Motif ID: Zfp423

Z-value: 0.552


Transcription factors associated with Zfp423:

Gene SymbolEntrez IDGene Name
Zfp423 ENSMUSG00000045333.9 Zfp423

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zfp423mm10_v2_chr8_-_87804411_87804463-0.066.4e-01Click!


Activity profile for motif Zfp423.

activity profile for motif Zfp423


Sorted Z-values histogram for motif Zfp423

Sorted Z-values for motif Zfp423



Network of associatons between targets according to the STRING database.



First level regulatory network of Zfp423

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_22344690 3.663 ENSMUST00000062372.7
ENSMUST00000161356.1
 Reln

reelin

chr2_-_29253001 3.623 ENSMUST00000071201.4
 Ntng2
netrin G2
chr2_+_180499893 3.469 ENSMUST00000029084.2
 Ntsr1
neurotensin receptor 1
chr7_-_70360593 3.016 ENSMUST00000032768.7
 Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr4_+_42917234 2.925 ENSMUST00000107976.2
ENSMUST00000069184.2
 N28178

expressed sequence N28178

chr7_+_29307924 2.329 ENSMUST00000108230.1
ENSMUST00000065181.5
 Dpf1

D4, zinc and double PHD fingers family 1

chr12_+_102948843 2.233 ENSMUST00000101099.5
 Unc79
unc-79 homolog (C. elegans)
chr2_-_147085445 2.119 ENSMUST00000067020.2
 Nkx2-4
NK2 homeobox 4
chr10_-_62110945 2.091 ENSMUST00000142821.1
ENSMUST00000124615.1
ENSMUST00000064050.4
ENSMUST00000125704.1
ENSMUST00000142796.1
 2010107G23Rik




RIKEN cDNA 2010107G23 gene




chr14_+_119138415 2.067 ENSMUST00000065904.3
 Hs6st3
heparan sulfate 6-O-sulfotransferase 3
chr1_-_51941261 2.062 ENSMUST00000097103.3
 Gm8420
predicted gene 8420
chr10_+_13966268 2.045 ENSMUST00000015645.4
 Hivep2
human immunodeficiency virus type I enhancer binding protein 2
chr15_-_66286224 1.958 ENSMUST00000070256.7
 Kcnq3
potassium voltage-gated channel, subfamily Q, member 3
chr5_-_135934590 1.897 ENSMUST00000055808.5
 Ywhag
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
chr8_+_58912257 1.656 ENSMUST00000160055.1
 BC030500
cDNA sequence BC030500
chr7_-_105633525 1.608 ENSMUST00000153371.1
ENSMUST00000106789.1
ENSMUST00000057525.7
 Trim3


tripartite motif-containing 3


chr11_-_94474088 1.606 ENSMUST00000107786.1
ENSMUST00000107791.1
ENSMUST00000103166.2
ENSMUST00000107792.1
ENSMUST00000100561.3
ENSMUST00000107793.1
ENSMUST00000107788.1
ENSMUST00000107790.1
ENSMUST00000107789.1
ENSMUST00000107785.1
ENSMUST00000021234.8
 Cacna1g










calcium channel, voltage-dependent, T type, alpha 1G subunit










chr19_-_10869757 1.446 ENSMUST00000120524.1
ENSMUST00000025645.7
 Tmem132a

transmembrane protein 132A

chr6_+_110645572 1.382 ENSMUST00000071076.6
ENSMUST00000172951.1
 Grm7

glutamate receptor, metabotropic 7

chr7_-_105633479 1.341 ENSMUST00000147044.1
ENSMUST00000106791.1
 Trim3

tripartite motif-containing 3

chr15_-_78718113 1.323 ENSMUST00000088592.4
 Elfn2
leucine rich repeat and fibronectin type III, extracellular 2
chr6_-_124415037 1.283 ENSMUST00000035861.5
ENSMUST00000112532.1
ENSMUST00000080557.5
 Pex5


peroxisomal biogenesis factor 5


chr17_+_55986494 1.277 ENSMUST00000011733.8
 Fsd1
fibronectin type 3 and SPRY domain-containing protein
chr19_+_6401675 1.111 ENSMUST00000113471.1
ENSMUST00000113469.2
 Rasgrp2

