Motif ID: Atoh1_Bhlhe23

Z-value: 0.694

Transcription factors associated with Atoh1_Bhlhe23:

Gene SymbolEntrez IDGene Name
Atoh1 ENSMUSG00000073043.4 Atoh1
Bhlhe23 ENSMUSG00000045493.3 Bhlhe23

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Bhlhe23mm10_v2_chr2_-_180776749_1807767490.566.3e-04Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Atoh1_Bhlhe23

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_177444653 8.911 ENSMUST00000094276.3
Zbtb18
zinc finger and BTB domain containing 18
chr2_-_79456750 6.408 ENSMUST00000041099.4
Neurod1
neurogenic differentiation 1
chr11_-_98329641 5.426 ENSMUST00000041685.6
Neurod2
neurogenic differentiation 2
chr11_+_58954675 5.407 ENSMUST00000047697.5
ENSMUST00000108817.3
Trim17
Hist3h2a
tripartite motif-containing 17
histone cluster 3, H2a
chr9_-_21918089 4.509 ENSMUST00000128442.1
ENSMUST00000119055.1
ENSMUST00000122211.1
ENSMUST00000115351.3
Rab3d



RAB3D, member RAS oncogene family



chr2_-_29253001 4.061 ENSMUST00000071201.4
Ntng2
netrin G2
chr3_-_84259812 3.468 ENSMUST00000107691.1
Trim2
tripartite motif-containing 2
chr4_-_110292719 3.147 ENSMUST00000106601.1
Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr15_-_91191733 3.102 ENSMUST00000069511.6
Abcd2
ATP-binding cassette, sub-family D (ALD), member 2
chr9_+_72985568 2.679 ENSMUST00000150826.2
ENSMUST00000085350.4
ENSMUST00000140675.1
Ccpg1


cell cycle progression 1


chr5_-_66618772 2.468 ENSMUST00000162994.1
ENSMUST00000159512.1
ENSMUST00000159786.1
Apbb2


amyloid beta (A4) precursor protein-binding, family B, member 2


chr1_+_177445660 2.466 ENSMUST00000077225.6
Zbtb18
zinc finger and BTB domain containing 18
chr9_+_72985504 2.426 ENSMUST00000156879.1
Ccpg1
cell cycle progression 1
chr6_+_112273758 2.277 ENSMUST00000032376.5
Lmcd1
LIM and cysteine-rich domains 1
chr17_-_6449571 2.254 ENSMUST00000180035.1
Tmem181b-ps
transmembrane protein 181B, pseudogene
chr1_-_150392719 2.243 ENSMUST00000006167.6
ENSMUST00000094477.2
ENSMUST00000097547.3
BC003331


cDNA sequence BC003331


chr10_+_69706326 2.193 ENSMUST00000182992.1
Ank3
ankyrin 3, epithelial
chr2_+_62046623 2.181 ENSMUST00000112480.2
Slc4a10
solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
chr2_+_62046580 2.155 ENSMUST00000054484.8
Slc4a10
solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
chr5_-_144223516 2.077 ENSMUST00000085701.6
Tecpr1
tectonin beta-propeller repeat containing 1
chr5_+_124194894 1.922 ENSMUST00000159053.1
ENSMUST00000162577.1
Gm16338

predicted gene 16338

chr2_-_52558539 1.825 ENSMUST00000102760.3
ENSMUST00000102761.2
Cacnb4

calcium channel, voltage-dependent, beta 4 subunit

chr3_-_120886691 1.751 ENSMUST00000182099.1
ENSMUST00000183168.1
ENSMUST00000183276.1
ENSMUST00000182124.1
6530403H02Rik



RIKEN cDNA 6530403H02 gene



chr1_+_15287259 1.739 ENSMUST00000175681.1
Kcnb2
potassium voltage gated channel, Shab-related subfamily, member 2
chr6_+_17743582 1.713 ENSMUST00000000674.6
ENSMUST00000077080.2
St7

