Motif ID: Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec

Z-value: 0.984

Transcription factors associated with Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec:

Gene SymbolEntrez IDGene Name
Arntl ENSMUSG00000055116.7 Arntl
Mitf ENSMUSG00000035158.9 Mitf
Mlx ENSMUSG00000017801.9 Mlx
Mlxipl ENSMUSG00000005373.7 Mlxipl
Tfe3 ENSMUSG00000000134.11 Tfe3
Tfec ENSMUSG00000029553.7 Tfec

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mlxiplmm10_v2_chr5_+_135106881_135106918-0.637.6e-05Click!
Arntlmm10_v2_chr7_+_113207465_113207595-0.531.6e-03Click!
Mlxmm10_v2_chr11_+_101087277_1010873230.459.0e-03Click!
Mitfmm10_v2_chr6_+_97807014_97807067-0.459.1e-03Click!
Tfe3mm10_v2_chrX_+_7762652_7762695-0.421.4e-02Click!


Activity profile for motif Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec.

activity profile for motif Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec


Sorted Z-values histogram for motif Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec

Sorted Z-values for motif Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec



Network of associatons between targets according to the STRING database.



First level regulatory network of Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_79456750 5.444 ENSMUST00000041099.4
 Neurod1
neurogenic differentiation 1
chr17_-_66077022 4.459 ENSMUST00000150766.1
ENSMUST00000038116.5
 Ankrd12

ankyrin repeat domain 12

chr11_+_70000578 4.208 ENSMUST00000019362.8
 Dvl2
dishevelled 2, dsh homolog (Drosophila)
chr1_-_75142360 4.168 ENSMUST00000041213.5
 Cnppd1
cyclin Pas1/PHO80 domain containing 1
chr11_+_69991061 4.135 ENSMUST00000018711.8
 Gabarap
gamma-aminobutyric acid receptor associated protein
chr11_-_70239794 4.047 ENSMUST00000040428.3
 Rnasek
ribonuclease, RNase K
chrY_-_1245685 4.012 ENSMUST00000143286.1
ENSMUST00000137048.1
ENSMUST00000069309.7
ENSMUST00000139365.1
 Uty



ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome



chr9_-_103761820 3.746 ENSMUST00000049452.8
 Tmem108
transmembrane protein 108
chr7_-_45466894 3.717 ENSMUST00000033093.8
 Bax
BCL2-associated X protein
chr7_+_35802593 3.699 ENSMUST00000052454.2
 E130304I02Rik
RIKEN cDNA E130304I02 gene
chr4_-_117887292 3.671 ENSMUST00000150204.1
ENSMUST00000147845.1
ENSMUST00000036380.7
ENSMUST00000136596.1
 Atp6v0b



ATPase, H+ transporting, lysosomal V0 subunit B



chr1_+_75142775 3.627 ENSMUST00000097694.4
 Fam134a
family with sequence similarity 134, member A
chr10_-_95416850 3.608 ENSMUST00000020215.9
 Socs2
suppressor of cytokine signaling 2
chr11_-_102230127 3.572 ENSMUST00000107150.1
ENSMUST00000156337.1
ENSMUST00000107151.2
ENSMUST00000107152.2
 Hdac5



histone deacetylase 5



chr10_+_127063527 3.556 ENSMUST00000006911.5
 Cdk4
cyclin-dependent kinase 4
chr1_-_75219245 3.457 ENSMUST00000079464.6
 Tuba4a
tubulin, alpha 4A
chr1_+_5083105 3.455 ENSMUST00000044369.7
 Atp6v1h
ATPase, H+ transporting, lysosomal V1 subunit H
chr15_+_66577536 3.411 ENSMUST00000048188.8
 Phf20l1
PHD finger protein 20-like 1
chr11_-_102230091 3.386 ENSMUST00000008999.5
 Hdac5
histone deacetylase 5
chr11_+_98348404 3.279 ENSMUST00000078694.6
 Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 476 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 15.2 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.7 7.0 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.3 6.8 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.8 6.4 GO:0071557 histone H3-K27 demethylation(GO:0071557)
1.5 6.0 GO:0010288 response to lead ion(GO:0010288)
0.1 5.7 GO:0048477 oogenesis(GO:0048477)
0.1 5.6 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
1.4 5.4 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.4 4.8 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.2 4.6 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.2 4.5 GO:0009303 rRNA transcription(GO:0009303)
1.4 4.3 GO:0010845 positive regulation of reciprocal meiotic recombination(GO:0010845)
0.8 4.2 GO:0014022 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.2 3.9 GO:0060213 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
1.2 3.7 GO:1902445 regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445)
0.3 3.5 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.2 3.3 GO:0002115 store-operated calcium entry(GO:0002115)
0.1 3.3 GO:0045214 sarcomere organization(GO:0045214)
1.1 3.2 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.6 3.0 GO:0035984 response to trichostatin A(GO:0035983) cellular response to trichostatin A(GO:0035984)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 199 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 10.0 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
1.1 7.9 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 7.6 GO:0030426 growth cone(GO:0030426)
0.9 7.3 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.1 7.3 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.3 5.9 GO:0000421 autophagosome membrane(GO:0000421)
0.2 4.6 GO:0031082 BLOC complex(GO:0031082)
0.6 4.3 GO:0033503 HULC complex(GO:0033503)
0.1 4.1 GO:0005844 polysome(GO:0005844)
0.1 4.0 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.5 3.7 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 3.6 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.9 3.5 GO:0031084 BLOC-2 complex(GO:0031084)
0.1 3.1 GO:0005685 U1 snRNP(GO:0005685)
0.5 2.9 GO:0071986 Ragulator complex(GO:0071986)
0.3 2.9 GO:0000813 ESCRT I complex(GO:0000813)
0.3 2.8 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.2 2.8 GO:0035102 PRC1 complex(GO:0035102)
0.0 2.8 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.9 2.6 GO:1990879 CST complex(GO:1990879)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 312 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 10.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
1.4 10.0 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
1.5 7.4 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.0 6.5 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.9 6.4 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.1 6.0 GO:0030332 cyclin binding(GO:0030332)
0.1 5.9 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 5.7 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.3 5.5 GO:0036442 hydrogen-exporting ATPase activity(GO:0036442) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 5.4 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 5.0 GO:0045182 translation regulator activity(GO:0045182)
0.1 4.7 GO:0050681 androgen receptor binding(GO:0050681)
0.0 4.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 4.4 GO:0005109 frizzled binding(GO:0005109)
0.1 4.1 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 3.9 GO:0004521 endoribonuclease activity(GO:0004521)
0.1 3.9 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.4 3.8 GO:0032050 clathrin heavy chain binding(GO:0032050)
1.2 3.7 GO:0031750 D3 dopamine receptor binding(GO:0031750)
0.5 3.7 GO:0051434 BH3 domain binding(GO:0051434)