RAS, guanyl releasing protein 2

chr14_+_70553687 1.013 ENSMUST00000161069.1
 Hr
hairless
chr7_-_25754701 0.989 ENSMUST00000108401.1
ENSMUST00000043765.7
 Hnrnpul1

heterogeneous nuclear ribonucleoprotein U-like 1

chr7_-_19458494 0.860 ENSMUST00000085715.5
 Mark4
MAP/microtubule affinity-regulating kinase 4
chr19_+_7268296 0.853 ENSMUST00000066646.4
 Rcor2
REST corepressor 2
chr12_-_14152038 0.843 ENSMUST00000020926.6
 Fam84a
family with sequence similarity 84, member A
chr10_+_82954344 0.837 ENSMUST00000095396.3
 Gm4799
predicted gene 4799
chr17_-_29347902 0.831 ENSMUST00000095427.4
ENSMUST00000118366.1
 Mtch1

mitochondrial carrier homolog 1 (C. elegans)

chr15_+_89253035 0.811 ENSMUST00000088788.3
 Ppp6r2
protein phosphatase 6, regulatory subunit 2
chr4_+_129513581 0.806 ENSMUST00000062356.6
 Marcksl1
MARCKS-like 1
chr2_+_133552159 0.761 ENSMUST00000028836.6
 Bmp2
bone morphogenetic protein 2
chr7_-_120670256 0.761 ENSMUST00000033178.2
 Pdzd9
PDZ domain containing 9
chr11_-_33203588 0.745 ENSMUST00000037746.6
 Tlx3
T cell leukemia, homeobox 3
chr8_-_41016749 0.725 ENSMUST00000117735.1
 Mtus1
mitochondrial tumor suppressor 1
chr12_+_109459843 0.720 ENSMUST00000173812.1
 Dlk1
delta-like 1 homolog (Drosophila)
chr15_+_101174096 0.716 ENSMUST00000000544.9
 Acvr1b
activin A receptor, type 1B
chr19_+_4231899 0.711 ENSMUST00000025773.3
 Pold4
polymerase (DNA-directed), delta 4
chr2_+_164785823 0.622 ENSMUST00000174070.1
ENSMUST00000172577.1
ENSMUST00000056181.6
 Snx21


sorting nexin family member 21


chr7_-_45870928 0.619 ENSMUST00000146672.1
 Grin2d
glutamate receptor, ionotropic, NMDA2D (epsilon 4)
chr9_+_120492606 0.605 ENSMUST00000007139.4
 Eif1b
eukaryotic translation initiation factor 1B
chr2_+_164785994 0.595 ENSMUST00000152471.1
 Snx21
sorting nexin family member 21
chr11_+_82101836 0.578 ENSMUST00000000194.3
 Ccl12
chemokine (C-C motif) ligand 12
chr10_-_14705459 0.568 ENSMUST00000149485.1
ENSMUST00000154132.1
 Vta1

Vps20-associated 1 homolog (S. cerevisiae)

chr8_-_83699095 0.498 ENSMUST00000005616.8
 Pkn1
protein kinase N1
chr7_-_5014645 0.416 ENSMUST00000165320.1
 Fiz1
Flt3 interacting zinc finger protein 1
chr5_+_24423805 0.388 ENSMUST00000153274.1
 Slc4a2
solute carrier family 4 (anion exchanger), member 2
chr7_+_127485221 0.378 ENSMUST00000048896.6
 Fbrs
fibrosin
chr2_+_106693185 0.358 ENSMUST00000111063.1
 Mpped2
metallophosphoesterase domain containing 2
chr7_-_34196608 0.355 ENSMUST00000148381.1
ENSMUST00000002710.3
 Pdcd2l