suppression of tumorigenicity 7

chr8_-_106337987 1.696 ENSMUST00000067512.7
Smpd3
sphingomyelin phosphodiesterase 3, neutral
chr2_+_62046462 1.569 ENSMUST00000102735.3
Slc4a10
solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
chr5_-_124187150 1.565 ENSMUST00000161938.1
Pitpnm2
phosphatidylinositol transfer protein, membrane-associated 2
chr2_+_25403128 1.531 ENSMUST00000154809.1
ENSMUST00000055921.7
ENSMUST00000141567.1
Npdc1


neural proliferation, differentiation and control 1


chr11_+_31872100 1.517 ENSMUST00000020543.6
ENSMUST00000109412.2
Cpeb4

cytoplasmic polyadenylation element binding protein 4

chr11_-_69602741 1.494 ENSMUST00000138694.1
Atp1b2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr2_+_65930117 1.457 ENSMUST00000176109.1
Csrnp3
cysteine-serine-rich nuclear protein 3
chr15_+_78913916 1.439 ENSMUST00000089378.4
Pdxp
pyridoxal (pyridoxine, vitamin B6) phosphatase
chr15_+_82256023 1.418 ENSMUST00000143238.1
1500009C09Rik
RIKEN cDNA 1500009C09 gene
chr3_-_126998408 1.410 ENSMUST00000182764.1
ENSMUST00000044443.8
Ank2

ankyrin 2, brain

chr2_+_155382186 1.298 ENSMUST00000134218.1
Trp53inp2
transformation related protein 53 inducible nuclear protein 2
chr18_+_77185979 1.293 ENSMUST00000075290.6
St8sia5
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
chrX_+_159708593 1.259 ENSMUST00000080394.6
Sh3kbp1
SH3-domain kinase binding protein 1
chr10_-_70655934 1.240 ENSMUST00000162144.1
ENSMUST00000162793.1
Phyhipl

phytanoyl-CoA hydroxylase interacting protein-like

chr1_-_111864869 1.219 ENSMUST00000035462.5
Dsel
dermatan sulfate epimerase-like
chr2_-_54085542 1.168 ENSMUST00000100089.2
Rprm
reprimo, TP53 dependent G2 arrest mediator candidate
chr16_+_11008898 1.110 ENSMUST00000180624.1
Gm4262
predicted gene 4262
chr6_+_90462562 1.097 ENSMUST00000032174.5
Klf15
Kruppel-like factor 15
chr5_-_66618636 1.089 ENSMUST00000162382.1
ENSMUST00000160870.1
ENSMUST00000087256.5
ENSMUST00000160103.1
ENSMUST00000162349.1
Apbb2




amyloid beta (A4) precursor protein-binding, family B, member 2




chr1_+_150392794 1.036 ENSMUST00000124973.2
Tpr
translocated promoter region
chr4_+_127172866 1.006 ENSMUST00000106094.2
Dlgap3
discs, large (Drosophila) homolog-associated protein 3
chr19_-_37207293 0.990 ENSMUST00000132580.1
ENSMUST00000079754.4
ENSMUST00000136286.1
ENSMUST00000126188.1
ENSMUST00000126781.1
Cpeb3




cytoplasmic polyadenylation element binding protein 3




chr5_+_3343893 0.982 ENSMUST00000165117.1
Cdk6
cyclin-dependent kinase 6
chr19_-_37176055 0.885 ENSMUST00000142973.1
ENSMUST00000154376.1
Cpeb3

cytoplasmic polyadenylation element binding protein 3

chr15_+_30172570 0.885 ENSMUST00000081728.5
Ctnnd2
catenin (cadherin associated protein), delta 2
chrX_-_53608979 0.800 ENSMUST00000123034.1
Gm14597
predicted gene 14597
chr6_-_12749193 0.781 ENSMUST00000046121.6
ENSMUST00000172356.1
Thsd7a

thrombospondin, type I, domain containing 7A

chr2_+_69670100 0.734 ENSMUST00000100050.3
Klhl41
kelch-like 41
chr7_-_141437829 0.715 ENSMUST00000019226.7
Slc25a22
solute carrier family 25 (mitochondrial carrier, glutamate), member 22
chr19_+_7268296 0.668 ENSMUST00000066646.4
Rcor2
REST corepressor 2
chr8_+_25602236 0.653 ENSMUST00000146919.1
ENSMUST00000142395.1
ENSMUST00000139966.1
Whsc1l1


