Motif ID: Zscan4c

Z-value: 1.141


Transcription factors associated with Zscan4c:

Gene SymbolEntrez IDGene Name
Zscan4c ENSMUSG00000054272.5 Zscan4c



Activity profile for motif Zscan4c.

activity profile for motif Zscan4c


Sorted Z-values histogram for motif Zscan4c

Sorted Z-values for motif Zscan4c



Network of associatons between targets according to the STRING database.



First level regulatory network of Zscan4c

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_55681257 23.332 ENSMUST00000044767.8
 Neurod6
neurogenic differentiation 6
chr4_+_49059256 14.533 ENSMUST00000076670.2
 E130309F12Rik
RIKEN cDNA E130309F12 gene
chr8_+_118283719 14.403 ENSMUST00000117160.1
 Cdh13
cadherin 13
chr7_+_130936172 14.239 ENSMUST00000006367.7
 Htra1
HtrA serine peptidase 1
chr4_-_46991842 13.866 ENSMUST00000107749.2
 Gabbr2
gamma-aminobutyric acid (GABA) B receptor, 2
chr15_-_78718113 11.633 ENSMUST00000088592.4
 Elfn2
leucine rich repeat and fibronectin type III, extracellular 2
chr9_+_26733728 9.780 ENSMUST00000160899.1
ENSMUST00000161431.1
ENSMUST00000159799.1
 B3gat1


beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)


chr9_-_49798905 9.770 ENSMUST00000114476.2
 Ncam1
neural cell adhesion molecule 1
chr3_-_158562199 9.738 ENSMUST00000106044.1
 Lrrc7
leucine rich repeat containing 7
chr9_-_49798729 9.324 ENSMUST00000166811.2
 Ncam1
neural cell adhesion molecule 1
chr16_+_45094036 9.040 ENSMUST00000061050.5
 Ccdc80
coiled-coil domain containing 80
chr18_-_23041641 8.061 ENSMUST00000097651.3
 Nol4
nucleolar protein 4
chr9_+_26733845 7.074 ENSMUST00000115269.2
 B3gat1
beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)
chr9_+_89909775 6.909 ENSMUST00000034912.4
ENSMUST00000034909.4
 Rasgrf1

RAS protein-specific guanine nucleotide-releasing factor 1

chr2_+_68861564 6.245 ENSMUST00000176018.1
 Cers6
ceramide synthase 6
chr9_+_57940104 6.122 ENSMUST00000043059.7
 Sema7a
sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
chr2_-_36105271 6.115 ENSMUST00000112960.1
ENSMUST00000112967.5
ENSMUST00000112963.1
 Lhx6


LIM homeobox protein 6


chr14_-_60177482 6.068 ENSMUST00000140924.1
 Atp8a2
ATPase, aminophospholipid transporter-like, class I, type 8A, member 2
chr11_+_16257706 5.912 ENSMUST00000109645.2
ENSMUST00000109647.2
 Vstm2a

V-set and transmembrane domain containing 2A

chr13_+_58807884 5.815 ENSMUST00000079828.5
 Ntrk2
neurotrophic tyrosine kinase, receptor, type 2
chr5_-_44799643 5.518 ENSMUST00000070748.5
 Ldb2
LIM domain binding 2
chr4_-_87806276 5.186 ENSMUST00000148059.1
 Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr10_-_42276688 5.156 ENSMUST00000175881.1
ENSMUST00000056974.3
 Foxo3

forkhead box O3

chr2_+_68861433 5.047 ENSMUST00000028426.2
 Cers6
ceramide synthase 6
chr7_-_47132698 5.015 ENSMUST00000033142.5
 Ptpn5
protein tyrosine phosphatase, non-receptor type 5
chr19_-_28963863 4.946 ENSMUST00000161813.1
 4430402I18Rik
RIKEN cDNA 4430402I18 gene
chr10_+_43579161 4.726 ENSMUST00000058714.8
 Cd24a
CD24a antigen
chr9_+_21936986 4.634 ENSMUST00000046371.6
 BC018242
cDNA sequence BC018242
chr4_-_45530330 4.594 ENSMUST00000061986.5
 Shb
src homology 2 domain-containing transforming protein B
chr4_-_87806296 4.342 ENSMUST00000126353.1
ENSMUST00000149357.1
 Mllt3

