Motif ID: Zfhx3

Z-value: 0.960


Transcription factors associated with Zfhx3:

Gene SymbolEntrez IDGene Name
Zfhx3 ENSMUSG00000038872.8 Zfhx3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zfhx3mm10_v2_chr8_+_108714644_108714644-0.123.8e-01Click!


Activity profile for motif Zfhx3.

activity profile for motif Zfhx3


Sorted Z-values histogram for motif Zfhx3

Sorted Z-values for motif Zfhx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Zfhx3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_143933204 13.714 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr13_-_110280103 13.477 ENSMUST00000167824.1
 Rab3c
RAB3C, member RAS oncogene family
chrX_-_143933089 12.037 ENSMUST00000087313.3
 Dcx
doublecortin
chr10_-_110000219 9.854 ENSMUST00000032719.7
 Nav3
neuron navigator 3
chr1_-_126830632 7.365 ENSMUST00000112583.1
ENSMUST00000094609.3
 Nckap5

NCK-associated protein 5

chr3_+_28263205 7.206 ENSMUST00000159236.2
 Tnik
TRAF2 and NCK interacting kinase
chr14_+_64588112 7.108 ENSMUST00000181808.1
 A930011O12Rik
RIKEN cDNA A930011O12 gene
chr17_+_35076902 6.863 ENSMUST00000172494.1
ENSMUST00000172678.1
ENSMUST00000013910.4
 Ly6g6e


lymphocyte antigen 6 complex, locus G6E


chr4_+_13743424 6.822 ENSMUST00000006761.3
 Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr4_+_101507947 6.524 ENSMUST00000149047.1
ENSMUST00000106929.3
 Dnajc6

DnaJ (Hsp40) homolog, subfamily C, member 6

chr6_-_101377897 6.040 ENSMUST00000075994.6
 Pdzrn3
PDZ domain containing RING finger 3
chr16_-_74411776 5.806 ENSMUST00000116586.2
 Robo2
roundabout homolog 2 (Drosophila)
chr1_-_158814469 5.788 ENSMUST00000161589.2
 Pappa2
pappalysin 2
chr18_+_37518341 5.678 ENSMUST00000097609.1
 Pcdhb22
protocadherin beta 22
chr11_+_24078173 5.662 ENSMUST00000109514.1
 Bcl11a
B cell CLL/lymphoma 11A (zinc finger protein)
chr9_+_86485407 5.647 ENSMUST00000034987.8
 Dopey1
dopey family member 1
chr2_+_82053222 5.163 ENSMUST00000047527.7
 Zfp804a
zinc finger protein 804A
chr3_+_136670076 4.838 ENSMUST00000070198.7
 Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr5_+_107497718 4.674 ENSMUST00000112671.2
 A830010M20Rik
RIKEN cDNA A830010M20 gene
chr11_+_24078022 4.517 ENSMUST00000000881.6
 Bcl11a
B cell CLL/lymphoma 11A (zinc finger protein)
chr13_+_83732438 4.514 ENSMUST00000182701.1
 C130071C03Rik
RIKEN cDNA C130071C03 gene
chr2_-_63184253 4.231 ENSMUST00000075052.3
ENSMUST00000112454.1
 Kcnh7

potassium voltage-gated channel, subfamily H (eag-related), member 7

chr1_-_12991109 4.116 ENSMUST00000115403.2
ENSMUST00000115402.1
 Slco5a1

solute carrier organic anion transporter family, member 5A1

chr1_+_179961110 3.930 ENSMUST00000076687.5
ENSMUST00000097450.3
 Cdc42bpa

CDC42 binding protein kinase alpha

chr1_-_24612700 3.881 ENSMUST00000088336.1
 Gm10222
predicted gene 10222
chr11_+_24078111 3.833 ENSMUST00000109516.1
 Bcl11a
B cell CLL/lymphoma 11A (zinc finger protein)
chrM_+_9870 3.811 ENSMUST00000084013.1
 mt-Nd4l
mitochondrially encoded NADH dehydrogenase 4L
chrX_+_163911401 3.567 ENSMUST00000140845.1
 Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr8_+_47713266 3.464 ENSMUST00000180928.1
 E030037K01Rik
RIKEN cDNA E030037K01 gene
chr12_+_71170589 3.313 ENSMUST00000129376.1
 2700049A03Rik
RIKEN cDNA 2700049A03 gene
chr5_+_107497762 3.284 ENSMUST00000152474.1
ENSMUST00000060553.7
 A830010M20Rik

