Motif ID: Creb3

Z-value: 0.755


Transcription factors associated with Creb3:

Gene SymbolEntrez IDGene Name
Creb3 ENSMUSG00000028466.9 Creb3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Creb3mm10_v2_chr4_+_43562672_43562947-0.654.5e-05Click!


Activity profile for motif Creb3.

activity profile for motif Creb3


Sorted Z-values histogram for motif Creb3

Sorted Z-values for motif Creb3



Network of associatons between targets according to the STRING database.



First level regulatory network of Creb3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_144939823 3.421 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr7_+_128523576 3.140 ENSMUST00000033136.7
 Bag3
BCL2-associated athanogene 3
chr9_-_20976762 2.858 ENSMUST00000054197.5
 S1pr2
sphingosine-1-phosphate receptor 2
chr11_-_94653964 2.571 ENSMUST00000039949.4
 Eme1
essential meiotic endonuclease 1 homolog 1 (S. pombe)
chr7_-_45092130 2.531 ENSMUST00000148175.1
 Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr4_-_134012381 2.493 ENSMUST00000176113.1
 Lin28a
lin-28 homolog A (C. elegans)
chr13_-_38528412 2.255 ENSMUST00000035988.8
 Txndc5
thioredoxin domain containing 5
chr2_-_105399286 2.168 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1
chr17_+_35439155 2.144 ENSMUST00000071951.6
ENSMUST00000078205.7
ENSMUST00000116598.3
ENSMUST00000076256.7
 H2-Q7



histocompatibility 2, Q region locus 7



chr15_+_79516396 2.010 ENSMUST00000010974.7
 Kdelr3
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
chr9_-_32541589 1.912 ENSMUST00000016231.7
 Fli1
Friend leukemia integration 1
chr15_+_6386598 1.896 ENSMUST00000080880.5
ENSMUST00000110664.2
ENSMUST00000110663.2
ENSMUST00000161812.1
ENSMUST00000160134.1
 Dab2




disabled 2, mitogen-responsive phosphoprotein




chr3_-_36571952 1.878 ENSMUST00000029270.3
 Ccna2
cyclin A2
chr4_+_3938888 1.877 ENSMUST00000121110.1
ENSMUST00000108386.1
ENSMUST00000149544.1
 Chchd7


coiled-coil-helix-coiled-coil-helix domain containing 7


chr18_+_84720019 1.864 ENSMUST00000161429.1
ENSMUST00000052501.1
 Fam69c

family with sequence similarity 69, member C

chr7_-_45091713 1.785 ENSMUST00000141576.1
 Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr3_+_116878227 1.779 ENSMUST00000040260.6
 Frrs1
ferric-chelate reductase 1
chr10_-_84533884 1.696 ENSMUST00000053871.3
 Ckap4
cytoskeleton-associated protein 4
chrX_+_153139941 1.688 ENSMUST00000039720.4
ENSMUST00000144175.2
 Rragb

Ras-related GTP binding B

chr5_+_120431770 1.683 ENSMUST00000031591.7
 Lhx5
LIM homeobox protein 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 115 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.9 GO:0010664 negative regulation of striated muscle cell apoptotic process(GO:0010664)
0.0 3.8 GO:0032526 response to retinoic acid(GO:0032526)
0.5 3.4 GO:0006621 protein retention in ER lumen(GO:0006621)
0.5 3.4 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
1.0 2.9 GO:1901552 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.2 2.9 GO:0006613 cotranslational protein targeting to membrane(GO:0006613)
0.5 2.6 GO:0072429 response to cell cycle checkpoint signaling(GO:0072396) response to DNA integrity checkpoint signaling(GO:0072402) response to DNA damage checkpoint signaling(GO:0072423) response to intra-S DNA damage checkpoint signaling(GO:0072429)
0.3 2.5 GO:1901724 positive regulation of cell proliferation involved in kidney development(GO:1901724)
0.3 2.4 GO:1903298 regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903297) negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903298)
0.1 2.3 GO:0043277 apoptotic cell clearance(GO:0043277)
0.3 2.1 GO:0070561 vitamin D receptor signaling pathway(GO:0070561)
0.1 2.1 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.1 2.0 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.4 1.9 GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
0.1 1.9 GO:0035855 megakaryocyte development(GO:0035855)
0.0 1.9 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 1.9 GO:0048146 positive regulation of fibroblast proliferation(GO:0048146)
0.2 1.7 GO:0021937 cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation(GO:0021937)
0.1 1.7 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.0 1.7 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.9 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 3.3 GO:0005811 lipid particle(GO:0005811)
0.2 3.2 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 3.1 GO:0030018 Z disc(GO:0030018)
0.1 2.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.5 2.6 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.0 2.5 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.3 2.1 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.2 2.1 GO:0042612 MHC class I protein complex(GO:0042612)
0.2 2.1 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.2 2.0 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.5 1.9 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.3 1.9 GO:0001940 male pronucleus(GO:0001940)
0.0 1.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.3 1.7 GO:1990131 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.1 1.7 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.3 1.6 GO:0030870 Mre11 complex(GO:0030870)
0.2 1.6 GO:0000800 lateral element(GO:0000800)
0.0 1.6 GO:0035371 microtubule plus-end(GO:0035371)
0.4 1.3 GO:0043527 tRNA methyltransferase complex(GO:0043527)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 93 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.0 GO:0005509 calcium ion binding(GO:0005509)
0.9 3.4 GO:0046923 ER retention sequence binding(GO:0046923)
0.2 3.4 GO:0070064 proline-rich region binding(GO:0070064)
0.5 3.1 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.4 2.9 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 2.9 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 2.6 GO:0004519 endonuclease activity(GO:0004519)
0.0 2.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 2.5 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1 2.5 GO:0035198 miRNA binding(GO:0035198)
0.1 2.3 GO:0019789 SUMO transferase activity(GO:0019789)
0.2 2.1 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.2 2.1 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.3 2.0 GO:0008312 7S RNA binding(GO:0008312)
0.2 1.9 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 1.9 GO:0020037 heme binding(GO:0020037)
0.4 1.8 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.2 1.7 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.2 1.6 GO:0000150 recombinase activity(GO:0000150)
0.2 1.6 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)