Motif ID: Vsx2_Dlx3

Z-value: 1.220

Transcription factors associated with Vsx2_Dlx3:

Gene SymbolEntrez IDGene Name
Dlx3 ENSMUSG00000001510.7 Dlx3
Vsx2 ENSMUSG00000021239.6 Vsx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Vsx2mm10_v2_chr12_+_84569762_845698400.392.4e-03Click!


Activity profile for motif Vsx2_Dlx3.

activity profile for motif Vsx2_Dlx3


Sorted Z-values histogram for motif Vsx2_Dlx3

Sorted Z-values for motif Vsx2_Dlx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Vsx2_Dlx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 126 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_139543889 58.044 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr6_-_23248264 42.215 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr2_-_168767136 25.176 ENSMUST00000029061.5
ENSMUST00000103074.1
 Sall4

sal-like 4 (Drosophila)

chr2_-_168767029 18.445 ENSMUST00000075044.3
 Sall4
sal-like 4 (Drosophila)
chr3_-_154328634 17.476 ENSMUST00000167744.1
 Lhx8
LIM homeobox protein 8
chr3_+_159839729 13.631 ENSMUST00000068952.5
 Wls
wntless homolog (Drosophila)
chr12_-_56535047 11.814 ENSMUST00000178477.2
 Nkx2-1
NK2 homeobox 1
chr14_-_48662740 11.643 ENSMUST00000122009.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr17_-_70853482 10.355 ENSMUST00000118283.1
 Tgif1
TGFB-induced factor homeobox 1
chr7_-_49636847 9.294 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr9_-_79977782 8.218 ENSMUST00000093811.4
 Filip1
filamin A interacting protein 1
chr5_-_98566762 7.273 ENSMUST00000086912.4
 1700010H22Rik
RIKEN cDNA 1700010H22 gene
chr3_-_116253467 7.132 ENSMUST00000090473.5
 Gpr88
G-protein coupled receptor 88
chr3_+_55782500 6.685 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr10_+_128337761 6.227 ENSMUST00000005826.7
 Cs
citrate synthase
chr9_+_119063429 5.575 ENSMUST00000141185.1
ENSMUST00000126251.1
ENSMUST00000136561.1
 Vill


villin-like


chr3_-_49757257 5.406 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr17_+_43952999 5.337 ENSMUST00000177857.1
 Rcan2
regulator of calcineurin 2
chr9_+_75775355 5.069 ENSMUST00000012281.7
 Bmp5
bone morphogenetic protein 5
chr2_+_109917639 4.924 ENSMUST00000046548.7
ENSMUST00000111037.2
 Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
7.3 58.0 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
7.6 45.3 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
2.4 43.6 GO:0001833 inner cell mass cell proliferation(GO:0001833)
1.0 13.6 GO:0031017 exocrine pancreas development(GO:0031017)
3.9 11.8 GO:0021759 globus pallidus development(GO:0021759)
2.9 11.6 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.7 10.9 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.2 9.7 GO:0021884 forebrain neuron development(GO:0021884)
0.5 9.3 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
1.1 7.5 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.4 6.2 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.3 5.6 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.1 5.6 GO:0051693 actin filament capping(GO:0051693)
0.3 5.4 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
1.6 4.9 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.2 4.6 GO:0009409 response to cold(GO:0009409)
0.2 4.4 GO:0008340 determination of adult lifespan(GO:0008340)
0.9 4.3 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.3 3.8 GO:0071803 positive regulation of podosome assembly(GO:0071803)
1.2 3.6 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 119.8 GO:0005634 nucleus(GO:0005634)
0.3 43.6 GO:0000792 heterochromatin(GO:0000792)
2.9 17.5 GO:0001674 female germ cell nucleus(GO:0001674)
0.4 13.6 GO:0032590 dendrite membrane(GO:0032590)
0.0 6.2 GO:0005759 mitochondrial matrix(GO:0005759)
0.2 3.8 GO:0002102 podosome(GO:0002102)
0.3 3.5 GO:0061700 GATOR2 complex(GO:0061700)
0.2 3.4 GO:0016460 myosin II complex(GO:0016460)
0.6 3.3 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.5 3.2 GO:0061689 paranodal junction(GO:0033010) tricellular tight junction(GO:0061689)
0.1 2.7 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.6 2.4 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)
0.2 2.4 GO:0033655 host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655)
0.1 2.4 GO:0016459 myosin complex(GO:0016459)
0.4 2.3 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0 2.2 GO:0005871 kinesin complex(GO:0005871)
0.1 2.1 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 2.1 GO:0070469 respiratory chain(GO:0070469)
0.0 2.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 1.6 GO:0060091 kinocilium(GO:0060091)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 141.8 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.2 36.1 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
1.4 13.6 GO:0031852 mu-type opioid receptor binding(GO:0031852)
1.0 11.8 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.5 10.4 GO:0070410 co-SMAD binding(GO:0070410)
0.0 8.1 GO:0004930 G-protein coupled receptor activity(GO:0004930)
1.0 6.2 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.9 5.6 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.5 5.1 GO:0070700 BMP receptor binding(GO:0070700)
0.0 5.1 GO:0000287 magnesium ion binding(GO:0000287)
0.4 4.9 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 4.7 GO:0003779 actin binding(GO:0003779)
0.0 4.6 GO:0003774 motor activity(GO:0003774)
0.2 4.3 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.2 3.6 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.2 3.6 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.6 3.5 GO:0070728 leucine binding(GO:0070728)
0.3 3.4 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 3.4 GO:0035254 glutamate receptor binding(GO:0035254)
0.3 3.3 GO:0043522 leucine zipper domain binding(GO:0043522)