Motif ID: Vsx1_Uncx_Prrx2_Shox2_Noto

Z-value: 0.992

Transcription factors associated with Vsx1_Uncx_Prrx2_Shox2_Noto:

Gene SymbolEntrez IDGene Name
Noto ENSMUSG00000068302.7 Noto
Prrx2 ENSMUSG00000039476.7 Prrx2
Shox2 ENSMUSG00000027833.10 Shox2
Uncx ENSMUSG00000029546.11 Uncx
Vsx1 ENSMUSG00000033080.8 Vsx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Uncxmm10_v2_chr5_+_139543889_1395439040.581.7e-06Click!
Prrx2mm10_v2_chr2_+_30834972_308349720.462.5e-04Click!
Shox2mm10_v2_chr3_-_66981279_669813180.364.7e-03Click!


Activity profile for motif Vsx1_Uncx_Prrx2_Shox2_Noto.

activity profile for motif Vsx1_Uncx_Prrx2_Shox2_Noto


Sorted Z-values histogram for motif Vsx1_Uncx_Prrx2_Shox2_Noto

Sorted Z-values for motif Vsx1_Uncx_Prrx2_Shox2_Noto



Network of associatons between targets according to the STRING database.



First level regulatory network of Vsx1_Uncx_Prrx2_Shox2_Noto

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_48665098 40.273 ENSMUST00000118578.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr5_+_139543889 25.787 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr2_-_168767136 22.552 ENSMUST00000029061.5
ENSMUST00000103074.1
 Sall4

sal-like 4 (Drosophila)

chr13_-_53473074 21.050 ENSMUST00000021922.8
 Msx2
msh homeobox 2
chr2_-_168767029 20.978 ENSMUST00000075044.3
 Sall4
sal-like 4 (Drosophila)
chr3_+_159839729 20.610 ENSMUST00000068952.5
 Wls
wntless homolog (Drosophila)
chr17_+_34592248 19.940 ENSMUST00000038149.6
 Pbx2
pre B cell leukemia homeobox 2
chr7_-_49636847 17.458 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr8_-_61902669 16.249 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein

chr10_-_45470201 16.232 ENSMUST00000079390.6
 Lin28b
lin-28 homolog B (C. elegans)
chr13_-_102905740 14.127 ENSMUST00000167462.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr3_+_125404072 12.946 ENSMUST00000173932.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr13_-_102906046 12.791 ENSMUST00000171791.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr3_+_125404292 12.583 ENSMUST00000144344.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr3_+_55782500 11.455 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr3_-_154328634 11.102 ENSMUST00000167744.1
 Lhx8
LIM homeobox protein 8
chr6_-_147264124 10.704 ENSMUST00000052296.6
 Pthlh
parathyroid hormone-like peptide
chr9_+_119063429 10.588 ENSMUST00000141185.1
ENSMUST00000126251.1
ENSMUST00000136561.1
 Vill


villin-like


chr2_-_72986716 10.278 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr9_+_72806874 9.645 ENSMUST00000055535.8
 Prtg
protogenin homolog (Gallus gallus)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 172 entries
Log-likelihood per target Total log-likelihoodTermDescription
11.0 44.2 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
2.4 43.5 GO:0001833 inner cell mass cell proliferation(GO:0001833)
3.2 25.8 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
7.0 21.0 GO:0048818 embryonic nail plate morphogenesis(GO:0035880) positive regulation of hair follicle maturation(GO:0048818) positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364)
1.6 20.6 GO:0031017 exocrine pancreas development(GO:0031017)
2.2 17.8 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
1.1 17.5 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
1.8 16.2 GO:0010587 miRNA catabolic process(GO:0010587)
1.1 16.2 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.9 15.1 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
4.7 14.2 GO:0048389 BMP signaling pathway involved in heart induction(GO:0003130) endodermal-mesodermal cell signaling(GO:0003133) endodermal-mesodermal cell signaling involved in heart induction(GO:0003134) intermediate mesoderm development(GO:0048389) regulation of transcription from RNA polymerase II promoter involved in kidney development(GO:0060994) pattern specification involved in mesonephros development(GO:0061227) regulation of hepatocyte differentiation(GO:0070366) comma-shaped body morphogenesis(GO:0072049) S-shaped body morphogenesis(GO:0072050) anterior/posterior pattern specification involved in kidney development(GO:0072098) negative regulation of glomerular mesangial cell proliferation(GO:0072125) ureter urothelium development(GO:0072190) negative regulation of glomerulus development(GO:0090194) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.5 12.7 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.4 11.6 GO:0006270 DNA replication initiation(GO:0006270)
0.2 11.2 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
1.8 10.9 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.2 10.6 GO:0051693 actin filament capping(GO:0051693)
0.8 10.1 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 9.7 GO:0007067 mitotic nuclear division(GO:0007067)
0.3 8.0 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.1 7.8 GO:0030178 negative regulation of Wnt signaling pathway(GO:0030178)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 49.3 GO:0005667 transcription factor complex(GO:0005667)
0.3 43.4 GO:0000792 heterochromatin(GO:0000792)
0.1 21.0 GO:0030427 site of polarized growth(GO:0030427)
0.6 20.6 GO:0032839 dendrite cytoplasm(GO:0032839)
0.6 16.2 GO:0002102 podosome(GO:0002102)
0.0 15.1 GO:0005829 cytosol(GO:0005829)
0.0 13.9 GO:0005615 extracellular space(GO:0005615)
1.9 11.1 GO:0001674 female germ cell nucleus(GO:0001674)
0.3 9.6 GO:0032809 neuronal cell body membrane(GO:0032809)
1.3 7.7 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.3 7.5 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 7.3 GO:0005759 mitochondrial matrix(GO:0005759)
0.6 7.1 GO:0005915 zonula adherens(GO:0005915)
0.0 6.2 GO:0000776 kinetochore(GO:0000776)
0.1 6.0 GO:0016459 myosin complex(GO:0016459)
0.1 5.8 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 5.4 GO:0016607 nuclear speck(GO:0016607)
1.8 5.3 GO:0000172 ribonuclease MRP complex(GO:0000172)
1.0 4.9 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 4.8 GO:0043198 dendritic shaft(GO:0043198)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 115 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 101.2 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.2 67.5 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.2 31.0 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1 26.2 GO:0000287 magnesium ion binding(GO:0000287)
2.6 25.6 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.1 24.7 GO:0003779 actin binding(GO:0003779)
3.4 23.6 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
2.5 17.8 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
1.2 17.7 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
1.6 14.2 GO:0039706 co-receptor binding(GO:0039706)
0.3 11.1 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.6 10.8 GO:0005540 hyaluronic acid binding(GO:0005540)
1.0 9.8 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 9.6 GO:0008270 zinc ion binding(GO:0008270)
0.4 9.3 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 8.6 GO:0008134 transcription factor binding(GO:0008134)
0.6 7.7 GO:0043522 leucine zipper domain binding(GO:0043522)
0.6 7.6 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.5 7.5 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.6 7.1 GO:0070097 delta-catenin binding(GO:0070097)