programmed cell death 2-like

chr17_+_69156791 0.354 ENSMUST00000112680.1
ENSMUST00000080208.5
 Epb4.1l3

erythrocyte protein band 4.1-like 3

chr7_-_105744312 0.347 ENSMUST00000141116.1
 Taf10
TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr6_-_128200598 0.339 ENSMUST00000071101.6
 Gm10010
predicted gene 10010
chr1_-_54926311 0.337 ENSMUST00000179030.1
ENSMUST00000044359.9
 Ankrd44

ankyrin repeat domain 44

chr9_-_21127346 0.334 ENSMUST00000001036.10
 Tyk2
tyrosine kinase 2
chr14_-_70520254 0.332 ENSMUST00000022693.7
 Bmp1
bone morphogenetic protein 1
chr2_-_30359278 0.329 ENSMUST00000163668.2
ENSMUST00000028214.8
ENSMUST00000113621.3
 Sh3glb2


SH3-domain GRB2-like endophilin B2


chr4_-_117125618 0.321 ENSMUST00000183310.1
 Btbd19
BTB (POZ) domain containing 19
chr1_+_167598450 0.312 ENSMUST00000111386.1
ENSMUST00000111384.1
 Rxrg

retinoid X receptor gamma

chr11_-_115535804 0.262 ENSMUST00000117589.1
ENSMUST00000121185.1
 Sumo2

SMT3 suppressor of mif two 3 homolog 2 (yeast)

chr4_+_31964081 0.244 ENSMUST00000037607.4
ENSMUST00000080933.6
ENSMUST00000108183.1
ENSMUST00000108184.2
 Map3k7



mitogen-activated protein kinase kinase kinase 7



chr2_-_30359190 0.195 ENSMUST00000100215.4
ENSMUST00000113620.3
 Sh3glb2

SH3-domain GRB2-like endophilin B2

chr1_+_167598384 0.165 ENSMUST00000015987.3
 Rxrg
retinoid X receptor gamma
chr9_+_57130690 0.126 ENSMUST00000160147.1
ENSMUST00000161663.1
ENSMUST00000034836.9
ENSMUST00000161182.1
 Man2c1



mannosidase, alpha, class 2C, member 1



chr12_-_69183986 0.125 ENSMUST00000110620.1
ENSMUST00000110619.1
 Rpl36al

ribosomal protein L36A-like

chr11_-_115536181 0.119 ENSMUST00000118155.1
ENSMUST00000153892.1
 Sumo2

SMT3 suppressor of mif two 3 homolog 2 (yeast)

chr9_-_37552904 0.094 ENSMUST00000065668.5
 Nrgn
neurogranin
chr11_-_106160101 0.085 ENSMUST00000045923.3
 Limd2
LIM domain containing 2
chr7_-_67372846 0.077 ENSMUST00000156690.1
ENSMUST00000107476.1
ENSMUST00000076325.5
ENSMUST00000032776.8
ENSMUST00000133074.1
 Mef2a




myocyte enhancer factor 2A




chr5_+_115429944 0.058 ENSMUST00000067168.5
 Msi1
musashi RNA-binding protein 1
chr13_+_3538075 0.048 ENSMUST00000059515.6
 Gdi2
guanosine diphosphate (GDP) dissociation inhibitor 2
chr7_+_45705518 0.036 ENSMUST00000107740.1
ENSMUST00000107741.1
 Dbp