RIKEN cDNA A830010M20 gene

chr9_+_113812547 3.109 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
 Clasp2


CLIP associating protein 2


chr1_-_132390301 3.054 ENSMUST00000132435.1
 Tmcc2
transmembrane and coiled-coil domains 2
chr8_+_93810832 2.929 ENSMUST00000034198.8
ENSMUST00000125716.1
 Gnao1

guanine nucleotide binding protein, alpha O

chr2_-_37647199 2.927 ENSMUST00000028279.3
 Strbp
spermatid perinuclear RNA binding protein
chr4_-_32923455 2.719 ENSMUST00000035719.4
ENSMUST00000084749.1
 Ankrd6

ankyrin repeat domain 6

chr1_-_126830786 2.444 ENSMUST00000162646.1
 Nckap5
NCK-associated protein 5
chr8_+_83666827 2.394 ENSMUST00000019608.5
 Ptger1
prostaglandin E receptor 1 (subtype EP1)
chrM_+_14138 2.322 ENSMUST00000082421.1
 mt-Cytb
mitochondrially encoded cytochrome b
chr2_-_63184170 2.078 ENSMUST00000112452.1
 Kcnh7
potassium voltage-gated channel, subfamily H (eag-related), member 7
chr6_-_38124568 2.006 ENSMUST00000040259.4
 Atp6v0a4
ATPase, H+ transporting, lysosomal V0 subunit A4
chr8_-_9976294 1.941 ENSMUST00000095476.4
 Lig4
ligase IV, DNA, ATP-dependent
chr6_+_127453667 1.940 ENSMUST00000112193.1
 Parp11
poly (ADP-ribose) polymerase family, member 11
chr1_+_172698046 1.914 ENSMUST00000038495.3
 Crp
C-reactive protein, pentraxin-related
chr10_+_115384951 1.892 ENSMUST00000036044.8
 Zfc3h1
zinc finger, C3H1-type containing
chr9_+_95857597 1.877 ENSMUST00000034980.7
 Atr
ataxia telangiectasia and Rad3 related
chr2_-_140671462 1.855 ENSMUST00000110057.2
 Flrt3
fibronectin leucine rich transmembrane protein 3
chrM_-_14060 1.830 ENSMUST00000082419.1
 mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr1_+_179960472 1.797 ENSMUST00000097453.2
ENSMUST00000111117.1
 Cdc42bpa

CDC42 binding protein kinase alpha

chr12_-_12941827 1.767 ENSMUST00000043396.7
 Mycn
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr5_-_107875035 1.688 ENSMUST00000138111.1
ENSMUST00000112642.1
 Evi5

ecotropic viral integration site 5

chr2_+_3770673 1.668 ENSMUST00000177037.1
 Fam107b
family with sequence similarity 107, member B
chr2_-_165368723 1.636 ENSMUST00000141140.1
ENSMUST00000103085.1
 Zfp663

zinc finger protein 663

chr9_-_120068263 1.577 ENSMUST00000064165.3
ENSMUST00000177637.1
 Cx3cr1

chemokine (C-X3-C) receptor 1

chr10_-_56228636 1.471 ENSMUST00000099739.3
 Tbc1d32
TBC1 domain family, member 32
chr3_+_76075583 1.470 ENSMUST00000160261.1
 Fstl5
follistatin-like 5
chr2_-_140671440 1.435 ENSMUST00000099301.1
 Flrt3
fibronectin leucine rich transmembrane protein 3
chr2_-_140671400 1.390 ENSMUST00000056760.3
 Flrt3
fibronectin leucine rich transmembrane protein 3
chr1_-_157256682 1.349 ENSMUST00000134543.1
 Rasal2
RAS protein activator like 2
chr9_-_22208546 1.343 ENSMUST00000167359.1
 1810064F22Rik
RIKEN cDNA 1810064F22 gene
chr7_+_19119853 1.219 ENSMUST00000053109.3
 Fbxo46
F-box protein 46
chr10_-_17947997 1.163 ENSMUST00000037879.6
 Heca
headcase homolog (Drosophila)
chr2_-_120245157 1.083 ENSMUST00000090071.4
 Pla2g4e
phospholipase A2, group IVE
chr5_+_25246775 1.007 ENSMUST00000144971.1
 Galnt11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11
chr11_+_4986824 0.971 ENSMUST00000009234.9
ENSMUST00000109897.1
 Ap1b1

