Motif ID: Zic4

Z-value: 0.899


Transcription factors associated with Zic4:

Gene SymbolEntrez IDGene Name
Zic4 ENSMUSG00000036972.8 Zic4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zic4mm10_v2_chr9_+_91378636_91378646-0.104.3e-01Click!


Activity profile for motif Zic4.

activity profile for motif Zic4


Sorted Z-values histogram for motif Zic4

Sorted Z-values for motif Zic4



Network of associatons between targets according to the STRING database.



First level regulatory network of Zic4

PNG image of the network

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Top targets:


Showing 1 to 20 of 189 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_141524379 5.756 ENSMUST00000032362.9
 Slco1c1
solute carrier organic anion transporter family, member 1c1
chr19_-_57008187 4.810 ENSMUST00000118800.1
ENSMUST00000111584.2
ENSMUST00000122359.1
ENSMUST00000148049.1
 Afap1l2



actin filament associated protein 1-like 2



chr1_+_91179822 4.531 ENSMUST00000097648.4
ENSMUST00000165855.1
 Ramp1

receptor (calcitonin) activity modifying protein 1

chr4_-_64046925 4.345 ENSMUST00000107377.3
 Tnc
tenascin C
chr11_+_5861886 4.158 ENSMUST00000102923.3
 Aebp1
AE binding protein 1
chr11_-_102946688 3.748 ENSMUST00000057849.5
 C1ql1
complement component 1, q subcomponent-like 1
chr6_-_115251839 3.684 ENSMUST00000032462.6
 Timp4
tissue inhibitor of metalloproteinase 4
chr19_+_4855129 3.416 ENSMUST00000119694.1
 Ctsf
cathepsin F
chr2_+_147187424 3.279 ENSMUST00000144411.1
 6430503K07Rik
RIKEN cDNA 6430503K07 gene
chr2_-_152951456 3.265 ENSMUST00000123121.2
 Dusp15
dual specificity phosphatase-like 15
chr9_-_29412204 2.834 ENSMUST00000115237.1
 Ntm
neurotrimin
chr11_+_121702591 2.757 ENSMUST00000125580.1
 Metrnl
meteorin, glial cell differentiation regulator-like
chr2_+_85136355 2.690 ENSMUST00000057019.7
 Aplnr
apelin receptor
chr7_-_16476765 2.690 ENSMUST00000002053.8
 Npas1
neuronal PAS domain protein 1
chr17_-_71310952 2.684 ENSMUST00000024849.9
 Emilin2
elastin microfibril interfacer 2
chr2_+_180598219 2.654 ENSMUST00000103059.1
 Col9a3
collagen, type IX, alpha 3
chr2_-_152951547 2.653 ENSMUST00000037715.6
 Dusp15
dual specificity phosphatase-like 15
chr19_+_4099998 2.551 ENSMUST00000049658.7
 Pitpnm1
phosphatidylinositol transfer protein, membrane-associated 1
chr14_-_64455903 2.490 ENSMUST00000067927.7
 Msra
methionine sulfoxide reductase A
chr2_-_152951688 2.414 ENSMUST00000109811.3
 Dusp15
dual specificity phosphatase-like 15

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 84 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.8 GO:0046330 positive regulation of JNK cascade(GO:0046330)
0.2 5.9 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742) positive regulation of ERBB signaling pathway(GO:1901186)
0.6 5.8 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.3 4.6 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.9 4.5 GO:0060050 positive regulation of protein glycosylation(GO:0060050)
1.1 4.3 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
1.2 3.7 GO:0061743 motor learning(GO:0061743)
0.7 3.7 GO:2001025 positive regulation of response to drug(GO:2001025)
0.7 3.7 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.7 3.6 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.5 3.6 GO:0070458 detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458)
0.0 2.9 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.6 2.8 GO:2000507 positive regulation of energy homeostasis(GO:2000507)
0.2 2.7 GO:0010748 negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) positive regulation of fatty acid beta-oxidation(GO:0032000)
0.2 2.7 GO:0042711 maternal behavior(GO:0042711)
0.5 2.5 GO:0030091 protein repair(GO:0030091)
0.8 2.3 GO:0018199 peptidyl-glutamine modification(GO:0018199)
0.7 2.2 GO:0021759 globus pallidus development(GO:0021759)
0.5 2.1 GO:1903802 positive regulation of arachidonic acid secretion(GO:0090238) L-glutamate(1-) import into cell(GO:1903802) L-glutamate import into cell(GO:1990123)
0.7 2.0 GO:0060854 patterning of lymph vessels(GO:0060854)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.0 GO:0031012 extracellular matrix(GO:0031012)
0.0 5.2 GO:0043235 receptor complex(GO:0043235)
0.0 4.6 GO:0031225 anchored component of membrane(GO:0031225)
0.3 4.3 GO:0005614 interstitial matrix(GO:0005614)
0.7 3.7 GO:0044301 climbing fiber(GO:0044301)
0.6 3.7 GO:1990635 proximal dendrite(GO:1990635)
0.1 3.2 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 3.0 GO:0005581 collagen trimer(GO:0005581)
0.7 2.7 GO:0005594 collagen type IX trimer(GO:0005594)
0.2 2.7 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 2.7 GO:0005811 lipid particle(GO:0005811)
0.1 2.4 GO:0031430 M band(GO:0031430)
0.5 2.1 GO:0032280 symmetric synapse(GO:0032280)
0.1 2.0 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.4 1.9 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1 1.2 GO:0031045 dense core granule(GO:0031045)
0.0 1.2 GO:0045171 intercellular bridge(GO:0045171)
0.2 1.1 GO:0033010 paranodal junction(GO:0033010)
0.0 1.1 GO:0097440 apical dendrite(GO:0097440)
0.0 1.1 GO:0005801 cis-Golgi network(GO:0005801)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.8 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
1.4 5.8 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.9 5.5 GO:0045545 syndecan binding(GO:0045545)
0.4 5.3 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.4 4.8 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.2 4.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
1.1 4.5 GO:0097642 calcitonin family receptor activity(GO:0097642)
0.3 3.7 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 3.6 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0 3.4 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 3.1 GO:0035064 methylated histone binding(GO:0035064)
0.0 2.8 GO:0005179 hormone activity(GO:0005179)
0.2 2.5 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.3 2.4 GO:0034711 inhibin binding(GO:0034711)
0.0 2.4 GO:0005080 protein kinase C binding(GO:0005080)
0.2 2.3 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.2 2.2 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.1 2.1 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.1 2.1 GO:0001784 phosphotyrosine binding(GO:0001784)
0.3 2.0 GO:0001224 RNA polymerase II transcription cofactor binding(GO:0001224)