Motif ID: Aire

Z-value: 1.005


Transcription factors associated with Aire:

Gene SymbolEntrez IDGene Name
Aire ENSMUSG00000000731.9 Aire



Activity profile for motif Aire.

activity profile for motif Aire


Sorted Z-values histogram for motif Aire

Sorted Z-values for motif Aire



Network of associatons between targets according to the STRING database.


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_61185558 38.156 ENSMUST00000166381.1
 Cdr1
cerebellar degeneration related antigen 1
chr13_-_110280103 6.963 ENSMUST00000167824.1
 Rab3c
RAB3C, member RAS oncogene family
chr8_+_69808672 6.101 ENSMUST00000036074.8
ENSMUST00000123453.1
 Gmip

Gem-interacting protein

chr5_-_84417359 5.546 ENSMUST00000113401.1
 Epha5
Eph receptor A5
chr10_+_123264076 4.767 ENSMUST00000050756.7
 Fam19a2
family with sequence similarity 19, member A2
chr12_-_78983476 4.553 ENSMUST00000070174.7
 Tmem229b
transmembrane protein 229B
chr3_-_116968969 4.512 ENSMUST00000143611.1
ENSMUST00000040097.7
 Palmd

palmdelphin

chr16_+_36875119 3.424 ENSMUST00000135406.1
ENSMUST00000114812.1
ENSMUST00000134616.1
ENSMUST00000023534.6
 Golgb1


Golgb1
golgi autoantigen, golgin subfamily b, macrogolgin 1


golgi autoantigen, golgin subfamily b, macrogolgin 1
chr2_+_55435918 3.182 ENSMUST00000067101.3
 Kcnj3
potassium inwardly-rectifying channel, subfamily J, member 3
chr9_-_53610329 3.086 ENSMUST00000034547.5
 Acat1
acetyl-Coenzyme A acetyltransferase 1
chr7_+_60155538 2.927 ENSMUST00000057611.4
 Gm7367
predicted pseudogene 7367
chr7_-_127895578 2.691 ENSMUST00000033074.6
 Vkorc1
vitamin K epoxide reductase complex, subunit 1
chr10_-_130280218 2.663 ENSMUST00000061571.3
 Neurod4
neurogenic differentiation 4
chr7_-_14562171 2.552 ENSMUST00000181796.1
 Vmn1r90
vomeronasal 1 receptor 90
chr18_+_37400845 2.548 ENSMUST00000057228.1
 Pcdhb9
protocadherin beta 9
chr2_-_134644079 2.226 ENSMUST00000110119.1
 Tmx4
thioredoxin-related transmembrane protein 4
chr7_+_28863831 2.178 ENSMUST00000138272.1
 Lgals7
lectin, galactose binding, soluble 7
chr10_+_86021961 2.149 ENSMUST00000130320.1
 Fbxo7
F-box protein 7
chr14_+_76476913 2.115 ENSMUST00000140251.2
 Tsc22d1
TSC22 domain family, member 1
chr19_-_28963863 2.089 ENSMUST00000161813.1
 4430402I18Rik
RIKEN cDNA 4430402I18 gene
chr1_-_5070281 2.018 ENSMUST00000147158.1
ENSMUST00000118000.1
 Rgs20

regulator of G-protein signaling 20

chr18_+_37725706 1.974 ENSMUST00000066149.6
 Pcdhga9
protocadherin gamma subfamily A, 9
chr16_-_91618986 1.914 ENSMUST00000143058.1
ENSMUST00000049244.8
ENSMUST00000169982.1
ENSMUST00000133731.1
 Dnajc28



DnaJ (Hsp40) homolog, subfamily C, member 28



chr5_+_24100578 1.896 ENSMUST00000030841.5
ENSMUST00000163409.1
 Klhl7

kelch-like 7

chrM_+_14138 1.653 ENSMUST00000082421.1
 mt-Cytb
mitochondrially encoded cytochrome b
chr9_-_97111117 1.522 ENSMUST00000085206.4
 Slc25a36
solute carrier family 25, member 36
chr5_+_140735526 1.426 ENSMUST00000120630.2
 Amz1
archaelysin family metallopeptidase 1
chr10_-_81014902 1.423 ENSMUST00000126317.1
ENSMUST00000092285.3
ENSMUST00000117805.1
 Gng7


guanine nucleotide binding protein (G protein), gamma 7


chr14_+_21481428 1.421 ENSMUST00000182996.1
 Kat6b
K(lysine) acetyltransferase 6B
chr11_-_115627948 1.390 ENSMUST00000154623.1
ENSMUST00000106503.3
ENSMUST00000141614.1
 Slc25a19


solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19


chrM_-_14060 1.375 ENSMUST00000082419.1
 mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr2_-_134644125 1.332 ENSMUST00000038228.4
 Tmx4
thioredoxin-related transmembrane protein 4
chr12_+_84052114 1.326 ENSMUST00000120927.1
 Acot3
acyl-CoA thioesterase 3
chr2_+_164948219 1.305 ENSMUST00000017881.2
 Mmp9
matrix metallopeptidase 9
chr3_-_89411781 1.278 ENSMUST00000107429.3
ENSMUST00000129308.2
ENSMUST00000107426.1
ENSMUST00000050398.4
ENSMUST00000162701.1
 Flad1