adaptor protein complex AP-1, beta 1 subunit

chr10_+_23796946 0.929 ENSMUST00000119597.1
ENSMUST00000179321.1
 Slc18b1

solute carrier family 18, subfamily B, member 1

chr2_+_120977017 0.905 ENSMUST00000067582.7
 Tmem62
transmembrane protein 62
chr7_+_55794146 0.860 ENSMUST00000032627.3
 Tubgcp5
tubulin, gamma complex associated protein 5
chr2_+_110597298 0.838 ENSMUST00000045972.6
ENSMUST00000111026.2
 Slc5a12

solute carrier family 5 (sodium/glucose cotransporter), member 12

chr7_-_34655500 0.748 ENSMUST00000032709.1
 Kctd15
potassium channel tetramerisation domain containing 15
chr10_+_23797052 0.697 ENSMUST00000133289.1
 Slc18b1
solute carrier family 18, subfamily B, member 1
chr3_-_130730375 0.632 ENSMUST00000079085.6
 Rpl34
ribosomal protein L34
chrM_+_7759 0.610 ENSMUST00000082407.1
ENSMUST00000082408.1
 mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr2_+_177768044 0.589 ENSMUST00000108942.3
 Gm14322
predicted gene 14322
chr8_-_67818284 0.549 ENSMUST00000120071.1
 Psd3
pleckstrin and Sec7 domain containing 3
chr1_-_168432270 0.498 ENSMUST00000072863.4
 Pbx1
pre B cell leukemia homeobox 1
chr9_+_36832684 0.483 ENSMUST00000034630.8
 Fez1
fasciculation and elongation protein zeta 1 (zygin I)
chr4_+_82065924 0.346 ENSMUST00000161588.1
 Gm5860
predicted gene 5860
chr2_-_121235689 0.322 ENSMUST00000142400.1
 Trp53bp1
transformation related protein 53 binding protein 1
chrX_-_111536325 0.315 ENSMUST00000156639.1
 Rps6ka6
ribosomal protein S6 kinase polypeptide 6
chr2_-_86347764 0.307 ENSMUST00000099894.2
 Olfr1055
olfactory receptor 1055
chr1_+_164275559 0.236 ENSMUST00000027867.6
 Ccdc181
coiled-coil domain containing 181
chr19_+_48206025 0.206 ENSMUST00000078880.5
 Sorcs3
sortilin-related VPS10 domain containing receptor 3
chr6_-_122340499 0.132 ENSMUST00000160843.1
 Phc1
polyhomeotic-like 1 (Drosophila)
chr4_+_109343029 0.078 ENSMUST00000030281.5
 Eps15
epidermal growth factor receptor pathway substrate 15
chr12_-_54695829 0.051 ENSMUST00000162106.1
ENSMUST00000160085.1
ENSMUST00000161592.1
ENSMUST00000163433.1
 Eapp



