Motif ID: Zbtb4

Z-value: 0.726


Transcription factors associated with Zbtb4:

Gene SymbolEntrez IDGene Name
Zbtb4 ENSMUSG00000018750.8 Zbtb4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zbtb4mm10_v2_chr11_+_69765970_697660270.571.9e-06Click!


Activity profile for motif Zbtb4.

activity profile for motif Zbtb4


Sorted Z-values histogram for motif Zbtb4

Sorted Z-values for motif Zbtb4



Network of associatons between targets according to the STRING database.



First level regulatory network of Zbtb4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_103422010 8.413 ENSMUST00000182089.1
 Gm26992
predicted gene, 26992
chr6_+_141524379 5.895 ENSMUST00000032362.9
 Slco1c1
solute carrier organic anion transporter family, member 1c1
chr1_+_34678176 5.196 ENSMUST00000159747.2
 Arhgef4
Rho guanine nucleotide exchange factor (GEF) 4
chr7_-_19699008 5.178 ENSMUST00000174355.1
ENSMUST00000172983.1
ENSMUST00000174710.1
ENSMUST00000167646.2
ENSMUST00000003066.9
ENSMUST00000174064.1
 Apoe





apolipoprotein E





chr16_+_11984581 5.064 ENSMUST00000170672.2
ENSMUST00000023138.7
 Shisa9

shisa homolog 9 (Xenopus laevis)

chr2_-_170427828 4.039 ENSMUST00000013667.2
ENSMUST00000109152.2
ENSMUST00000068137.4
 Bcas1


breast carcinoma amplified sequence 1


chr11_-_3504766 3.655 ENSMUST00000044507.5
 Inpp5j
inositol polyphosphate 5-phosphatase J
chr15_+_74563738 3.139 ENSMUST00000170845.1
 Bai1
brain-specific angiogenesis inhibitor 1
chr9_-_70657121 3.120 ENSMUST00000049031.5
 Fam63b
family with sequence similarity 63, member B
chr8_-_105637403 3.056 ENSMUST00000182046.1
 Gm5914
predicted gene 5914
chr11_+_100574904 3.040 ENSMUST00000103120.4
 Cnp
2',3'-cyclic nucleotide 3' phosphodiesterase
chr18_-_39490649 2.925 ENSMUST00000115567.1
 Nr3c1
nuclear receptor subfamily 3, group C, member 1
chr2_+_124610278 2.517 ENSMUST00000051419.8
ENSMUST00000077847.5
ENSMUST00000078621.5
ENSMUST00000076335.5
 Sema6d



sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D



chr8_-_64693027 2.464 ENSMUST00000048967.7
 Cpe
carboxypeptidase E
chr2_-_73386396 2.216 ENSMUST00000112044.1
ENSMUST00000112043.1
ENSMUST00000076463.5
 Gpr155


G protein-coupled receptor 155


chr6_+_48841476 2.182 ENSMUST00000101426.4
 Tmem176a
transmembrane protein 176A
chr6_+_48841633 2.171 ENSMUST00000168406.1
 Tmem176a
transmembrane protein 176A
chr6_-_24515036 2.165 ENSMUST00000052277.4
 Iqub
IQ motif and ubiquitin domain containing
chr2_+_124610573 2.058 ENSMUST00000103239.3
ENSMUST00000103240.2
 Sema6d

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D

chr8_+_95352258 2.056 ENSMUST00000034243.5
 Mmp15
matrix metallopeptidase 15

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 6.1 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
1.2 5.8 GO:2000325 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.3 5.4 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
1.7 5.2 GO:2001139 negative regulation of postsynaptic membrane organization(GO:1901627) negative regulation of dendritic spine maintenance(GO:1902951) negative regulation of phospholipid efflux(GO:1902999) regulation of lipid transport across blood brain barrier(GO:1903000) negative regulation of lipid transport across blood brain barrier(GO:1903001) positive regulation of lipid transport across blood brain barrier(GO:1903002) negative regulation of phospholipid transport(GO:2001139)
0.5 4.8 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.2 4.6 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.2 3.7 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.0 3.7 GO:0046847 filopodium assembly(GO:0046847)
1.1 3.2 GO:0030070 insulin processing(GO:0030070)
0.1 3.1 GO:0001919 regulation of receptor recycling(GO:0001919)
0.1 3.0 GO:0009214 cyclic nucleotide catabolic process(GO:0009214)
0.6 2.9 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.1 2.3 GO:0008209 androgen metabolic process(GO:0008209)
0.5 2.1 GO:0097494 regulation of vesicle size(GO:0097494)
0.4 2.1 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.5 2.0 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.3 2.0 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.1 1.9 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.1 1.8 GO:0097320 membrane tubulation(GO:0097320)
0.3 1.7 GO:0035234 ectopic germ cell programmed cell death(GO:0035234)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.7 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 5.7 GO:0016607 nuclear speck(GO:0016607)
1.7 5.2 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.5 5.1 GO:0032591 dendritic spine membrane(GO:0032591)
0.6 4.5 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.0 3.7 GO:0043198 dendritic shaft(GO:0043198)
0.3 3.4 GO:0043083 synaptic cleft(GO:0043083)
0.0 2.7 GO:0017053 transcriptional repressor complex(GO:0017053)
0.2 2.5 GO:0031045 dense core granule(GO:0031045)
0.0 2.3 GO:0043195 terminal bouton(GO:0043195)
0.1 2.1 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.5 2.0 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 1.9 GO:0001669 acrosomal vesicle(GO:0001669)
0.2 1.8 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 1.7 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.5 1.5 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.1 1.3 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 1.3 GO:0097470 ribbon synapse(GO:0097470)
0.0 1.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.2 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 5.9 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.3 5.8 GO:0032183 SUMO binding(GO:0032183)
0.0 5.7 GO:0030165 PDZ domain binding(GO:0030165)
1.7 5.2 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.2 5.2 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 4.6 GO:0030215 semaphorin receptor binding(GO:0030215)
1.2 3.7 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.5 3.4 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 3.0 GO:0004112 cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.7 2.9 GO:0038049 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.2 2.5 GO:0050897 cobalt ion binding(GO:0050897)
0.1 2.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 2.1 GO:0019003 GDP binding(GO:0019003)
0.0 2.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.9 GO:0000049 tRNA binding(GO:0000049)
0.0 1.8 GO:0017124 SH3 domain binding(GO:0017124)
0.3 1.7 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 1.7 GO:0016505 peptidase activator activity involved in apoptotic process(GO:0016505)
0.1 1.7 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.4 1.6 GO:0042806 fucose binding(GO:0042806)