D site albumin promoter binding protein

chr12_+_69184158 0.034 ENSMUST00000060579.8
 Mgat2
mannoside acetylglucosaminyltransferase 2
chr7_-_16286744 0.024 ENSMUST00000150528.2
ENSMUST00000118976.2
ENSMUST00000146609.2
 Ccdc9


coiled-coil domain containing 9


chr6_-_124756478 0.004 ENSMUST00000088357.5
 Atn1
atrophin 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.7 GO:0097477 lateral motor column neuron migration(GO:0097477)
0.9 3.5 GO:1903802 positive regulation of arachidonic acid secretion(GO:0090238) L-glutamate(1-) import into cell(GO:1903802) L-glutamate import into cell(GO:1990123)
0.6 3.0 GO:0060838 lymphatic endothelial cell fate commitment(GO:0060838) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.5 1.6 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.4 1.3 GO:0016561 protein import into peroxisome matrix, translocation(GO:0016561)
0.3 2.1 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.3 1.4 GO:0001661 conditioned taste aversion(GO:0001661)
0.3 0.8 GO:0060129 BMP signaling pathway involved in heart induction(GO:0003130) endodermal-mesodermal cell signaling(GO:0003133) endodermal-mesodermal cell signaling involved in heart induction(GO:0003134) thyroid-stimulating hormone-secreting cell differentiation(GO:0060129) mesenchymal cell proliferation involved in ureteric bud development(GO:0072138)
0.2 2.2 GO:0048149 behavioral response to ethanol(GO:0048149)
0.2 0.6 GO:2000501 natural killer cell chemotaxis(GO:0035747) negative regulation of lymphocyte migration(GO:2000402) regulation of natural killer cell chemotaxis(GO:2000501)
0.2 0.7 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.1 2.0 GO:0060081 membrane hyperpolarization(GO:0060081)
0.1 0.6 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.1 0.1 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
0.1 0.5 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.1 0.3 GO:0070365 hepatocyte differentiation(GO:0070365)
0.0 0.2 GO:0097343 ripoptosome assembly(GO:0097343) ripoptosome assembly involved in necroptotic process(GO:1901026)
0.0 0.7 GO:0002087 regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
0.0 0.7 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.0 0.6 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.0 0.7 GO:0000731 DNA synthesis involved in DNA repair(GO:0000731)
0.0 1.1 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 0.7 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 2.1 GO:0010921 regulation of phosphatase activity(GO:0010921)
0.0 0.4 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.0 0.1 GO:0006013 mannose metabolic process(GO:0006013)
0.0 0.5 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.8 GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0006919)
0.0 0.3 GO:0061036 positive regulation of cartilage development(GO:0061036)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.5 GO:0032280 symmetric synapse(GO:0032280)
0.2 0.7 GO:0048179 activin receptor complex(GO:0048179)
0.2 0.7 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.2 1.4 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.1 3.6 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 2.3 GO:0071565 nBAF complex(GO:0071565)
0.1 2.0 GO:0043194 axon initial segment(GO:0043194)
0.1 0.3 GO:0000125 PCAF complex(GO:0000125)
0.0 1.3 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 1.6 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.6 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 3.7 GO:0043204 perikaryon(GO:0043204)
0.0 1.2 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.1 GO:0044327 dendritic spine head(GO:0044327)
0.0 0.5 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0070905 serine binding(GO:0070905)
0.4 1.6 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.3 3.0 GO:0001972 retinoic acid binding(GO:0001972)
0.3 2.0 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.3 1.3 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.2 3.5 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.2 0.7 GO:0016361 activin receptor activity, type I(GO:0016361)
0.2 0.5 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.2 0.5 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 0.6 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.1 0.8 GO:0019211 phosphatase activator activity(GO:0019211)
0.1 0.3 GO:0005131 growth hormone receptor binding(GO:0005131)
0.1 2.0 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 1.9 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.1 2.1 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
0.1 1.0 GO:0042809 vitamin D receptor binding(GO:0042809)
0.1 0.6 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.9 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 1.3 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.4 GO:0031386 protein tag(GO:0031386)
0.0 1.2 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.7 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.0 GO:0005093 Rab GDP-dissociation inhibitor activity(GO:0005093)
0.0 2.7 GO:0061630 ubiquitin protein ligase activity(GO:0061630)