E2F-associated phosphoprotein



chr17_-_32886083 0.028 ENSMUST00000178401.1
 Zfp870
zinc finger protein 870

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.8 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
1.6 4.8 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
1.6 4.7 GO:0003345 proepicardium cell migration involved in pericardium morphogenesis(GO:0003345)
1.4 7.2 GO:0007256 activation of JNKK activity(GO:0007256)
1.4 25.8 GO:0021860 pyramidal neuron development(GO:0021860)
1.1 6.5 GO:0072318 clathrin coat disassembly(GO:0072318)
1.1 14.0 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.6 1.9 GO:1904884 telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.5 3.1 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.5 2.3 GO:0033762 response to glucagon(GO:0033762)
0.4 1.6 GO:1900272 negative regulation of long-term synaptic potentiation(GO:1900272)
0.3 2.0 GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.3 1.9 GO:0097680 double-strand break repair via classical nonhomologous end joining(GO:0097680)
0.3 1.9 GO:0032929 negative regulation of macrophage derived foam cell differentiation(GO:0010745) negative regulation of superoxide anion generation(GO:0032929)
0.3 4.1 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.2 5.7 GO:0007097 nuclear migration(GO:0007097)
0.2 1.5 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.2 6.9 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.2 2.7 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 1.0 GO:0018243 protein O-linked glycosylation via threonine(GO:0018243)
0.1 0.9 GO:0051418 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.1 6.0 GO:0007528 neuromuscular junction development(GO:0007528)
0.1 12.1 GO:0019882 antigen processing and presentation(GO:0019882)
0.1 6.8 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.1 3.8 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.1 2.9 GO:0007638 mechanosensory behavior(GO:0007638)
0.1 1.8 GO:0048712 negative regulation of astrocyte differentiation(GO:0048712)
0.1 2.9 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.1 1.0 GO:0048268 clathrin coat assembly(GO:0048268)
0.1 3.6 GO:0036465 synaptic vesicle recycling(GO:0036465)
0.1 0.5 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
0.0 1.9 GO:0006998 nuclear envelope organization(GO:0006998)
0.0 6.3 GO:0051291 protein heterooligomerization(GO:0051291)
0.0 1.1 GO:0009395 phospholipid catabolic process(GO:0009395)
0.0 0.3 GO:0007608 sensory perception of smell(GO:0007608)
0.0 0.6 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.3 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.0 1.3 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)
0.0 1.7 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 0.5 GO:0030325 adrenal gland development(GO:0030325)
0.0 3.3 GO:0007224 smoothened signaling pathway(GO:0007224)
0.0 1.4 GO:0060349 bone morphogenesis(GO:0060349)
0.0 1.7 GO:0007605 sensory perception of sound(GO:0007605)
0.0 2.4 GO:0032496 response to lipopolysaccharide(GO:0032496)
0.0 0.2 GO:1900452 regulation of long term synaptic depression(GO:1900452)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.1 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.8 4.8 GO:0005955 calcineurin complex(GO:0005955)
0.4 1.9 GO:0032807 DNA ligase IV complex(GO:0032807)
0.3 2.3 GO:0045275 respiratory chain complex III(GO:0045275)
0.3 2.0 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.2 0.9 GO:0000931 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.2 5.8 GO:0030673 axolemma(GO:0030673)
0.1 5.7 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 1.3 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 4.7 GO:0044295 axonal growth cone(GO:0044295)
0.1 1.9 GO:0001741 XY body(GO:0001741)
0.1 3.8 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 13.5 GO:0008021 synaptic vesicle(GO:0008021)
0.1 6.0 GO:0031594 neuromuscular junction(GO:0031594)
0.1 6.8 GO:0016363 nuclear matrix(GO:0016363)
0.1 2.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 7.2 GO:0055037 recycling endosome(GO:0055037)
0.1 24.1 GO:0005874 microtubule(GO:0005874)
0.1 5.7 GO:0042641 actomyosin(GO:0042641)
0.1 3.6 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 1.0 GO:0030131 clathrin adaptor complex(GO:0030131)
0.1 1.6 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 0.6 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 3.3 GO:0005814 centriole(GO:0005814)
0.0 10.5 GO:0016604 nuclear body(GO:0016604)
0.0 6.7 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 1.9 GO:0030175 filopodium(GO:0030175)
0.0 1.9 GO:0005643 nuclear pore(GO:0005643)
0.0 6.0 GO:0005635 nuclear envelope(GO:0005635)
0.0 9.4 GO:0005887 integral component of plasma membrane(GO:0005887)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 6.9 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
1.1 25.8 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.8 4.8 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.6 5.8 GO:0008046 axon guidance receptor activity(GO:0008046)
0.6 2.4 GO:0004954 icosanoid receptor activity(GO:0004953) prostanoid receptor activity(GO:0004954) prostaglandin receptor activity(GO:0004955)
0.6 13.5 GO:0031489 myosin V binding(GO:0031489)
0.5 2.9 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.4 1.9 GO:0001849 complement component C1q binding(GO:0001849)
0.4 4.1 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.3 1.9 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.3 6.3 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.3 1.6 GO:0019960 C-X3-C chemokine binding(GO:0019960)
0.3 1.9 GO:0032405 MutLalpha complex binding(GO:0032405) MutSalpha complex binding(GO:0032407)
0.3 2.3 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.2 3.1 GO:0051010 microtubule plus-end binding(GO:0051010)
0.2 4.7 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.2 2.0 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 1.9 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 3.1 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.9 GO:0051011 microtubule minus-end binding(GO:0051011)
0.1 14.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 7.2 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.1 5.8 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 1.1 GO:0004623 phospholipase A2 activity(GO:0004623)
0.1 6.5 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 0.8 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 0.3 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 1.0 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 4.5 GO:0008565 protein transporter activity(GO:0008565)
0.0 2.9 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 6.0 GO:0000287 magnesium ion binding(GO:0000287)
0.0 6.0 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 0.5 GO:0043015 gamma-tubulin binding(GO:0043015)