RFad1, flavin adenine dinucleotide synthetase, homolog (yeast)




chr10_+_58446845 1.270 ENSMUST00000003310.5
 Ranbp2
RAN binding protein 2
chr9_-_53667429 1.257 ENSMUST00000166367.1
ENSMUST00000034529.7
 Cul5

cullin 5

chr1_+_65186727 1.192 ENSMUST00000097707.4
ENSMUST00000081154.7
 Pikfyve

phosphoinositide kinase, FYVE finger containing

chr8_+_64947177 1.157 ENSMUST00000079896.7
ENSMUST00000026595.5
 Tmem192

transmembrane protein 192

chr17_+_35236556 1.152 ENSMUST00000068261.8
 Atp6v1g2
ATPase, H+ transporting, lysosomal V1 subunit G2
chr13_-_62371936 1.145 ENSMUST00000107989.3
 Gm3604
predicted gene 3604
chr3_-_62506970 1.133 ENSMUST00000029336.4
 Dhx36
DEAH (Asp-Glu-Ala-His) box polypeptide 36
chr8_-_4217261 1.125 ENSMUST00000168386.2
 BC068157
cDNA sequence BC068157
chr2_-_121473993 0.967 ENSMUST00000056732.3
 Mfap1b
microfibrillar-associated protein 1B
chr12_+_10390756 0.939 ENSMUST00000020947.5
 Rdh14
retinol dehydrogenase 14 (all-trans and 9-cis)
chr8_-_4217133 0.939 ENSMUST00000175906.1
 BC068157
cDNA sequence BC068157
chr2_-_165400398 0.932 ENSMUST00000029213.4
 Ocstamp
osteoclast stimulatory transmembrane protein
chr9_+_13662460 0.914 ENSMUST00000177755.1
 Maml2
mastermind like 2 (Drosophila)
chr4_-_19570073 0.903 ENSMUST00000029885.4
 Cpne3
copine III
chr5_-_135251209 0.874 ENSMUST00000062572.2
 Fzd9
frizzled homolog 9 (Drosophila)
chr10_-_111997204 0.806 ENSMUST00000074805.5
 Glipr1
GLI pathogenesis-related 1 (glioma)
chr12_+_36157124 0.803 ENSMUST00000041640.3
 Ankmy2
ankyrin repeat and MYND domain containing 2
chr7_-_141434532 0.781 ENSMUST00000133021.1
ENSMUST00000106007.3
ENSMUST00000150026.1
ENSMUST00000133206.2
 Slc25a22



solute carrier family 25 (mitochondrial carrier, glutamate), member 22



chr10_+_52358767 0.771 ENSMUST00000180473.1
 Gm26741
predicted gene, 26741
chr8_-_4216912 0.708 ENSMUST00000177491.1
 BC068157
cDNA sequence BC068157
chr9_+_109054839 0.705 ENSMUST00000154184.1
 Shisa5
shisa homolog 5 (Xenopus laevis)
chr17_+_22689771 0.693 ENSMUST00000055305.8
 Gm9805
predicted gene 9805
chr9_+_76014855 0.531 ENSMUST00000008052.6
ENSMUST00000183425.1
ENSMUST00000183979.1
ENSMUST00000117981.2
 Hmgcll1



3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1



chr6_+_126939957 0.500 ENSMUST00000032497.3
 D6Wsu163e
DNA segment, Chr 6, Wayne State University 163, expressed
chr12_-_36156781 0.467 ENSMUST00000020856.4
 Bzw2
basic leucine zipper and W2 domains 2
chr7_+_45896941 0.432 ENSMUST00000069772.7
ENSMUST00000107716.1
 Tmem143

transmembrane protein 143

chr19_-_6118491 0.419 ENSMUST00000113533.1
 Sac3d1
SAC3 domain containing 1
chr19_+_3323301 0.416 ENSMUST00000025835.4
 Cpt1a
carnitine palmitoyltransferase 1a, liver
chr3_+_89715016 0.398 ENSMUST00000098924.2
 Adar
adenosine deaminase, RNA-specific
chr9_-_113708209 0.368 ENSMUST00000111861.3
ENSMUST00000035086.6
 Pdcd6ip

