Motif ID: Alx4

Z-value: 0.769


Transcription factors associated with Alx4:

Gene SymbolEntrez IDGene Name
Alx4 ENSMUSG00000040310.6 Alx4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Alx4mm10_v2_chr2_+_93642307_936423880.681.2e-05Click!


Activity profile for motif Alx4.

activity profile for motif Alx4


Sorted Z-values histogram for motif Alx4

Sorted Z-values for motif Alx4



Network of associatons between targets according to the STRING database.



First level regulatory network of Alx4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_109917639 4.185 ENSMUST00000046548.7
ENSMUST00000111037.2
 Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr1_+_24177610 3.426 ENSMUST00000054588.8
 Col9a1
collagen, type IX, alpha 1
chr3_+_146121655 3.423 ENSMUST00000039450.4
 Mcoln3
mucolipin 3
chr10_-_77166545 2.944 ENSMUST00000081654.6
 Col18a1
collagen, type XVIII, alpha 1
chr13_-_81710937 2.824 ENSMUST00000161920.1
ENSMUST00000048993.5
 Polr3g

polymerase (RNA) III (DNA directed) polypeptide G

chr10_-_8886033 2.819 ENSMUST00000015449.5
 Sash1
SAM and SH3 domain containing 1
chr11_-_102946688 2.800 ENSMUST00000057849.5
 C1ql1
complement component 1, q subcomponent-like 1
chr10_+_97479470 2.796 ENSMUST00000105287.3
 Dcn
decorin
chr19_+_55895508 2.777 ENSMUST00000111646.1
 Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr5_-_138170992 2.742 ENSMUST00000139983.1
 Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chrX_+_73483602 2.527 ENSMUST00000033741.8
ENSMUST00000169489.1
 Bgn

biglycan

chr3_-_36475688 2.520 ENSMUST00000029266.8
 Anxa5
annexin A5
chr2_-_144270852 2.461 ENSMUST00000110030.3
 Snx5
sorting nexin 5
chr13_-_100786402 2.364 ENSMUST00000174038.1
ENSMUST00000091295.7
ENSMUST00000072119.8
 Ccnb1


cyclin B1


chr15_+_84232030 2.326 ENSMUST00000023072.6
 Parvb
parvin, beta
chr13_-_102905740 2.324 ENSMUST00000167462.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr9_+_119063429 2.252 ENSMUST00000141185.1
ENSMUST00000126251.1
ENSMUST00000136561.1
 Vill


villin-like


chr3_-_100489324 2.229 ENSMUST00000061455.8
 Fam46c
family with sequence similarity 46, member C
chr15_-_37459327 2.220 ENSMUST00000119730.1
ENSMUST00000120746.1
 Ncald

neurocalcin delta

chr11_+_59306920 2.210 ENSMUST00000000128.3
ENSMUST00000108783.3
 Wnt9a

wingless-type MMTV integration site 9A


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 119 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 5.3 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.4 5.1 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
1.4 4.2 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.2 3.4 GO:0003417 growth plate cartilage development(GO:0003417)
0.2 2.9 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.9 2.8 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.9 2.8 GO:0061743 motor learning(GO:0061743)
0.5 2.8 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.3 2.8 GO:0048625 myoblast fate commitment(GO:0048625)
0.6 2.5 GO:0097211 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.1 2.5 GO:0006907 pinocytosis(GO:0006907)
0.6 2.4 GO:0043987 histone H3-S10 phosphorylation(GO:0043987)
0.1 2.3 GO:0051693 actin filament capping(GO:0051693)
0.0 2.3 GO:0042491 auditory receptor cell differentiation(GO:0042491)
0.0 2.3 GO:0030032 lamellipodium assembly(GO:0030032)
0.1 2.2 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.1 2.1 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 2.1 GO:0006270 DNA replication initiation(GO:0006270)
0.4 2.0 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.1 2.0 GO:0033234 negative regulation of protein sumoylation(GO:0033234)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 5.8 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.3 5.1 GO:0042555 MCM complex(GO:0042555)
0.0 5.1 GO:0005925 focal adhesion(GO:0005925)
0.9 3.4 GO:0005594 collagen type IX trimer(GO:0005594)
0.1 2.9 GO:0005581 collagen trimer(GO:0005581)
0.6 2.8 GO:0044301 climbing fiber(GO:0044301)
0.3 2.8 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 2.8 GO:0098644 complex of collagen trimers(GO:0098644)
0.4 2.5 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.1 2.5 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 2.5 GO:0072562 blood microparticle(GO:0072562)
0.6 2.4 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.1 2.4 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 2.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 2.1 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 2.1 GO:0005923 bicellular tight junction(GO:0005923)
0.2 1.9 GO:0005884 actin filament(GO:0005884)
0.5 1.8 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.0 1.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 89 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.1 GO:0005198 structural molecule activity(GO:0005198)
0.0 7.8 GO:0003779 actin binding(GO:0003779)
0.1 5.3 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 5.1 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.3 4.2 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 4.1 GO:0005109 frizzled binding(GO:0005109)
0.1 2.9 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.1 2.8 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 2.8 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 2.7 GO:0000287 magnesium ion binding(GO:0000287)
0.0 2.6 GO:0000049 tRNA binding(GO:0000049)
0.4 2.5 GO:1990932 5.8S rRNA binding(GO:1990932)
0.4 2.5 GO:0034452 dynactin binding(GO:0034452)
0.2 2.5 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.5 2.4 GO:0005113 patched binding(GO:0005113)
0.1 2.4 GO:0001056 RNA polymerase III activity(GO:0001056)
0.1 2.2 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 2.1 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.7 2.0 GO:0019770 IgG receptor activity(GO:0019770)
0.1 2.0 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)