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

chr10_-_42276744 4.213 ENSMUST00000105502.1
ENSMUST00000105501.1
 Foxo3

forkhead box O3

chr4_+_123183722 4.189 ENSMUST00000152194.1
 Hpcal4
hippocalcin-like 4
chr2_+_102658640 4.071 ENSMUST00000080210.3
 Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr19_+_28963892 3.962 ENSMUST00000045674.2
 Ppapdc2
phosphatidic acid phosphatase type 2 domain containing 2
chr2_-_116064721 3.758 ENSMUST00000110906.2
 Meis2
Meis homeobox 2
chr7_-_98178254 3.638 ENSMUST00000040971.7
 Capn5
calpain 5
chr2_-_116064512 3.592 ENSMUST00000074285.6
 Meis2
Meis homeobox 2
chr5_-_145201829 3.505 ENSMUST00000162220.1
ENSMUST00000031632.8
 Zkscan14

zinc finger with KRAB and SCAN domains 14

chr8_-_95142477 3.467 ENSMUST00000034240.7
ENSMUST00000169748.1
 Kifc3

kinesin family member C3

chr9_-_50739365 3.356 ENSMUST00000117093.1
ENSMUST00000121634.1
 Dixdc1

DIX domain containing 1

chr9_-_44799179 3.305 ENSMUST00000114705.1
ENSMUST00000002100.7
 Tmem25

transmembrane protein 25

chr2_-_116065047 3.194 ENSMUST00000028639.6
ENSMUST00000102538.4
 Meis2

Meis homeobox 2

chr10_+_81292961 3.193 ENSMUST00000163075.1
ENSMUST00000105327.3
ENSMUST00000045469.8
 Pip5k1c


phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma


chr8_-_48555846 3.157 ENSMUST00000110345.1
ENSMUST00000110343.1
 Tenm3

teneurin transmembrane protein 3

chr13_-_56296551 2.925 ENSMUST00000021970.9
 Cxcl14
chemokine (C-X-C motif) ligand 14
chr5_+_27261916 2.913 ENSMUST00000101471.3
 Dpp6
dipeptidylpeptidase 6
chr2_-_63184253 2.788 ENSMUST00000075052.3
ENSMUST00000112454.1
 Kcnh7

potassium voltage-gated channel, subfamily H (eag-related), member 7

chr2_-_91182848 2.787 ENSMUST00000111370.2
ENSMUST00000111376.1
ENSMUST00000099723.2
 Madd


MAP-kinase activating death domain


chr3_-_107760221 2.728 ENSMUST00000153114.1
ENSMUST00000118593.1
ENSMUST00000120243.1
 Csf1


colony stimulating factor 1 (macrophage)


chrX_+_48519245 2.650 ENSMUST00000033430.2
 Rab33a
RAB33A, member of RAS oncogene family
chr10_+_74967164 2.526 ENSMUST00000037813.4
 Gnaz
guanine nucleotide binding protein, alpha z subunit
chr19_+_8664005 2.355 ENSMUST00000035444.3
ENSMUST00000163785.1
 Chrm1

cholinergic receptor, muscarinic 1, CNS

chrX_+_161717498 2.343 ENSMUST00000061514.7
 Rai2
retinoic acid induced 2
chr8_+_117257019 2.332 ENSMUST00000166750.1
 Cmip
c-Maf inducing protein
chr18_-_79109391 2.295 ENSMUST00000025430.8
ENSMUST00000161465.2
 Setbp1

