Motif ID: Clock

Z-value: 0.440


Transcription factors associated with Clock:

Gene SymbolEntrez IDGene Name
Clock ENSMUSG00000029238.8 Clock

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Clockmm10_v2_chr5_-_76304474_763045480.441.1e-02Click!


Activity profile for motif Clock.

activity profile for motif Clock


Sorted Z-values histogram for motif Clock

Sorted Z-values for motif Clock



Network of associatons between targets according to the STRING database.



First level regulatory network of Clock

PNG image of the network

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Top targets:


Showing 1 to 20 of 132 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_186705980 2.671 ENSMUST00000045288.8
Tgfb2
transforming growth factor, beta 2
chr12_-_90738438 2.503 ENSMUST00000082432.3
Dio2
deiodinase, iodothyronine, type II
chr15_+_81811414 1.705 ENSMUST00000023024.7
Tef
thyrotroph embryonic factor
chr19_+_4510472 1.658 ENSMUST00000068004.6
Pcx
pyruvate carboxylase
chr11_-_55033398 1.424 ENSMUST00000108883.3
ENSMUST00000102727.2
Anxa6

annexin A6

chr15_-_44788016 1.271 ENSMUST00000090057.4
ENSMUST00000110269.1
Sybu

syntabulin (syntaxin-interacting)

chr16_-_45158566 1.182 ENSMUST00000181177.1
Slc35a5
solute carrier family 35, member A5
chr12_+_16653470 1.169 ENSMUST00000111064.1
Ntsr2
neurotensin receptor 2
chr16_-_45158650 1.114 ENSMUST00000023344.3
Slc35a5
solute carrier family 35, member A5
chr16_-_45158624 1.058 ENSMUST00000180636.1
Slc35a5
solute carrier family 35, member A5
chr6_+_108660616 1.045 ENSMUST00000032194.4
Bhlhe40
basic helix-loop-helix family, member e40
chr16_-_45158453 1.041 ENSMUST00000181750.1
Slc35a5
solute carrier family 35, member A5
chr4_-_82705735 1.008 ENSMUST00000155821.1
Nfib
nuclear factor I/B
chr11_-_101785252 0.969 ENSMUST00000164750.1
ENSMUST00000107176.1
ENSMUST00000017868.6
Etv4


ets variant gene 4 (E1A enhancer binding protein, E1AF)


chrX_+_36328353 0.945 ENSMUST00000016383.3
Lonrf3
LON peptidase N-terminal domain and ring finger 3
chr4_+_97777780 0.908 ENSMUST00000107062.2
ENSMUST00000052018.5
ENSMUST00000107057.1
Nfia


nuclear factor I/A


chr16_-_45158183 0.885 ENSMUST00000114600.1
Slc35a5
solute carrier family 35, member A5
chr4_+_129960760 0.880 ENSMUST00000139884.1
1700003M07Rik
RIKEN cDNA 1700003M07 gene
chr5_-_74702891 0.868 ENSMUST00000117388.1
Lnx1
ligand of numb-protein X 1
chr7_-_25658726 0.867 ENSMUST00000071329.6
Bckdha
branched chain ketoacid dehydrogenase E1, alpha polypeptide

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.2 GO:0008643 carbohydrate transport(GO:0008643)
0.1 3.6 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.9 2.7 GO:0048818 positive regulation of hair follicle maturation(GO:0048818) positive regulation of catagen(GO:0051795) regulation of epithelial to mesenchymal transition involved in endocardial cushion formation(GO:1905005)
0.5 2.5 GO:0070460 thyroid-stimulating hormone secretion(GO:0070460)
0.6 1.7 GO:0019074 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
0.1 1.4 GO:0051560 mitochondrial calcium ion homeostasis(GO:0051560)
0.0 1.3 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.0 1.2 GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway(GO:0007200)
0.1 1.1 GO:0097186 amelogenesis(GO:0097186)
0.3 1.0 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.2 1.0 GO:0033600 negative regulation of mammary gland epithelial cell proliferation(GO:0033600) regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.1 0.9 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.3 0.8 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.2 0.8 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 0.8 GO:0033690 positive regulation of osteoblast proliferation(GO:0033690)
0.2 0.7 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) negative regulation of interleukin-10 secretion(GO:2001180)
0.2 0.7 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.2 0.7 GO:0042373 vitamin K metabolic process(GO:0042373)
0.0 0.7 GO:0060074 synapse maturation(GO:0060074)
0.0 0.7 GO:0051443 positive regulation of ubiquitin-protein transferase activity(GO:0051443)

Gene overrepresentation in cellular_component category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.2 GO:0000139 Golgi membrane(GO:0000139)
0.0 2.3 GO:0005604 basement membrane(GO:0005604)
0.0 1.4 GO:0031902 late endosome membrane(GO:0031902)
0.2 1.3 GO:0097433 dense body(GO:0097433)
0.0 1.0 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.2 0.9 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.2 0.8 GO:0043259 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259)
0.0 0.8 GO:0005581 collagen trimer(GO:0005581)
0.2 0.7 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.2 0.6 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.2 0.6 GO:0016012 sarcoglycan complex(GO:0016012)
0.1 0.5 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.5 GO:0005797 Golgi medial cisterna(GO:0005797)
0.0 0.5 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.4 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.3 GO:0071564 npBAF complex(GO:0071564)
0.1 0.2 GO:0005899 insulin receptor complex(GO:0005899)
0.1 0.2 GO:0031084 BLOC-2 complex(GO:0031084)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.3 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.7 2.7 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.3 1.8 GO:0043426 MRF binding(GO:0043426)
0.3 1.7 GO:0009374 biotin binding(GO:0009374)
0.0 1.6 GO:0030332 cyclin binding(GO:0030332)
0.0 1.4 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 1.3 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 1.2 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.2 1.1 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 1.0 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 0.9 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.1 0.9 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.0 0.9 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 0.8 GO:0043208 glycosphingolipid binding(GO:0043208)
0.0 0.8 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.8 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.2 0.7 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.7 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1 0.6 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.6 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)