Wolf-Hirschhorn syndrome candidate 1-like 1 (human)


chr7_-_126704522 0.642 ENSMUST00000135087.1
Coro1a
coronin, actin binding protein 1A
chr2_-_39065505 0.630 ENSMUST00000039165.8
Golga1
golgi autoantigen, golgin subfamily a, 1
chr7_-_141437587 0.629 ENSMUST00000172654.1
ENSMUST00000106006.1
Slc25a22

solute carrier family 25 (mitochondrial carrier, glutamate), member 22

chr14_-_62454793 0.567 ENSMUST00000128573.1
Gucy1b2
guanylate cyclase 1, soluble, beta 2
chr16_+_43510267 0.563 ENSMUST00000114695.2
Zbtb20
zinc finger and BTB domain containing 20
chr2_+_150323702 0.553 ENSMUST00000133235.2
Gm10130
predicted gene 10130
chr2_-_121807024 0.550 ENSMUST00000138157.1
Frmd5
FERM domain containing 5
chr11_-_35980473 0.550 ENSMUST00000018993.6
Wwc1
WW, C2 and coiled-coil domain containing 1
chr11_+_53433299 0.549 ENSMUST00000018382.6
Gdf9
growth differentiation factor 9
chr3_+_138065052 0.540 ENSMUST00000163080.2
1110002E22Rik
RIKEN cDNA 1110002E22 gene
chr8_+_25601591 0.534 ENSMUST00000155861.1
Whsc1l1
Wolf-Hirschhorn syndrome candidate 1-like 1 (human)
chr11_+_73160403 0.525 ENSMUST00000006104.3
P2rx5
purinergic receptor P2X, ligand-gated ion channel, 5
chr2_-_39065438 0.521 ENSMUST00000112850.2
Golga1
golgi autoantigen, golgin subfamily a, 1
chr16_+_43235856 0.470 ENSMUST00000146708.1
Zbtb20
zinc finger and BTB domain containing 20
chr7_-_126704736 0.469 ENSMUST00000131415.1
Coro1a
coronin, actin binding protein 1A
chr5_-_24447587 0.432 ENSMUST00000127194.1
ENSMUST00000115033.1
ENSMUST00000123167.1
ENSMUST00000030799.8
Tmub1



transmembrane and ubiquitin-like domain containing 1



chr2_-_156180135 0.426 ENSMUST00000126992.1
ENSMUST00000146288.1
ENSMUST00000029149.6
ENSMUST00000109587.2
ENSMUST00000109584.1
Rbm39




RNA binding motif protein 39




chr11_+_120232921 0.424 ENSMUST00000122148.1
ENSMUST00000044985.7
Bahcc1

BAH domain and coiled-coil containing 1

chr5_+_129096740 0.422 ENSMUST00000056617.7
ENSMUST00000156437.1
Gpr133

G protein-coupled receptor 133

chr1_-_52800371 0.404 ENSMUST00000159725.1
Inpp1
inositol polyphosphate-1-phosphatase
chr10_+_61175206 0.399 ENSMUST00000079235.5
Tbata
thymus, brain and testes associated
chr18_+_74216118 0.380 ENSMUST00000025444.6
Cxxc1
CXXC finger 1 (PHD domain)
chr10_-_25200110 0.373 ENSMUST00000100012.2
Akap7
A kinase (PRKA) anchor protein 7
chr9_+_78175898 0.353 ENSMUST00000180974.1
C920006O11Rik
RIKEN cDNA C920006O11 gene
chr2_-_80128834 0.346 ENSMUST00000102654.4
ENSMUST00000102655.3
Pde1a