SET binding protein 1

chr12_-_69892989 2.186 ENSMUST00000110567.1
ENSMUST00000171211.1
 Map4k5

mitogen-activated protein kinase kinase kinase kinase 5

chr7_-_119184374 2.046 ENSMUST00000084650.4
 Gpr139
G protein-coupled receptor 139
chr16_-_38713235 1.900 ENSMUST00000023487.4
 Arhgap31
Rho GTPase activating protein 31
chr2_+_169633517 1.854 ENSMUST00000109157.1
 Tshz2
teashirt zinc finger family member 2
chr2_+_102659213 1.552 ENSMUST00000111213.1
 Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr14_-_70627008 1.514 ENSMUST00000110984.2
 Dmtn
dematin actin binding protein
chr4_+_123183456 1.456 ENSMUST00000126995.1
 Hpcal4
hippocalcin-like 4
chr15_-_37458523 1.364 ENSMUST00000116445.2
 Ncald
neurocalcin delta
chr10_+_118860826 1.325 ENSMUST00000059966.4
 4932442E05Rik
RIKEN cDNA 4932442E05 gene
chr1_+_132191436 1.111 ENSMUST00000112357.2
 Lemd1
LEM domain containing 1
chr3_-_108017806 1.096 ENSMUST00000126593.1
 Gstm1
glutathione S-transferase, mu 1
chr9_+_36832684 0.970 ENSMUST00000034630.8
 Fez1
fasciculation and elongation protein zeta 1 (zygin I)
chr2_+_106695594 0.960 ENSMUST00000016530.7
 Mpped2
metallophosphoesterase domain containing 2
chr13_+_42052015 0.949 ENSMUST00000060148.5
 Hivep1
human immunodeficiency virus type I enhancer binding protein 1
chr10_-_78295394 0.866 ENSMUST00000105387.1
 Agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr5_-_128953303 0.704 ENSMUST00000111346.1
 Rimbp2
RIMS binding protein 2
chr17_+_78508063 0.619 ENSMUST00000024880.9
 Vit
vitrin
chr8_+_82863351 0.575 ENSMUST00000078525.5
 Rnf150
ring finger protein 150
chr2_+_30364262 0.462 ENSMUST00000142801.1
ENSMUST00000100214.3
 Fam73b