programmed cell death 6 interacting protein

chr7_-_103741322 0.350 ENSMUST00000051346.2
 Olfr629
olfactory receptor 629
chr2_+_175283298 0.338 ENSMUST00000098998.3
 Gm14440
predicted gene 14440
chr11_-_28584260 0.331 ENSMUST00000093253.3
ENSMUST00000109502.2
ENSMUST00000042534.8
 Ccdc85a


coiled-coil domain containing 85A


chr19_+_34217588 0.322 ENSMUST00000119603.1
 Stambpl1
STAM binding protein like 1
chr16_-_36874806 0.319 ENSMUST00000075946.5
 Eaf2
ELL associated factor 2
chr2_-_94010807 0.318 ENSMUST00000111240.1
 Alkbh3
alkB, alkylation repair homolog 3 (E. coli)
chr9_+_64235201 0.311 ENSMUST00000039011.3
 Uchl4
ubiquitin carboxyl-terminal esterase L4
chr13_+_49504774 0.297 ENSMUST00000051504.7
 Ecm2
extracellular matrix protein 2, female organ and adipocyte specific
chr2_+_172248492 0.264 ENSMUST00000038532.1
 Mc3r
melanocortin 3 receptor
chr8_-_31739763 0.264 ENSMUST00000178878.1
 Gm5117
predicted gene 5117
chr2_+_176431829 0.262 ENSMUST00000172025.1
 Gm14435
predicted gene 14435
chr5_+_29378604 0.246 ENSMUST00000181005.1
 4632411P08Rik
RIKEN cDNA 4632411P08 gene
chrX_-_38576166 0.242 ENSMUST00000050083.5
 Cul4b
cullin 4B
chr1_-_65186456 0.205 ENSMUST00000169032.1
 Idh1
isocitrate dehydrogenase 1 (NADP+), soluble
chr10_+_53337686 0.171 ENSMUST00000046221.6
ENSMUST00000163319.1
 Pln

phospholamban

chr5_-_105343929 0.164 ENSMUST00000183149.1
 Gbp11
guanylate binding protein 11
chr14_-_18894255 0.161 ENSMUST00000124353.1
 Ube2e2
ubiquitin-conjugating enzyme E2E 2
chr2_-_94010729 0.152 ENSMUST00000040005.6
ENSMUST00000126378.1
 Alkbh3

alkB, alkylation repair homolog 3 (E. coli)

chr8_-_109962127 0.145 ENSMUST00000001722.7
ENSMUST00000051430.6
 Marveld3

MARVEL (membrane-associating) domain containing 3

chrM_+_11734 0.142 ENSMUST00000082418.1
 mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chr4_+_154869585 0.096 ENSMUST00000079269.7
ENSMUST00000163732.1
ENSMUST00000080559.6
 Mmel1