phosphodiesterase 1A, calmodulin-dependent

chr16_-_17722879 0.302 ENSMUST00000080936.6
ENSMUST00000012259.7
Med15

mediator complex subunit 15

chr17_-_6827990 0.292 ENSMUST00000181895.1
Gm2885
predicted gene 2885
chr5_-_66618752 0.211 ENSMUST00000162366.1
Apbb2
amyloid beta (A4) precursor protein-binding, family B, member 2
chr7_-_126704816 0.203 ENSMUST00000032949.7
Coro1a
coronin, actin binding protein 1A
chr17_+_35126316 0.133 ENSMUST00000061859.6
D17H6S53E
DNA segment, Chr 17, human D6S53E
chr2_+_21367532 0.100 ENSMUST00000055946.7
Gpr158
G protein-coupled receptor 158
chr10_+_80142358 0.089 ENSMUST00000105366.1
Atp5d
ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
chr9_-_88719798 0.070 ENSMUST00000113110.3
Gm2382
predicted gene 2382
chr5_+_123076275 0.069 ENSMUST00000067505.8
ENSMUST00000111619.3
ENSMUST00000160344.1
Tmem120b


transmembrane protein 120B


chr8_+_4243264 0.068 ENSMUST00000110996.1
Map2k7
mitogen-activated protein kinase kinase 7
chr14_-_16249675 0.061 ENSMUST00000022311.4
Oxsm
3-oxoacyl-ACP synthase, mitochondrial
chr8_+_94838321 0.045 ENSMUST00000034234.8
ENSMUST00000159871.1
Coq9

coenzyme Q9 homolog (yeast)

chr6_-_113501818 0.026 ENSMUST00000101059.1
Prrt3
proline-rich transmembrane protein 3
chr13_+_108046411 0.019 ENSMUST00000095458.4
Smim15
small integral membrane protein 15
chr18_+_55057557 0.005 ENSMUST00000181765.1
Gm4221
predicted gene 4221
chr15_-_76918010 0.002 ENSMUST00000048854.7
Zfp647
zinc finger protein 647

