Motif ID: Zic2

Z-value: 0.532


Transcription factors associated with Zic2:

Gene SymbolEntrez IDGene Name
Zic2 ENSMUSG00000061524.8 Zic2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zic2mm10_v2_chr14_+_122475397_1224754350.104.4e-01Click!


Activity profile for motif Zic2.

activity profile for motif Zic2


Sorted Z-values histogram for motif Zic2

Sorted Z-values for motif Zic2



Network of associatons between targets according to the STRING database.



First level regulatory network of Zic2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_19699008 4.071 ENSMUST00000174355.1
ENSMUST00000172983.1
ENSMUST00000174710.1
ENSMUST00000167646.2
ENSMUST00000003066.9
ENSMUST00000174064.1
 Apoe





apolipoprotein E





chr7_-_19698206 2.170 ENSMUST00000172808.1
ENSMUST00000174191.1
 Apoe

apolipoprotein E

chr7_-_19698383 2.019 ENSMUST00000173739.1
 Apoe
apolipoprotein E
chr8_+_80494032 1.789 ENSMUST00000063359.6
 Gypa
glycophorin A
chr4_+_42240639 1.771 ENSMUST00000117202.2
 Gm10600
predicted gene 10600
chr6_-_115251839 1.492 ENSMUST00000032462.6
 Timp4
tissue inhibitor of metalloproteinase 4
chr14_+_19751257 1.444 ENSMUST00000022340.3
 Nid2
nidogen 2
chr4_+_42091207 1.306 ENSMUST00000178882.1
 Gm3893
predicted gene 3893
chr14_+_27039001 1.208 ENSMUST00000035336.3
 Il17rd
interleukin 17 receptor D
chr10_+_125966214 1.187 ENSMUST00000074807.6
 Lrig3
leucine-rich repeats and immunoglobulin-like domains 3
chr5_-_148392810 1.133 ENSMUST00000138257.1
 Slc7a1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr7_+_117380937 1.116 ENSMUST00000032892.5
 Xylt1
xylosyltransferase 1
chr11_+_5861886 1.106 ENSMUST00000102923.3
 Aebp1
AE binding protein 1
chr16_-_10313940 1.090 ENSMUST00000078357.4
 Emp2
epithelial membrane protein 2
chr2_-_122611238 1.066 ENSMUST00000028624.8
 Gatm
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr5_-_70842617 1.044 ENSMUST00000031119.1
 Gabrg1
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
chr15_-_8710409 1.017 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr7_-_142666816 0.968 ENSMUST00000105935.1
 Igf2
insulin-like growth factor 2
chr11_+_63128973 0.960 ENSMUST00000108702.1
 Pmp22
peripheral myelin protein 22
chr3_+_117575268 0.936 ENSMUST00000039564.6
 4833424O15Rik
RIKEN cDNA 4833424O15 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 179 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.8 8.3 GO:2001139 negative regulation of postsynaptic membrane organization(GO:1901627) negative regulation of dendritic spine maintenance(GO:1902951) negative regulation of phospholipid efflux(GO:1902999) regulation of lipid transport across blood brain barrier(GO:1903000) negative regulation of lipid transport across blood brain barrier(GO:1903001) positive regulation of lipid transport across blood brain barrier(GO:1903002) negative regulation of phospholipid transport(GO:2001139)
0.1 1.9 GO:0032060 bleb assembly(GO:0032060)
0.4 1.8 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.0 1.8 GO:0008360 regulation of cell shape(GO:0008360)
0.2 1.7 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.3 1.5 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.3 1.5 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.4 1.2 GO:0032474 otolith morphogenesis(GO:0032474)
0.4 1.1 GO:0006601 creatine biosynthetic process(GO:0006601)
0.2 1.1 GO:1903352 ornithine transport(GO:0015822) L-ornithine transmembrane transport(GO:1903352)
0.1 1.1 GO:0048681 negative regulation of axon regeneration(GO:0048681)
0.1 1.1 GO:0042178 xenobiotic catabolic process(GO:0042178)
0.3 1.0 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.1 1.0 GO:0003056 regulation of vascular smooth muscle contraction(GO:0003056)