family with sequence similarity 73, member B

chr4_-_116464151 0.362 ENSMUST00000106486.1
ENSMUST00000106485.1
 Mast2

microtubule associated serine/threonine kinase 2

chr19_-_21472552 0.341 ENSMUST00000087600.3
 Gda
guanine deaminase
chr19_+_53310495 0.310 ENSMUST00000003870.7
 Mxi1
Max interacting protein 1
chr6_-_122340200 0.155 ENSMUST00000159384.1
 Phc1
polyhomeotic-like 1 (Drosophila)
chr18_-_39489776 0.151 ENSMUST00000025300.6
 Nr3c1
nuclear receptor subfamily 3, group C, member 1
chr6_-_122340499 0.028 ENSMUST00000160843.1
 Phc1
polyhomeotic-like 1 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
6.4 19.1 GO:0001928 regulation of exocyst assembly(GO:0001928)
3.6 14.4 GO:0055095 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096)
2.4 14.2 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
1.6 4.7 GO:0002842 T cell mediated immune response to tumor cell(GO:0002424) regulation of T cell mediated immune response to tumor cell(GO:0002840) positive regulation of T cell mediated immune response to tumor cell(GO:0002842) positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
1.3 9.4 GO:1905206 positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300) positive regulation of hydrogen peroxide-induced cell death(GO:1905206)
1.2 6.1 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
1.2 23.3 GO:0021542 dentate gyrus development(GO:0021542)
1.0 6.1 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
1.0 5.0 GO:2001025 positive regulation of response to drug(GO:2001025)
1.0 2.9 GO:2000501 natural killer cell chemotaxis(GO:0035747) regulation of natural killer cell chemotaxis(GO:2000501)
1.0 5.8 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
1.0 9.5 GO:0007379 segment specification(GO:0007379)
0.9 5.6 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.9 2.8 GO:1902277 negative regulation of pancreatic amylase secretion(GO:1902277)
0.9 2.7 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.9 6.1 GO:0061092 involuntary skeletal muscle contraction(GO:0003011) regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.8 16.9 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.7 4.6 GO:1900194 negative regulation of oocyte development(GO:0060283) negative regulation of oocyte maturation(GO:1900194)
0.6 3.5 GO:0045218 zonula adherens maintenance(GO:0045218)
0.5 13.9 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.5 1.5 GO:1901731 calcium-mediated signaling using extracellular calcium source(GO:0035585) positive regulation of platelet aggregation(GO:1901731)
0.4 3.2 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.4 3.2 GO:0097264 self proteolysis(GO:0097264)
0.4 2.4 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.4 6.9 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.3 3.4 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.2 11.3 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.2 12.3 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.2 9.8 GO:0008542 visual learning(GO:0008542)
0.1 0.3 GO:0046098 guanine metabolic process(GO:0046098)
0.1 3.6 GO:2000785 regulation of autophagosome assembly(GO:2000785)
0.1 9.7 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.1 2.9 GO:0090004 positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.1 2.5 GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
0.0 0.2 GO:0031914 negative regulation of synaptic plasticity(GO:0031914) negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.0 9.4 GO:0010976 positive regulation of neuron projection development(GO:0010976)
0.0 1.1 GO:0035690 cellular response to drug(GO:0035690)
0.0 1.4 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.0 0.3 GO:0008053 mitochondrial fusion(GO:0008053)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 13.9 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.9 2.7 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.8 5.0 GO:1990635 proximal dendrite(GO:1990635)
0.6 9.7 GO:0005614 interstitial matrix(GO:0005614)
0.5 4.7 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.4 1.5 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.3 39.6 GO:0031225 anchored component of membrane(GO:0031225)
0.3 6.9 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.3 9.7 GO:0043194 axon initial segment(GO:0043194)
0.3 3.5 GO:0005915 zonula adherens(GO:0005915)
0.2 9.5 GO:0008023 transcription elongation factor complex(GO:0008023)
0.2 5.6 GO:0030673 axolemma(GO:0030673)
0.2 5.8 GO:0048786 presynaptic active zone(GO:0048786)
0.2 2.4 GO:0032279 asymmetric synapse(GO:0032279)
0.1 0.3 GO:0031230 intrinsic component of cell outer membrane(GO:0031230) integral component of cell outer membrane(GO:0045203)
0.1 2.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 2.9 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 6.1 GO:0005802 trans-Golgi network(GO:0005802)
0.0 7.0 GO:0031012 extracellular matrix(GO:0031012)
0.0 1.8 GO:0043679 axon terminus(GO:0043679)
0.0 2.1 GO:0008021 synaptic vesicle(GO:0008021)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 14.4 GO:0055100 adiponectin binding(GO:0055100)
2.8 16.9 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
2.3 13.9 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
1.4 5.6 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
1.3 11.3 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
1.2 5.8 GO:0005030 neurotrophin receptor activity(GO:0005030)
1.0 19.1 GO:0030275 LRR domain binding(GO:0030275)
0.9 3.5 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.6 14.2 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.6 6.1 GO:0038191 neuropilin binding(GO:0038191)
0.5 9.0 GO:0001968 fibronectin binding(GO:0001968)
0.4 3.2 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.4 4.7 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.4 2.4 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.4 2.5 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.3 6.1 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.3 11.6 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.2 4.6 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.2 5.0 GO:0001784 phosphotyrosine binding(GO:0001784)
0.2 9.4 GO:0001221 transcription cofactor binding(GO:0001221)
0.2 3.6 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 7.1 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.1 2.8 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.1 2.2 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.1 5.6 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 2.0 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.1 0.9 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.1 4.3 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 1.1 GO:0016151 nickel cation binding(GO:0016151)
0.1 30.1 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 2.9 GO:0008009 chemokine activity(GO:0008009)
0.1 2.8 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 2.9 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 1.4 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.9 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 1.5 GO:0030507 spectrin binding(GO:0030507)
0.0 8.2 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 2.7 GO:0005126 cytokine receptor binding(GO:0005126)
0.0 1.0 GO:0044824 integrase activity(GO:0008907) T/G mismatch-specific endonuclease activity(GO:0043765) retroviral integrase activity(GO:0044823) retroviral 3' processing activity(GO:0044824)
0.0 1.9 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.3 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)