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.4 GO:2000297 negative regulation of synapse maturation(GO:2000297)
1.6 6.4 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
1.3 5.1 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.9 4.5 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.6 1.9 GO:1900365 positive regulation of mRNA polyadenylation(GO:1900365)
0.4 5.4 GO:0070914 UV-damage excision repair(GO:0070914)
0.4 1.5 GO:1903288 regulation of potassium ion import(GO:1903286) positive regulation of potassium ion import(GO:1903288)
0.3 1.0 GO:0032240 RNA import into nucleus(GO:0006404) mRNA export from nucleus in response to heat stress(GO:0031990) negative regulation of nucleobase-containing compound transport(GO:0032240) negative regulation of RNA export from nucleus(GO:0046832)
0.3 3.1 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.3 5.9 GO:0021860 pyramidal neuron development(GO:0021860)
0.3 1.0 GO:0043696 dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697)
0.3 1.7 GO:2000304 positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.2 1.2 GO:0030205 dermatan sulfate metabolic process(GO:0030205)
0.2 1.8 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.2 1.3 GO:0032796 uropod organization(GO:0032796)
0.2 2.3 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.2 2.2 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.2 1.4 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.1 11.4 GO:0021766 hippocampus development(GO:0021766)
0.1 1.4 GO:0030836 positive regulation of actin filament depolymerization(GO:0030836)
0.1 1.5 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.1 0.6 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.1 0.5 GO:0042701 progesterone secretion(GO:0042701)
0.1 1.2 GO:0000042 protein targeting to Golgi(GO:0000042)
0.1 2.1 GO:0097352 autophagosome maturation(GO:0097352)
0.1 1.1 GO:0072010 renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.1 0.5 GO:0043416 regulation of skeletal muscle tissue regeneration(GO:0043416)
0.1 0.4 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261) positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.1 0.7 GO:2000291 regulation of myoblast proliferation(GO:2000291)
0.0 1.2 GO:0070734 histone H3-K27 methylation(GO:0070734)
0.0 1.7 GO:0072661 protein targeting to plasma membrane(GO:0072661)
0.0 0.4 GO:0031507 heterochromatin assembly(GO:0031507)
0.0 0.9 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.0 1.0 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 4.9 GO:0007050 cell cycle arrest(GO:0007050)
0.0 0.4 GO:0046855 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855)
0.0 0.6 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.0 3.1 GO:1900006 positive regulation of dendrite development(GO:1900006)
0.0 0.6 GO:0015813 L-glutamate transport(GO:0015813)
0.0 1.5 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 1.3 GO:0010508 autophagosome assembly(GO:0000045) positive regulation of autophagy(GO:0010508)
0.0 3.5 GO:0043523 regulation of neuron apoptotic process(GO:0043523)
0.0 0.1 GO:0051790 short-chain fatty acid biosynthetic process(GO:0051790)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 5.9 GO:0097441 basilar dendrite(GO:0097441)
0.3 4.5 GO:0042588 zymogen granule(GO:0042588)
0.2 3.1 GO:0042788 polysomal ribosome(GO:0042788)
0.2 11.4 GO:0045171 intercellular bridge(GO:0045171)
0.2 1.5 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.2 1.0 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.2 3.4 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.2 5.4 GO:0000788 nuclear nucleosome(GO:0000788)
0.2 1.7 GO:0000137 Golgi cis cisterna(GO:0000137)
0.1 4.1 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 2.1 GO:0031430 M band(GO:0031430)
0.1 1.4 GO:0070938 contractile ring(GO:0070938)
0.1 2.2 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 2.1 GO:0000421 autophagosome membrane(GO:0000421)
0.1 0.6 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 1.0 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 1.3 GO:0001891 phagocytic cup(GO:0001891)
0.0 1.7 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 1.8 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 5.3 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 3.1 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.4 GO:0005677 chromatin silencing complex(GO:0005677)
0.0 0.5 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.4 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 1.3 GO:0005776 autophagosome(GO:0005776)
0.0 1.3 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 1.0 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.9 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.2 10.7 GO:0070888 E-box binding(GO:0070888)
0.2 3.4 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.2 1.3 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.2 1.7 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.2 1.0 GO:0070840 dynein complex binding(GO:0070840)
0.2 1.2 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.2 4.5 GO:0031489 myosin V binding(GO:0031489)
0.1 1.5 GO:0008556 sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556)
0.1 1.3 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 1.8 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 3.6 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 4.8 GO:0001540 beta-amyloid binding(GO:0001540)
0.1 3.1 GO:0017091 AU-rich element binding(GO:0017091)
0.1 3.5 GO:0017022 myosin binding(GO:0017022)
0.1 0.4 GO:0004441 inositol-1,4-bisphosphate 1-phosphatase activity(GO:0004441)
0.1 0.5 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 1.2 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.1 1.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 0.6 GO:0004383 guanylate cyclase activity(GO:0004383)
0.1 1.7 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 6.0 GO:0030674 protein binding, bridging(GO:0030674)
0.0 2.1 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.6 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.0 0.4 GO:0045322 unmethylated CpG binding(GO:0045322)
0.0 2.7 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 1.0 GO:0030332 cyclin binding(GO:0030332)
0.0 0.4 GO:0034237 AMP binding(GO:0016208) protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.1 GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity(GO:0004315)
0.0 2.9 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 1.4 GO:0031072 heat shock protein binding(GO:0031072)
0.0 0.5 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 11.8 GO:0043565 sequence-specific DNA binding(GO:0043565)