0.1 1.0 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.0 1.0 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.2 0.9 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.1 0.9 GO:0005980 polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.0 0.9 GO:0070207 protein homotrimerization(GO:0070207)
0.0 0.9 GO:0016601 Rac protein signal transduction(GO:0016601)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.8 8.3 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.0 4.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 2.6 GO:0005604 basement membrane(GO:0005604)
0.0 2.4 GO:0001726 ruffle(GO:0001726)
0.0 1.8 GO:0005901 caveola(GO:0005901)
0.4 1.5 GO:0043259 laminin-10 complex(GO:0043259)
0.0 1.2 GO:0072562 blood microparticle(GO:0072562)
0.0 1.1 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 1.0 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 1.0 GO:0043218 compact myelin(GO:0043218)
0.0 1.0 GO:0005643 nuclear pore(GO:0005643)
0.1 0.9 GO:0043205 fibril(GO:0043205)
0.0 0.9 GO:0005581 collagen trimer(GO:0005581)
0.3 0.8 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.2 0.7 GO:0097233 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.2 0.7 GO:0019815 B cell receptor complex(GO:0019815)
0.2 0.7 GO:0032127 dense core granule membrane(GO:0032127)
0.0 0.7 GO:0005605 basal lamina(GO:0005605)
0.0 0.7 GO:0032279 asymmetric synapse(GO:0032279)
0.0 0.7 GO:0045120 pronucleus(GO:0045120)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 136 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.8 8.3 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.0 2.3 GO:0051015 actin filament binding(GO:0051015)
0.0 1.9 GO:0005178 integrin binding(GO:0005178)
0.4 1.5 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.1 1.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 1.5 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 1.5 GO:0005507 copper ion binding(GO:0005507)
0.2 1.4 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.1 1.3 GO:0044653 trehalase activity(GO:0015927) dextrin alpha-glucosidase activity(GO:0044653) starch alpha-glucosidase activity(GO:0044654) beta-glucanase activity(GO:0052736) beta-6-sulfate-N-acetylglucosaminidase activity(GO:0052769) glucan endo-1,4-beta-glucosidase activity(GO:0052859)
0.4 1.2 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.1 1.2 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.4 1.1 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.1 1.1 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.1 1.1 GO:0017166 vinculin binding(GO:0017166)
0.0 1.1 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
0.2 1.0 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.1 1.0 GO:0050811 GABA-A receptor activity(GO:0004890) GABA receptor binding(GO:0050811)
0.0 1.0 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 0.9 GO:0043208 glycosphingolipid binding(GO:0043208)
0.0 0.9 GO:0043747 protein-N-terminal asparagine amidohydrolase activity(GO:0008418) UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity(GO:0008759) iprodione amidohydrolase activity(GO:0018748) (3,5-dichlorophenylurea)acetate amidohydrolase activity(GO:0018749) 4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity(GO:0034571) didemethylisoproturon amidohydrolase activity(GO:0034573) N-isopropylacetanilide amidohydrolase activity(GO:0034576) N-cyclohexylformamide amidohydrolase activity(GO:0034781) isonicotinic acid hydrazide hydrolase activity(GO:0034876) cis-aconitamide amidase activity(GO:0034882) gamma-N-formylaminovinylacetate hydrolase activity(GO:0034885) N2-acetyl-L-lysine deacetylase activity(GO:0043747) O-succinylbenzoate synthase activity(GO:0043748) indoleacetamide hydrolase activity(GO:0043864) N-acetylcitrulline deacetylase activity(GO:0043909) N-acetylgalactosamine-6-phosphate deacetylase activity(GO:0047419) diacetylchitobiose deacetylase activity(GO:0052773) chitooligosaccharide deacetylase activity(GO:0052790)