Motif ID: Dlx1

Z-value: 1.198


Transcription factors associated with Dlx1:

Gene SymbolEntrez IDGene Name
Dlx1 ENSMUSG00000041911.3 Dlx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dlx1mm10_v2_chr2_+_71529085_715291100.402.0e-02Click!


Activity profile for motif Dlx1.

activity profile for motif Dlx1


Sorted Z-values histogram for motif Dlx1

Sorted Z-values for motif Dlx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Dlx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_8710409 7.081 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_-_8710734 6.957 ENSMUST00000005493.7
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr5_-_70842617 5.866 ENSMUST00000031119.1
 Gabrg1
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
chr12_+_84069325 5.847 ENSMUST00000046422.4
ENSMUST00000072505.4
 Acot5

acyl-CoA thioesterase 5

chr15_-_37458523 5.342 ENSMUST00000116445.2
 Ncald
neurocalcin delta
chr18_-_10706688 5.132 ENSMUST00000002549.7
ENSMUST00000117726.1
ENSMUST00000117828.1
 Abhd3


abhydrolase domain containing 3


chr19_-_19001099 5.123 ENSMUST00000040153.8
ENSMUST00000112828.1
 Rorb

RAR-related orphan receptor beta

chr5_-_92278155 4.981 ENSMUST00000159345.1
ENSMUST00000113102.3
 Naaa

N-acylethanolamine acid amidase

chr14_+_118787894 4.882 ENSMUST00000047761.6
ENSMUST00000071546.7
 Cldn10

claudin 10

chr5_-_62765618 4.746 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr18_+_23415400 4.468 ENSMUST00000115832.2
ENSMUST00000047954.7
 Dtna

dystrobrevin alpha

chr10_-_8886033 4.385 ENSMUST00000015449.5
 Sash1
SAM and SH3 domain containing 1
chr4_+_102570065 4.174 ENSMUST00000097950.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr4_+_102589687 4.007 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chr14_+_118854695 3.912 ENSMUST00000100314.3
 Cldn10
claudin 10
chr6_+_145934113 3.838 ENSMUST00000032383.7
 Sspn
sarcospan
chr9_+_94669876 3.833 ENSMUST00000033463.9
 Slc9a9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr8_+_94172618 3.757 ENSMUST00000034214.6
 Mt2
metallothionein 2
chr5_-_62766153 3.734 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr6_-_124779686 3.667 ENSMUST00000147669.1
ENSMUST00000128697.1
ENSMUST00000032218.3
ENSMUST00000112475.2
 Lrrc23



leucine rich repeat containing 23




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 148 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.5 14.0 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.1 8.3 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.6 8.2 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 6.2 GO:0030032 lamellipodium assembly(GO:0030032)
0.2 6.1 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.2 5.9 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
1.5 5.8 GO:0032788 saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789)
0.9 5.1 GO:0042670 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.1 5.1 GO:0046470 phosphatidylcholine metabolic process(GO:0046470)
1.2 4.7 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
1.5 4.4 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.5 3.8 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.5 3.8 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.7 3.5 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
1.1 3.4 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
1.1 3.3 GO:0097212 lysosomal membrane organization(GO:0097212)
0.2 3.3 GO:0003417 growth plate cartilage development(GO:0003417)
0.3 3.2 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
1.0 3.0 GO:1904395 retinal rod cell differentiation(GO:0060221) regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904393) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.0 2.8 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 14.0 GO:0043205 fibril(GO:0043205)
0.5 8.3 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.4 8.2 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 7.3 GO:0005923 bicellular tight junction(GO:0005923)
0.0 7.0 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.3 6.1 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 5.9 GO:0031594 neuromuscular junction(GO:0031594)
0.0 4.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 3.4 GO:0008021 synaptic vesicle(GO:0008021)
0.0 3.4 GO:0016323 basolateral plasma membrane(GO:0016323)
0.8 3.3 GO:0005594 collagen type IX trimer(GO:0005594)
0.0 3.2 GO:0005802 trans-Golgi network(GO:0005802)
0.0 2.9 GO:0005811 lipid particle(GO:0005811)
0.1 2.8 GO:0043034 costamere(GO:0043034)
0.1 2.6 GO:0030673 axolemma(GO:0030673)
0.0 2.6 GO:0043198 dendritic shaft(GO:0043198)
0.1 2.5 GO:0005856 cytoskeleton(GO:0005856)
0.0 2.5 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 2.5 GO:0005911 cell-cell junction(GO:0005911)
0.6 2.4 GO:0019815 B cell receptor complex(GO:0019815)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 113 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.3 16.6 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.2 10.8 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.3 8.9 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 8.9 GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982)
0.0 8.3 GO:0005096 GTPase activator activity(GO:0005096)
0.2 8.2 GO:0043015 cAMP binding(GO:0030552) gamma-tubulin binding(GO:0043015)
0.3 6.1 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 5.2 GO:0030165 PDZ domain binding(GO:0030165)
1.7 5.1 GO:0052740 phosphatidylserine 1-acylhydrolase activity(GO:0052739) 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
1.7 5.1 GO:0008502 melatonin receptor activity(GO:0008502)
0.2 5.0 GO:0043747 protein-N-terminal asparagine amidohydrolase activity(GO:0008418) UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity(GO:0008759) iprodione amidohydrolase activity(GO:0018748) (3,5-dichlorophenylurea)acetate amidohydrolase activity(GO:0018749) 4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity(GO:0034571) didemethylisoproturon amidohydrolase activity(GO:0034573) N-isopropylacetanilide amidohydrolase activity(GO:0034576) N-cyclohexylformamide amidohydrolase activity(GO:0034781) isonicotinic acid hydrazide hydrolase activity(GO:0034876) cis-aconitamide amidase activity(GO:0034882) gamma-N-formylaminovinylacetate hydrolase activity(GO:0034885) N2-acetyl-L-lysine deacetylase activity(GO:0043747) O-succinylbenzoate synthase activity(GO:0043748) indoleacetamide hydrolase activity(GO:0043864) N-acetylcitrulline deacetylase activity(GO:0043909) N-acetylgalactosamine-6-phosphate deacetylase activity(GO:0047419) diacetylchitobiose deacetylase activity(GO:0052773) chitooligosaccharide deacetylase activity(GO:0052790)
0.2 4.7 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 4.4 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.5 3.8 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0 3.6 GO:0008168 methyltransferase activity(GO:0008168)
0.9 3.5 GO:0038049 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.4 3.4 GO:0042609 CD4 receptor binding(GO:0042609)
0.2 3.3 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.2 3.2 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
1.0 3.0 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)