Motif ID: Bhlhe40

Z-value: 0.533


Transcription factors associated with Bhlhe40:

Gene SymbolEntrez IDGene Name
Bhlhe40 ENSMUSG00000030103.5 Bhlhe40

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Bhlhe40mm10_v2_chr6_+_108660616_108660682-0.531.5e-03Click!


Activity profile for motif Bhlhe40.

activity profile for motif Bhlhe40


Sorted Z-values histogram for motif Bhlhe40

Sorted Z-values for motif Bhlhe40



Network of associatons between targets according to the STRING database.



First level regulatory network of Bhlhe40

PNG image of the network

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Top targets:


Showing 1 to 20 of 98 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_148039097 3.798 ENSMUST00000141283.1
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr4_+_148039035 3.113 ENSMUST00000097788.4
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr19_-_4201591 1.871 ENSMUST00000025740.6
 Rad9a
RAD9 homolog A
chrX_-_7188713 1.561 ENSMUST00000004428.7
 Clcn5
chloride channel 5
chr2_+_30286406 1.538 ENSMUST00000138666.1
ENSMUST00000113634.2
 Nup188

nucleoporin 188

chr2_+_30286383 1.404 ENSMUST00000064447.5
 Nup188
nucleoporin 188
chr4_-_137048695 1.258 ENSMUST00000049583.7
 Zbtb40
zinc finger and BTB domain containing 40
chr17_-_12769605 1.159 ENSMUST00000024599.7
 Igf2r
insulin-like growth factor 2 receptor
chr11_-_75348261 1.155 ENSMUST00000000767.5
ENSMUST00000092907.5
 Rpa1

replication protein A1

chr1_+_166254095 0.977 ENSMUST00000111416.1
 Ildr2
immunoglobulin-like domain containing receptor 2
chr3_+_85574109 0.919 ENSMUST00000127348.1
ENSMUST00000107672.1
ENSMUST00000107674.1
 Pet112


PET112 homolog (S. cerevisiae)


chrX_-_134600976 0.874 ENSMUST00000033621.6
 Gla
galactosidase, alpha
chr3_-_96727453 0.866 ENSMUST00000141377.1
ENSMUST00000125183.1
 Polr3c

polymerase (RNA) III (DNA directed) polypeptide C

chr12_-_79296266 0.854 ENSMUST00000021547.6
 Zfyve26
zinc finger, FYVE domain containing 26
chr3_-_90052463 0.842 ENSMUST00000029553.9
ENSMUST00000064639.8
ENSMUST00000090908.6
 Ubap2l


ubiquitin associated protein 2-like


chr8_+_111033890 0.820 ENSMUST00000034441.7
 Aars
alanyl-tRNA synthetase
chr12_-_3426700 0.818 ENSMUST00000180149.1
 1110002L01Rik
RIKEN cDNA 1110002L01 gene
chr3_-_96727566 0.778 ENSMUST00000029741.2
 Polr3c
polymerase (RNA) III (DNA directed) polypeptide C
chrX_+_136270253 0.768 ENSMUST00000178632.1
ENSMUST00000053540.4
 Ngfrap1

nerve growth factor receptor (TNFRSF16) associated protein 1

chr3_-_96727436 0.762 ENSMUST00000154679.1
 Polr3c
polymerase (RNA) III (DNA directed) polypeptide C

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 6.9 GO:0070829 heterochromatin maintenance(GO:0070829)
0.0 2.9 GO:0006405 RNA export from nucleus(GO:0006405)
0.1 2.4 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 2.1 GO:0048873 homeostasis of number of cells within a tissue(GO:0048873)
0.2 1.9 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.0 1.4 GO:0032526 response to retinoic acid(GO:0032526)
0.0 1.3 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.2 1.1 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.0 1.1 GO:0097178 ruffle assembly(GO:0097178)
0.1 1.0 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.9 GO:0000725 double-strand break repair via homologous recombination(GO:0000724) recombinational repair(GO:0000725)
0.3 0.8 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.1 0.8 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.2 0.7 GO:0010845 positive regulation of reciprocal meiotic recombination(GO:0010845)
0.2 0.7 GO:0072429 response to cell cycle checkpoint signaling(GO:0072396) response to DNA integrity checkpoint signaling(GO:0072402) response to DNA damage checkpoint signaling(GO:0072423) response to intra-S DNA damage checkpoint signaling(GO:0072429)
0.2 0.7 GO:0046032 ADP catabolic process(GO:0046032)
0.1 0.7 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.7 GO:0033363 secretory granule organization(GO:0033363) 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0 0.7 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.0 0.7 GO:0015804 neutral amino acid transport(GO:0015804)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 2.9 GO:0044611 nuclear pore inner ring(GO:0044611)
0.1 2.4 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.3 1.9 GO:0030896 checkpoint clamp complex(GO:0030896)
0.1 1.2 GO:0000800 lateral element(GO:0000800)
0.1 1.2 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 1.1 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.8 GO:0031519 PcG protein complex(GO:0031519)
0.1 0.7 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.1 0.7 GO:0033503 HULC complex(GO:0033503)
0.1 0.7 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.7 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.7 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.1 0.4 GO:0032280 symmetric synapse(GO:0032280)
0.1 0.4 GO:0033263 CORVET complex(GO:0033263)
0.0 0.4 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.3 GO:0097422 tubular endosome(GO:0097422)
0.0 0.3 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.1 0.2 GO:0043202 lysosomal lumen(GO:0043202)
0.0 0.2 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0 0.1 GO:1990037 Lewy body core(GO:1990037)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 6.9 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.1 2.9 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 2.4 GO:0001056 RNA polymerase III activity(GO:0001056)
0.5 1.9 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.1 1.3 GO:0005123 death receptor binding(GO:0005123)
0.1 1.2 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 1.2 GO:0003684 damaged DNA binding(GO:0003684)
0.1 1.1 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0 1.0 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 0.9 GO:0016936 galactoside binding(GO:0016936)
0.0 0.9 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.3 0.8 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.1 0.8 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 0.7 GO:0001069 regulatory region RNA binding(GO:0001069)
0.1 0.7 GO:0047631 adenosine-diphosphatase activity(GO:0043262) ADP-ribose diphosphatase activity(GO:0047631)
0.0 0.7 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.7 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.7 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 0.7 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.2 0.6 GO:0008311 double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311)