO:0070445 oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.2 2.5 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.2 7.9 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.2 1.4 GO:0051503 adenine nucleotide transport(GO:0051503)
0.2 6.7 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
0.2 1.9 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.2 1.9 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.2 0.7 GO:0002756 MyD88-independent toll-like receptor signaling pathway(GO:0002756)
0.2 0.5 GO:0003100 regulation of systemic arterial blood pressure by endothelin(GO:0003100) regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900)
0.2 0.3 GO:0071072 negative regulation of phospholipid biosynthetic process(GO:0071072)
0.2 1.9 GO:0032808 lacrimal gland development(GO:0032808)
0.2 1.7 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.1 1.0 GO:0000050 urea cycle(GO:0000050) urea metabolic process(GO:0019627) cellular response to lithium ion(GO:0071285)
0.1 4.5 GO:1902476 chloride transmembrane transport(GO:1902476)
0.1 1.6 GO:0050965 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.1 1.6 GO:0016188 synaptic vesicle maturation(GO:0016188)
0.1 1.3 GO:0006895 Golgi to endosome transport(GO:0006895)
0.1 0.4 GO:0060075 regulation of resting membrane potential(GO:0060075)
0.1 0.5 GO:1904217 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.1 1.5 GO:0016180 snRNA processing(GO:0016180)
0.1 2.4 GO:0030201 heparan sulfate proteoglycan metabolic process(GO:0030201)
0.1 0.2 GO:0033860 regulation of NAD(P)H oxidase activity(GO:0033860)
0.0 1.9 GO:0048255 mRNA stabilization(GO:0048255)
0.0 1.6 GO:0033014 porphyrin-containing compound biosynthetic process(GO:0006779) tetrapyrrole biosynthetic process(GO:0033014)
0.0 1.4 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.3 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.4 GO:0099500 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.0 0.4 GO:0060766 negative regulation of androgen receptor signaling pathway(GO:0060766)
0.0 2.4 GO:0045740 positive regulation of DNA replication(GO:0045740)
0.0 0.3 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.0 0.7 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0 0.6 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.5 GO:0000305 response to oxygen radical(GO:0000305)
0.0 2.7 GO:0006909 phagocytosis(GO:0006909)
0.0 1.7 GO:0042594 response to starvation(GO:0042594)
0.0 2.5 GO:0045444 fat cell differentiation(GO:0045444)
0.0 0.3 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.4 GO:0045070 positive regulation of viral genome replication(GO:0045070)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 7.7 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
1.7 6.7 GO:0043293 apoptosome(GO:0043293)
1.5 4.4 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
1.4 4.1 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
1.1 6.8 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
1.0 3.9 GO:0043259 laminin-10 complex(GO:0043259)
0.9 11.1 GO:0097542 ciliary tip(GO:0097542)
0.6 2.4 GO:1990590 ATF1-ATF4 transcription factor complex(GO:1990590)
0.6 5.4 GO:0072687 meiotic spindle(GO:0072687)
0.5 2.5 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.3 1.0 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.2 1.9 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.1 1.9 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 3.3 GO:0000242 pericentriolar material(GO:0000242)
0.1 2.9 GO:0002102 podosome(GO:0002102)
0.1 1.7 GO:0031045 dense core granule(GO:0031045)
0.1 0.8 GO:0001520 outer dense fiber(GO:0001520)
0.1 1.5 GO:0032039 integrator complex(GO:0032039)
0.1 0.7 GO:0005916 fascia adherens(GO:0005916)
0.1 1.9 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 0.4 GO:0031201 SNARE complex(GO:0031201)
0.1 1.4 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.5 GO:0031931 TORC1 complex(GO:0031931)
0.0 2.7 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 7.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 12.6 GO:0031012 extracellular matrix(GO:0031012)
0.0 1.9 GO:0005844 polysome(GO:0005844)
0.0 0.3 GO:0097470 ribbon synapse(GO:0097470)
0.0 1.8 GO:0031526 brush border membrane(GO:0031526)
0.0 3.8 GO:0000793 condensed chromosome(GO:0000793)
0.0 1.4 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 3.0 GO:0005884 actin filament(GO:0005884)
0.0 1.7 GO:0043195 terminal bouton(GO:0043195)
0.0 1.8 GO:0034399 nuclear periphery(GO:0034399)
0.0 4.9 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.3 GO:0031902 late endosome membrane(GO:0031902)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 7.7 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
1.2 3.6 GO:0005110 frizzled-2 binding(GO:0005110)