membrane metallo-endopeptidase-like 1


chr4_+_42714926 0.090 ENSMUST00000178454.1
 Gm21955
predicted gene, 21955
chr17_-_6961156 0.084 ENSMUST00000063683.6
 Tagap1
T cell activation GTPase activating protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.7 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.6 5.5 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.4 1.3 GO:0042726 flavin-containing compound metabolic process(GO:0042726)
0.4 1.3 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.3 1.3 GO:0032788 saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789)
0.3 1.7 GO:0033762 response to glucagon(GO:0033762)
0.3 0.9 GO:0034241 positive regulation of macrophage fusion(GO:0034241) regulation of osteoclast proliferation(GO:0090289)
0.3 2.7 GO:0035881 amacrine cell differentiation(GO:0035881)
0.3 1.3 GO:0031915 positive regulation of synaptic plasticity(GO:0031915) regulation of keratinocyte migration(GO:0051547) positive regulation of keratinocyte migration(GO:0051549) positive regulation of receptor binding(GO:1900122)
0.2 0.9 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.2 2.0 GO:0090244 Wnt signaling pathway involved in somitogenesis(GO:0090244)
0.2 0.5 GO:0035552 oxidative single-stranded DNA demethylation(GO:0035552)
0.1 1.4 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 0.5 GO:0046950 cellular ketone body metabolic process(GO:0046950)
0.1 0.4 GO:1900369 negative regulation of RNA interference(GO:1900369)
0.1 3.2 GO:0010107 potassium ion import(GO:0010107)
0.1 1.3 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
0.1 0.9 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 1.9 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.1 0.9 GO:0042572 retinol metabolic process(GO:0042572)
0.1 0.4 GO:0090611 ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611) positive regulation of extracellular exosome assembly(GO:1903553)
0.1 0.2 GO:0006097 glyoxylate cycle(GO:0006097)
0.1 6.3 GO:0019882 antigen processing and presentation(GO:0019882)
0.1 2.1 GO:0045620 negative regulation of lymphocyte differentiation(GO:0045620)
0.1 1.5 GO:0006862 nucleotide transport(GO:0006862)
0.1 3.2 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 2.2 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 1.2 GO:0032288 myelin assembly(GO:0032288)
0.0 1.1 GO:0043330 response to exogenous dsRNA(GO:0043330)
0.0 0.3 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0 0.4 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.0 0.8 GO:0015813 L-glutamate transport(GO:0015813)
0.0 4.5 GO:0008360 regulation of cell shape(GO:0008360)
0.0 0.5 GO:0033006 regulation of mast cell activation involved in immune response(GO:0033006) regulation of mast cell degranulation(GO:0043304)
0.0 0.2 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.2 GO:0086023 adrenergic receptor signaling pathway involved in heart process(GO:0086023)
0.0 0.1 GO:1902414 protein localization to cell junction(GO:1902414)
0.0 1.4 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.9 GO:0035567 non-canonical Wnt signaling pathway(GO:0035567)
0.0 1.4 GO:0098792 xenophagy(GO:0098792)
0.0 0.3 GO:0045475 locomotor rhythm(GO:0045475)
0.0 0.7 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0 2.1 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.0 0.3 GO:0007608 sensory perception of smell(GO:0007608)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.2 1.7 GO:0045275 respiratory chain complex III(GO:0045275)
0.1 1.2 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 1.5 GO:0017119 Golgi transport complex(GO:0017119)
0.1 2.0 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.1 1.0 GO:0001527 microfibril(GO:0001527)
0.1 3.4 GO:0005801 cis-Golgi network(GO:0005801)
0.1 5.5 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 1.2 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 0.4 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 7.0 GO:0008021 synaptic vesicle(GO:0008021)
0.0 3.2 GO:0030315 T-tubule(GO:0030315)
0.0 1.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.2 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 4.5 GO:0043197 dendritic spine(GO:0043197)
0.0 0.3 GO:0005614 interstitial matrix(GO:0005614)
0.0 1.4 GO:0000786 nucleosome(GO:0000786)
0.0 0.4 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 1.3 GO:0005643 nuclear pore(GO:0005643)
0.0 0.2 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.9 GO:0070469 respiratory chain(GO:0070469)
0.0 2.1 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 5.5 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.6 3.2 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.5 3.1 GO:0016453 acetyl-CoA C-acetyltransferase activity(GO:0003985) C-acetyltransferase activity(GO:0016453)
0.3 7.0 GO:0031489 myosin V binding(GO:0031489)
0.2 1.1 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.2 2.7 GO:0048038 quinone binding(GO:0048038)
0.2 1.7 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.2 0.5 GO:0051747 cytosine C-5 DNA demethylase activity(GO:0051747)
0.2 3.2 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1 1.2 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.1 0.5 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.1 0.4 GO:0003692 left-handed Z-DNA binding(GO:0003692)
0.1 0.4 GO:0031871 proteinase activated receptor binding(GO:0031871)
0.1 0.3 GO:0070052 collagen V binding(GO:0070052)
0.1 1.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 0.3 GO:0004980 melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980)
0.1 1.5 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.1 0.4 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095)
0.1 1.3 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.1 2.0 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 0.2 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.1 0.3 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 0.2 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.1 1.5 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 1.3 GO:0001968 fibronectin binding(GO:0001968)
0.0 1.3 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.9 GO:0035380 C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity(GO:0000252) mevaldate reductase activity(GO:0004495) gluconate dehydrogenase activity(GO:0008875) epoxide dehydrogenase activity(GO:0018451) 5-exo-hydroxycamphor dehydrogenase activity(GO:0018452) 2-hydroxytetrahydrofuran dehydrogenase activity(GO:0018453) acetoin dehydrogenase activity(GO:0019152) phenylcoumaran benzylic ether reductase activity(GO:0032442) D-xylose:NADP reductase activity(GO:0032866) L-arabinose:NADP reductase activity(GO:0032867) D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity(GO:0033709) (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity(GO:0034831) 3-hydroxymenthone dehydrogenase activity(GO:0034840) very long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0035380) dihydrotestosterone 17-beta-dehydrogenase activity(GO:0035410) (R)-2-hydroxyisocaproate dehydrogenase activity(GO:0043713) L-arabinose 1-dehydrogenase (NADP+) activity(GO:0044103) L-xylulose reductase (NAD+) activity(GO:0044105) 3-ketoglucose-reductase activity(GO:0048258) D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity(GO:0052677)
0.0 0.8 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.0 0.9 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.3 GO:0016920 pyroglutamyl-peptidase activity(GO:0016920)
0.0 0.8 GO:0070566 adenylyltransferase activity(GO:0070566)
0.0 0.2 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.9 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 1.4 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 0.7 GO:0050699 WW domain binding(GO:0050699)
0.0 1.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 4.0 GO:0005096 GTPase activator activity(GO:0005096)
0.0 2.2 GO:0030246 carbohydrate binding(GO:0030246)