1.1 6.8 GO:0034943 acyl-CoA ligase activity(GO:0003996) 3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid CoA ligase activity(GO:0010435) 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity(GO:0018854) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity(GO:0018855) benzoyl acetate-CoA ligase activity(GO:0018856) 2,4-dichlorobenzoate-CoA ligase activity(GO:0018857) pivalate-CoA ligase activity(GO:0034783) cyclopropanecarboxylate-CoA ligase activity(GO:0034793) adipate-CoA ligase activity(GO:0034796) citronellyl-CoA ligase activity(GO:0034823) mentha-1,3-dione-CoA ligase activity(GO:0034841) thiophene-2-carboxylate-CoA ligase activity(GO:0034842) 2,4,4-trimethylpentanoate-CoA ligase activity(GO:0034865) cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034942) trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034943) branched-chain acyl-CoA synthetase (ADP-forming) activity(GO:0043759) aryl-CoA synthetase (ADP-forming) activity(GO:0043762) 3-hydroxypropionyl-CoA synthetase activity(GO:0043955) perillic acid:CoA ligase (ADP-forming) activity(GO:0052685) perillic acid:CoA ligase (AMP-forming) activity(GO:0052686) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity(GO:0052687) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity(GO:0052688) pristanate-CoA ligase activity(GO:0070251) malonyl-CoA synthetase activity(GO:0090409)
1.1 11.0 GO:0070700 BMP receptor binding(GO:0070700)
0.7 7.9 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.7 3.3 GO:0042610 CD8 receptor binding(GO:0042610)
0.6 3.8 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.5 4.4 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.5 4.1 GO:0003688 DNA replication origin binding(GO:0003688)
0.5 1.4 GO:0046964 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity(GO:0046964)
0.4 4.1 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.4 2.7 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.3 4.7 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.3 1.9 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.3 3.1 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.3 1.3 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.2 2.1 GO:0001972 retinoic acid binding(GO:0001972)
0.2 1.8 GO:0035184 histone threonine kinase activity(GO:0035184)
0.2 2.4 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.2 5.6 GO:0003746 translation elongation factor activity(GO:0003746)
0.2 3.5 GO:0015026 coreceptor activity(GO:0015026)
0.2 0.5 GO:0004517 nitric-oxide synthase activity(GO:0004517) arginine binding(GO:0034618)
0.2 1.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 1.2 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.1 4.3 GO:0005112 Notch binding(GO:0005112)
0.1 1.7 GO:0004185 serine-type carboxypeptidase activity(GO:0004185) cobalt ion binding(GO:0050897)
0.1 14.6 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 0.7 GO:0034916 4-methyloctanoyl-CoA dehydrogenase activity(GO:0034580) naphthyl-2-methyl-succinyl-CoA dehydrogenase activity(GO:0034845) 2-methylhexanoyl-CoA dehydrogenase activity(GO:0034916) propionyl-CoA dehydrogenase activity(GO:0043820) thiol-driven fumarate reductase activity(GO:0043830) coenzyme F420-dependent 2,4,6-trinitrophenol reductase activity(GO:0052758) coenzyme F420-dependent 2,4,6-trinitrophenol hydride reductase activity(GO:0052759) coenzyme F420-dependent 2,4-dinitrophenol reductase activity(GO:0052760)
0.1 0.3 GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597)
0.1 0.3 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.1 1.3 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 3.1 GO:0005109 frizzled binding(GO:0005109)
0.1 1.9 GO:0032794 GTPase activating protein binding(GO:0032794)
0.1 0.8 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.1 0.5 GO:0000339 RNA cap binding(GO:0000339) translation activator activity(GO:0008494)
0.1 0.7 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 1.6 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.1 2.6 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 1.7 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 0.4 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 2.5 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 1.9 GO:0004407 histone deacetylase activity(GO:0004407)
0.0 1.6 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 1.5 GO:0045182 translation regulator activity(GO:0045182)
0.0 1.9 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 15.1 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0 3.4 GO:0005125 cytokine activity(GO:0005125)
0.0 0.4 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.5 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 3.9 GO:0005178 integrin binding(GO:0005178)
0.0 1.3 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 2.1 GO:0008201 heparin binding(GO:0008201)
0.0 1.8 GO:0003779 actin binding(GO:0003779)
0.0 2.5 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 2.9 GO:0003729 mRNA binding(GO:0003729)
0.0 5.4 GO:0005525 GTP binding(GO:0005525)
0.0 2.8 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity(GO:0008757)
0.0 0.3 GO:0042974 retinoic acid receptor binding(GO:0042974)